Detailed information for compound 1184678

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 252.331 | Formula: C16H12OS
  • H donors: 0 H acceptors: 0 LogP: 4.14 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(c1)oc(cc2=S)c1ccccc1
  • InChi: 1S/C16H12OS/c1-11-7-8-13-15(9-11)17-14(10-16(13)18)12-5-3-2-4-6-12/h2-10H,1H3
  • InChiKey: NTVVZIFVZWJZGD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0053 0.0937 0.8922
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.1048 1
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0643 0.3945
Mycobacterium leprae Probable lipase LipE 0.0041 0.0643 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0137 0.3182 0.4637
Brugia malayi beta-lactamase 0.0041 0.0643 0.0937
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0044 0.0044
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.4558 0.4558
Schistosoma mansoni DNA polymerase eta 0.0019 0.0044 0.0097
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0581 0.0581
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0013 0.0013
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0037 0.0037
Echinococcus granulosus chromobox protein 1 0.0078 0.161 0.161
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0044 0.008
Brugia malayi Muscleblind-like protein 0.0146 0.34 0.4954
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0044 0.0305
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0703 0.4323
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.058 0.3555
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0305
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0247 0.2073
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0053 0.0937 0.8922
Schistosoma mansoni survival motor neuron protein 0.0056 0.1039 0.2279
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0044 0.0305
Loa Loa (eye worm) hypothetical protein 0.0276 0.6862 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0053 0.0937 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0044 0.0119
Mycobacterium tuberculosis Conserved protein 0.0041 0.0643 0.093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0296 0.1774
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0053 0.0937 0.0937
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.098 0.1428
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0703 0.4009
Onchocerca volvulus 0.0041 0.0643 0.3042
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0305
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0643 0.0643
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0652 0.4005
Trichomonas vaginalis esterase, putative 0.0041 0.0643 0.3945
Echinococcus granulosus dna polymerase kappa 0.0019 0.0044 0.0044
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0643 0.6084
Loa Loa (eye worm) hypothetical protein 0.0041 0.0643 0.0937
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0044 0.0044
Entamoeba histolytica hypothetical protein 0.0039 0.0581 0.6047
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0247 0.233
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.022 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.058 0.3555
Brugia malayi hypothetical protein 0.0037 0.0516 0.0752
Schistosoma mansoni hypothetical protein 0.0039 0.0581 0.1275
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.4558 1
Mycobacterium tuberculosis Conserved protein 0.0041 0.0643 0.093
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0044 0.0044
Leishmania major hypothetical protein, conserved 0.0057 0.1048 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0189 0.4558 0.6642
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0053 0.0937 0.8922
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0044 0.0097
Loa Loa (eye worm) hypothetical protein 0.0057 0.1048 0.1528
Brugia malayi chromobox protein homolog 3 0.0044 0.0703 0.1025
Loa Loa (eye worm) hypothetical protein 0.0041 0.0643 0.0937
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0044 0.0305
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0305
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0053 0.0937 0.1365
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0643 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0053 0.0937 0.8922
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0037 0.0152
Loa Loa (eye worm) hypothetical protein 0.0037 0.0526 0.0767
Toxoplasma gondii LsmAD domain-containing protein 0.0057 0.1048 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0296 0.1774
Echinococcus multilocularis muscleblind protein 0.0146 0.34 0.34
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0937 0.5786
Brugia malayi hypothetical protein 0.0039 0.0581 0.0847
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0643 0.093
Loa Loa (eye worm) hypothetical protein 0.0019 0.0044 0.0064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.4558 0.4558
Trypanosoma brucei PAB1-binding protein , putative 0.0057 0.1048 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0044 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0449 0.2732
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0265 0.6551 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.34 0.4954
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0044 0.0305
Schistosoma mansoni hypothetical protein 0.0025 0.022 0.0483
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.022 0.022
Loa Loa (eye worm) heterochromatin protein 1 0.0078 0.161 0.2346
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0013 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0365 0.2208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.058 0.3555
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.098 0.1428
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0044 0.0305
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0652 0.4005
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0044 0.0064
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0044 0.0011
Trichomonas vaginalis chromobox protein, putative 0.0078 0.161 1
Mycobacterium ulcerans lipase LipD 0.0041 0.0643 1
Trypanosoma brucei unspecified product 0.0019 0.0044 0.0305
Toxoplasma gondii ABC1 family protein 0.0041 0.0643 0.599
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.1048 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0037 0.5
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0643 0.0643
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0037 0.0235
Onchocerca volvulus 0.0056 0.1039 0.9392
Loa Loa (eye worm) hypothetical protein 0.0041 0.0643 0.0937
Plasmodium vivax ataxin-2 like protein, putative 0.0057 0.1048 1
Echinococcus granulosus flap endonuclease 1 0.0026 0.0247 0.0247
Schistosoma mansoni hypothetical protein 0.0037 0.0526 0.1155
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0037 0.0235
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0305
Brugia malayi beta-lactamase family protein 0.0041 0.0643 0.0937
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0643 0.0937
Loa Loa (eye worm) phosphatidylinositol 3 0.0053 0.0937 0.1365
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0305
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0044 0.0198
Entamoeba histolytica hypothetical protein 0.0039 0.0581 0.6047
Mycobacterium tuberculosis Conserved protein 0.0041 0.0643 0.093
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0305
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0042 0.0653 0.6187
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0053 0.0937 0.8922
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0305
Loa Loa (eye worm) beta-lactamase 0.0041 0.0643 0.0937
Schistosoma mansoni ap endonuclease 0.0019 0.0037 0.0081
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0053 0.0937 0.0937
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0189 0.4558 0.6642
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0791 0.5418
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0247 0.233
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0037 0.0235
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0652 0.4005
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0526 0.0767
Loa Loa (eye worm) hypothetical protein 0.0054 0.098 0.1428
Leishmania major DNA polymerase kappa, putative 0.0019 0.0044 0.0305
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0044 0.0305
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.1048 1
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0643 0.6084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0377 0.2282
Echinococcus multilocularis chromobox protein 1 0.0078 0.161 0.161
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0044 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0377 0.2282
Loa Loa (eye worm) hypothetical protein 0.0041 0.0643 0.0937
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0037 0.0054
Entamoeba histolytica hypothetical protein 0.0039 0.0581 0.6047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.058 0.3555
Loa Loa (eye worm) hypothetical protein 0.0146 0.34 0.4954
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0041 0.0643 0.0937
Echinococcus multilocularis dna polymerase eta 0.0019 0.0044 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0365 0.2208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.058 0.3555
Schistosoma mansoni hypothetical protein 0.0056 0.1039 0.2279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0937 0.5786
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.4558 1
Brugia malayi MH2 domain containing protein 0.0137 0.3182 0.4637
Trypanosoma cruzi target of rapamycin kinase 3 0.0042 0.0653 0.6187
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0643 0.0937
Toxoplasma gondii target of rapamycin (TOR), putative 0.0039 0.058 0.5374
Giardia lamblia DINP protein human, muc B family 0.0019 0.0044 0.008
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0044 0.0011
Brugia malayi hypothetical protein 0.0057 0.1048 0.1528
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0044 0.0198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.058 0.3555
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0044 0.0305
Loa Loa (eye worm) hypothetical protein 0.0058 0.1076 0.1569
Mycobacterium ulcerans hypothetical protein 0.0041 0.0643 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0013 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0369 0.2231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0297 0.1781
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0053 0.0937 0.2055
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0247 0.2259
Loa Loa (eye worm) hypothetical protein 0.0044 0.0703 0.1025
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0581 0.0581
Echinococcus multilocularis chromobox protein 1 0.0078 0.161 0.161
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0643 0.599
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.1039 0.1513
Leishmania major hypothetical protein, conserved 0.0041 0.0643 0.6084
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0044 0.0305
Echinococcus multilocularis survival motor neuron protein 1 0.0276 0.6862 0.6862
Echinococcus granulosus dna polymerase eta 0.0019 0.0044 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0652 0.4005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0937 0.5786
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.1048 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0643 0.3945
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0643 0.093
Echinococcus granulosus survival motor neuron protein 1 0.0276 0.6862 0.6862
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0643 0.093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0296 0.1774
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0297 0.1781
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0053 0.0937 0.8922
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0247 0.2259
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0247 0.2073
Brugia malayi Flap endonuclease-1 0.0026 0.0247 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0369 0.2231
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0247 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0652 0.4005
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0042 0.0653 0.6187
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0053 0.0937 1
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0643 0.093
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0643 0.141
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0643 0.093
Trichomonas vaginalis chromobox protein, putative 0.0078 0.161 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0305
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0044 0.0097
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0643 0.3945
Schistosoma mansoni chromobox protein 0.0078 0.161 0.3532
Brugia malayi beta-lactamase family protein 0.0041 0.0643 0.0937
Schistosoma mansoni cellular tumor antigen P53 0.0058 0.1076 0.2362
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0703 0.4323
Entamoeba histolytica hypothetical protein 0.0039 0.0581 0.6047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0377 0.2282
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0643 0.6084
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0643 0.3945
Loa Loa (eye worm) hypothetical protein 0.0041 0.0643 0.0937
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0025 0.0204 0.1847
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.4558 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0044 0.0305
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.098 0.1428
Schistosoma mansoni flap endonuclease-1 0.0024 0.0179 0.0393
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0581 0.1275
Schistosoma mansoni ap endonuclease 0.0019 0.0037 0.0081
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0791 0.4873
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.4558 0.4558
Loa Loa (eye worm) transcription factor SMAD2 0.0137 0.3182 0.4637
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0037 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0479 0.292
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.4558 0.4558
Schistosoma mansoni chromobox protein 0.0078 0.161 0.3532
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0733 0.4513
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0034 0.0453 0.066
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0037 0.0235
Leishmania major DNA polymerase eta, putative 0.0019 0.0044 0.0305
Brugia malayi hypothetical protein 0.0276 0.6862 1
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0643 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0305
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0037 0.0152
Echinococcus granulosus muscleblind protein 0.0146 0.34 0.34
Onchocerca volvulus 0.0041 0.0643 0.3042
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0247 0.2259
Mycobacterium ulcerans beta-lactamase 0.0041 0.0643 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0305
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.058 0.3555
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0044 0.0305
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0044 0.0064
Onchocerca volvulus 0.0041 0.0643 0.3042
Echinococcus granulosus chromobox protein 1 0.0078 0.161 0.161
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0643 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0643 0.141
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0022 0.0124 0.1074
Echinococcus multilocularis muscleblind protein 1 0.0146 0.34 0.34
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0643 0.093
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0791 0.4873
Giardia lamblia GTOR 0.0053 0.0937 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0013 0.0018
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0643 0.3945
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0297 0.1781
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0643 0.093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0297 0.1781
Onchocerca volvulus 0.0058 0.1076 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0037 0.0054
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0247 0.1465
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0013 0.0013
Brugia malayi Heterochromatin protein 1 0.0078 0.161 0.2346
Plasmodium falciparum flap endonuclease 1 0.0026 0.0247 0.2073

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) Inhibition of human recombinant MAOA expressed in BTI-TN-5B1-4 cells at 100 uM by para-tyramine oxidation assay ChEMBL. 20045650
Inhibition (binding) = 40 % Inhibition of human recombinant MAOB expressed in BTI-TN-5B1-4 cells at 100 uM by para-tyramine oxidation assay ChEMBL. 20045650

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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