TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 472.6 | Formula: C28H33FN6
H donors: 1 H acceptors: 3 LogP: 6.07 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCN1CCC(CC1)c1ccn2c(c1)nc(c2c1ccnc(n1)N)c1ccc(cc1)F
InChi: 1S/C28H33FN6/c1-2-3-4-5-15-34-16-11-20(12-17-34)22-13-18-35-25(19-22)33-26(21-6-8-23(29)9-7-21)27(35)24-10-14-31-28(30)32-24/h6-10,13-14,18-20H,2-5,11-12,15-17H2,1H3,(H2,30,31,32)
InChiKey: PLHOVKDRPXOFDW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Eimeria tenella	cGMP-dependent protein kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	expressed conserved protein	Get druggable targets OG5_127599	All targets in OG5_127599
Plasmodium knowlesi	cGMP-dependent protein kinase, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Plasmodium berghei	cGMP-dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus multilocularis	cGMP dependent protein kinase 1	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	cGMP-dependent protein kinase, isozyme 1, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus granulosus	cGMP dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	cGMP-dependent protein kinase, isozyme 1, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	cGMP-dependent protein kinase 2, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Theileria parva	cGMP-dependent protein kinase, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Babesia bovis	cGMP dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Cryptosporidium hominis	cGMP-dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	cGMP-dependent protein kinase, isozyme 1, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus granulosus	cGMP dependent protein kinase 1	Get druggable targets OG5_127599	All targets in OG5_127599
Brugia malayi	Egg laying defective protein 4	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127599	All targets in OG5_127599
Loa Loa (eye worm)	AGC/PKG protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Cryptosporidium parvum	cyclic nucleotide (cGMP)-dependent protein kinase with 3 cNMP binding domains and a Ser/Thr kinase domain	Get druggable targets OG5_127599	All targets in OG5_127599
Plasmodium falciparum	cGMP-dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus multilocularis	cGMP dependent protein kinase 1	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	ko:K07376 protein kinase, cGMP-dependent, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus granulosus	cGMP dependent protein kinase 1	Get druggable targets OG5_127599	All targets in OG5_127599
Neospora caninum	AGC kinase TgPKG1, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Plasmodium yoelii	cGMP-dependent protein kinase-related	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	ko:K07376 protein kinase, cGMP-dependent, putative	Get druggable targets OG5_127599	All targets in OG5_127599

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0109	0.1401	0.1904
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0107	0.1376	0.187
Echinococcus granulosus	dna polymerase kappa	0.002	0.0078	0.0073
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.068	0.4638
Echinococcus granulosus	zinc finger protein	0.0019	0.0063	0.0051
Onchocerca volvulus		0.0107	0.1376	0.395
Echinococcus granulosus	dna polymerase eta	0.002	0.0078	0.0073
Brugia malayi	beta-lactamase	0.0107	0.1376	0.3927
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0107	0.1376	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0107	0.1376	1
Echinococcus granulosus	geminin	0.05	0.7248	1
Echinococcus granulosus	mothers against decapentaplegic 5	0.0017	0.0029	0.0004
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0078	0.0569
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0078	0.0569
Mycobacterium leprae	Probable lipase LipE	0.0107	0.1376	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0107	0.1376	1
Echinococcus granulosus	tumor protein p63	0.0367	0.5266	0.7256
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0042	0.04	0.2906
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0064	0.073	0.0975
Loa Loa (eye worm)	MH1 domain-containing protein	0.0017	0.0029	0.0009
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0017	0.0029	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0338	0.0902
Mycobacterium tuberculosis	Probable hydrolase	0.0107	0.1376	0.1308
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0078	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1376	0.3903
Trypanosoma brucei	hypothetical protein, conserved	0.0107	0.1376	1
Schistosoma mansoni	Smad4	0.0017	0.0029	0.004
Echinococcus multilocularis	smad	0.0017	0.0029	0.0004
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0078	0.0569
Leishmania major	hypothetical protein, conserved	0.0024	0.0142	0.103
Mycobacterium ulcerans	lipase LipD	0.0107	0.1376	1
Brugia malayi	MH1 domain containing protein	0.0017	0.0029	0.0048
Brugia malayi	MH2 domain containing protein	0.0017	0.0029	0.0048
Toxoplasma gondii	aldehyde dehydrogenase	0.006	0.068	0.4363
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1376	0.3903
Echinococcus granulosus	Smad4	0.0017	0.0029	0.0004
Loa Loa (eye worm)	MH2 domain-containing protein	0.0017	0.0029	0.0009
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0058	0.065	0.0865
Echinococcus granulosus	cGMP dependent protein kinase	0.0064	0.073	0.0975
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0078	0.0569
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0042	0.04	0.0518
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0078	0.0569
Plasmodium vivax	hypothetical protein, conserved	0.0107	0.1376	1
Entamoeba histolytica	hypothetical protein	0.0109	0.1401	1
Schistosoma mansoni	smad1 5 8 and	0.0017	0.0029	0.004
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0078	0.0569
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0078	0.0191
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0189	0.2596	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0078	0.0569
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0058	0.065	0.0865
Mycobacterium ulcerans	hypothetical protein	0.0107	0.1376	1
Schistosoma mansoni	serine/threonine protein kinase	0.0064	0.073	0.1007
Entamoeba histolytica	hypothetical protein	0.0109	0.1401	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.0142	0.103
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0142	0.103
Mycobacterium ulcerans	hypothetical protein	0.0063	0.0724	0.4975
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1376	0.3903
Echinococcus multilocularis	expressed conserved protein	0.0064	0.073	0.0975
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.1125	0.1522
Schistosoma mansoni	cellular tumor antigen P53	0.0054	0.058	0.08
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0017	0.0029	0.004
Onchocerca volvulus		0.0107	0.1376	0.395
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.1125	0.1552
Echinococcus multilocularis	dna polymerase eta	0.002	0.0078	0.0073
Brugia malayi	MH2 domain containing protein	0.0248	0.3486	1
Brugia malayi	MH1 domain containing protein	0.0017	0.0029	0.0048
Entamoeba histolytica	hypothetical protein	0.0109	0.1401	1
Trypanosoma brucei	DNA polymerase eta, putative	0.002	0.0078	0.0569
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.002	0.0078	0.0569
Echinococcus multilocularis	Smad4	0.0017	0.0029	0.0004
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0042	0.04	0.1116
Brugia malayi	hypothetical protein	0.0109	0.1401	0.3999
Brugia malayi	N-terminal motif family protein	0.0189	0.2596	0.744
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0078	0.0569
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0107	0.1376	0.1899
Loa Loa (eye worm)	bromodomain containing protein	0.0017	0.0035	0.0026
Brugia malayi	beta-lactamase family protein	0.0107	0.1376	0.3927
Echinococcus multilocularis	geminin	0.05	0.7248	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0042	0.04	0.2477
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.04	0.2477
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1376	0.3903
Onchocerca volvulus		0.0107	0.1376	0.395
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1376	0.3903
Plasmodium falciparum	cGMP-dependent protein kinase	0.0064	0.073	1
Mycobacterium tuberculosis	Conserved protein	0.0107	0.1376	0.1308
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0109	0.1401	0.1904
Mycobacterium tuberculosis	Conserved protein	0.0107	0.1376	0.1308
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0042	0.04	0.0518
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.002	0.0078	0.0073
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0042	0.04	0.2906
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.068	0.4638
Loa Loa (eye worm)	hypothetical protein	0.0042	0.04	0.1081
Entamoeba histolytica	hypothetical protein	0.0109	0.1401	1
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.002	0.0078	0.0152
Schistosoma mansoni	smad1 5 8 and	0.0017	0.0029	0.004
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0017	0.0029	0.0004
Mycobacterium tuberculosis	Conserved protein	0.0107	0.1376	0.1308
Mycobacterium ulcerans	esterase/lipase LipP	0.0107	0.1376	1
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.068	0.0939
Brugia malayi	hypothetical protein	0.0024	0.0142	0.0373
Brugia malayi	beta-lactamase family protein	0.0107	0.1376	0.3927
Trypanosoma brucei	unspecified product	0.002	0.0078	0.0569
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.068	0.0906
Echinococcus multilocularis	tumor protein p63	0.0367	0.5266	0.7256
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0107	0.1376	0.1308
Schistosoma mansoni	hypothetical protein	0.05	0.7248	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0078	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0042	0.04	0.1083
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0026	0.0035
Loa Loa (eye worm)	hypothetical protein	0.002	0.0078	0.0152
Echinococcus granulosus	fetal alzheimer antigen falz	0.0022	0.0106	0.0111
Loa Loa (eye worm)	beta-lactamase	0.0107	0.1376	0.3903
Trichomonas vaginalis	D-aminoacylase, putative	0.0107	0.1376	1
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.002	0.0078	0.0073
Trypanosoma cruzi	DNA polymerase eta, putative	0.002	0.0078	0.0569
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.002	0.0078	0.0108
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0302	0.0383
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0107	0.1376	0.1308
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0078	0.0151
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0064	0.073	0.0975
Trypanosoma cruzi	hypothetical protein, conserved	0.0107	0.1376	1
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0042	0.04	0.2906
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0026	0.0035
Toxoplasma gondii	ABC1 family protein	0.0107	0.1376	1
Schistosoma mansoni	terminal deoxycytidyl transferase	0.002	0.0078	0.0108
Schistosoma mansoni	DNA polymerase eta	0.002	0.0078	0.0108
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0042	0.04	0.2477
Loa Loa (eye worm)	hypothetical protein	0.0054	0.058	0.1601
Schistosoma mansoni	hypothetical protein	0.05	0.7248	1
Loa Loa (eye worm)	hypothetical protein	0.0189	0.2596	0.743
Trichomonas vaginalis	esterase, putative	0.0107	0.1376	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.1125	0.1552
Trichomonas vaginalis	D-aminoacylase, putative	0.0107	0.1376	1
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0064	0.073	0.0975
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0107	0.1376	0.1899
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0142	0.0335
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0042	0.04	0.2906
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0064	0.073	0.2034
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0042	0.04	0.0518
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0078	0.0569
Echinococcus multilocularis	ubiquitin specific protease 41	0.0042	0.04	0.0518
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.068	0.0906
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0026	0.0035
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.1125	0.1522
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1376	0.3903
Loa Loa (eye worm)	MH2 domain-containing protein	0.0248	0.3486	1
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0064	0.073	0.4762
Echinococcus granulosus	smad	0.0017	0.0029	0.0004
Echinococcus multilocularis	zinc finger protein	0.0019	0.0063	0.0051
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0078	0.0569
Schistosoma mansoni	smad	0.0017	0.0029	0.004
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0078	0.0569
Schistosoma mansoni	zinc finger protein	0.0019	0.0063	0.0086
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0078	0.0569
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0142	0.103
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0811	0.2271
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0042	0.04	0.0552
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0078	0.0569
Echinococcus granulosus	beta LACTamase domain containing family member	0.0107	0.1376	0.187
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0064	0.073	0.0975
Brugia malayi	Smad1	0.0017	0.0029	0.0048
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0078	0.0191
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0107	0.1376	0.1308
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0022	0.0106	0.0111
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.006	0.068	0.4943
Mycobacterium leprae	conserved hypothetical protein	0.0107	0.1376	0.5
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0022	0.0106	0.0146
Schistosoma mansoni	hypothetical protein	0.0109	0.1401	0.1933
Brugia malayi	PHD-finger family protein	0.0024	0.0141	0.037
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.006	0.068	0.0607
Schistosoma mansoni	serine/threonine protein kinase	0.0064	0.073	0.1007
Trichomonas vaginalis	penicillin-binding protein, putative	0.0107	0.1376	1
Mycobacterium ulcerans	beta-lactamase	0.0107	0.1376	1
Echinococcus granulosus	ubiquitin specific protease 41	0.0042	0.04	0.0518
Schistosoma mansoni	bromodomain containing protein	0.0062	0.0703	0.0969
Loa Loa (eye worm)	transcription factor SMAD2	0.0248	0.3486	1
Echinococcus multilocularis	dna polymerase kappa	0.002	0.0078	0.0073
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0042	0.04	0.2431
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0017	0.0029	0.0004
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0078	0.0569
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0026	0.0035
Leishmania major	DNA polymerase kappa, putative	0.002	0.0078	0.0569
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.1125	0.1522
Mycobacterium tuberculosis	Probable lipase LipD	0.0107	0.1376	0.1308
Schistosoma mansoni	hypothetical protein	0.002	0.0078	0.0108
Trichomonas vaginalis	D-aminoacylase, putative	0.0107	0.1376	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0302	0.0383
Mycobacterium tuberculosis	Probable esterase LipL	0.0107	0.1376	0.1308
Leishmania major	DNA polymerase eta, putative	0.002	0.0078	0.0569
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.1125	0.1552
Loa Loa (eye worm)	hypothetical protein	0.004	0.0372	0.1002
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0078	0.0569
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0107	0.1376	0.3927
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0042	0.04	1
Schistosoma mansoni	smad1 5 8 and	0.0017	0.0029	0.004
Brugia malayi	Bromodomain containing protein	0.0037	0.0337	0.0935
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0042	0.04	0.0518
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0107	0.1376	0.3903
Brugia malayi	Egg laying defective protein 4	0.0064	0.073	0.2066
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.068	0.0939
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.1125	0.1522
Mycobacterium tuberculosis	Probable lipase LipE	0.0107	0.1376	0.1308
Schistosoma mansoni	transcription factor LCR-F1	0.0109	0.1401	0.1933
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.009	0.1125	0.3176
Brugia malayi	MH2 domain containing protein	0.0017	0.0029	0.0048
Loa Loa (eye worm)	Smad1	0.0017	0.0029	0.0009
Brugia malayi	Bromodomain containing protein	0.0073	0.0874	0.2482
Leishmania major	hypothetical protein, conserved	0.0107	0.1376	1
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0042	0.04	0.0552
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.068	0.4638
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.009	0.1125	0.3203

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.13 nM	Inhibition of Eimeria tenella cGMP-dependent protein kinase	ChEMBL.	17981367

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL498759

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1184031