Detailed information for compound 1184619

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 337.318 | Formula: C12H14F3N3O3S
  • H donors: 2 H acceptors: 4 LogP: 1.7 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CSc1nc(O)cc(n1)C(F)(F)F)NCC1CCCO1
  • InChi: 1S/C12H14F3N3O3S/c13-12(14,15)8-4-9(19)18-11(17-8)22-6-10(20)16-5-7-2-1-3-21-7/h4,7H,1-3,5-6H2,(H,16,20)(H,17,18,19)
  • InChiKey: LADHOPFGRPNGER-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi CXXC zinc finger family protein 0.0029 0.0251 0.0852
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0388 0.0975
Brugia malayi MH2 domain containing protein 0.0017 0.0099 0.0316
Schistosoma mansoni microtubule-associated protein tau 0.0785 0.9265 1
Schistosoma mansoni smad 0.0017 0.0099 0.0107
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0099 0.0316
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0262 0.3021 1
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0055 0.0064
Trichomonas vaginalis esterase, putative 0.0041 0.0388 0.1188
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0278 0.0301
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0432 0.1095
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0021 0.0021
Brugia malayi Smad1 0.0017 0.0099 0.0316
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0013 0.0055 0.0159
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0388 0.1188
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0158 0.0171
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0099 0.0107
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0096 0.0103
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0388 0.0206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.2194 0.2368
Onchocerca volvulus 0.0041 0.0388 0.0526
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0388 0.1336
Trichomonas vaginalis set domain proteins, putative 0.0248 0.2857 1
Onchocerca volvulus 0.0032 0.0278 0.0107
Loa Loa (eye worm) hypothetical protein 0.0013 0.0055 0.0159
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0388 0.1188
Schistosoma mansoni hypothetical protein 0.0066 0.0687 0.0742
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0819 1
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0013 0.0055 0.0055
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0041 0.0388 0.1336
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0076
Echinococcus multilocularis 0.0036 0.0332 0.0332
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0388 0.0418
Loa Loa (eye worm) cytochrome P450 0.0036 0.0332 0.114
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.2194 0.2194
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0096 0.0096
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0158 0.037
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.002 0.0036
Brugia malayi Calcitonin receptor-like protein seb-1 0.0209 0.239 0.8416
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0096 0.0177
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0278 0.0301
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0036 0.0332 0.0823
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0063 0.0654 0.2059
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0036 0.0332 0.0823
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0388 0.0206
Echinococcus multilocularis microtubule associated protein 2 0.0785 0.9265 0.9265
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0036 0.0332 0.0823
Leishmania major cytochrome p450-like protein 0.0036 0.0332 0.0764
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.0687 0.2395
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0278 0.0301
Brugia malayi cytochrome P450 0.0036 0.0332 0.114
Brugia malayi hypothetical protein 0.0037 0.0339 0.1166
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0013 0.0055 0.0059
Leishmania major cytochrome p450-like protein 0.0036 0.0332 0.0764
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0659 0.0711
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0819 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0657 0.0709
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0096 0.0103
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0096 0.0538
Loa Loa (eye worm) beta-lactamase 0.0041 0.0388 0.1336
Loa Loa (eye worm) hypothetical protein 0.0041 0.0388 0.1336
Toxoplasma gondii ABC1 family protein 0.0041 0.0388 0.4561
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0209 0.239 0.8416
Schistosoma mansoni hypothetical protein 0.0013 0.0053 0.0057
Echinococcus multilocularis Smad4 0.0017 0.0099 0.0099
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0388 0.1188
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0158 0.422
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0192 0.2194 0.7722
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0388 0.0354
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.2194 0.2368
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0096 0.0304
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0657 0.2288
Brugia malayi jmjC domain containing protein 0.0016 0.0096 0.0304
Mycobacterium tuberculosis Conserved protein 0.0041 0.0388 0.0206
Schistosoma mansoni hypothetical protein 0.0037 0.0339 0.0366
Trypanosoma cruzi cytochrome P450, putative 0.0063 0.0654 0.1703
Onchocerca volvulus 0.0041 0.0388 0.0526
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.0637 0.0688
Loa Loa (eye worm) hypothetical protein 0.0016 0.0096 0.0304
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0021 0.0023
Plasmodium vivax SET domain protein, putative 0.0032 0.0278 0.3184
Echinococcus granulosus dnaJ subfamily B 0.042 0.4907 0.5296
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0251 0.0852
Onchocerca volvulus Huntingtin homolog 0.0126 0.1399 0.4406
Loa Loa (eye worm) hypothetical protein 0.0032 0.0278 0.095
Brugia malayi beta-lactamase family protein 0.0041 0.0388 0.1336
Schistosoma mansoni hypothetical protein 0.0707 0.8337 0.8998
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0158 0.1357
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.0687 0.0742
Loa Loa (eye worm) MH2 domain-containing protein 0.0246 0.2838 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0158 0.1668
Entamoeba histolytica hypothetical protein 0.0037 0.0339 1
Echinococcus granulosus neuropeptide s receptor 0.0474 0.5561 0.6002
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0209 0.239 0.8416
Schistosoma mansoni hypothetical protein 0.0066 0.0687 0.0742
Brugia malayi Pre-SET motif family protein 0.0032 0.0278 0.095
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0339 0.0339
Brugia malayi Cytochrome P450 family protein 0.0063 0.0654 0.2278
Toxoplasma gondii hypothetical protein 0.0051 0.051 0.6107
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0388 0.0354
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0099 0.0107
Schistosoma mansoni cpg binding protein 0.0031 0.0271 0.0292
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0388 0.4561
Mycobacterium tuberculosis Conserved hypothetical protein 0.0167 0.1895 0.5813
Echinococcus granulosus smad 0.0017 0.0099 0.0107
Echinococcus granulosus bloom syndrome protein 0.0022 0.0158 0.0171
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0192 0.2194 0.7722
Brugia malayi jmjC domain containing protein 0.0062 0.0637 0.2218
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0013 0.0055 0.036
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0096 0.0113
Loa Loa (eye worm) hypothetical protein 0.0016 0.0096 0.0304
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0339 0.0366
Toxoplasma gondii cytochrome p450 superfamily protein 0.0036 0.0332 0.3862
Brugia malayi hypothetical protein 0.0077 0.0819 0.286
Schistosoma mansoni cytochrome P450 0.0036 0.0332 0.0359
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.0687 0.2395
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0388 0.0388
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0209 0.239 0.8416
Leishmania major hypothetical protein, conserved 0.0041 0.0388 0.0916
Brugia malayi hypothetical protein 0.0126 0.1399 0.4911
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0096 0.0096
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0031 0.0034
Loa Loa (eye worm) cytochrome P450 family protein 0.0063 0.0654 0.2278
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0099 0.0107
Echinococcus granulosus geminin 0.0707 0.8337 0.8998
Schistosoma mansoni DNA helicase recq1 0.0022 0.0158 0.0171
Brugia malayi jmjC domain containing protein 0.0064 0.0657 0.2288
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0096 0.0177
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.0687 0.0687
Loa Loa (eye worm) cytochrome P450 family protein 0.0154 0.1734 0.6096
Brugia malayi jmjC domain containing protein 0.0016 0.0096 0.0304
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.0637 0.0637
Loa Loa (eye worm) RecQ helicase 0.0022 0.0158 0.0525
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0819 0.2153
Echinococcus multilocularis neuropeptide receptor A26 0.0474 0.5561 0.5561
Loa Loa (eye worm) hypothetical protein 0.0066 0.0687 0.2395
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0278 0.0301
Brugia malayi MH1 domain containing protein 0.0017 0.0099 0.0316
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0657 0.0709
Loa Loa (eye worm) hypothetical protein 0.0041 0.0388 0.1336
Onchocerca volvulus Huntingtin homolog 0.0126 0.1399 0.4406
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0158 0.1668
Loa Loa (eye worm) hypothetical protein 0.0022 0.0158 0.0525
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.015 0.1693 0.4507
Loa Loa (eye worm) hypothetical protein 0.0041 0.0388 0.1336
Leishmania major hypothetical protein, conserved 0.0016 0.0096 0.0113
Brugia malayi Cytochrome P450 family protein 0.0036 0.0332 0.114
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0096 0.0103
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.2499 0.8801
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0158 0.0158
Schistosoma mansoni hypothetical protein 0.0036 0.0332 0.0359
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0096 0.0103
Loa Loa (eye worm) CYP4Cod1 0.0063 0.0654 0.2278
Brugia malayi MH2 domain containing protein 0.0017 0.0099 0.0316
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0388 0.0206
Mycobacterium leprae Probable lipase LipE 0.0041 0.0388 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0312 0.0336
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.0637 0.0637
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0318 0.3689 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0158 0.0525
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0096 0.0103
Entamoeba histolytica hypothetical protein 0.0037 0.0339 1
Mycobacterium ulcerans lipase LipD 0.0041 0.0388 0.0354
Loa Loa (eye worm) hypothetical protein 0.0143 0.1602 0.5629
Plasmodium vivax ataxin-2 like protein, putative 0.0077 0.0819 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0096 0.0304
Schistosoma mansoni hypothetical protein 0.0707 0.8337 0.8998
Onchocerca volvulus 0.0248 0.2857 1
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0031 0.0161
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0388 0.0206
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.2194 0.2368
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0116 0.0125
Mycobacterium tuberculosis Conserved protein 0.0041 0.0388 0.0206
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0158 0.0525
Brugia malayi latrophilin 2 splice variant baaae 0.0143 0.1602 0.5629
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0388 0.0206
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0096 0.0103
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.2194 0.2368
Schistosoma mansoni hypothetical protein 0.0035 0.0312 0.0336
Entamoeba histolytica hypothetical protein 0.0037 0.0339 1
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0158 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0388 0.1188
Schistosoma mansoni smad1 5 8 and 0.0017 0.0099 0.0107
Onchocerca volvulus 0.0041 0.0388 0.0526
Toxoplasma gondii LsmAD domain-containing protein 0.0077 0.0819 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0158 0.0158
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0099 0.0099
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0388 0.0418
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0388 0.0418
Echinococcus multilocularis cpg binding protein 0.0031 0.0271 0.0271
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0013 0.0055 0.036
Leishmania major cytochrome p450-like protein 0.0063 0.0654 0.1649
Brugia malayi Latrophilin receptor protein 2 0.0066 0.0687 0.2395
Loa Loa (eye worm) histone methyltransferase 0.001 0.0021 0.0041
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0013 0.0055 0.091
Schistosoma mansoni Smad4 0.0017 0.0099 0.0107
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0579 0.6973
Loa Loa (eye worm) hypothetical protein 0.0077 0.0819 0.286
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0432 0.1095
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.0687 0.0742
Echinococcus granulosus Smad4 0.0017 0.0099 0.0107
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0013 0.0055 0.0059
Entamoeba histolytica hypothetical protein 0.0037 0.0339 1
Mycobacterium ulcerans hypothetical protein 0.0167 0.1895 1
Echinococcus granulosus cytochrome P450 2K1 0.0036 0.0332 0.0359
Plasmodium vivax JmjC domain containing protein 0.0016 0.0096 0.0878
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0318 0.3689 1
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0096 0.0103
Brugia malayi jmjC domain containing protein 0.0016 0.0096 0.0304
Leishmania major hypothetical protein, conserved 0.0077 0.0819 0.2103
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0388 0.0206
Mycobacterium tuberculosis Conserved protein 0.0041 0.0388 0.0206
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0158 0.0158
Echinococcus granulosus cpg binding protein 0.0031 0.0271 0.0292
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0339 0.0366
Brugia malayi Cytochrome P450 family protein 0.0154 0.1734 0.6096
Echinococcus multilocularis dnaJ subfamily B 0.042 0.4907 0.4907
Echinococcus multilocularis geminin 0.0707 0.8337 0.8337
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0318 0.3689 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0158 0.0348
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0031 0.0063
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0278 0.3184
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0278 0.0301
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.2194 0.2368
Schistosoma mansoni smad1 5 8 and 0.0017 0.0099 0.0107
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0096 0.0096
Brugia malayi jmjC domain containing protein 0.0016 0.0096 0.0304
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0036 0.0332 0.0764
Treponema pallidum ATP-dependent DNA helicase 0.0011 0.0031 0.5
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0388 0.1336
Loa Loa (eye worm) hypothetical protein 0.0126 0.1399 0.4911
Schistosoma mansoni DNA helicase recq5 0.0022 0.0158 0.0171
Loa Loa (eye worm) cytochrome P450 family protein 0.0063 0.0654 0.2278
Loa Loa (eye worm) Smad1 0.0017 0.0099 0.0316
Schistosoma mansoni cpg binding protein 0.0031 0.0271 0.0292
Brugia malayi Pre-SET motif family protein 0.0218 0.2499 0.8801
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0432 0.1095
Schistosoma mansoni smad1 5 8 and 0.0017 0.0099 0.0107
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0036 0.0332 0.0764
Trypanosoma brucei PAB1-binding protein , putative 0.0077 0.0819 0.2103
Loa Loa (eye worm) hypothetical protein 0.0126 0.1399 0.4911
Schistosoma mansoni hypothetical protein 0.0066 0.0687 0.0742
Echinococcus granulosus CTD small phosphatase protein like 0.0013 0.0055 0.0059
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0388 0.0916
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0099 0.0316
Loa Loa (eye worm) hypothetical protein 0.0041 0.0388 0.1336
Trypanosoma cruzi cytochrome P450, putative 0.0063 0.0654 0.1703
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0096 0.0103
Brugia malayi hypothetical protein 0.005 0.0493 0.1708
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0158 0.0171
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0388 0.0206
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0158 0.0525
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0548 0.1414
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0388 1
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0013 0.0055 0.036
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0312 0.0312
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0031 0.0063
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0278 0.0278
Loa Loa (eye worm) hypothetical protein 0.0016 0.0096 0.0304
Mycobacterium ulcerans hypothetical protein 0.0041 0.0388 0.0354
Brugia malayi beta-lactamase 0.0041 0.0388 0.1336
Mycobacterium ulcerans beta-lactamase 0.0041 0.0388 0.0354
Echinococcus multilocularis neuropeptide s receptor 0.0474 0.5561 0.5561
Brugia malayi Cytochrome P450 family protein 0.0063 0.0654 0.2278
Schistosoma mansoni cpg binding protein 0.0029 0.0251 0.027
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0096 0.0304
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0096 0.0878
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.015 0.1693 0.4542
Echinococcus granulosus neuropeptide receptor A26 0.0474 0.5561 0.6002
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.015 0.1693 0.4507
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.0687 0.0687
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0158 0.0285
Schistosoma mansoni hypothetical protein 0.0066 0.0687 0.0742
Schistosoma mansoni jumonji domain containing protein 0.0062 0.0637 0.0688
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0158 0.1357
Brugia malayi MH1 domain containing protein 0.0017 0.0099 0.0316
Echinococcus granulosus GPCR family 2 0.0066 0.0687 0.0742
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.2194 0.2194
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0013 0.0055 0.0059
Echinococcus multilocularis 0.0013 0.0055 0.0055
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0432 0.1038
Loa Loa (eye worm) hypothetical protein 0.0013 0.0053 0.0152
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0388 0.0975
Loa Loa (eye worm) transcription factor SMAD2 0.0246 0.2838 1
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0388 0.1188
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0257 0.0278
Schistosoma mansoni hypothetical protein 0.042 0.4907 0.5296
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0158 0.0285
Echinococcus granulosus phd:f box containing protein 0.0016 0.0096 0.0103
Loa Loa (eye worm) hypothetical protein 0.0041 0.0388 0.1336
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0096 0.0878
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0076
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0158 0.037
Brugia malayi MH2 domain containing protein 0.0246 0.2838 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0116 0.0116
Leishmania major mitochondrial DNA polymerase beta 0.0318 0.3689 1
Echinococcus multilocularis smad 0.0017 0.0099 0.0099
Echinococcus granulosus lysine specific demethylase 5A 0.0064 0.0657 0.0709
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0026 0.0028
Brugia malayi beta-lactamase family protein 0.0041 0.0388 0.1336
Loa Loa (eye worm) hypothetical protein 0.0027 0.0221 0.0746
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0278 0.0278
Echinococcus multilocularis GPCR, family 2 0.0066 0.0687 0.0687
Schistosoma mansoni hypothetical protein 0.0143 0.1602 0.1729
Echinococcus granulosus microtubule associated protein 2 0.0785 0.9265 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0158 0.0525
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0819 0.2153
Trypanosoma brucei cytochrome P450, putative 0.0063 0.0654 0.1649
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0158 0.037

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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