Detailed information for compound 1184953

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 354.357 | Formula: C14H15FN4O4S
  • H donors: 1 H acceptors: 4 LogP: 1.49 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)OCCOCn1nc(nc1Sc1cccc(c1)F)C(=O)N
  • InChi: 1S/C14H15FN4O4S/c1-9(20)23-6-5-22-8-19-14(17-13(18-19)12(16)21)24-11-4-2-3-10(15)7-11/h2-4,7H,5-6,8H2,1H3,(H2,16,21)
  • InChiKey: ANUGHVUWMRMVTL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis lamin dm0 0.0027 0.0808 0.0728
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.2284 0.3374
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0086 0.0126
Echinococcus multilocularis tar DNA binding protein 0.0062 0.3155 0.3096
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.3155 0.466
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0808 0.1193
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0808 0.1193
Echinococcus multilocularis musashi 0.0027 0.0808 0.0728
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3155 0.3096
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0086 0.0126
Onchocerca volvulus 0.0027 0.0808 0.5
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.3155 0.466
Loa Loa (eye worm) hypothetical protein 0.0034 0.1267 0.1871
Brugia malayi intermediate filament protein 0.0027 0.0808 0.1193
Loa Loa (eye worm) hypothetical protein 0.0026 0.0776 0.1146
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3155 0.3096
Echinococcus multilocularis lamin 0.0027 0.0808 0.0728
Brugia malayi MH2 domain containing protein 0.0118 0.677 1
Onchocerca volvulus 0.0027 0.0808 0.5
Echinococcus granulosus lamin 0.0027 0.0808 0.0728
Loa Loa (eye worm) hypothetical protein 0.0027 0.0808 0.1193
Brugia malayi RNA binding protein 0.0062 0.3155 0.466
Schistosoma mansoni hypothetical protein 0.0034 0.1267 0.1191
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3155 0.3096
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.677 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.2284 0.3374
Loa Loa (eye worm) RNA binding protein 0.0062 0.3155 0.466
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3155 0.3096
Schistosoma mansoni lamin 0.0027 0.0808 0.0728
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.677 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.1267 0.1871
Echinococcus granulosus lamin dm0 0.0027 0.0808 0.0728
Brugia malayi TAR-binding protein 0.0062 0.3155 0.466
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3155 0.3096
Schistosoma mansoni lamin 0.0027 0.0808 0.0728
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0808 0.1193
Echinococcus granulosus intermediate filament protein 0.0027 0.0808 0.0728
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.0126
Loa Loa (eye worm) TAR-binding protein 0.0062 0.3155 0.466
Loa Loa (eye worm) hypothetical protein 0.0049 0.2284 0.3374
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.2284 0.3374
Echinococcus granulosus tar DNA binding protein 0.0062 0.3155 0.3096
Schistosoma mansoni intermediate filament proteins 0.0027 0.0808 0.0728
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0086 0.0126

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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