Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0055 | 0.1488 | 1 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0055 | 0.1488 | 0.3516 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.2218 | 0.5135 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0851 | 0.0916 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.2218 | 0.5135 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0084 | 0.2664 | 0.7582 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0851 | 0.0916 |
Schistosoma mansoni | cytochrome P450 | 0.0055 | 0.1488 | 0.2148 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0055 | 0.1488 | 0.3516 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0851 | 0.0851 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0055 | 0.1488 | 0.4236 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0851 | 0.2421 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0055 | 0.1488 | 0.0721 |
Schistosoma mansoni | hypothetical protein | 0.0187 | 0.6929 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.2218 | 0.5135 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.057 | 0.6706 |
Brugia malayi | Cytochrome P450 family protein | 0.0084 | 0.2664 | 0.2868 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0055 | 0.1488 | 0.0721 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0055 | 0.1488 | 0.0721 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0055 | 0.1488 | 0.0721 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0055 | 0.1488 | 0.3516 |
Brugia malayi | Cytochrome P450 family protein | 0.0055 | 0.1488 | 0.1602 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.0055 | 0.1488 | 0.3516 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0055 | 0.1488 | 0.4236 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0055 | 0.1488 | 0.0721 |
Onchocerca volvulus | 0.0033 | 0.057 | 0.057 | |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0851 | 0.0916 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0254 | 0.9688 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0055 | 0.1488 | 0.0721 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0851 | 0.2421 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0055 | 0.1488 | 0.0721 |
Trypanosoma brucei | cytochrome P450, putative | 0.0084 | 0.2664 | 0.6809 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0851 | 0.0851 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0851 | 0.0916 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.2218 | 0.5135 |
Giardia lamblia | Kinase, PLK | 0.0104 | 0.3513 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0055 | 0.1488 | 0.4236 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0104 | 0.3513 | 0.3513 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0055 | 0.1488 | 0.3516 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.052 | 0.0751 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0055 | 0.1488 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0055 | 0.1488 | 0.0721 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.2218 | 0.5135 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0073 | 0.2218 | 0.6313 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0055 | 0.1488 | 0.0721 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0104 | 0.3513 | 0.3782 |
Toxoplasma gondii | ABC1 family protein | 0.004 | 0.0851 | 0.5716 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.0055 | 0.1488 | 0.3516 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0073 | 0.2218 | 0.6313 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0055 | 0.1488 | 0.0721 |
Brugia malayi | cytochrome P450 | 0.0055 | 0.1488 | 0.1602 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0851 | 0.0851 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0055 | 0.1488 | 0.0721 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0244 | 0.9288 | 1 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0055 | 0.1488 | 0.3516 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0055 | 0.1488 | 0.4236 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0055 | 0.1488 | 0.0721 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.057 | 0.0823 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0851 | 0.1228 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0104 | 0.3513 | 0.3782 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.0851 | 1 |
Leishmania major | cathepsin L-like protease | 0.0073 | 0.2218 | 0.6313 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0084 | 0.2664 | 0.7582 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0851 | 0.0916 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0851 | 0.0916 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0084 | 0.2664 | 0.2868 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0104 | 0.3513 | 0.3513 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0851 | 0.0851 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0066 | 0.1957 | 0.557 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0851 | 0.1228 |
Schistosoma mansoni | kinase | 0.0053 | 0.1397 | 0.2017 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.057 | 0.0823 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0851 | 0.0916 |
Loa Loa (eye worm) | cytochrome P450 | 0.0055 | 0.1488 | 0.1602 |
Brugia malayi | Cytochrome P450 family protein | 0.0084 | 0.2664 | 0.2868 |
Leishmania major | cathepsin L-like protease | 0.0073 | 0.2218 | 0.6313 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.2218 | 0.5135 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0104 | 0.3513 | 0.3513 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0052 | 0.1341 | 0.1341 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0055 | 0.1488 | 0.0721 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0055 | 0.1488 | 0.3516 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0055 | 0.1488 | 0.0721 |
Mycobacterium leprae | putative cytochrome p450 | 0.0055 | 0.1488 | 1 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0055 | 0.1488 | 0.3516 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0851 | 0.0916 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0182 | 0.6728 | 0.7244 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0055 | 0.1488 | 0.0721 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0033 | 0.057 | 0.0823 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0055 | 0.1488 | 0.3516 |
Echinococcus granulosus | geminin | 0.0187 | 0.6929 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0229 | 0.869 | 0.9356 |
Schistosoma mansoni | hypothetical protein | 0.0187 | 0.6929 | 1 |
Echinococcus multilocularis | geminin | 0.0187 | 0.6929 | 1 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0055 | 0.1488 | 0.3516 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0055 | 0.1488 | 0.4236 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0055 | 0.1488 | 0.0721 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0851 | 0.1228 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0851 | 0.0851 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0104 | 0.3513 | 0.507 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.0055 | 0.1488 | 0.3516 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0055 | 0.1488 | 0.3516 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.057 | 0.0614 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0055 | 0.1488 | 0.3516 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0055 | 0.1488 | 0.3516 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.057 | 0.0823 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0104 | 0.3513 | 0.3513 |
Onchocerca volvulus | 0.004 | 0.0851 | 0.0851 | |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0104 | 0.3513 | 0.3513 |
Onchocerca volvulus | 0.004 | 0.0851 | 0.0851 | |
Leishmania major | cytochrome p450-like protein | 0.0084 | 0.2664 | 0.7582 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0104 | 0.3513 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0851 | 0.0916 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0104 | 0.3513 | 0.507 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0055 | 0.1488 | 0.2394 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.1488 | 0.2148 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0851 | 0.0916 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.057 | 0.3833 |
Brugia malayi | follicle stimulating hormone receptor | 0.0244 | 0.9288 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0851 | 0.0916 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0055 | 0.1488 | 0.0721 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0104 | 0.3513 | 0.507 |
Brugia malayi | Cytochrome P450 family protein | 0.0182 | 0.6728 | 0.7244 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0084 | 0.2664 | 0.2868 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0057 | 0.1574 | 0.4481 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0055 | 0.1488 | 0.3516 |
Trypanosoma brucei | polo-like protein kinase | 0.0104 | 0.3513 | 1 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0851 | 0.2421 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0851 | 0.1228 |
Leishmania major | cytochrome p450-like protein | 0.0055 | 0.1488 | 0.4236 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0104 | 0.3513 | 1 |
Onchocerca volvulus | 0.004 | 0.0851 | 0.0851 | |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0055 | 0.1488 | 0.3516 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0104 | 0.3513 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.2218 | 0.5135 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0084 | 0.2664 | 0.2868 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.057 | 0.0823 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.2218 | 0.5135 |
Brugia malayi | Pre-SET motif family protein | 0.0229 | 0.869 | 0.9356 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0073 | 0.2218 | 0.6313 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0052 | 0.1341 | 0.1341 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.2218 | 0.5135 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.2218 | 0.5135 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0073 | 0.2218 | 0.6313 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.057 | 0.0823 |
Trichomonas vaginalis | esterase, putative | 0.004 | 0.0851 | 0.0851 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0386 | 0.0416 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0055 | 0.1488 | 0.2148 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0055 | 0.1488 | 0.3516 |
Brugia malayi | beta-lactamase | 0.004 | 0.0851 | 0.0916 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0104 | 0.3513 | 0.3513 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.057 | 0.0614 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0055 | 0.1488 | 0.3516 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.057 | 0.0823 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0104 | 0.3513 | 0.3513 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0084 | 0.2664 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.2218 | 0.5135 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0104 | 0.3513 | 1 |
Echinococcus multilocularis | 0.0055 | 0.1488 | 0.2148 | |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0055 | 0.1488 | 0.0721 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0104 | 0.3513 | 0.3513 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0055 | 0.1488 | 0.0721 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0055 | 0.1488 | 0.0721 |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0055 | 0.1488 | 0.3516 |
Leishmania major | cathepsin L-like protease | 0.0073 | 0.2218 | 0.6313 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 0.01 % | Stability in 50% human serum assessed as amount of parent drug released from cattle bone meal powder over 24 hrs | ChEMBL. | 18834106 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.