Detailed information for compound 1184592

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 246.312 | Formula: C12H18N6
  • H donors: 2 H acceptors: 4 LogP: 2.83 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCC1Cc2c(C1)c(n[nH]2)c1[nH]nnn1
  • InChi: 1S/C12H18N6/c1-2-3-4-5-8-6-9-10(7-8)13-14-11(9)12-15-17-18-16-12/h8H,2-7H2,1H3,(H,13,14)(H,15,16,17,18)
  • InChiKey: KUZAUIKUALJEFP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxycarboxylic acid receptor 2 Starlite/ChEMBL References
Mus musculus hydroxycarboxylic acid receptor 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis G-protein coupled receptor, putative hydroxycarboxylic acid receptor 2 363 aa 294 aa 20.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0133 0.0245 0.1138
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0274 0.0553 0.3086
Echinococcus granulosus hypothetical protein 0.0082 0.0132 0.0372
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0043 0.0144
Plasmodium falciparum phd finger protein, putative 0.0029 0.0017 0.0056
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0015 0.0048
Schistosoma mansoni opsin-like receptor 0.0082 0.0132 0.037
Brugia malayi RE15519p 0.0082 0.0132 0.0736
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Echinococcus granulosus serotonin receptor 0.0082 0.0132 0.0372
Schistosoma mansoni neuropeptide receptor 0.0082 0.0132 0.037
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0094 0.6048
Onchocerca volvulus 0.0087 0.0145 0.0645
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0052 0.0225
Echinococcus multilocularis dnaJ subfamily B 0.0774 0.1649 0.1649
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0094 0.6048
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0389 0.0806 0.0806
Brugia malayi Dopamine receptor protein 2 0.0082 0.0132 0.0736
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0351 0.0721 0.8806
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0052 0.2804
Loa Loa (eye worm) MH1 domain-containing protein 0.0022 0.0001 0.0004
Onchocerca volvulus 0.0082 0.0132 0.0585
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0052 0.0539
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0058 0.0631
Schistosoma mansoni neuropeptide f receptor 76f 0.0082 0.0132 0.037
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.0064 0.0064
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0058 0.0257
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.008 0.0751
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0093 0.0259
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0043 0.0235
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0132 0.0132
Schistosoma mansoni growth hormone secretagogue receptor 0.0082 0.0132 0.037
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0043 0.0235
Schistosoma mansoni polycystin 1-related 0.0054 0.0071 0.0198
Brugia malayi Patched protein homolog 1 0.0027 0.0014 0.0072
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0065 0.0292
Schistosoma mansoni cpg binding protein 0.0061 0.0088 0.0244
Echinococcus granulosus Niemann Pick C1 protein 0.0646 0.1369 0.3844
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0028 0.008
Brugia malayi hypothetical protein 0.0027 0.0014 0.0072
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0006 0.0018
Brugia malayi AKH receptor 0.0082 0.0132 0.0736
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0037 0.0034 0.014
Echinococcus granulosus Smad4 0.0022 0.0001 0.0002
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0351 0.0721 0.8806
Brugia malayi putative neuropeptide receptor 0.0082 0.0132 0.0736
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0043 0.0235
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0071 0.4325
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Brugia malayi glutathione reductase 0.0057 0.0079 0.0438
Schistosoma mansoni amine GPCR 0.0082 0.0132 0.037
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0043 0.0043
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0082 0.0132 0.0372
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0093 0.0518
Schistosoma mansoni ap endonuclease 0.0058 0.008 0.0224
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0226 0.0448 0.1257
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0214 0.0422 0.0422
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0094 0.6048
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0387 0.0802 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0028 0.0028
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0031 0.0022 0.0013
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0015 0.0048
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0065 0.0183
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0034 0.014
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Loa Loa (eye worm) transcription factor SMAD2 0.0316 0.0646 0.3606
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.008 0.0383
Plasmodium vivax acetyl-CoA synthetase, putative 0.0031 0.0022 0.0117
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0071 0.0816
Trichomonas vaginalis D-aminoacylase, putative 0.0087 0.0145 0.068
Echinococcus granulosus tar DNA binding protein 0.0064 0.0093 0.0261
Brugia malayi AMP-binding enzyme family protein 0.0031 0.0022 0.0118
Echinococcus multilocularis g protein coupled receptor 0.0082 0.0132 0.0132
Brugia malayi ORL1-like opioid receptor 0.0082 0.0132 0.0736
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0043 0.0144
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0106 0.0186 0.0236
Brugia malayi F/Y-rich N-terminus family protein 0.0034 0.0029 0.0157
Loa Loa (eye worm) hypothetical protein 0.0071 0.011 0.0612
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.0022 0.0013
Mycobacterium tuberculosis Conserved protein 0.0087 0.0145 0.0179
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Onchocerca volvulus 0.0955 0.2046 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0109 0.0192 0.054
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0041 0.0039
Loa Loa (eye worm) hypothetical protein 0.0079 0.0127 0.0711
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0351 0.0721 0.8968
Onchocerca volvulus 0.0082 0.0132 0.0585
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0031 0.0022 0.0492
Trypanosoma cruzi metacaspase, putative 0.0037 0.0034 0.1462
Echinococcus granulosus dnaJ subfamily B 0.0774 0.1649 0.4629
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0043 0.0043
Echinococcus multilocularis G-protein coupled receptor, putative 0.0082 0.0132 0.0132
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0031 0.0022 0.0118
Trypanosoma cruzi DNA repair protein, putative 0.0033 0.0026 0.0847
Schistosoma mansoni ap endonuclease 0.0058 0.008 0.0224
Brugia malayi hypothetical protein 0.0082 0.0132 0.0736
Echinococcus granulosus dro:myosuppressin receptor 0.0082 0.0132 0.0372
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Schistosoma mansoni thyroid hormone receptor 0.0292 0.0592 0.1661
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0043 0.0043
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0351 0.0721 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0082 0.0132 0.0736
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0109 0.0192 0.054
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.0132 0.0372
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0065 0.3864
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0272 0.0352
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0226 0.0448 0.1257
Echinococcus multilocularis sterol regulatory element binding protein 0.0194 0.0379 0.0379
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Loa Loa (eye worm) melatonin receptor type 1A 0.0082 0.0132 0.0739
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0079 0.0127 0.0156
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0064 0.0181
Brugia malayi hypothetical protein 0.0027 0.0014 0.0072
Brugia malayi beta-lactamase family protein 0.0087 0.0145 0.0803
Loa Loa (eye worm) hypothetical protein 0.0041 0.0043 0.0239
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0132 0.0132
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0043 0.012
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0151 0.0284 0.0794
Brugia malayi hypothetical protein 0.0082 0.0132 0.0736
Mycobacterium tuberculosis Probable esterase LipL 0.0087 0.0145 0.0179
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0452 0.0944 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0087 0.0145 0.0179
Brugia malayi Melatonin receptor type 1A 0.0082 0.0132 0.0736
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.008 0.008
Echinococcus multilocularis protein patched 0.0194 0.0379 0.0379
Loa Loa (eye worm) hypothetical protein 0.0022 0.0001 0.0004
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0183 0.0355 0.0355
Onchocerca volvulus Cell death protein 3 homolog 0.0071 0.011 0.0473
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Schistosoma mansoni adenoreceptor 0.0082 0.0132 0.037
Echinococcus granulosus neuropeptide s receptor 0.0994 0.213 0.5981
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0031 0.0022 0.0117
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0065 0.761
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.004 0.0131
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0274 0.0553 0.1552
Schistosoma mansoni biogenic amine receptor 0.0082 0.0132 0.037
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0082 0.0132 0.037
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0037 0.0034 0.014
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0047 0.0201
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0131 0.024 0.0309
Loa Loa (eye worm) apoptosis regulator protein 0.0274 0.0553 0.3088
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0022 0.0001 0.0001
Echinococcus granulosus alpha 1A adrenergic receptor 0.0082 0.0132 0.0372
Brugia malayi AMP-binding enzyme family protein 0.0106 0.0186 0.1036
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0064 0.0359
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0389 0.0806 0.2263
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0131 0.024 0.0309
Echinococcus multilocularis neuropeptides capa receptor 0.0082 0.0132 0.0132
Brugia malayi Bromodomain containing protein 0.0038 0.0036 0.0196
Echinococcus multilocularis lysosomal alpha glucosidase 0.0128 0.0233 0.0233
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0519 0.1089 0.6077
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0058 0.0631
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0015 0.0048
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0044 0.0247
Leishmania major cathepsin L-like protease 0.0064 0.0094 0.2123
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0034 0.014
Trichomonas vaginalis glucosylceramidase, putative 0.034 0.0699 0.3397
Brugia malayi hypothetical protein 0.0035 0.003 0.0161
Schistosoma mansoni hypothetical protein 0.0183 0.0355 0.0996
Loa Loa (eye worm) Smad1 0.0022 0.0001 0.0004
Echinococcus multilocularis tumor protein p63 0.0336 0.069 0.069
Loa Loa (eye worm) hypothetical protein 0.0087 0.0145 0.0806
Plasmodium falciparum metacaspase 1 0.0037 0.0034 0.0294
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Echinococcus multilocularis mothers against decapentaplegic 5 0.0022 0.0001 0.0001
Schistosoma mansoni biogenic amine (5HT) receptor 0.0082 0.0132 0.037
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0274 0.0553 0.1554
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0043 0.0118
Brugia malayi neuropeptide F receptor 0.0082 0.0132 0.0736
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.008 0.0944
Loa Loa (eye worm) hypothetical protein 0.0022 0.0001 0.0004
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0065 0.0065
Schistosoma mansoni histamine h1 receptor 0.0082 0.0132 0.037
Brugia malayi Patched family protein 0.0027 0.0014 0.0072
Schistosoma mansoni alpha-1 adrenergic receptor 0.0082 0.0132 0.037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.02 0.0392 0.11
Onchocerca volvulus Neuropeptide F receptor homolog 0.0082 0.0132 0.0585
Schistosoma mansoni peptidase Clp (S14 family) 0.0351 0.0721 0.2024
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0043 0.012
Brugia malayi Glycosyl hydrolases family 31 protein 0.0028 0.0015 0.0083
Trypanosoma cruzi metacaspase, putative 0.0037 0.0034 0.1462
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0082 0.0132 0.0132
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0031 0.0022 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0043 0.0239
Brugia malayi Patched family protein 0.0027 0.0014 0.0072
Loa Loa (eye worm) hypothetical protein 0.0144 0.0268 0.1498
Loa Loa (eye worm) MH2 domain-containing protein 0.0316 0.0646 0.3606
Schistosoma mansoni hypothetical protein 0.0274 0.0553 0.1552
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Loa Loa (eye worm) mbt repeat family protein 0.0096 0.0163 0.0911
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Echinococcus granulosus RUN 0.0054 0.0071 0.02
Schistosoma mansoni neuropeptide F-like receptor 0.0082 0.0132 0.037
Brugia malayi Pre-SET motif family protein 0.0121 0.0219 0.1221
Loa Loa (eye worm) hypothetical protein 0.0022 0.0001 0.0004
Schistosoma mansoni hypothetical protein 0.0051 0.0064 0.0179
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0065 0.3864
Echinococcus multilocularis caspase 3 0.0061 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Echinococcus multilocularis Niemann Pick C1 protein 0.0646 0.1369 0.1369
Brugia malayi hypothetical protein 0.0054 0.0071 0.0394
Brugia malayi PHD-finger family protein 0.0029 0.0017 0.0094
Echinococcus granulosus g protein coupled receptor 0.0082 0.0132 0.0372
Echinococcus multilocularis chromobox protein 1 0.0071 0.0108 0.0108
Plasmodium falciparum thioredoxin reductase 0.0057 0.0079 0.0927
Trypanosoma brucei protein kinase, putative 0.0051 0.0065 0.3864
Echinococcus granulosus caspase 2 0.0071 0.011 0.0308
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0065 0.3864
Toxoplasma gondii propionate-CoA ligase 0.0031 0.0022 0.0117
Schistosoma mansoni inositol monophosphatase 0.0045 0.0052 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0043 0.0235
Trypanosoma brucei metacaspase MCA2 0.0037 0.0034 0.1462
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0106 0.0186 0.2108
Onchocerca volvulus Glucosylceramidase homolog 0.034 0.0699 0.3372
Echinococcus granulosus tumor protein p63 0.0336 0.069 0.1939
Loa Loa (eye worm) bromodomain containing protein 0.0039 0.0039 0.0218
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0043 0.0118
Echinococcus multilocularis serotonin receptor 0.0082 0.0132 0.0132
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0065 0.0732
Echinococcus granulosus G protein coupled receptor 139 0.0082 0.0132 0.0372
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0034 0.014
Trichomonas vaginalis D-aminoacylase, putative 0.0087 0.0145 0.068
Schistosoma mansoni microtubule-associated protein tau 0.1647 0.3562 1
Plasmodium falciparum acyl-CoA synthetase 0.0079 0.0127 0.1609
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0132 0.037
Schistosoma mansoni hypothetical protein 0.0274 0.0553 0.1552
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Echinococcus multilocularis apoptotic protease activating factor 1 0.0034 0.0029 0.0029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0132 0.037
Loa Loa (eye worm) oxidoreductase 0.0031 0.0022 0.0122
Loa Loa (eye worm) patched family protein 0.0027 0.0014 0.0076
Schistosoma mansoni hypothetical protein 0.0152 0.0286 0.08
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0226 0.0448 0.1257
Schistosoma mansoni hypothetical protein 0.0054 0.0071 0.0198
Leishmania major 4-coumarate:coa ligase-like protein 0.0106 0.0186 0.4645
Brugia malayi putative neuropeptide receptor NPR1 0.0082 0.0132 0.0736
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0121 0.0219 0.2909
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0043 0.0239
Entamoeba histolytica acyl-CoA synthetase, putative 0.0106 0.0186 0.184
Brugia malayi sulfakinin receptor protein 0.0082 0.0132 0.0736
Echinococcus granulosus mothers against decapentaplegic 5 0.0022 0.0001 0.0002
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.023 0.0457 0.0602
Echinococcus multilocularis neuropeptide receptor 0.0082 0.0132 0.0132
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0058 0.0631
Schistosoma mansoni chromobox protein 0.0071 0.0108 0.0302
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0109 0.0192 0.107
Brugia malayi MAP kinase sur-1 0.0051 0.0065 0.0361
Trichomonas vaginalis glucosylceramidase, putative 0.0519 0.1089 0.5311
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0082 0.0132 0.037
Echinococcus granulosus neuropeptide FF receptor 2 0.0082 0.0132 0.0372
Onchocerca volvulus 0.0049 0.0061 0.0235
Trichomonas vaginalis penicillin-binding protein, putative 0.0087 0.0145 0.068
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0226 0.0448 0.1259
Loa Loa (eye worm) MBCTL1 0.0109 0.0192 0.1073
Echinococcus granulosus lipoxygenase domain containing protein 0.0054 0.0071 0.02
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0151 0.0285 0.0285
Schistosoma mansoni sex comb on midleg homolog 0.0096 0.0163 0.0457
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0043 0.0239
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0058 0.0257
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0082 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0022 0.0001 0.0004
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0121 0.0218 0.2889
Brugia malayi Probable ClpP-like protease 0.0351 0.0721 0.4023
Brugia malayi jmjC domain containing protein 0.0042 0.0046 0.0254
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0037 0.0034 0.0294
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Echinococcus granulosus neuropeptide Y receptor 0.0082 0.0132 0.0372
Brugia malayi G protein-coupled receptor F59B2.13 0.0082 0.0132 0.0736
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0087 0.0145 0.0179
Brugia malayi latrophilin 2 splice variant baaae 0.0109 0.0193 0.1074
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0043 0.0235
Loa Loa (eye worm) CXXC zinc finger family protein 0.0054 0.0073 0.0405
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0032 0.0024 0.0064
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0037 0.0034 0.0294
Brugia malayi Patched family protein 0.0027 0.0014 0.0072
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0052 0.0225
Schistosoma mansoni myosin xvIII 0.0082 0.0132 0.037
Trypanosoma cruzi metacaspase, putative 0.0037 0.0034 0.1462
Brugia malayi Muscleblind-like protein 0.015 0.0281 0.1567
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Schistosoma mansoni bromodomain containing protein 0.0134 0.0246 0.069
Loa Loa (eye worm) hypothetical protein 0.0051 0.0064 0.0359
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0043 0.0235
Loa Loa (eye worm) hypothetical protein 0.0087 0.0145 0.0806
Schistosoma mansoni lipoxygenase 0.0117 0.021 0.0588
Mycobacterium ulcerans esterase/lipase LipP 0.0087 0.0145 0.1573
Loa Loa (eye worm) hypothetical protein 0.0054 0.0071 0.0398
Echinococcus multilocularis neuropeptide FF receptor 2 0.0082 0.0132 0.0132
Onchocerca volvulus 0.0096 0.0163 0.0737
Schistosoma mansoni cpg binding protein 0.0061 0.0088 0.0244
Echinococcus granulosus biogenic amine 5HT receptor 0.0082 0.0132 0.0372
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0031 0.0022 0.0173
Schistosoma mansoni biogenic amine receptor 0.0082 0.0132 0.037
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0196 0.0383 0.1074
Onchocerca volvulus 0.0031 0.0022 0.0041
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0031 0.0022 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.0132 0.0372
Trichomonas vaginalis maltase-glucoamylase, putative 0.0028 0.0015 0.0048
Onchocerca volvulus 0.0082 0.0132 0.0585
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0082 0.0132 0.0132
Echinococcus granulosus peptidase Clp S14 family 0.023 0.0457 0.1283
Echinococcus multilocularis geminin 0.0394 0.0818 0.0818
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0047 0.0164
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0031 0.0022 0.0492
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0031 0.0022 0.0492
Brugia malayi nuclear receptor NHR-88 0.0041 0.0043 0.0235
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0106 0.0186 0.2108
Loa Loa (eye worm) hypothetical protein 0.0041 0.0043 0.0239
Schistosoma mansoni coup transcription factor 0.0041 0.0043 0.0118
Trichomonas vaginalis glucosylceramidase, putative 0.034 0.0699 0.3397
Echinococcus granulosus geminin 0.0394 0.0818 0.2295
Echinococcus granulosus zinc finger protein 0.0046 0.0054 0.0152
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0121 0.0219 0.0614
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0034 0.014
Mycobacterium tuberculosis Conserved protein 0.0087 0.0145 0.0179
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0151 0.0284 0.1361
Brugia malayi Patched family protein 0.0027 0.0014 0.0072
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0082 0.0132 0.037
Brugia malayi beta-lactamase family protein 0.0087 0.0145 0.0803
Echinococcus granulosus allatostatin A receptor 0.0082 0.0132 0.0372
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0094 0.6048
Echinococcus granulosus neuropeptide receptor A26 0.0994 0.213 0.5981
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Schistosoma mansoni transcription factor LCR-F1 0.0183 0.0355 0.0996
Loa Loa (eye worm) hypothetical protein 0.0031 0.0022 0.0122
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0043 0.0118
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0043 0.012
Echinococcus granulosus caspase 8 0.0037 0.0034 0.0096
Trypanosoma cruzi ISWI complex protein 0.0031 0.0021 0.041
Schistosoma mansoni hypothetical protein 0.0082 0.0132 0.037
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0196 0.0383 0.4632
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0274 0.0553 0.0553
Trichomonas vaginalis sucrase-isomaltase, putative 0.0028 0.0015 0.0048
Trypanosoma brucei metacaspase 0.0037 0.0034 0.1462
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0034 0.014
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0041 0.008
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0031 0.0022 0.0068
Brugia malayi Patched family protein 0.0027 0.0014 0.0072
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0082 0.0132 0.0739
Leishmania major acetyl-CoA synthetase, putative 0.0031 0.0022 0.0173
Loa Loa (eye worm) hypothetical protein 0.0041 0.0043 0.0239
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0128 0.0233 0.1299
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Echinococcus granulosus caspase 3 0.0061 0.0086 0.0243
Schistosoma mansoni hypothetical protein 0.0187 0.0363 0.1018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0094 0.6048
Brugia malayi G-protein coupled receptor 0.0082 0.0132 0.0736
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0082 0.0132 0.0132
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0043 0.0235
Brugia malayi hypothetical protein 0.0144 0.0268 0.1494
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0557 0.1174 0.1574
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0082 0.0132 0.037
Schistosoma mansoni zinc finger protein 0.0046 0.0054 0.015
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0052 0.2804
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.0064 0.0181
Loa Loa (eye worm) hypothetical protein 0.0031 0.0022 0.0122
Mycobacterium ulcerans beta-lactamase 0.0087 0.0145 0.1573
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0082 0.0132 0.0739
Onchocerca volvulus 0.0082 0.0132 0.0585
Brugia malayi Patched related family protein 4 0.0027 0.0014 0.0072
Echinococcus multilocularis GPCR, family 2 0.0051 0.0064 0.0064
Entamoeba histolytica acyl-CoA synthetase, putative 0.0106 0.0186 0.184
Trypanosoma brucei trypanothione reductase 0.0057 0.0079 0.4936
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0017 0.0098
Mycobacterium tuberculosis Probable lipase LipE 0.0087 0.0145 0.0179
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0082 0.0132 0.0132
Brugia malayi hypothetical protein 0.0082 0.0132 0.0736
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0043 0.0235
Echinococcus multilocularis lysosomal alpha glucosidase 0.0128 0.0233 0.0233
Echinococcus multilocularis microtubule associated protein 2 0.1647 0.3562 0.3562
Schistosoma mansoni hypothetical protein 0.0394 0.0818 0.2294
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0075 0.0118 0.0143
Echinococcus multilocularis caspase 2 0.0071 0.011 0.011
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0351 0.0721 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0082 0.0132 0.0736
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0106 0.0186 0.2108
Brugia malayi AMP-binding enzyme family protein 0.0031 0.0022 0.0118
Onchocerca volvulus 0.0082 0.0132 0.0585
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0082 0.0132 0.0132
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0086 0.0478
Schistosoma mansoni hypothetical protein 0.0041 0.0044 0.0122
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0116 0.0207 0.0582
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0043 0.0235
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0096 0.0163 0.0457
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0108 0.0604
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0031 0.0022 0.0122
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.004 0.3568
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0031 0.0022 0.0492
Schistosoma mansoni opsin-like receptor 0.0082 0.0132 0.037
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0196 0.0383 1
Trypanosoma cruzi DNA repair protein, putative 0.0033 0.0026 0.0847
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0046 0.0128
Brugia malayi Patched related family protein 12 0.0027 0.0014 0.0072
Echinococcus multilocularis sex peptide receptor 0.0082 0.0132 0.0132
Schistosoma mansoni hypothetical protein 0.0051 0.0064 0.0179
Loa Loa (eye worm) hypothetical protein 0.0106 0.0186 0.1039
Brugia malayi Doublecortin family protein 0.0054 0.0071 0.0394
Onchocerca volvulus 0.0031 0.0022 0.0041
Schistosoma mansoni mixed-lineage leukemia protein mll 0.012 0.0216 0.0604
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0064 0.0356
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0065 0.3864
Schistosoma mansoni hypothetical protein 0.0082 0.0132 0.037
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0121 0.0218 0.0806
Onchocerca volvulus 0.0082 0.0132 0.0585
Echinococcus multilocularis peregrin 0.0038 0.0036 0.0036
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0043 0.0235
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0037 0.0034 0.014
Trichomonas vaginalis glucosylceramidase, putative 0.0359 0.0739 0.3594
Echinococcus multilocularis neuropeptides capa receptor 0.0082 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Loa Loa (eye worm) patched family protein 0.0027 0.0014 0.0076
Trypanosoma brucei Metacaspase-4 0.0037 0.0034 0.1462
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0132 0.037
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0043 0.0043
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0151 0.0284 0.0794
Loa Loa (eye worm) doublecortin family protein 0.0054 0.0071 0.0398
Onchocerca volvulus 0.0082 0.0132 0.0585
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0031 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0041 0.0043 0.0239
Schistosoma mansoni myelin transcription factor 1 myt1 0.0109 0.0192 0.0538
Echinococcus multilocularis zinc finger protein 0.0046 0.0054 0.0054
Brugia malayi larval opioid receptor 0.0082 0.0132 0.0736
Echinococcus multilocularis beta LACTamase domain containing family member 0.0087 0.0145 0.0145
Onchocerca volvulus 0.0082 0.0132 0.0585
Brugia malayi AMP-binding enzyme family protein 0.0031 0.0022 0.0118
Mycobacterium ulcerans acyl-CoA synthetase 0.0106 0.0186 0.2108
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0037 0.0034 0.0095
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Loa Loa (eye worm) pigment dispersing factor receptor c 0.016 0.0304 0.1697
Loa Loa (eye worm) hypothetical protein 0.0041 0.0043 0.0239
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0082 0.0132 0.037
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.008 1
Echinococcus granulosus microtubule associated protein 2 0.1647 0.3562 1
Loa Loa (eye worm) TYRA-2 protein 0.0082 0.0132 0.0739
Brugia malayi hypothetical protein 0.0082 0.0132 0.0736
Plasmodium falciparum glutathione reductase 0.0057 0.0079 0.0927
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Echinococcus granulosus apoptotic protease activating factor 1 0.0034 0.0029 0.0081
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0031 0.0022 0.0117
Echinococcus granulosus TGF beta signal transducer SmadC 0.0022 0.0001 0.0002
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0043 0.0239
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0093 0.0259
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0028 0.0078
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0031 0.0022 0.0061
Schistosoma mansoni Replicative DNA helicase 0.0387 0.0802 0.225
Schistosoma mansoni cpg binding protein 0.0054 0.0073 0.0202
Echinococcus granulosus g protein coupled receptor 0.0082 0.0132 0.0372
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0093 0.0259
Brugia malayi hypothetical protein 0.0082 0.0132 0.0736
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0093 0.0514
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0379 0.1827
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Schistosoma mansoni survival motor neuron protein 0.0152 0.0286 0.08
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0082 0.0132 0.037
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0043 0.0235
Schistosoma mansoni neuropeptide receptor 0.0082 0.0132 0.037
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Brugia malayi chromobox protein homolog 3 0.004 0.004 0.0221
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Brugia malayi TAR-binding protein 0.0064 0.0093 0.0514
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Echinococcus granulosus expressed conserved protein 0.0425 0.0884 0.2482
Echinococcus multilocularis histone acetyltransferase MYST2 0.0109 0.0192 0.0192
Schistosoma mansoni patched 1 0.0194 0.0379 0.1061
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0052 0.0984
Brugia malayi CHE-14 protein 0.0194 0.0379 0.2109
Onchocerca volvulus Huntingtin homolog 0.0144 0.0268 0.1254
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0043 0.0118
Brugia malayi beta-lactamase 0.0087 0.0145 0.0803
Trichomonas vaginalis glucosylceramidase, putative 0.0519 0.1089 0.5311
Brugia malayi Patched related family protein 10 0.0027 0.0014 0.0072
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0079 0.0127 0.1354
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0043 0.0144
Echinococcus granulosus GPCR family 2 0.0051 0.0064 0.0181
Loa Loa (eye worm) hypothetical protein 0.0041 0.0043 0.0239
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0043 0.0239
Schistosoma mansoni hypothetical protein 0.0187 0.0363 0.1018
Onchocerca volvulus 0.0031 0.0021 0.0039
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0001 0.0004
Brugia malayi Myosin head containing protein 0.0027 0.0014 0.0072
Echinococcus multilocularis caspase 0.0098 0.0167 0.0167
Schistosoma mansoni hypothetical protein 0.0274 0.0553 0.1552
Toxoplasma gondii melibiase subfamily protein 0.0226 0.0448 0.6144
Onchocerca volvulus 0.0054 0.0071 0.0284
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0087 0.0145 0.0404
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0096 0.0163 0.0737
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0214 0.0422 0.1185
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0017 0.0056
Loa Loa (eye worm) hypothetical protein 0.0087 0.0145 0.0806
Trichomonas vaginalis glucosylceramidase, putative 0.034 0.0699 0.3397
Mycobacterium tuberculosis Probable hydrolase 0.0087 0.0145 0.0179
Echinococcus granulosus Niemann Pick C1 protein 0.0452 0.0944 0.265
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0079 0.0222
Loa Loa (eye worm) patched family protein 0.0027 0.0014 0.0076
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0015 0.0048
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.008 0.0445
Trypanosoma brucei metacaspase 5, putative 0.0037 0.0034 0.1462
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0034 0.014
Brugia malayi Calcitonin receptor-like protein seb-1 0.016 0.0304 0.1694
Brugia malayi Melibiase family protein 0.0151 0.0284 0.1579
Echinococcus granulosus muscleblind protein 0.015 0.0281 0.079
Onchocerca volvulus 0.0054 0.0073 0.029
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0031 0.0022 0.0492
Loa Loa (eye worm) acetyltransferase 0.0151 0.0285 0.1588
Trypanosoma cruzi ISWI complex protein 0.0031 0.0021 0.041
Echinococcus granulosus SAM and MBT domain containing protein 0.0096 0.0163 0.0458
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0031 0.0022 0.0117
Loa Loa (eye worm) hypothetical protein 0.0054 0.0071 0.0398
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0093 0.0518
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Echinococcus granulosus 7tm_1 domain containing protein 0.0082 0.0132 0.0372
Brugia malayi Patched family protein 0.0027 0.0014 0.0072
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0065 0.0292
Echinococcus granulosus histone lysine methyltransferase setb 0.0156 0.0294 0.0827
Mycobacterium ulcerans recombinase A 0.0108 0.019 0.2161
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0192
Schistosoma mansoni alpha glucosidase 0.0028 0.0015 0.0042
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0043 0.012
Brugia malayi Glycosyl hydrolases family 31 protein 0.0128 0.0233 0.1296
Brugia malayi hypothetical protein 0.0054 0.0071 0.0394
Echinococcus granulosus somatostatin receptor 0.0082 0.0132 0.0372
Onchocerca volvulus 0.0082 0.0132 0.0585
Brugia malayi Patched family protein 0.0027 0.0014 0.0072
Echinococcus granulosus 7TM GPCR rhodopsin 0.0082 0.0132 0.0372
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0082 0.0132 0.037
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0272 0.1029
Loa Loa (eye worm) neuropeptide F receptor 0.0082 0.0132 0.0739
Brugia malayi AMP-binding enzyme family protein 0.0031 0.0022 0.0118
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0081 0.5107
Toxoplasma gondii Alpha-galactosidase 0.0032 0.0024 0.0141
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0075 0.0118 0.0143
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0068 0.0378
Treponema pallidum recombinase A 0.0108 0.019 0.1525
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0082 0.0132 0.0132
Brugia malayi hypothetical protein 0.0082 0.0132 0.0736
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0047 0.0201
Echinococcus multilocularis peptidase Clp (S14 family) 0.023 0.0457 0.0457
Echinococcus granulosus tm gpcr rhodopsin 0.0082 0.0132 0.0372
Echinococcus multilocularis smad 0.0022 0.0001 0.0001
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0196 0.0383 0.0502
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3117 0.6782 0.9172
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0132 0.037
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0079 0.0927
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Onchocerca volvulus 0.0082 0.0132 0.0585
Brugia malayi Patched family protein 0.0027 0.0014 0.0072
Trichomonas vaginalis glucosylceramidase, putative 0.034 0.0699 0.3397
Trypanosoma cruzi metacaspase, putative 0.0037 0.0034 0.1462
Brugia malayi hypothetical protein 0.0082 0.0132 0.0736
Echinococcus multilocularis serotonin receptor 0.0082 0.0132 0.0132
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0052 0.039
Mycobacterium tuberculosis Conserved protein 0.0087 0.0145 0.0179
Brugia malayi Patched family protein 0.0027 0.0014 0.0072
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0121 0.0218 0.2889
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0082 0.0132 0.037
Loa Loa (eye worm) glutathione reductase 0.0057 0.0079 0.0442
Onchocerca volvulus 0.0087 0.0145 0.0645
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.0022 0.0013
Loa Loa (eye worm) neuropeptide F receptor 0.0082 0.0132 0.0739
Echinococcus multilocularis lipoxygenase domain containing protein 0.0054 0.0071 0.0071
Echinococcus multilocularis fmrfamide receptor 0.0082 0.0132 0.0132
Schistosoma mansoni biogenic amine receptor 0.0082 0.0132 0.037
Echinococcus multilocularis SAM and MBT domain containing protein 0.0096 0.0163 0.0163
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0351 0.0721 0.8968
Echinococcus multilocularis caspase 8 0.0037 0.0034 0.0034
Onchocerca volvulus Huntingtin homolog 0.0144 0.0268 0.1254
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0061 0.017
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.008 0.0092
Schistosoma mansoni lipoxygenase 0.0214 0.0422 0.1183
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0028 0.0078
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Echinococcus multilocularis neuropeptide receptor A26 0.0994 0.213 0.213
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0082 0.0132 0.0132
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0132 0.037
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0065 0.3864
Loa Loa (eye worm) hypothetical protein 0.0041 0.0043 0.0239
Brugia malayi Cytochrome P450 family protein 0.0052 0.0068 0.0374
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0065 0.0292
Schistosoma mansoni inositol monophosphatase 0.0045 0.0052 0.0143
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0132 0.0132
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0098 0.0167 0.047
Loa Loa (eye worm) hypothetical protein 0.015 0.0281 0.157
Brugia malayi RNA binding protein 0.0064 0.0093 0.0514
Schistosoma mansoni sex comb on midleg homolog 0.0096 0.0163 0.0457
Brugia malayi Patched family protein 0.0027 0.0014 0.0072
Loa Loa (eye worm) hypothetical protein 0.0142 0.0265 0.1476
Echinococcus multilocularis chromobox protein 1 0.0071 0.0108 0.0108
Onchocerca volvulus 0.0106 0.0186 0.085
Schistosoma mansoni neuropeptide receptor 0.0082 0.0132 0.037
Schistosoma mansoni thyroid hormone receptor 0.0292 0.0592 0.1661
Plasmodium vivax multidomain scavenger receptor, putative 0.0054 0.0071 0.0815
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0043 0.0239
Echinococcus multilocularis neuropeptide Y receptor 0.0082 0.0132 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.004 0.004 0.0169
Loa Loa (eye worm) hypothetical protein 0.0041 0.0043 0.0239
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0127 0.0231 0.0648
Plasmodium vivax acyl-CoA synthetase, putative 0.0079 0.0127 0.1609
Mycobacterium tuberculosis Probable dehydrogenase 0.0131 0.024 0.0309
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0251 0.0503 0.1412
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0132 0.0132
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0152 0.0286 0.1591
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.02 0.0392 0.11
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Brugia malayi jmjC domain containing protein 0.0096 0.0163 0.0907
Trichomonas vaginalis glucosylceramidase, putative 0.034 0.0699 0.3397
Schistosoma mansoni hypothetical protein 0.0082 0.0132 0.037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0094 0.6048
Schistosoma mansoni amine GPCR 0.0082 0.0132 0.037
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0108 0.019 0.1849
Schistosoma mansoni chromobox protein 0.0071 0.0108 0.0302
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0046 0.013
Onchocerca volvulus 0.0087 0.0145 0.0645
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0087 0.0145 0.0179
Schistosoma mansoni rab6-interacting 0.0054 0.0071 0.0198
Schistosoma mansoni alpha-glucosidase 0.011 0.0194 0.0543
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0048 0.0059 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0043 0.0235
Loa Loa (eye worm) patched family protein 0.0027 0.0014 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0015 0.0045
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0106 0.0186 0.0676
Echinococcus multilocularis neuropeptide Y receptor 0.0082 0.0132 0.0132
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.008 0.0699
Echinococcus granulosus sex peptide receptor 0.0082 0.0132 0.0372
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0194 0.0379 0.2112
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.0022 0.0013
Echinococcus granulosus peregrin 0.0038 0.0036 0.01
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0071 0.0816
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0132 0.037
Brugia malayi steroid hormone receptor 0.0041 0.0043 0.0235
Brugia malayi hypothetical protein 0.0743 0.1582 0.8827
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0133 0.0245 0.0686
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0017 0.0056
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0183 0.0355 0.0998
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0052 0.2804
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0094 0.6048
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0251 0.0503 0.0503
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0017 0.0049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0043 0.0239
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0082 0.0132 0.037
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0108 0.0502
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0071 0.4325
Leishmania major hypothetical protein, conserved 0.0031 0.0021 0.0144
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0156 0.0294 0.0825
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0082 0.0132 0.037
Echinococcus multilocularis expressed conserved protein 0.0425 0.0884 0.0884
Leishmania major metacaspase, putative 0.0037 0.0034 0.0513
Echinococcus multilocularis polycomb protein SCMH1 0.0096 0.0163 0.0163
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0087 0.0145 0.0806
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0351 0.0721 0.0721
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0098
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0082 0.0132 0.0132
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0131 0.024 0.0309
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0094 0.6048
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0052 0.0052
Echinococcus multilocularis fmrfamide receptor 0.0082 0.0132 0.0132
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0037 0.0034 0.0188
Schistosoma mansoni rab6-interacting 0.0054 0.0071 0.0198
Echinococcus granulosus tm gpcr rhodopsin 0.0082 0.0132 0.0372
Brugia malayi Patched family protein 0.0027 0.0014 0.0072
Schistosoma mansoni hypothetical protein 0.0051 0.0064 0.0179
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0015 0.0048
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0121 0.0218 0.1908
Echinococcus multilocularis Niemann Pick C1 protein 0.0452 0.0944 0.0944
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0015 0.0045
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Loa Loa (eye worm) hypothetical protein 0.0022 0.0001 0.0004
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0037 0.0034 0.014
Loa Loa (eye worm) hypothetical protein 0.0087 0.0145 0.0806
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0065 0.1356
Echinococcus multilocularis dro:myosuppressin receptor 0.0082 0.0132 0.0132
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0226 0.0448 0.0448
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0043 0.0118
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0387 0.0802 0.3206
Brugia malayi mbt repeat family protein 0.0096 0.0163 0.0908
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0131 0.024 0.0309
Loa Loa (eye worm) hypothetical protein 0.0106 0.0186 0.1039
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0075 0.0118 0.0143
Loa Loa (eye worm) hypothetical protein 0.0031 0.0021 0.012
Onchocerca volvulus 0.0074 0.0115 0.05
Schistosoma mansoni hypothetical protein 0.0034 0.0029 0.0079
Mycobacterium ulcerans acyl-CoA synthetase 0.0106 0.0186 0.2108
Loa Loa (eye worm) MH2 domain-containing protein 0.0022 0.0001 0.0004
Onchocerca volvulus Alhambra homolog 0.0029 0.0017 0.0019
Schistosoma mansoni hypothetical protein 0.0774 0.1649 0.4628
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0082 0.0132 0.0372
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0112 0.0313
Echinococcus granulosus chromobox protein 1 0.0071 0.0108 0.0304
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0196 0.0383 0.4632
Brugia malayi hypothetical protein 0.0082 0.0132 0.0736
Trypanosoma cruzi metacaspase 5, putative 0.0037 0.0034 0.1462
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0017 0.0017
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0226 0.0448 0.0448
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Echinococcus granulosus tm gpcr rhodopsin 0.0082 0.0132 0.0372
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0037 0.0034 0.014
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.008 0.1765
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0087 0.0145 0.1573
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.008 0.5029
Loa Loa (eye worm) hypothetical protein 0.0151 0.0284 0.1582
Echinococcus multilocularis allatostatin A receptor 0.0082 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0048 0.0059 0.0165
Brugia malayi Serotonin receptor 0.0082 0.0132 0.0736
Onchocerca volvulus 0.0082 0.0132 0.0585
Mycobacterium tuberculosis Probable reductase 0.0131 0.024 0.0309
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0082 0.0132 0.0132
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0043 0.012
Brugia malayi nuclear hormone receptor 0.0041 0.0043 0.0235
Brugia malayi Cell death protein 3 precursor 0.0071 0.011 0.0608
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0064 0.0356
Echinococcus granulosus lysosomal alpha glucosidase 0.0128 0.0233 0.0654
Loa Loa (eye worm) hypothetical protein 0.0079 0.0127 0.0711
Loa Loa (eye worm) twinkle helicase 0.0111 0.0196 0.1093
Trypanosoma brucei hypothetical protein, conserved 0.0087 0.0145 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0292 0.0592 0.0592
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0082 0.0132 0.037
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0106 0.0186 0.0676
Schistosoma mansoni hypothetical protein 0.0394 0.0818 0.2294
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0065 0.0065
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0351 0.0721 0.8884
Brugia malayi AMP-binding enzyme family protein 0.0106 0.0186 0.1036
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0046 0.0257
Echinococcus granulosus lipoxygenase domain containing protein 0.0054 0.0071 0.02
Brugia malayi MH2 domain containing protein 0.0316 0.0646 0.3604
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Leishmania major 4-coumarate:coa ligase-like protein 0.0106 0.0186 0.4645
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0082 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Onchocerca volvulus 0.0034 0.0029 0.0075
Plasmodium vivax hypothetical protein, conserved 0.0087 0.0145 0.1851
Trichomonas vaginalis D-aminoacylase, putative 0.0087 0.0145 0.068
Onchocerca volvulus 0.0031 0.0022 0.0041
Brugia malayi neuropeptide F receptor 0.0082 0.0132 0.0736
Schistosoma mansoni jumonji domain containing protein 0.0076 0.012 0.0335
Echinococcus granulosus beta LACTamase domain containing family member 0.0087 0.0145 0.0406
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Schistosoma mansoni caspase-3 (C14 family) 0.0098 0.0167 0.0468
Brugia malayi Dopamine receptor protein 1 0.0082 0.0132 0.0736
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0093 0.0259
Trichomonas vaginalis glucosylceramidase, putative 0.034 0.0699 0.3397
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0028 0.0015 0.0027
Schistosoma mansoni hypothetical protein 0.0187 0.0363 0.1018
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0031 0.0031
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0043 0.012
Loa Loa (eye worm) hypothetical protein 0.0077 0.0122 0.0682
Mycobacterium leprae Conserved hypothetical protein 0.1142 0.2455 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0347 0.0714 0.3982
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0064 0.0064
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0272 0.0352
Treponema pallidum replicative DNA helicase (dnaB) 0.0387 0.0802 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0079 0.0079
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0839 0.1792 1
Loa Loa (eye worm) hypothetical protein 0.015 0.0281 0.157
Plasmodium falciparum LCCL domain-containing protein 0.0054 0.0071 0.0815
Entamoeba histolytica hypothetical protein 0.0183 0.0355 0.3661
Trichomonas vaginalis glucosylceramidase, putative 0.034 0.0699 0.3397
Brugia malayi Inositol-1 0.0045 0.0052 0.0285
Loa Loa (eye worm) hypothetical protein 0.005 0.0063 0.0353
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.004 0.0263
Echinococcus granulosus neuropeptide receptor 0.0082 0.0132 0.0372
Trichomonas vaginalis set domain proteins, putative 0.0955 0.2046 1
Entamoeba histolytica hypothetical protein 0.0183 0.0355 0.3661
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0082 0.0132 0.0372
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0183 0.0354 0.1976
Schistosoma mansoni amine GPCR 0.0082 0.0132 0.037
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0274 0.0553 0.1554
Trichomonas vaginalis conserved hypothetical protein 0.004 0.004 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0043 0.0235
Toxoplasma gondii exonuclease III APE 0.0058 0.008 0.0944
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.02 0.0392 0.1102
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0351 0.0721 1
Onchocerca volvulus 0.0082 0.0132 0.0585
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0127 0.0231 0.0231
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0082 0.0132 0.037
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0156 0.0294 0.0825
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0156 0.0294 0.0294
Brugia malayi mbt repeat family protein 0.0096 0.0163 0.0908
Brugia malayi acetyltransferase, GNAT family protein 0.0151 0.0285 0.1585
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0017 0.0056
Plasmodium vivax metacaspase 1, putative 0.0037 0.0034 0.0294
Brugia malayi Patched family protein 0.0027 0.0014 0.0072
Schistosoma mansoni zinc finger protein 0.0031 0.0021 0.0057
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0459 0.0959 0.2692
Echinococcus granulosus biogenic amine 5HT receptor 0.0082 0.0132 0.0372
Leishmania major cathepsin L-like protease 0.0064 0.0094 0.2123
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0132 0.0132
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0151 0.0285 0.0797
Echinococcus granulosus g protein coupled receptor 0.0082 0.0132 0.0372
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.0132 0.0372
Trichomonas vaginalis glucosylceramidase, putative 0.0519 0.1089 0.5311
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0001 0.0002
Schistosoma mansoni amine GPCR 0.0082 0.0132 0.037
Brugia malayi follicle stimulating hormone receptor 0.0347 0.0714 0.398
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0196 0.0383 0.2135
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0094 0.6048
Echinococcus granulosus g-protein coupled receptor 0.0082 0.0132 0.0372
Trypanosoma brucei ISWI complex protein 0.0031 0.0021 0.041
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0033 0.0026 0.0847
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0046 0.0128
Mycobacterium ulcerans lipase LipD 0.0087 0.0145 0.1573
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0034 0.0294
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0043 0.012
Loa Loa (eye worm) hypothetical protein 0.0096 0.0163 0.0911
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0108 0.0502
Echinococcus multilocularis protein dispatched 1 0.0221 0.0439 0.0439
Brugia malayi Heterochromatin protein 1 0.0071 0.0108 0.0601
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.023 0.0457 0.1788
Echinococcus multilocularis g-protein coupled receptor 0.0082 0.0132 0.0132
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.0022 0.0118
Echinococcus multilocularis RUN 0.0054 0.0071 0.0071
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0037 0.0034 0.014
Loa Loa (eye worm) hypothetical protein 0.0109 0.0192 0.1073
Toxoplasma gondii ABC1 family protein 0.0087 0.0145 0.1851
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0082 0.0132 0.0132
Schistosoma mansoni hypothetical protein 0.0109 0.0193 0.0541
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.3397 0.7394 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0265 0.0744
Schistosoma mansoni hypothetical protein 0.0082 0.0132 0.037
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0196 0.0383 0.0383
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0163 0.0458
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0079 0.4936
Trypanosoma cruzi hypothetical protein, conserved 0.0087 0.0145 1
Brugia malayi Thioredoxin reductase 0.0057 0.0079 0.0438
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0017 0.0047
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.0022 0.0013
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Echinococcus multilocularis Polycystic kidney disease protein 0.0054 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Schistosoma mansoni hypothetical protein 0.0031 0.0021 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0043 0.0235
Echinococcus multilocularis somatostatin receptor 0.0082 0.0132 0.0132
Echinococcus multilocularis cpg binding protein 0.0061 0.0088 0.0088
Echinococcus granulosus sterol regulatory element binding protein 0.0194 0.0379 0.1063
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0131 0.024 0.0898
Brugia malayi hypothetical protein 0.0183 0.0355 0.198
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0106 0.0186 0.2108
Leishmania major 4-coumarate:coa ligase-like protein 0.0106 0.0186 0.4645
Schistosoma mansoni hypothetical protein 0.0594 0.1255 0.3521
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Brugia malayi G protein-coupled receptor 0.0082 0.0132 0.0736
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0043 0.0118
Loa Loa (eye worm) hypothetical protein 0.0452 0.0944 0.5267
Brugia malayi hypothetical protein 0.0027 0.0014 0.0072
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0094 0.6048
Trichomonas vaginalis penicillin-binding protein, putative 0.0087 0.0145 0.068
Brugia malayi Pre-SET motif family protein 0.0839 0.1792 1
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0094 0.6048
Brugia malayi Patched family protein 0.0027 0.0014 0.0072
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.0132 0.0372
Echinococcus granulosus polycomb protein SCMH1 0.0096 0.0163 0.0458
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0037 0.0034 0.0294
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0094 0.6048
Loa Loa (eye worm) hypothetical protein 0.0106 0.0186 0.1039
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0015 0.0048
Schistosoma mansoni hypothetical protein 0.0024 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0109 0.0193 0.1078
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0121 0.0219 0.0219
Echinococcus granulosus neutral alpha glucosidase AB 0.0028 0.0015 0.0043
Loa Loa (eye worm) hypothetical protein 0.0274 0.0553 0.3088
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0031 0.0022 0.0013
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0031 0.0022 0.0013
Brugia malayi hypothetical protein 0.0082 0.0132 0.0736
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0065 0.0365
Echinococcus granulosus Protein patched homolog 1 0.0194 0.0379 0.1063
Onchocerca volvulus 0.0054 0.0071 0.0284
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0065 0.0182
Schistosoma mansoni apoptosis regulator bax 0.0274 0.0553 0.1552
Mycobacterium tuberculosis Probable lipase LipD 0.0087 0.0145 0.0179
Schistosoma mansoni hypothetical protein 0.0187 0.0363 0.1018
Trichomonas vaginalis esterase, putative 0.0087 0.0145 0.068
Brugia malayi hypothetical protein 0.0082 0.0132 0.0736
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0082 0.0132 0.0585
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0108 0.019 0.0693
Echinococcus granulosus chromobox protein 1 0.0071 0.0108 0.0304
Loa Loa (eye worm) hypothetical protein 0.0049 0.0061 0.0342
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0087 0.0145 0.0404
Echinococcus multilocularis G protein coupled receptor 139 0.0082 0.0132 0.0132
Brugia malayi Dopamine receptor 0.0082 0.0132 0.0736
Schistosoma mansoni hypothetical protein 0.0051 0.0064 0.0179
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0037 0.0034 0.014
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0351 0.0721 0.8926
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0132 0.037
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0058 0.0163
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0082 0.0132 0.0372
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0043 0.0043
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0043 0.0118
Echinococcus granulosus cpg binding protein 0.0061 0.0088 0.0246
Schistosoma mansoni amine GPCR 0.0082 0.0132 0.037
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0082 0.0132 0.0736
Echinococcus multilocularis neuropeptide receptor 0.0082 0.0132 0.0132
Trichomonas vaginalis glucosylceramidase, putative 0.0359 0.0739 0.3594
Brugia malayi Patched family protein 0.0027 0.0014 0.0072
Loa Loa (eye worm) hypothetical protein 0.0238 0.0474 0.2646
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0031 0.0022 0.0492
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0028 0.0015 0.0086
Onchocerca volvulus 0.0082 0.0132 0.0585
Loa Loa (eye worm) inositol-1 0.0045 0.0052 0.0288
Trichomonas vaginalis glucosylceramidase, putative 0.0519 0.1089 0.5311
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0014 0.0037
Schistosoma mansoni caspase-7 (C14 family) 0.0071 0.011 0.0306
Echinococcus multilocularis muscleblind protein 1 0.015 0.0281 0.0281
Echinococcus multilocularis muscleblind protein 0.015 0.0281 0.0281
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.004 0.0373
Echinococcus granulosus orexin receptor type 2 0.0082 0.0132 0.0372
Brugia malayi Bromodomain containing protein 0.0157 0.0298 0.166
Entamoeba histolytica acyl-coA synthetase, putative 0.0106 0.0186 0.184
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0043 0.012
Brugia malayi protein C24B5.3 0.0027 0.0014 0.0072
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.02 0.0392 0.1102
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0037 0.0034 0.014
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0351 0.0721 0.2875
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0043 0.0119
Echinococcus granulosus smad 0.0022 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0144 0.0268 0.1498
Entamoeba histolytica hypothetical protein 0.0183 0.0355 0.3661
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0163 0.0163
Echinococcus granulosus Polycystic kidney disease protein 0.0054 0.0071 0.02
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.008 0.0226
Toxoplasma gondii thioredoxin reductase 0.0057 0.0079 0.0927
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0132 0.0132
Schistosoma mansoni caspase-7 (C14 family) 0.0098 0.0167 0.0468
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0082 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0034 0.0029 0.0161
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0043 0.0235
Loa Loa (eye worm) hypothetical protein 0.0087 0.0145 0.0806
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0274 0.0553 0.0553
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0079 0.0091
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0031 0.0022 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0087 0.0145 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0196 0.0383 0.1076
Loa Loa (eye worm) hypothetical protein 0.0079 0.0127 0.0711
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0094 0.6048
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0043 0.0118
Mycobacterium leprae conserved hypothetical protein 0.0087 0.0145 0.0504
Brugia malayi G-protein coupled receptor 0.0082 0.0132 0.0736
Toxoplasma gondii histone lysine methyltransferase SET1 0.0116 0.0207 0.2732
Brugia malayi GnHR receptor homolog 0.0082 0.0132 0.0736
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0082 0.0132 0.0739
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0052 0.0382
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0082 0.0132 0.0132
Echinococcus multilocularis orexin receptor type 2 0.0082 0.0132 0.0132
Mycobacterium leprae Probable lipase LipE 0.0087 0.0145 0.0504
Onchocerca volvulus 0.0082 0.0132 0.0585
Entamoeba histolytica hypothetical protein 0.0183 0.0355 0.3661
Trichomonas vaginalis antibiotic synthetase, putative 0.0031 0.0022 0.0079
Leishmania major trypanothione reductase 0.0057 0.0079 0.1732
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.008 0.0366
Onchocerca volvulus 0.0044 0.0051 0.0183
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Echinococcus granulosus fetal alzheimer antigen falz 0.0048 0.0059 0.0167
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.02 0.0392 0.2187
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0226 0.0448 0.1257
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0043 0.0043
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0387 0.0802 1
Leishmania major acetyl-CoA synthetase, putative 0.0031 0.0022 0.0173
Loa Loa (eye worm) hypothetical protein 0.0087 0.0145 0.0806
Echinococcus multilocularis survival motor neuron protein 1 0.0743 0.1582 0.1582
Echinococcus granulosus neuropeptide Y receptor 0.0082 0.0132 0.0372
Loa Loa (eye worm) G-protein coupled receptor 0.0082 0.0132 0.0739
Brugia malayi Serotonin receptor 0.0082 0.0132 0.0736
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Echinococcus granulosus neuropeptide receptor 0.0082 0.0132 0.0372
Loa Loa (eye worm) G-protein coupled receptor 0.0082 0.0132 0.0739
Echinococcus multilocularis g protein coupled receptor 0.0082 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.016 0.0304 0.1697
Loa Loa (eye worm) RNA binding protein 0.0064 0.0093 0.0518
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0064 0.3726
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0094 0.6048
Loa Loa (eye worm) hypothetical protein 0.0079 0.0127 0.0711
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0043 0.0118
Loa Loa (eye worm) hypothetical protein 0.0194 0.0379 0.2112
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0132 0.0132
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0043 0.0118
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0043 0.012
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.008 0.0366
Chlamydia trachomatis replicative DNA helicase 0.0387 0.0802 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0082 0.0132 0.0736
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0071 0.4325
Loa Loa (eye worm) hypothetical protein 0.0085 0.0141 0.0784
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.008 0.5029
Brugia malayi protein C24B5.3 0.0027 0.0014 0.0072
Echinococcus multilocularis neuropeptide s receptor 0.0994 0.213 0.213
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0351 0.0721 1
Brugia malayi Patched family protein 0.0027 0.0014 0.0072
Schistosoma mansoni neuropeptide receptor 0.0082 0.0132 0.037
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0071 0.0816
Loa Loa (eye worm) patched family protein 0.0027 0.0014 0.0076
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0109 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0079 0.0127 0.0711
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Onchocerca volvulus 0.0082 0.0132 0.0585
Schistosoma mansoni acetyl-CoA synthetase 0.0031 0.0022 0.006
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Brugia malayi PHD-finger family protein 0.0057 0.0078 0.043
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0098 0.0167 0.0167
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.008 0.5029
Echinococcus granulosus peptide allatostatin:somatostatin 0.0082 0.0132 0.0372
Trypanosoma brucei metacaspase MCA3 0.0037 0.0034 0.1462
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0132 0.037
Trichomonas vaginalis glucosylceramidase, putative 0.0519 0.1089 0.5311
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.0132 0.0372
Plasmodium vivax glutathione reductase, putative 0.0057 0.0079 0.0927
Loa Loa (eye worm) hypothetical protein 0.0156 0.0294 0.1643
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.016 0.0304 0.1694
Echinococcus granulosus neuropeptides capa receptor 0.0082 0.0132 0.0372
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0106 0.0186 0.0236
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0052 0.0225
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0094 0.6048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0043 0.0239
Leishmania major hypothetical protein, conserved 0.0054 0.0071 0.1518
Echinococcus multilocularis lipoxygenase domain containing protein 0.0054 0.0071 0.0071
Chlamydia trachomatis recombinase RecA 0.0108 0.019 0.0933
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.0132 0.0372
Loa Loa (eye worm) beta-lactamase 0.0087 0.0145 0.0806
Schistosoma mansoni hypothetical protein 0.0251 0.0503 0.141
Brugia malayi Niemann-Pick C1 protein precursor 0.0452 0.0944 0.5265
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0082 0.0132 0.0736
Plasmodium vivax SET domain protein, putative 0.0121 0.0219 0.2909
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0071 0.0816
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0037 0.0034 0.014
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0015 0.0048
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0087 0.0145 0.0803
Onchocerca volvulus 0.0082 0.0132 0.0585
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0031 0.0022 0.0122
Schistosoma mansoni neuropeptide F-like receptor 0.0082 0.0132 0.037
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0272 0.0352
Onchocerca volvulus 0.0082 0.0132 0.0585
Echinococcus multilocularis Smad4 0.0022 0.0001 0.0001
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0043 0.0043
Toxoplasma gondii hypothetical protein 0.0121 0.0218 0.2889
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0132 0.037
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0065 0.1356
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0079 0.0442
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0082 0.0132 0.037
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Brugia malayi AMP-binding enzyme family protein 0.0106 0.0186 0.1036
Schistosoma mansoni loxhd1 0.0054 0.0071 0.0198
Trichomonas vaginalis antibiotic synthetase, putative 0.0031 0.0022 0.0079
Plasmodium falciparum metacaspase-like protein 0.0037 0.0034 0.0294
Brugia malayi Bromodomain containing protein 0.008 0.013 0.0721
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0082 0.0132 0.0372
Schistosoma mansoni hypothetical protein 0.0029 0.0017 0.0047
Schistosoma mansoni biogenic amine (5HT) receptor 0.0082 0.0132 0.037
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0031 0.0022 0.0013
Mycobacterium ulcerans hypothetical protein 0.0087 0.0145 0.1573
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0225
Trichomonas vaginalis glucosylceramidase, putative 0.0519 0.1089 0.5311
Loa Loa (eye worm) hypothetical protein 0.0054 0.0071 0.0398
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.02 0.0392 0.219
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0132 0.0132
Leishmania major cathepsin L-like protease 0.0064 0.0094 0.2123
Mycobacterium ulcerans acyl-CoA synthetase 0.0106 0.0186 0.2108
Mycobacterium ulcerans hypothetical protein 0.0106 0.0186 0.2108
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0519 0.1089 0.6078
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.02 0.0392 0.11
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.023 0.0457 0.0602
Schistosoma mansoni alpha-glucosidase 0.011 0.0194 0.0543
Loa Loa (eye worm) hypothetical protein 0.0351 0.0721 0.4025
Onchocerca volvulus 0.0152 0.0286 0.1339
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0082 0.0132 0.0736
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.02 0.0392 0.0392
Echinococcus granulosus tachykinin peptides receptor 99D 0.0082 0.0132 0.0372
Echinococcus granulosus neuropeptides capa receptor 0.0082 0.0132 0.0372
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Onchocerca volvulus 0.0041 0.0043 0.0144
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0076
Echinococcus granulosus fmrfamide receptor 0.0082 0.0132 0.0372
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Leishmania major hypothetical protein, conserved 0.0087 0.0145 0.351
Trypanosoma cruzi metacaspase 5, putative 0.0037 0.0034 0.1462
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0351 0.0721 0.2025
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0043 0.0235
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.008 0.0944
Loa Loa (eye worm) hypothetical protein 0.0082 0.0132 0.0739
Loa Loa (eye worm) hypothetical protein 0.0092 0.0156 0.0869
Brugia malayi hypothetical protein 0.0054 0.0071 0.0394
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0052 0.0145
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0082 0.0132 0.0372
Echinococcus granulosus caspase 0.0098 0.0167 0.047
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0065 0.0292
Schistosoma mansoni opsin-like receptor 0.0082 0.0132 0.037
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0093 0.0259
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0075 0.0118 0.0143
Brugia malayi hypothetical protein 0.0034 0.0029 0.0157
Loa Loa (eye worm) hypothetical protein 0.0743 0.1582 0.8827
Brugia malayi CXXC zinc finger family protein 0.0054 0.0073 0.0401
Brugia malayi hypothetical protein 0.0027 0.0014 0.0072
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.008 0.0449
Echinococcus multilocularis g protein coupled receptor 0.0082 0.0132 0.0132
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.02 0.0392 0.0392
Echinococcus granulosus survival motor neuron protein 1 0.0743 0.1582 0.4442
Echinococcus multilocularis neutral alpha glucosidase AB 0.0028 0.0015 0.0015
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0065 0.0183
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0082 0.0132 0.0739
Brugia malayi ecdysteroid receptor 0.0041 0.0043 0.0235
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.0132 0.0372

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3.6 uM Displacement of [3H]nicotinic acid from mouse GPR109a receptor ChEMBL. 19307116
IC50 (binding) = 4.8 uM Displacement of [3H]nicotinic acid from human GPR109a receptor ChEMBL. 19307116

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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