Detailed information for compound 1184125

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 455.573 | Formula: C23H29N5O3S
  • H donors: 1 H acceptors: 2 LogP: 2.15 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c1CCN(Cc1s2)C
  • InChi: 1S/C23H29N5O3S/c1-25-8-7-16-19(15-25)32-21-20(16)22(29)28(23(30)24-21)14-11-26-9-12-27(13-10-26)17-5-3-4-6-18(17)31-2/h3-6H,7-15H2,1-2H3,(H,24,30)
  • InChiKey: NSBHHQLLSIAEMH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni transcription factor btf3 0.0037 0.0256 0.0284
Onchocerca volvulus Heterochromatin protein 1 homolog 0.008 0.0775 0.1195
Echinococcus granulosus intermediate filament protein 0.0028 0.0154 0.0162
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0377 0.0428
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.083 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0087 0.0848 0.1323
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0101 0.0037
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.2688 0.3191
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0377 0.0359
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0135 0.0306
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0181 0.0162
Brugia malayi jmjC domain containing protein 0.0099 0.0995 0.1964
Brugia malayi Bromodomain containing protein 0.0045 0.036 0.0711
Plasmodium falciparum phd finger protein, putative 0.003 0.0181 0.1996
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0085 0.083 1
Brugia malayi Bromodomain containing protein 0.0085 0.0833 0.1645
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0086 0.0177
Leishmania major importin beta-1 subunit, putative 0.0024 0.0106 0.0229
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0382 0.0533
Loa Loa (eye worm) hypothetical protein 0.0023 0.0101 0.0199
Schistosoma mansoni lamin 0.0028 0.0154 0.0162
Loa Loa (eye worm) hypothetical protein 0.0085 0.083 0.1639
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0086 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0256 0.0312
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.216 0.3673
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0023 0.0101 0.1012
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0386 0.0964
Brugia malayi Importin beta-1 subunit 0.003 0.0172 0.034
Schistosoma mansoni smad1 5 8 and 0.0017 0.0026 0.0009
Onchocerca volvulus 0.05 0.5744 1
Brugia malayi chromobox protein homolog 3 0.008 0.0775 0.1531
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.044 0.0504
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0261 0.2912 0.2899
Schistosoma mansoni importin beta-1 0.003 0.0172 0.0183
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0106 0.0229
Onchocerca volvulus Glucosylceramidase homolog 0.0197 0.216 0.3649
Leishmania major basic transcription factor 3a, putative 0.0037 0.0256 0.0624
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0256 0.0238
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0048 0.0386 0.0998
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.216 0.3673
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0106 0.0046
Echinococcus granulosus histone lysine methyltransferase setb 0.0082 0.0789 0.0921
Schistosoma mansoni zinc finger protein 0.0025 0.0119 0.012
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0087 0.085 0.1678
Echinococcus granulosus snurportin 1 0.0315 0.3552 0.4224
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.044 0.1139
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0101 0.0037
Trichomonas vaginalis glucosylceramidase, putative 0.0301 0.3386 0.5836
Loa Loa (eye worm) hypothetical protein 0.0052 0.0436 0.0861
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.044 0.1106
Brugia malayi VAB-10A protein 0.0037 0.026 0.0514
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0086 0.0214
Brugia malayi Pre-SET motif family protein 0.0063 0.0569 0.1123
Brugia malayi hypothetical protein 0.0026 0.0135 0.0267
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0106 0.0046
Entamoeba histolytica hypothetical protein 0.0038 0.0269 0.8313
Schistosoma mansoni hypothetical protein 0.0023 0.0101 0.0098
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0154 0.0304
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.0995 0.0978
Brugia malayi RNA, U transporter 1 0.0084 0.0816 0.1611
Brugia malayi Protein cec-1. 0.0023 0.0101 0.0199
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.216 0.3673
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0101 0.0037
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0086 0.0011
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0026 0.0007
Entamoeba histolytica hypothetical protein 0.0023 0.0101 0.0925
Brugia malayi MH2 domain containing protein 0.0252 0.2807 0.5543
Loa Loa (eye worm) spectraplakin 0.0037 0.026 0.0514
Loa Loa (eye worm) hypothetical protein 0.0037 0.026 0.0514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0377 0.0359
Brugia malayi jmjC domain containing protein 0.0039 0.028 0.0554
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0382 0.0434
Loa Loa (eye worm) MH2 domain-containing protein 0.0252 0.2807 0.5543
Loa Loa (eye worm) hypothetical protein 0.0023 0.0101 0.0199
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0131 0.1368 0.1352
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0154 0.1651 0.1952
Schistosoma mansoni hypothetical protein 0.0084 0.0819 0.0957
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0181 0.0194
Toxoplasma gondii hypothetical protein 0.0055 0.0469 0.5549
Echinococcus granulosus Chromobox protein 3 0.0023 0.0101 0.0098
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.017 0.1862
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0086 0.017
Brugia malayi MH1 domain containing protein 0.0017 0.0026 0.0051
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0082 0.0789 0.0771
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0082 0.0789 0.0921
Echinococcus granulosus lamin 0.0028 0.0154 0.0162
Loa Loa (eye worm) hypothetical protein 0.0133 0.1401 0.2766
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0135 0.0306
Echinococcus multilocularis neuropeptide receptor A26 0.0485 0.5559 0.5551
Schistosoma mansoni hypothetical protein 0.0049 0.0407 0.0464
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0269 0.0299
Loa Loa (eye worm) ICD-1 protein 0.0037 0.0256 0.0506
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0082 0.0789 0.0921
Loa Loa (eye worm) hypothetical protein 0.0027 0.0148 0.0292
Echinococcus multilocularis snurportin 1 0.0315 0.3552 0.354
Schistosoma mansoni Smad4 0.0017 0.0026 0.0009
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0382 0.4476
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0135 0.1438
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0101 0.1012
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0172 0.189
Echinococcus multilocularis lamin dm0 0.0028 0.0154 0.0135
Trichomonas vaginalis glucosylceramidase, putative 0.0301 0.3386 0.5836
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0086 0.0214
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.044 0.5026 0.9923
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0085 0.083 0.0813
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0101 0.0925
Onchocerca volvulus 0.0087 0.0847 0.1322
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.008 0.0157
Giardia lamblia DINP protein human, muc B family 0.0022 0.0086 0.0175
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0172 0.0438
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0382 0.0533
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.216 0.3673
Loa Loa (eye worm) bromodomain containing protein 0.0023 0.0094 0.0186
Echinococcus granulosus dna polymerase eta 0.0022 0.0086 0.0081
Echinococcus granulosus importin subunit beta 1 0.003 0.0172 0.0183
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0307 0.3557
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.044 0.1106
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.044 0.0422
Brugia malayi Latrophilin receptor protein 2 0.0084 0.0819 0.1617
Schistosoma mansoni DNA polymerase eta 0.0022 0.0086 0.0081
Trichomonas vaginalis Heterochromatin protein, putative 0.0023 0.0101 0.0037
Echinococcus multilocularis Spectrin alpha actinin 0.0037 0.026 0.0242
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0386 0.0964
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.044 0.0636
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0339 0.383 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0086 0.0352
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0101 0.0037
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0101 0.0925
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0086 0.017
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0085 0.083 0.5
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0042 0.0028
Echinococcus granulosus tumor protein p63 0.0368 0.4176 0.497
Loa Loa (eye worm) hypothetical protein 0.0023 0.0101 0.0199
Entamoeba histolytica hypothetical protein 0.0038 0.0269 0.8313
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0086 0.0081
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0086 0.0011
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.083 0.4028
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.008 0.0061
Loa Loa (eye worm) apoptosis regulator protein 0.0087 0.085 0.1678
Loa Loa (eye worm) hypothetical protein 0.0054 0.046 0.0908
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.008 0.0197
Plasmodium vivax importin-beta 2, putative 0.003 0.0172 0.189
Loa Loa (eye worm) Smad1 0.0017 0.0026 0.0051
Giardia lamblia PHD finger protein 15 0.003 0.0181 0.2799
Mycobacterium tuberculosis Conserved hypothetical protein 0.0178 0.1933 1
Schistosoma mansoni hypothetical protein 0.0017 0.002 0.0001
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0026 0.0009
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0569 0.6781
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0172 0.0438
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0086 0.0214
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0086 0.0177
Entamoeba histolytica hypothetical protein 0.0038 0.0269 0.8313
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0085 0.083 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0085 0.083 1
Leishmania major hypothetical protein, conserved 0.0026 0.0135 0.0306
Echinococcus multilocularis X box binding protein 1 0.0302 0.3397 0.3384
Brugia malayi PHD-finger family protein 0.003 0.0181 0.0357
Echinococcus granulosus peregrin 0.0037 0.0255 0.0283
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0256 0.0624
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0026 0.0125 0.0128
Schistosoma mansoni chromobox protein 0.0144 0.1522 0.1797
Brugia malayi CHD4 protein 0.0026 0.0125 0.0248
Trichomonas vaginalis chromobox protein, putative 0.0087 0.0848 0.1356
Loa Loa (eye worm) hypothetical protein 0.0042 0.0317 0.0626
Trichomonas vaginalis glucosylceramidase, putative 0.0301 0.3386 0.5836
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.083 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0301 0.3386 0.6685
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.083 0.4028
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0497 0.0737
Loa Loa (eye worm) hypothetical protein 0.0163 0.1747 0.345
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0023 0.0101 0.1012
Leishmania major GTP-binding protein, putative 0.0022 0.008 0.016
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0086 0.0214
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0056 0.0483 0.2425
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.0636 0.0618
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.044 0.0869
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.044 0.1106
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0377 0.0428
Schistosoma mansoni hypothetical protein 0.0084 0.0819 0.0957
Toxoplasma gondii hypothetical protein 0.0029 0.017 0.1862
Echinococcus granulosus Chromo domain 0.0023 0.0101 0.0098
Schistosoma mansoni intermediate filament proteins 0.0028 0.0154 0.0162
Echinococcus granulosus X box binding protein 1 0.0302 0.3397 0.4038
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.044 0.0504
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0101 0.0037
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0377 0.0744
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0101 0.0925
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0084 0.0819 0.0802
Trypanosoma brucei transcription factor BTF3, putative 0.0037 0.0256 0.0659
Trypanosoma cruzi kinetoplast DNA-associated protein, putative 0.0037 0.026 0.0634
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0101 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0086 0.0214
Schistosoma mansoni lamin 0.0028 0.0154 0.0162
Schistosoma mansoni hypothetical protein 0.0087 0.085 0.0994
Onchocerca volvulus Huntingtin homolog 0.0133 0.1401 0.2304
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0086 0.017
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.008 0.0753
Loa Loa (eye worm) hypothetical protein 0.0063 0.0569 0.1124
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0269 0.0299
Loa Loa (eye worm) hypothetical protein 0.0023 0.0101 0.0199
Schistosoma mansoni hypothetical protein 0.0022 0.0088 0.0084
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.0636 0.0738
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0026 0.0009
Loa Loa (eye worm) hypothetical protein 0.0084 0.0819 0.1617
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0497 0.0737
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0086 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0101 0.0037
Brugia malayi hypothetical protein 0.0038 0.0269 0.0531
Echinococcus multilocularis musashi 0.0028 0.0154 0.0135
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.0995 0.1167
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0026 0.0051
Schistosoma mansoni chromobox protein 0.0023 0.0101 0.0098
Trichomonas vaginalis glucosylceramidase, putative 0.0301 0.3386 0.5836
Brugia malayi M-phase phosphoprotein, mpp8 0.0023 0.0101 0.0199
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0266 0.2972 0.5867
Loa Loa (eye worm) latrophilin receptor protein 2 0.0084 0.0819 0.1617
Entamoeba histolytica hypothetical protein 0.0038 0.0269 0.8313
Brugia malayi MH2 domain containing protein 0.0017 0.0026 0.0051
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0023 0.0101 0.0082
Trichomonas vaginalis set domain proteins, putative 0.05 0.5744 1
Echinococcus granulosus Smad4 0.0017 0.0026 0.0009
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0026 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0086 0.0214
Trichomonas vaginalis glucosylceramidase, putative 0.0208 0.2286 0.3895
Toxoplasma gondii NAC domain-containing protein 0.0037 0.0256 0.2929
Plasmodium vivax heterochromatin protein 1, putative 0.0023 0.0101 0.1012
Schistosoma mansoni hypothetical protein 0.0302 0.3397 0.4038
Loa Loa (eye worm) CHromoDomain protein family member 0.0026 0.0125 0.0248
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0106 0.0046
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.216 0.3673
Plasmodium vivax basic transcription factor 3b, putative 0.0037 0.0256 0.2929
Echinococcus granulosus zinc finger protein 0.0025 0.0119 0.012
Leishmania major hypothetical protein, conserved 0.0017 0.002 0.0003
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0019 0.0037
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0569 0.0658
Echinococcus granulosus neuropeptide receptor A26 0.0485 0.5559 0.6624
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0101 0.0037
Brugia malayi latrophilin 2 splice variant baaae 0.0182 0.1975 0.39
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0086 0.0214
Trichomonas vaginalis hypothetical protein 0.0023 0.0101 0.0037
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.028 0.0313
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0026 0.0125 0.0128
Brugia malayi Associated with TFs and helicases family protein 0.0023 0.0101 0.0199
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0339 0.383 1
Schistosoma mansoni ran 0.0022 0.008 0.0073
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.216 0.3673
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0086 0.0068
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.008 0.0753
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0026 0.0051
Echinococcus multilocularis smad 0.0017 0.0026 0.0007
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0101 0.0098
Onchocerca volvulus 0.0063 0.0569 0.083
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0056 0.0483 0.4744
Echinococcus multilocularis Chromobox protein 3 0.0023 0.0101 0.0082
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0307 1
Schistosoma mansoni hypothetical protein 0.0084 0.0819 0.0957
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0088 0.0175
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0042 0.0028
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0154 0.0304
Brugia malayi Calcitonin receptor-like protein seb-1 0.0266 0.2972 0.5867
Echinococcus granulosus peptidase Clp S14 family 0.0056 0.0483 0.0555
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0382 0.4476
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0301 0.3386 0.6685
Loa Loa (eye worm) hypothetical protein 0.0023 0.0101 0.0199
Echinococcus multilocularis Smad4 0.0017 0.0026 0.0007
Brugia malayi SET domain containing protein 0.0026 0.0128 0.0253
Plasmodium vivax hypothetical protein, conserved 0.003 0.0181 0.1996
Plasmodium falciparum heterochromatin protein 1 0.0023 0.0101 0.1012
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0135 0.0343
Loa Loa (eye worm) hypothetical protein 0.0087 0.085 0.1678
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0113 0.0095
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0086 0.0277
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0181 0.1996
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0019 0.0037
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.016 0.1719 0.4483
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0026 0.0009
Trichomonas vaginalis chromobox protein, putative 0.0144 0.1522 0.2546
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0267
Schistosoma mansoni hypothetical protein 0.0182 0.1975 0.2339
Loa Loa (eye worm) hypothetical protein 0.005 0.0416 0.0822
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0086 0.0214
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0286 0.0267
Echinococcus multilocularis Chromo domain 0.0023 0.0101 0.0082
Schistosoma mansoni hypothetical protein 0.0087 0.085 0.0994
Echinococcus multilocularis GPCR, family 2 0.0084 0.0819 0.0802
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.044 0.5192
Brugia malayi hypothetical protein 0.0017 0.0024 0.0048
Echinococcus granulosus GPCR family 2 0.0084 0.0819 0.0957
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0086 0.0177
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0086 0.0177
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0026 0.0125 0.0107
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.044 1
Echinococcus multilocularis tumor protein p63 0.0368 0.4176 0.4165
Brugia malayi Pre-SET motif family protein 0.044 0.5026 0.9923
Echinococcus multilocularis muscleblind protein 1 0.0163 0.1747 0.1732
Loa Loa (eye worm) hypothetical protein 0.008 0.0775 0.1531
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.028 0.0313
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0087 0.085 0.0994
Entamoeba histolytica hypothetical protein 0.0023 0.0101 0.0925
Trypanosoma brucei ISWI complex protein 0.0017 0.002 0.004
Echinococcus multilocularis geminin 0.0373 0.4238 0.4227
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0569 0.0551
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0261 0.2912 0.3459
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0101 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0101 0.0037
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0269 0.0251
Schistosoma mansoni chromobox protein 0.0144 0.1522 0.1797
Plasmodium falciparum importin beta, putative 0.003 0.0172 0.189
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0113 0.0113
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0321 0.0361
Echinococcus multilocularis lamin 0.0028 0.0154 0.0135
Brugia malayi MH2 domain containing protein 0.0017 0.0026 0.0051
Entamoeba histolytica hypothetical protein 0.0024 0.0106 0.115
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0256 0.0312
Schistosoma mansoni hypothetical protein 0.0038 0.0269 0.0299
Echinococcus granulosus chromobox protein 1 0.0144 0.1522 0.1797
Echinococcus granulosus transcription factor btf3 0.0037 0.0256 0.0284
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0101 0.0037
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0087 0.085 0.0833
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0377 0.0428
Onchocerca volvulus 0.0049 0.0407 0.0543
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0087 0.085 0.0994
Schistosoma mansoni peptidase Clp (S14 family) 0.0085 0.083 0.097
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0541 0.0625
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.216 0.3673
Brugia malayi isocitrate dehydrogenase 0.0017 0.0019 0.0037
Echinococcus granulosus histone acetyltransferase KAT2B 0.0148 0.157 0.1855
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0256 0.0624
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.008 0.016
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0085 0.083 0.5
Brugia malayi Smad1 0.0017 0.0026 0.0051
Loa Loa (eye worm) hypothetical protein 0.0443 0.5065 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0101 0.0037
Onchocerca volvulus 0.0023 0.0101 0.000000055388
Echinococcus multilocularis muscleblind protein 0.0163 0.1747 0.1732
Loa Loa (eye worm) hypothetical protein 0.0023 0.0101 0.0199
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.044 0.1106
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0256 0.0312
Loa Loa (eye worm) hypothetical protein 0.003 0.0181 0.0357
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0086 0.0177
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0086 0.0352
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.044 0.0504
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0181 0.1996
Brugia malayi MH1 domain containing protein 0.0017 0.0026 0.0051
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0101 0.0037
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0101 0.0098
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0377 0.0428
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0101 0.0098
Schistosoma mansoni zinc finger protein 0.0017 0.002 0.0001
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0113 0.0113
Schistosoma mansoni hypothetical protein 0.003 0.0181 0.0194
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0101 0.0037
Loa Loa (eye worm) hypothetical protein 0.0163 0.1747 0.345
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.044 0.1106
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0019 0.0037
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0339 0.383 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0085 0.083 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0141 0.1492 0.1477
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.044 0.0636
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0086 0.0081
Echinococcus multilocularis microtubule associated protein 2 0.0723 0.8383 0.838
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0101 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0101 0.0037
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0101 0.0037
Trypanosoma cruzi ISWI complex protein 0.0017 0.002 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0086 0.0214
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0101 0.1012
Echinococcus granulosus smad 0.0017 0.0026 0.0009
Echinococcus multilocularis zinc finger protein 0.0025 0.0119 0.01
Brugia malayi Heterochromatin protein 1 0.0144 0.1522 0.3005
Echinococcus granulosus geminin 0.0373 0.4238 0.5044
Loa Loa (eye worm) helicase 0.0023 0.0101 0.0199
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.2688 0.2674
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0023 0.0101 0.0199
Echinococcus granulosus muscleblind protein 0.0163 0.1747 0.2067
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0135 0.1438
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0307 0.6318
Onchocerca volvulus Alhambra homolog 0.003 0.0181 0.0141
Trichomonas vaginalis glucosylceramidase, putative 0.0301 0.3386 0.5836
Loa Loa (eye worm) hypothetical protein 0.0022 0.0086 0.017
Leishmania major DNA polymerase eta, putative 0.0022 0.0086 0.0177
Schistosoma mansoni apoptosis regulator bax 0.0087 0.085 0.0994
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0087 0.085 0.0994
Loa Loa (eye worm) hypothetical protein 0.0028 0.0154 0.0304
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.028 0.0313
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0101 0.0037
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.028 0.0554
Onchocerca volvulus 0.0028 0.0154 0.0094
Schistosoma mansoni microtubule-associated protein tau 0.0723 0.8383 1
Brugia malayi MAP kinase sur-1 0.0052 0.044 0.0869
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0087 0.0847 0.099
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0181 0.0357
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0286 0.0319
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0084 0.0819 0.1617
Loa Loa (eye worm) hypothetical protein 0.003 0.0172 0.034
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.017 0.1862
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.046 0.0527
Trichomonas vaginalis glucosylceramidase, putative 0.0301 0.3386 0.5836
Echinococcus multilocularis dna polymerase eta 0.0022 0.0086 0.0068
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0058 0.0509 0.1288
Schistosoma mansoni hypothetical protein 0.0087 0.085 0.0994
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0086 0.0081
Schistosoma mansoni ran 0.0022 0.008 0.0073
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0315 0.3552 0.7013
Plasmodium falciparum basic transcription factor 3b, putative 0.0037 0.0256 0.2929
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0101 0.1012
Echinococcus multilocularis peptidase Clp (S14 family) 0.0056 0.0483 0.0465
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0377 0.0744
Echinococcus multilocularis peregrin 0.0037 0.0255 0.0237
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0101 0.0037
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.016 0.1719 0.4462
Loa Loa (eye worm) hypothetical protein 0.0023 0.0101 0.0199
Brugia malayi Probable ClpP-like protease 0.0085 0.083 0.1639
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.008 0.016
Trichomonas vaginalis chromobox protein, putative 0.0087 0.0848 0.1356
Brugia malayi Bromodomain containing protein 0.0037 0.0255 0.0504
Loa Loa (eye worm) hypothetical protein 0.0182 0.1975 0.39
Loa Loa (eye worm) heterochromatin protein 1 0.0144 0.1522 0.3005
Echinococcus granulosus chromobox protein 1 0.0144 0.1522 0.1797
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0085 0.083 0.097
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0377 0.0428
Schistosoma mansoni chromobox protein 0.0023 0.0101 0.0098
Onchocerca volvulus 0.0028 0.0154 0.0094
Trypanosoma brucei unspecified product 0.0022 0.0086 0.0214
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0562 0.1109
Echinococcus granulosus microtubule associated protein 2 0.0723 0.8383 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.008 0.0157
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.008 0.0073
Plasmodium vivax SET domain protein, putative 0.0063 0.0569 0.6781
Onchocerca volvulus Huntingtin homolog 0.0133 0.1401 0.2304
Echinococcus granulosus chromobox protein 2 0.0023 0.0101 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0101 0.0037
Brugia malayi PHD-finger family protein 0.0031 0.0188 0.037
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0056 0.0483 0.2425
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0019 0.0037
Trichomonas vaginalis glucosylceramidase, putative 0.0208 0.2286 0.3895
Echinococcus granulosus neuropeptide s receptor 0.0485 0.5559 0.6624
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.016 0.1719 0.4462
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.044 0.0636
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.044 0.0422
Schistosoma mansoni hypothetical protein 0.0373 0.4238 0.5044
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0086 0.0214
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0443 0.5065 1
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0754 0.0879
Loa Loa (eye worm) acetyltransferase 0.0154 0.1651 0.326
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.008 0.0753
Leishmania major mitochondrial DNA polymerase beta 0.0339 0.383 1
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0775 0.1228
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0042 0.0028
Loa Loa (eye worm) hypothetical protein 0.0077 0.0734 0.1449
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0086 0.0214
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0101 0.0037
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0131 0.1368 0.1614
Schistosoma mansoni smad1 5 8 and 0.0017 0.0026 0.0009
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0154 0.0304
Mycobacterium ulcerans hypothetical protein 0.0178 0.1933 1
Echinococcus granulosus Spectrin alpha actinin 0.0037 0.026 0.0289
Brugia malayi acetyltransferase, GNAT family protein 0.0154 0.1651 0.326
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0101 0.1012
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.044 0.1106
Trichomonas vaginalis chromobox protein, putative 0.0144 0.1522 0.2546
Loa Loa (eye worm) hypothetical protein 0.0082 0.0789 0.1557
Schistosoma mansoni smad1 5 8 and 0.0017 0.0026 0.0009
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0382 0.4476
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0101 0.0037
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0042 0.0024
Brugia malayi hypothetical protein 0.0133 0.1401 0.2766
Echinococcus multilocularis importin subunit beta 1 0.003 0.0172 0.0154
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0321 0.0303
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0181 0.0194
Schistosoma mansoni thyroid hormone receptor 0.0141 0.1492 0.1762
Loa Loa (eye worm) hypothetical protein 0.0048 0.0392 0.0773
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0101 0.0037
Entamoeba histolytica hypothetical protein 0.0023 0.0101 0.0925
Brugia malayi Valyl-tRNA synthetase 0.0023 0.0101 0.0199
Loa Loa (eye worm) transcription factor SMAD2 0.0252 0.2807 0.5543
Brugia malayi Muscleblind-like protein 0.0163 0.1747 0.345
Loa Loa (eye worm) hypothetical protein 0.0133 0.1401 0.2766
Schistosoma mansoni hypothetical protein 0.0037 0.026 0.0289
Entamoeba histolytica hypothetical protein 0.0037 0.0256 0.776
Echinococcus multilocularis chromobox protein 1 0.0144 0.1522 0.1506
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0086 0.0177
Brugia malayi Growth-Arrest-Specific Protein 2 Domain containing protein 0.0037 0.026 0.0514
Trypanosoma cruzi ISWI complex protein 0.0017 0.002 0.0003
Brugia malayi intermediate filament protein 0.0028 0.0154 0.0304
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0101 0.0037
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0085 0.083 0.5
Echinococcus granulosus lamin dm0 0.0028 0.0154 0.0162
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0101 0.1012
Trypanosoma brucei protein kinase, putative 0.0052 0.044 0.1139
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0086 0.0214
Entamoeba histolytica transcription factor BTF3, putative 0.0037 0.0256 0.776
Brugia malayi hypothetical protein 0.0242 0.2688 0.5306
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0087 0.085 0.0833
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0048 0.0386 0.0964
Schistosoma mansoni hypothetical protein 0.0315 0.3552 0.4224
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0135 0.1438
Schistosoma mansoni smad 0.0017 0.0026 0.0009
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0154 0.1651 0.1636
Onchocerca volvulus 0.0054 0.046 0.0636
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0407 0.0804
Echinococcus multilocularis chromobox protein 2 0.0023 0.0101 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0775 0.1228
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0135 0.1438
Echinococcus multilocularis chromobox protein 1 0.0144 0.1522 0.1506
Schistosoma mansoni bromodomain containing protein 0.0073 0.0682 0.0793
Schistosoma mansoni hypothetical protein 0.0037 0.026 0.0289
Loa Loa (eye worm) hypothetical protein 0.0242 0.2688 0.5306
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0084 0.0819 0.0957
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.044 0.0636
Echinococcus multilocularis neuropeptide s receptor 0.0485 0.5559 0.5551
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0101 0.0037
Brugia malayi beta-NAC-like protein 0.0037 0.0256 0.0506
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0023 0.0101 0.0098
Schistosoma mansoni thyroid hormone receptor 0.0141 0.1492 0.1762
Echinococcus multilocularis transcription factor btf3 0.0037 0.0256 0.0238
Leishmania major DNA polymerase kappa, putative 0.0022 0.0086 0.0177
Schistosoma mansoni survival motor neuron protein 0.0049 0.0407 0.0464
Schistosoma mansoni hypothetical protein 0.0084 0.0819 0.0957
Schistosoma mansoni hypothetical protein 0.0373 0.4238 0.5044
Schistosoma mansoni hypothetical protein 0.0131 0.1368 0.1614
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0086 0.0214
Echinococcus granulosus dna polymerase kappa 0.0022 0.0086 0.0081
Brugia malayi hypothetical protein 0.0023 0.0101 0.0199

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 65 % Antagonist activity at 5HT2A receptor in Sprague-Dawley rat assessed as inhibition of 5HT-induced pulmonary arterial pressure at 100 uM relative to 5HT ChEMBL. 20149493

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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