Detailed information for compound 1184765

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 276.218 | Formula: C10H13FN2O6
  • H donors: 4 H acceptors: 5 LogP: -1.89 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H](C([C@H](C1O)F)O)n1ccc(=O)[nH]c1=O
  • InChi: 1S/C10H13FN2O6/c11-6-7(16)4(3-14)19-9(8(6)17)13-2-1-5(15)12-10(13)18/h1-2,4,6-9,14,16-17H,3H2,(H,12,15,18)/t4-,6+,7?,8?,9-/m1/s1
  • InChiKey: QGWLQEMDCINRKW-JDINWHEISA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0633 1
Echinococcus granulosus mothers against decapentaplegic 2 0.0008 0.005 0.0084
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0716 0.1158
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.1661 0.2739
Echinococcus multilocularis mothers against decapentaplegic 2 0.0008 0.005 0.005
Brugia malayi MAP kinase sur-1 0.0056 0.0633 0.1055
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0006 0.0033 0.0054
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0633 0.1055
Echinococcus multilocularis Smad4 0.0017 0.0164 0.0164
Onchocerca volvulus 0.05 0.6001 1
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0028 0.0296 0.0494
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2403 0.4004
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0398 0.1248
Schistosoma mansoni GTP-binding protein alpha subunit 0.0006 0.0033 0.0015
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0006 0.0033 0.0015
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.1148 0.1914
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0006 0.0033 0.0054
Loa Loa (eye worm) hypothetical protein 0.0009 0.0072 0.012
Plasmodium vivax SET domain protein, putative 0.0029 0.0309 0.6637
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0692 0.1071
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0371 0.5269
Brugia malayi MH1 domain containing protein 0.0009 0.0072 0.012
Loa Loa (eye worm) hypothetical protein 0.0031 0.0335 0.0558
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0006 0.0033 0.0054
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0309 0.0477
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0716 0.1158
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0006 0.0033 0.0015
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0164 0.0164
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0398 0.0626
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.1689 0.2786
Echinococcus granulosus caspase 2 0.0028 0.0296 0.0494
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.1689 0.1689
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0006 0.0033 0.0054
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0633 0.8494
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0633 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0459 0.0765
Toxoplasma gondii Erv1 / Alr family protein 0.0005 0.0024 0.0162
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.0371 0.0371
Schistosoma mansoni smad1 5 8 and 0.0017 0.0164 0.0234
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0296 0.0924
Schistosoma mansoni hypothetical protein 0.0067 0.0772 0.1252
Brugia malayi mothers against decapentaplegic homolog 3 0.0008 0.005 0.0084
Loa Loa (eye worm) hypothetical protein 0.05 0.6001 1
Mycobacterium ulcerans glutaminase 0.0264 0.3147 1
Schistosoma mansoni caspase-7 (C14 family) 0.0028 0.0296 0.0456
Plasmodium vivax hypothetical protein, conserved 0.0005 0.0024 0.0246
Echinococcus multilocularis expressed protein 0.0006 0.0033 0.0033
Echinococcus multilocularis GPCR, family 2 0.0031 0.0335 0.0335
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0371 0.5269
Schistosoma mansoni survival motor neuron protein 0.0101 0.1176 0.1927
Brugia malayi MH1 domain containing protein 0.0017 0.0164 0.0273
Brugia malayi Augmenter of liver regeneration 0.0034 0.0371 0.0618
Mycobacterium leprae Probable lipase LipE 0.0036 0.0398 0.5
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0296 0.0924
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0633 1
Brugia malayi hypothetical protein 0.0494 0.5926 0.9876
Schistosoma mansoni hypothetical protein 0.0031 0.0335 0.052
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0028 0.0296 0.0494
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0006 0.0033 0.0033
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0633 1
Schistosoma mansoni hypothetical protein 0.0031 0.0335 0.052
Echinococcus granulosus sulfhydryl oxidase 1 0.0005 0.0024 0.004
Brugia malayi hypothetical protein 0.0006 0.0033 0.0054
Brugia malayi MH2 domain containing protein 0.025 0.2977 0.4962
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0296 0.6352
Loa Loa (eye worm) hypothetical protein 0.0099 0.1148 0.1914
Trypanosoma brucei metacaspase MCA3 0.0028 0.0296 0.4681
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0398 0.0626
Onchocerca volvulus 0.0101 0.1176 0.1927
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0008 0.005 0.0044
Schistosoma mansoni smad1 5 8 and 0.0017 0.0164 0.0234
Loa Loa (eye worm) hypothetical protein 0.0005 0.0024 0.004
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0633 0.1996
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0335 0.0558
Trypanosoma cruzi metacaspase, putative 0.0028 0.0296 0.4472
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0716 0.1158
Schistosoma mansoni hypothetical protein 0.05 0.6001 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0692 0.0692
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0296 0.0924
Schistosoma mansoni Smad4 0.0008 0.005 0.0044
Plasmodium falciparum metacaspase 1 0.0028 0.0296 0.6924
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0006 0.0033 0.0054
Brugia malayi MH1 domain containing protein 0.0009 0.0072 0.012
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.2768 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0296 0.0924
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0309 0.0309
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0398 0.6146
Onchocerca volvulus 0.0029 0.0309 0.0477
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.1689 0.1689
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0164 0.0273
Loa Loa (eye worm) hypothetical protein 0.0036 0.0398 0.0663
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0006 0.0033 0.0085
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0309 0.0477
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0398 0.0663
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0692 0.1119
Brugia malayi TAR-binding protein 0.0063 0.0716 0.1193
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0006 0.0033 0.0015
Brugia malayi Pre-SET motif family protein 0.0202 0.2403 0.4004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0398 0.0663
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0417 1
Onchocerca volvulus 0.0036 0.0398 0.0626
Echinococcus multilocularis caspase 0.0028 0.0296 0.0296
Loa Loa (eye worm) glutaminase 2 0.0264 0.3147 0.5244
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0006 0.0033 0.0015
Trypanosoma cruzi metacaspase, putative 0.0028 0.0296 0.4472
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0164 0.0273
Loa Loa (eye worm) hypothetical protein 0.0005 0.0024 0.004
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0006 0.0033 0.0054
Loa Loa (eye worm) hypothetical protein 0.0036 0.0398 0.0663
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0006 0.0033 0.0033
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0028 0.0296 0.0296
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0417 1
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0006 0.0033 0.0015
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0164 0.0234
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0006 0.0033 0.0054
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0398 0.8637
Echinococcus granulosus baculoviral IAP repeat containing protein 0.05 0.6001 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0398 0.6146
Schistosoma mansoni caspase-3 (C14 family) 0.0028 0.0296 0.0456
Schistosoma mansoni smad 0.0017 0.0164 0.0234
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0006 0.0033 0.0015
Schistosoma mansoni smad1 5 8 and 0.0017 0.0164 0.0234
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0006 0.0033 0.0015
Brugia malayi MH2 domain containing protein 0.0017 0.0164 0.0273
Loa Loa (eye worm) glutaminase 0.0264 0.3147 0.5244
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0335 0.0335
Brugia malayi glutaminase DH11.1 0.0264 0.3147 0.5244
Trypanosoma brucei Metacaspase-4 0.0028 0.0296 0.4681
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.05 0.6001 1
Onchocerca volvulus 0.023 0.274 0.4545
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0296 0.0924
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0692 0.1154
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0335 0.0558
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0006 0.0033 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0296 0.0924
Echinococcus multilocularis survival motor neuron protein 1 0.0494 0.5926 0.5926
Loa Loa (eye worm) hypothetical protein 0.0006 0.0033 0.0054
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0296 0.0924
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.1148 0.1914
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0296 0.0924
Leishmania major hypothetical protein, conserved 0.0036 0.0398 0.2572
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0692 0.1119
Plasmodium falciparum metacaspase-like protein 0.0028 0.0296 0.6924
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.05 0.6001 0.6001
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0006 0.0033 0.0054
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0633 0.1996
Brugia malayi beta-lactamase family protein 0.0036 0.0398 0.0663
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0633 0.1055
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0006 0.0033 0.0033
Echinococcus multilocularis mothers against decapentaplegic 6 0.0008 0.005 0.005
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0335 0.0558
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.0371 0.0618
Brugia malayi Smad1 0.0017 0.0164 0.0273
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0296 0.0924
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0398 0.0663
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.1689 0.2815
Onchocerca volvulus 0.0036 0.0398 0.0626
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.1689 0.2815
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0006 0.0033 0.0033
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0633 0.9122
Brugia malayi Erv1 / Alr family protein 0.0005 0.0024 0.004
Trypanosoma brucei protein kinase, putative 0.0056 0.0633 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0633 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0716 0.1193
Schistosoma mansoni smad 0.0008 0.005 0.0044
Onchocerca volvulus 0.0006 0.0033 0.0015
Loa Loa (eye worm) hypothetical protein 0.0036 0.0398 0.0663
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0398 0.6291
Loa Loa (eye worm) hypothetical protein 0.0036 0.0398 0.0663
Trichomonas vaginalis set domain proteins, putative 0.023 0.274 0.8706
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0006 0.0033 0.0085
Loa Loa (eye worm) hypothetical protein 0.0028 0.0296 0.0494
Loa Loa (eye worm) hypothetical protein 0.0029 0.0309 0.0515
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0006 0.0033 0.0033
Brugia malayi Pre-SET motif family protein 0.0029 0.0309 0.0515
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0335 0.0558
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0633 0.1019
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0309 0.0309
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.05 0.6001 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0398 0.0663
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0006 0.0033 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0309 0.0477
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0309 0.0515
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0716 0.1193
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.1661 0.1661
Trypanosoma brucei metacaspase 5, putative 0.0028 0.0296 0.4681
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0716 0.0716
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0692 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0633 0.8494
Trypanosoma brucei metacaspase MCA2 0.0028 0.0296 0.4681
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0164 0.0273
Brugia malayi G-protein alpha subunit 0.0006 0.0033 0.0054
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.005 0.0084
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.1613 0.2688
Onchocerca volvulus Deterin homolog 0.05 0.6001 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0033 0.0054
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0371 0.5699
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0371 0.8824
Echinococcus multilocularis inhibitor of apoptosis protein 0.05 0.6001 0.6001
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0633 1
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0006 0.0033 0.0054
Echinococcus granulosus caspase 8 0.0028 0.0296 0.0494
Echinococcus granulosus expressed protein 0.0006 0.0033 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0296 0.0924
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0006 0.0033 0.0085
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0006 0.0033 0.0054
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0296 0.0924
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.0371 0.0618
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0459 0.1442
Trypanosoma cruzi metacaspase 5, putative 0.0028 0.0296 0.4472
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0398 0.1248
Plasmodium vivax metacaspase 1, putative 0.0028 0.0296 0.6352
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0459 0.6563
Loa Loa (eye worm) hypothetical protein 0.0006 0.0033 0.0054
Toxoplasma gondii ABC1 family protein 0.0036 0.0398 0.5669
Echinococcus granulosus Smad4 0.0017 0.0164 0.0273
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0398 0.1248
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0633 0.1055
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0006 0.0033 0.0054
Onchocerca volvulus 0.0006 0.0033 0.0015
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0692 0.1071
Loa Loa (eye worm) beta-lactamase 0.0036 0.0398 0.0663
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0309 0.4356
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0716 0.1158
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.1148 0.1914
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0716 0.1158
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0296 0.0924
Loa Loa (eye worm) hypothetical protein 0.05 0.6001 1
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0633 0.0633
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0296 0.0493
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0371 0.5699
Schistosoma mansoni caspase-7 (C14 family) 0.0028 0.0296 0.0456
Loa Loa (eye worm) hypothetical protein 0.0028 0.0296 0.0494
Loa Loa (eye worm) RNA binding protein 0.0063 0.0716 0.1193
Schistosoma mansoni hypothetical protein 0.0101 0.1176 0.1927
Echinococcus granulosus survival motor neuron protein 1 0.0494 0.5926 0.9876
Loa Loa (eye worm) Smad1 0.0017 0.0164 0.0273
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0692 0.1071
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0006 0.0033 0.0054
Loa Loa (eye worm) Erv1/Alr family protein 0.0005 0.0024 0.004
Loa Loa (eye worm) MH2 domain-containing protein 0.025 0.2977 0.4962
Brugia malayi Cell death protein 3 precursor 0.0028 0.0296 0.0494
Echinococcus multilocularis sulfhydryl oxidase 1 0.0005 0.0024 0.0024
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0028 0.0296 0.4169
Schistosoma mansoni Smad4 0.0008 0.005 0.0044
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0371 0.5699
Loa Loa (eye worm) nuclear factor I 0.0009 0.0072 0.012
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0006 0.0033 0.0085
Trypanosoma cruzi metacaspase, putative 0.0028 0.0296 0.4472
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0459 1
Trichomonas vaginalis esterase, putative 0.0036 0.0398 0.1248
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0006 0.0033 0.0085
Trichomonas vaginalis glutaminase, putative 0.0264 0.3147 1
Brugia malayi beta-lactamase family protein 0.0036 0.0398 0.0663
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0296 0.0924
Echinococcus granulosus inhibitor of apoptosis protein 0.05 0.6001 1
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0006 0.0033 0.0015
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0692 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.1689 0.2786
Loa Loa (eye worm) hypothetical protein 0.0006 0.0033 0.0054
Loa Loa (eye worm) hypothetical protein 0.0006 0.0033 0.0054
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0633 0.0633
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0006 0.0033 0.0085
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0692 0.1242
Brugia malayi quiescin Q6 0.0005 0.0024 0.004
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0006 0.0033 0.0054
Brugia malayi MH2 domain containing protein 0.0017 0.0164 0.0273
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0633 0.1996
Loa Loa (eye worm) quiescin Q6 0.0005 0.0024 0.004
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0006 0.0033 0.0015
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0164 0.0164
Loa Loa (eye worm) G protein alpha subunit 3 0.0006 0.0033 0.0054
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0371 0.8027
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0398 0.0398
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0296 0.0924
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0398 0.5
Echinococcus multilocularis smad 0.0017 0.0164 0.0164
Brugia malayi beta-lactamase 0.0036 0.0398 0.0663
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0716 0.1193
Trypanosoma cruzi metacaspase, putative 0.0028 0.0296 0.4472
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0309 0.0477
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.1689 0.2786
Echinococcus granulosus GPCR family 2 0.0031 0.0335 0.0558
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0006 0.0033 0.0054
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0028 0.0296 0.4169
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0006 0.0033 0.0054
Brugia malayi MH2 domain containing protein 0.0008 0.005 0.0084
Onchocerca volvulus 0.0036 0.0398 0.0626
Echinococcus granulosus caspase 0.0028 0.0296 0.0494
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0101 0.1176 0.1959
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0398 0.1248
Trypanosoma brucei quiescin sulfhydryl oxidase 0.0005 0.0024 0.0377
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0006 0.0033 0.0085
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0398 0.1248
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.1689 0.2815
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0028 0.0296 0.4169
Echinococcus multilocularis caspase 2 0.0028 0.0296 0.0296
Loa Loa (eye worm) transcription factor SMAD2 0.025 0.2977 0.4962
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0006 0.0033 0.0054
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0459 0.1442
Brugia malayi MH1 domain containing protein 0.0017 0.0164 0.0273
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0006 0.0033 0.0085
Leishmania major hypothetical protein, conserved 0.0034 0.0371 0.1886
Loa Loa (eye worm) hypothetical protein 0.0067 0.0772 0.1286
Trypanosoma cruzi metacaspase 5, putative 0.0028 0.0296 0.4472
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0633 0.1996
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0164 0.0273
Echinococcus granulosus smad 0.0017 0.0164 0.0273
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.005 0.0084
Loa Loa (eye worm) hypothetical protein 0.0008 0.005 0.0084
Schistosoma mansoni hypothetical protein 0.0031 0.0335 0.052
Onchocerca volvulus Cell death protein 3 homolog 0.0028 0.0296 0.0456
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0296 0.0924
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.1689 0.2815
Trypanosoma brucei metacaspase 0.0028 0.0296 0.4681
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.1661 0.2768
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.05 0.6001 1
Echinococcus multilocularis caspase 8 0.0028 0.0296 0.0296
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0335 0.0558
Schistosoma mansoni glutaminase 0.0264 0.3147 0.5225
Schistosoma mansoni inhibitor of apoptosis protein 0.05 0.6001 1
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0028 0.0296 0.0456
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0006 0.0033 0.0054
Echinococcus granulosus tar DNA binding protein 0.0063 0.0716 0.1193
Echinococcus granulosus mothers against decapentaplegic 6 0.0008 0.005 0.0084
Loa Loa (eye worm) hypothetical protein 0.0036 0.0398 0.0663
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0371 0.5862
Loa Loa (eye worm) acetyltransferase 0.0141 0.1661 0.2768
Schistosoma mansoni hypothetical protein 0.0031 0.0335 0.052
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0006 0.0033 0.0054
Loa Loa (eye worm) hypothetical protein 0.0494 0.5926 0.9876
Onchocerca volvulus 0.0006 0.0033 0.0015
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0772 0.1286
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0459 0.6563
Brugia malayi RNA binding protein 0.0063 0.0716 0.1193
Schistosoma mansoni Smad4 0.0017 0.0164 0.0234
Schistosoma mansoni GTP-binding protein alpha subunit 0.0006 0.0033 0.0015
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0335 0.0335

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 3.46 mM Inhibition of rabbit muscle glycogen phosphorylase inactive form b ChEMBL. 20430629

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.