Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1489 | 0.1489 |
Leishmania major | importin beta-1 subunit, putative | 0.0027 | 0.0496 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0678 | 0.0678 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.1243 | 0.1243 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0038 | 0.082 | 0.1323 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1489 | 0.1489 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0033 | 0.0678 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.1243 | 0.1243 |
Brugia malayi | Importin beta-1 subunit | 0.0033 | 0.0678 | 0.1094 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.1243 | 0.1243 |
Plasmodium vivax | importin-beta 2, putative | 0.0033 | 0.0678 | 0.5 |
Brugia malayi | RNA binding protein | 0.0061 | 0.1489 | 0.2401 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0038 | 0.082 | 0.082 |
Echinococcus multilocularis | GPCR, family 2 | 0.0038 | 0.082 | 0.082 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.1489 | 0.2401 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0033 | 0.0678 | 0.0678 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0038 | 0.082 | 0.082 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.2103 | 0.2103 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.1243 | 0.2005 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.1243 | 0.1243 |
Echinococcus granulosus | importin subunit beta 1 | 0.0033 | 0.0678 | 0.0678 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.082 | 0.082 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0033 | 0.0678 | 0.5 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0027 | 0.0496 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.082 | 0.082 |
Brugia malayi | follicle stimulating hormone receptor | 0.0224 | 0.6201 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.3898 | 0.6285 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.082 | 0.082 |
Plasmodium falciparum | importin beta, putative | 0.0033 | 0.0678 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.1243 | 0.1243 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.3898 | 0.3898 |
Brugia malayi | RNA, U transporter 1 | 0.0094 | 0.2455 | 0.3958 |
Echinococcus granulosus | GPCR family 2 | 0.0038 | 0.082 | 0.082 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0027 | 0.0496 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.1243 | 0.1243 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0038 | 0.082 | 0.082 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.1489 | 0.1489 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.1489 | 0.1489 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1489 | 0.1489 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0082 | 0.2103 | 0.3391 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0224 | 0.6201 | 0.6201 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0038 | 0.082 | 0.082 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.1489 | 0.1489 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.082 | 0.082 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0038 | 0.082 | 0.082 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.1489 | 0.1489 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.1489 | 0.2401 |
Trichomonas vaginalis | importin beta-1, putative | 0.0027 | 0.0496 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1489 | 0.1489 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0027 | 0.0496 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.1489 | 0.1489 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.1243 | 0.1243 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.012 | 0.3208 | 0.3208 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.012 | 0.3208 | 0.5173 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.012 | 0.3208 | 0.5173 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.3208 | 0.3208 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.3898 | 0.3898 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0033 | 0.0678 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1489 | 0.1489 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0038 | 0.082 | 0.1323 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0.0496 | 0.5 |
Schistosoma mansoni | importin beta-1 | 0.0033 | 0.0678 | 0.0678 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.082 | 0.082 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.2103 | 0.2103 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.1243 | 0.1243 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.