Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0949 | 0.3363 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0681 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0419 | 0.042 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0334 | 0.1183 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0334 | 0.1183 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.1217 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0014 | 0.0182 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1134 | 0.1136 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.0419 | 0.4752 |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 0.0681 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.0377 | 0.3905 |
Brugia malayi | hypothetical protein | 0.0014 | 0.0182 | 0.0182 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0334 | 0.0335 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0027 | 0.0681 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0014 | 0.0182 | 0.0643 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0334 | 0.0335 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0034 | 0.0949 | 0.0951 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0134 | 0.4864 | 0.4872 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0334 | 0.0335 |
Onchocerca volvulus | 0.0054 | 0.1753 | 0.16 | |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0182 | 0.0182 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0034 | 0.0949 | 0.3363 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0266 | 0.9982 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.2824 | 0.2829 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.0377 | 0.3905 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0334 | 0.0335 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0681 | 0.0682 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0949 | 0.3363 |
Plasmodium falciparum | acyl-CoA synthetase | 0.002 | 0.0419 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0027 | 0.0681 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0334 | 0.1183 |
Brugia malayi | Pre-SET motif family protein | 0.0034 | 0.0949 | 0.0951 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0681 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0134 | 0.4864 | 0.4872 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0681 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0681 | 1 |
Brugia malayi | hypothetical protein | 0.004 | 0.1217 | 0.1219 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0681 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.2824 | 0.2829 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0182 | 0.0182 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.0419 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.2824 | 0.2829 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0014 | 0.0182 | 0.0643 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0034 | 0.0949 | 0.0951 |
Schistosoma mansoni | acetylcholinesterase | 0.0014 | 0.0182 | 0.0643 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0034 | 0.0949 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.1824 | 0.1827 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.1824 | 0.1827 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0334 | 0.0335 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0419 | 0.042 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 0.2824 | 0.2829 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.2824 | 0.2829 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0334 | 0.0335 |
Onchocerca volvulus | 0.0027 | 0.0681 | 0.0509 | |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0949 | 0.0951 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0034 | 0.0949 | 0.0951 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.0377 | 0.3905 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0266 | 0.9982 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0681 | 0.0682 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0134 | 0.4864 | 0.4872 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.2824 | 0.2829 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0901 | 0.0903 |
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 0.2824 | 0.2829 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.1217 | 1 |
Brugia malayi | hypothetical protein | 0.0266 | 0.9982 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0182 | 0.0182 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0014 | 0.0182 | 0.0182 |
Brugia malayi | Carboxylesterase family protein | 0.0014 | 0.0182 | 0.0182 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0014 | 0.0182 | 0.0182 |
Onchocerca volvulus | 0.0034 | 0.0949 | 0.0782 | |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0182 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0182 | 0.0182 |
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 0.2824 | 0.2829 |
Echinococcus multilocularis | neuroligin | 0.0014 | 0.0182 | 0.0182 |
Loa Loa (eye worm) | carboxylesterase | 0.0014 | 0.0182 | 0.0182 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.1217 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0014 | 0.0182 | 0.0643 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.1217 | 0.1219 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0681 | 0.0682 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0681 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0027 | 0.0681 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0014 | 0.0182 | 0.0182 |
Brugia malayi | Carboxylesterase family protein | 0.0014 | 0.0182 | 0.0182 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0014 | 0.0182 | 0.0643 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.1217 | 0.4311 |
Brugia malayi | Carboxylesterase family protein | 0.0014 | 0.0182 | 0.0182 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0334 | 0.0335 |
Schistosoma mansoni | survival motor neuron protein | 0.0054 | 0.1753 | 0.6208 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.0377 | 0.3905 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0681 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0681 | 0.0682 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0014 | 0.0182 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.9982 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0681 | 0.0682 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0681 | 0.0682 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0334 | 0.0335 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0334 | 0.0335 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.2824 | 0.2829 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1134 | 0.4017 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0054 | 0.1753 | 0.1756 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0014 | 0.0182 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0182 | 0.0182 |
Echinococcus granulosus | neuroligin | 0.0014 | 0.0182 | 0.0182 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0014 | 0.0182 | 0.0182 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0027 | 0.0681 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.002 | 0.0419 | 0.4752 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0027 | 0.0681 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0419 | 0.042 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0419 | 0.042 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.1134 | 0.1136 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0182 | 0.0182 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.2824 | 0.2829 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.1217 | 0.4311 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 0.2824 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.1217 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0234 | 0.8743 | 0.8758 |
Schistosoma mansoni | gliotactin | 0.0014 | 0.0182 | 0.0643 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.1217 | 0.1219 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0334 | 0.0335 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0014 | 0.0182 | 0.0643 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0334 | 0.1183 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0419 | 0.042 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0234 | 0.8743 | 0.8758 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0681 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0949 | 0.3363 |
Plasmodium vivax | SET domain protein, putative | 0.0034 | 0.0949 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 0.2824 | 0.2829 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0027 | 0.0681 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0014 | 0.0182 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.2824 | 0.2829 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.1753 | 0.6208 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.1824 | 0.1827 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1824 | 0.1827 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of horse serum BuChE upto 500 uM by Ellman's method | ChEMBL. | 17574306 | |
IC50 (binding) | = 34.96 uM | Inhibition of Electrophorus electricus AChE by Ellman's method | ChEMBL. | 17574306 |
Inhibition (binding) | Inhibition of mushroom tyrosinase at 200 uM | ChEMBL. | 19800229 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.