Detailed information for compound 1185491

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 323.311 | Formula: C13H20F3N3O3
  • H donors: 2 H acceptors: 4 LogP: -0.49 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(F)(F)F.N#C[C@@H]1CCCN1C(=O)[C@H](C(C)(C)C)N
  • InChi: 1S/C11H19N3O.C2HF3O2/c1-11(2,3)9(13)10(15)14-6-4-5-8(14)7-12;3-2(4,5)1(6)7/h8-9H,4-6,13H2,1-3H3;(H,6,7)/t8-,9+;/m0./s1
  • InChiKey: QEUPZPGKNOHRLI-OULXEKPRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Sus scrofa Dipeptidyl peptidase IV Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Loa Loa (eye worm) prolyl oligopeptidase Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus granulosus dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) Get druggable targets OG5_128614 All targets in OG5_128614
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma japonicum ko:K01278 dipeptidyl-peptidase 4, putative Get druggable targets OG5_128614 All targets in OG5_128614
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog Get druggable targets OG5_128614 All targets in OG5_128614
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Dipeptidyl peptidase IV   766 aa 799 aa 30.3 %
Echinococcus granulosus Dipeptidyl peptidase 9 Dipeptidyl peptidase IV   766 aa 661 aa 26.3 %
Echinococcus multilocularis Dipeptidyl peptidase 9 Dipeptidyl peptidase IV   766 aa 614 aa 25.2 %
Dictyostelium discoideum hypothetical protein Dipeptidyl peptidase IV   766 aa 672 aa 25.6 %
Candida albicans dipeptidyl aminopeptidase similar to S. cerevisiae STE13 (YOR219C) involved in maturation of alpha-factor Dipeptidyl peptidase IV   766 aa 807 aa 25.4 %
Leishmania braziliensis dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B Dipeptidyl peptidase IV   766 aa 706 aa 24.6 %
Onchocerca volvulus Dipeptidyl peptidase IV   766 aa 646 aa 26.9 %
Candida albicans dipeptidyl aminopeptidase similar to S. cerevisiae STE13 (YOR219C) involved in maturation of alpha-factor Dipeptidyl peptidase IV   766 aa 807 aa 25.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0074 0.0396
Entamoeba histolytica protein kinase, putative 0.0186 0.0921 0.2624
Loa Loa (eye worm) hypothetical protein 0.0033 0.0018 0.0071
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.007 0.0239 0.1339
Loa Loa (eye worm) heat shock protein 90 0.0036 0.0036 0.0139
Giardia lamblia DINP protein human, muc B family 0.006 0.0181 0.0429
Schistosoma mansoni caspase-3 (C14 family) 0.0122 0.0544 0.1253
Leishmania major DNA polymerase eta, putative 0.0054 0.0143 0.0706
Plasmodium vivax hypothetical protein, conserved 0.0051 0.0127 0.1784
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0036 0.0084
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0471 0.129
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0181 0.1086
Schistosoma mansoni pyruvate kinase 0.0037 0.0043 0.0099
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0057 0.0162 0.2385
Echinococcus granulosus Dipeptidyl peptidase 9 0.007 0.0239 0.055
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0281 0.1482 0.3316
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0258 0.1348 0.5262
Trypanosoma brucei heat shock protein, putative 0.0036 0.0036 0.0146
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0823 0.2334
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0129 0.1829
Echinococcus granulosus geminin 0.0375 0.2039 0.4698
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0051 0.0127 0.0496
Leishmania major trypanothione reductase 0.0123 0.0548 0.3376
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0607 0.3411 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0036 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0295 0.183
Schistosoma mansoni heat shock protein 0.0036 0.0036 0.0082
Trichomonas vaginalis mercuric reductase, putative 0.0042 0.0074 0.0114
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0054 0.0143 0.0329
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0295 0.183
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0471 0.129
Plasmodium falciparum glutathione reductase 0.0042 0.0074 0.0752
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.006 0.0181 0.0955
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0177 0.276
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0074 0.0396
Schistosoma mansoni lozenge 0.0054 0.0141 0.0326
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0042 0.0074 0.0204
Brugia malayi Cell death protein 3 precursor 0.0081 0.0304 0.1188
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0066 0.0344
Schistosoma mansoni terminal deoxycytidyl transferase 0.0054 0.0143 0.0329
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.1616 0.9382 0.9379
Brugia malayi hypothetical protein 0.0136 0.0625 0.244
Mycobacterium tuberculosis Probable oxidoreductase 0.0042 0.0074 0.0031
Schistosoma mansoni heat shock protein 0.0036 0.0036 0.0082
Loa Loa (eye worm) hypothetical protein 0.0053 0.0137 0.0534
Loa Loa (eye worm) hypothetical protein 0.0463 0.2559 0.9994
Plasmodium falciparum thioredoxin reductase 0.0123 0.0548 1
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.0162 0.0632
Loa Loa (eye worm) intermediate filament protein 0.011 0.0473 0.1847
Brugia malayi Intermediate filament tail domain containing protein 0.011 0.0473 0.1847
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.006 0.0181 0.0138
Echinococcus granulosus intermediate filament protein 0.011 0.0473 0.109
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0129 0.0298
Brugia malayi heat shock protein 90 0.0036 0.0036 0.0139
Echinococcus multilocularis dual specificity 0.0186 0.0921 0.2061
Loa Loa (eye worm) beta-lactamase 0.011 0.0471 0.184
Loa Loa (eye worm) hypothetical protein 0.0037 0.0043 0.0168
Leishmania major pyruvate kinase 0.0037 0.0043 0.0048
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0177 0.0876
Loa Loa (eye worm) hypothetical protein 0.0054 0.0143 0.0558
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0177 0.0408
Onchocerca volvulus 0.011 0.0471 0.1996
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.0471 0.1086
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.0735 0.0695
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0162 0.246
Brugia malayi beta-lactamase 0.011 0.0471 0.184
Trypanosoma brucei heat shock protein, putative 0.0036 0.0036 0.0146
Onchocerca volvulus 0.0088 0.0343 0.1451
Mycobacterium ulcerans hypothetical protein 0.011 0.0471 0.2795
Mycobacterium tuberculosis Probable hydrolase 0.011 0.0471 0.043
Echinococcus granulosus muscleblind protein 0.0463 0.2559 0.5897
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0065 0.0208 0.0479
Schistosoma mansoni lamin 0.011 0.0473 0.109
Entamoeba histolytica hypothetical protein 0.0186 0.0921 0.2624
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0036 0.0142
Echinococcus granulosus lamin dm0 0.011 0.0473 0.109
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0109 0.0424
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0053 0.0137 0.0306
Mycobacterium ulcerans beta-lactamase 0.011 0.0471 0.2795
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0471 0.2973
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0129 0.029
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0042 0.0074 0.0171
Giardia lamblia NADH oxidase lateral transfer candidate 0.0042 0.0074 0.0114
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0607 0.3411 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0129 0.0754
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0471 0.2973
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0209 0.106 0.2443
Mycobacterium ulcerans DNA polymerase IV 0.008 0.0295 0.1646
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0281 0.1482 0.3415
Toxoplasma gondii exonuclease III APE 0.0057 0.0162 0.246
Trypanosoma cruzi Heat shock protein 83, putative 0.0036 0.0036 0.0146
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0036 0.0013
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0042 0.0074 0.0254
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0051 0.0127 0.0271
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0823 0.2334
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1348 0.3887
Brugia malayi jmjC domain containing protein 0.0065 0.0208 0.0812
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0127 0.0271
Brugia malayi Endoplasmin precursor 0.0036 0.0036 0.0139
Plasmodium vivax hypothetical protein, conserved 0.011 0.0471 0.85
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0042 0.0074 0.0752
Plasmodium falciparum glutathione reductase 0.0123 0.0548 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0074 0.0396
Treponema pallidum fructose-bisphosphate aldolase 0.0607 0.3411 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0129 0.0754
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0036 0.0002
Echinococcus multilocularis Dipeptidyl peptidase 9 0.007 0.0239 0.0535
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.0162 0.0632
Echinococcus granulosus pyruvate kinase 0.0037 0.0043 0.0099
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0281 0.1482 0.5787
Schistosoma mansoni endoplasmin 0.0036 0.0036 0.0082
Trypanosoma brucei metacaspase 5, putative 0.0051 0.0127 0.0739
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.0642 0.4082
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0042 0.0074 0.0204
Loa Loa (eye worm) hypothetical protein 0.011 0.0471 0.184
Echinococcus granulosus dna polymerase kappa 0.008 0.0295 0.068
Leishmania major DNA polymerase kappa, putative 0.006 0.0181 0.0955
Loa Loa (eye worm) hypothetical protein 0.0048 0.0109 0.0424
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0295 0.183
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0066 0.0344
Loa Loa (eye worm) hypothetical protein 0.011 0.0471 0.184
Onchocerca volvulus 0.0094 0.0379 0.1606
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0143 0.0841
Mycobacterium tuberculosis Possible penicillin-binding protein 0.07 0.3965 0.3939
Treponema pallidum recombinase A 0.0105 0.0441 0.11
Trypanosoma brucei trypanothione reductase 0.0123 0.0548 0.3473
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0127 0.0271
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.1554 1
Schistosoma mansoni hypothetical protein 0.0375 0.2039 0.4698
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0607 0.3411 1
Brugia malayi cytoplasmic intermediate filament protein 0.0059 0.0171 0.0668
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.0295 0.183
Echinococcus multilocularis musashi 0.011 0.0473 0.1058
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0036 0.015
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.007 0.0239 0.1465
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0054 0.0143 0.0329
Echinococcus granulosus caspase 8 0.0051 0.0127 0.0293
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0295 0.183
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0785 0.1756
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1348 0.3887
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.0295 0.183
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0042 0.0074 0.0752
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0036 0.0002
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0036 0.0142
Loa Loa (eye worm) hypothetical protein 0.0429 0.2361 0.9219
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0051 0.0127 0.0271
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0129 0.0617
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0036 0.0002
Schistosoma mansoni alpha-glucosidase 0.014 0.0651 0.15
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0042 0.0074 0.029
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.0036 0.0146
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0295 0.183
Trypanosoma cruzi metacaspase, putative 0.0051 0.0127 0.0739
Echinococcus multilocularis dna polymerase eta 0.0054 0.0143 0.0319
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0162 0.0374
Loa Loa (eye worm) hypothetical protein 0.011 0.0471 0.184
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0065 0.0208 0.0465
Mycobacterium ulcerans lipase LipD 0.011 0.0471 0.2795
Schistosoma mansoni glutaminase 0.0265 0.1389 0.3201
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0054 0.0143 0.0319
Mycobacterium ulcerans recombinase A 0.0105 0.0441 0.2599
Loa Loa (eye worm) transcription factor SMAD2 0.0248 0.1289 0.5032
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0471 0.129
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0081 0.0442
Loa Loa (eye worm) hypothetical protein 0.0043 0.0075 0.0291
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0247 0.0569
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0129 0.0278
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.0162 0.0362
Loa Loa (eye worm) hypothetical protein 0.011 0.0471 0.184
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.0471 0.2795
Plasmodium vivax thioredoxin reductase, putative 0.0123 0.0548 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0066 0.0344
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0043 0.0141
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0042 0.0074 0.0092
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.007 0.0239 0.1465
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0143 0.0558
Echinococcus multilocularis dna polymerase kappa 0.008 0.0295 0.066
Schistosoma mansoni DNA polymerase eta 0.0054 0.0143 0.0329
Onchocerca volvulus Huntingtin homolog 0.0136 0.0625 0.2647
Leishmania major pyruvate kinase 0.0037 0.0043 0.0048
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0043 0.0182
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0295 0.183
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0177 0.0408
Loa Loa (eye worm) hypothetical protein 0.0051 0.0125 0.0487
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0043 0.0168
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0127 0.0271
Loa Loa (eye worm) hypothetical protein 0.011 0.0471 0.184
Trypanosoma brucei metacaspase MCA2 0.0051 0.0127 0.0739
Echinococcus multilocularis caspase 3 0.007 0.024 0.0536
Onchocerca volvulus 0.011 0.0471 0.1996
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0051 0.0127 0.0271
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.0162 0.0964
Echinococcus granulosus microtubule associated protein 2 0.0764 0.434 1
Toxoplasma gondii thioredoxin reductase 0.0123 0.0548 1
Onchocerca volvulus 0.011 0.0473 0.2003
Brugia malayi glutathione reductase 0.0123 0.0548 0.2141
Trypanosoma brucei metacaspase MCA3 0.0051 0.0127 0.0739
Mycobacterium tuberculosis Conserved protein 0.011 0.0471 0.043
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0081 0.0442
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0059 0.0171 0.0668
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0042 0.0074 0.0254
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0186 0.0921 0.5835
Mycobacterium tuberculosis Conserved hypothetical protein 0.0054 0.0143 0.01
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.007 0.0239 0.1465
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0051 0.0127 0.0271
Echinococcus multilocularis muscleblind protein 1 0.0463 0.2559 0.5726
Trypanosoma brucei heat shock protein, putative 0.0036 0.0036 0.0146
Brugia malayi beta-lactamase family protein 0.011 0.0471 0.184
Loa Loa (eye worm) norepinephrine transporter 0.0088 0.0343 0.1337
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0043 0.0182
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0036 0.015
Chlamydia trachomatis recombinase RecA 0.0105 0.0441 1
Echinococcus multilocularis heat shock protein 0.0036 0.0036 0.008
Loa Loa (eye worm) hypothetical protein 0.0081 0.0304 0.1188
Echinococcus granulosus serotonin transporter 0.0088 0.0343 0.0789
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0066 0.0344
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.0471 0.2795
Trypanosoma brucei heat shock protein, putative 0.0036 0.0036 0.0146
Loa Loa (eye worm) hypothetical protein 0.0463 0.2559 0.9994
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0042 0.0074 0.0752
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0786 0.447 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0042 0.0074 0.0166
Trypanosoma brucei unspecified product 0.0037 0.0044 0.0196
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0129 0.0617
Plasmodium vivax glutathione reductase, putative 0.0123 0.0548 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0075 0.0398
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0036 0.0002
Trypanosoma cruzi metacaspase 5, putative 0.0051 0.0127 0.0739
Echinococcus multilocularis tumor protein p63 0.0345 0.1865 0.4172
Mycobacterium tuberculosis Conserved protein 0.011 0.0471 0.043
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0042 0.0074 0.0396
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0471 0.129
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0036 0.0002
Loa Loa (eye worm) hypothetical protein 0.0051 0.0125 0.0487
Plasmodium falciparum metacaspase-like protein 0.0051 0.0127 0.1784
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1348 0.3887
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0162 0.246
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0051 0.0127 0.0271
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.0471 0.043
Loa Loa (eye worm) hypothetical protein 0.0054 0.0141 0.055
Echinococcus granulosus tumor protein p63 0.0345 0.1865 0.4296
Trypanosoma cruzi trypanothione reductase, putative 0.0123 0.0548 0.3473
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0043 0.0182
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0036 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0281 0.1482 0.3415
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0463 0.2561 1
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0043 0.0168
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.012 0.069
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.0162 0.0262
Loa Loa (eye worm) thioredoxin reductase 0.0123 0.0548 0.2141
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.0295 0.183
Trypanosoma brucei unspecified product 0.0037 0.0044 0.0196
Brugia malayi hypothetical protein 0.0054 0.0141 0.055
Trypanosoma cruzi metacaspase 5, putative 0.0051 0.0127 0.0739
Entamoeba histolytica hypothetical protein 0.0072 0.0247 0.0626
Trypanosoma cruzi metacaspase, putative 0.0051 0.0127 0.0739
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0042 0.0074 0.0396
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0208 0.0479
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0177 0.0932
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0043 0.0192
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0186 0.0921 0.5895
Giardia lamblia Pyruvate kinase 0.0037 0.0043 0.0021
Schistosoma mansoni sodium/chloride dependent transporter 0.0088 0.0343 0.0789
Trypanosoma cruzi metacaspase, putative 0.0051 0.0127 0.0739
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0054 0.0143 0.0558
Loa Loa (eye worm) solute carrier family 6 member 4 0.0088 0.0343 0.1337
Trypanosoma brucei heat shock protein, putative 0.0036 0.0036 0.0146
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0471 0.1086
Echinococcus multilocularis lamin dm0 0.011 0.0473 0.1058
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0109 0.0424
Trypanosoma brucei heat shock protein 90, putative 0.0036 0.0036 0.0146
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0051 0.0127 0.1784
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0123 0.0548 0.0507
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0036 0.0081
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0042 0.0074 0.0171
Schistosoma mansoni lamin 0.011 0.0473 0.109
Mycobacterium leprae conserved hypothetical protein 0.011 0.0471 0.1257
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0043 0.0021
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.0785 0.3065
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.0257 0.1585
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0043 0.0168
Trypanosoma brucei unspecified product 0.0073 0.0257 0.1585
Brugia malayi follicle stimulating hormone receptor 0.0463 0.2561 1
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0209 0.106 0.2372
Brugia malayi Thioredoxin reductase 0.0123 0.0548 0.2141
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0051 0.0127 0.0271
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0129 0.0754
Brugia malayi Protein kinase domain containing protein 0.0186 0.0921 0.3598
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.0471 0.184
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0042 0.0074 0.0254
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0607 0.3411 1
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0209 0.106 0.2443
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0295 0.183
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0074 0.0396
Loa Loa (eye worm) MH2 domain-containing protein 0.0248 0.1289 0.5032
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0129 0.0278
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0129 0.0754
Loa Loa (eye worm) hypothetical protein 0.0136 0.0625 0.244
Loa Loa (eye worm) serotonin transporter b 0.0088 0.0343 0.1337
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0281 0.1482 0.3415
Echinococcus multilocularis pyruvate kinase 0.0037 0.0043 0.0096
Trypanosoma brucei Heat shock protein 83, putative 0.0036 0.0036 0.0146
Loa Loa (eye worm) runx1 0.0054 0.0141 0.0552
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0247 0.0569
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0036 0.0002
Loa Loa (eye worm) hypothetical protein 0.0051 0.0122 0.0476
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0177 0.0135
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0295 0.183
Trypanosoma brucei Metacaspase-4 0.0051 0.0127 0.0739
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.0162 0.0964
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0177 0.0396
Onchocerca volvulus 0.0051 0.0122 0.0516
Brugia malayi MAP kinase sur-1 0.0052 0.0129 0.0505
Schistosoma mansoni alpha glucosidase 0.0036 0.0036 0.0084
Schistosoma mansoni serine/threonine protein kinase 0.0186 0.0921 0.2123
Onchocerca volvulus 0.011 0.0473 0.2003
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0051 0.0127 0.1784
Echinococcus multilocularis caspase 0.0122 0.0544 0.1217
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0258 0.1348 0.5262
Echinococcus multilocularis geminin 0.0375 0.2039 0.4562
Brugia malayi glutaminase DH11.1 0.0265 0.1389 0.5425
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0162 0.0374
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0177 0.0408
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0122 0.0544 0.1253
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0036 0.0004
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.007 0.0239 0.055
Brugia malayi hypothetical protein 0.0072 0.0247 0.0964
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0042 0.0074 0.0396
Schistosoma mansoni ap endonuclease 0.0057 0.0162 0.0373
Trypanosoma brucei DNA polymerase IV, putative 0.008 0.0295 0.183
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0042 0.0074 0.0031
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0109 0.0424
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0143 0.0558
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0042 0.0074 0.0396
Loa Loa (eye worm) hypothetical protein 0.0108 0.0461 0.1801
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0295 0.183
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0042 0.0074 0.0031
Onchocerca volvulus Cell death protein 3 homolog 0.0081 0.0304 0.1288
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0296 0.1576 0.1539
Loa Loa (eye worm) endoplasmin 0.0036 0.0036 0.0139
Brugia malayi jmjC domain containing protein 0.0065 0.0208 0.0812
Brugia malayi hypothetical protein 0.0429 0.2361 0.9219
Echinococcus multilocularis caspase 8 0.0051 0.0127 0.0284
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.1554 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0074 0.0396
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0081 0.0442
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.0162 0.0373
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0129 0.0278
Echinococcus granulosus caspase 2 0.0081 0.0304 0.0701
Loa Loa (eye worm) glutaminase 0.0265 0.1389 0.5425
Echinococcus granulosus pyruvate kinase 0.0037 0.0043 0.0099
Toxoplasma gondii NADPH-glutathione reductase 0.0042 0.0074 0.0752
Trypanosoma brucei heat shock protein, putative 0.0036 0.0036 0.0146
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.0471 0.043
Trypanosoma brucei pyruvate kinase 1, putative 0.0037 0.0043 0.0192
Trypanosoma brucei DNA polymerase IV, putative 0.008 0.0295 0.183
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0785 0.1756
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0042 0.0074 0.0204
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.0162 0.0119
Trypanosoma cruzi trypanothione reductase, putative 0.0042 0.0074 0.0396
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.0036 0.0146
Toxoplasma gondii hypothetical protein 0.0047 0.0102 0.1295
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1348 0.3887
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0127 0.0271
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.008 0.0295 0.0769
Brugia malayi Muscleblind-like protein 0.0463 0.2559 0.9994
Schistosoma mansoni hypothetical protein 0.0375 0.2039 0.4698
Loa Loa (eye worm) prolyl oligopeptidase 0.0209 0.106 0.414
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0209 0.106 0.4491
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.0162 0.0374
Loa Loa (eye worm) hypothetical protein 0.011 0.0471 0.184
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0143 0.0841
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0043 0.0168
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0042 0.0074 0.0396
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0036 0.0002
Schistosoma mansoni jumonji domain containing protein 0.0065 0.0208 0.0479
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0051 0.0127 0.0271
Plasmodium vivax metacaspase 1, putative 0.0051 0.0127 0.1784
Echinococcus multilocularis caspase 2 0.0081 0.0304 0.068
Trichomonas vaginalis glutaminase, putative 0.0265 0.1389 0.401
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0127 0.0271
Trypanosoma brucei heat shock protein, putative 0.0036 0.0036 0.0146
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0208 0.0479
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0036 0.0002
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.0471 0.043
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0051 0.0127 0.0271
Onchocerca volvulus Glucosylceramidase homolog 0.0169 0.0823 0.3487
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.0471 0.043
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0043 0.0168
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0471 0.129
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0823 0.2334
Entamoeba histolytica hypothetical protein 0.0072 0.0247 0.0626
Echinococcus granulosus dual specificity 0.0186 0.0921 0.2123
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1348 0.3887
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.007 0.0239 0.1465
Onchocerca volvulus 0.0429 0.2361 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0065 0.0208 0.0465
Loa Loa (eye worm) hypothetical protein 0.0184 0.0913 0.3565
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0129 0.0298
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0088 0.0343 0.1337
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0129 0.0298
Schistosoma mansoni pyruvate kinase 0.0037 0.0043 0.0099
Loa Loa (eye worm) hypothetical protein 0.0088 0.0343 0.1337
Brugia malayi beta-lactamase family protein 0.011 0.0471 0.184
Schistosoma mansoni hypothetical protein 0.0072 0.0247 0.0569
Trypanosoma brucei heat shock protein, putative 0.0036 0.0036 0.0146
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0053 0.0137 0.0315
Echinococcus granulosus caspase 3 0.007 0.024 0.0552
Entamoeba histolytica hypothetical protein 0.0072 0.0247 0.0626
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0247 0.0552
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0296 0.1576 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.0162 0.0964
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0031 0.0008 0.0029
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0177 0.0876
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0877 0.2493
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0122 0.0544 0.1217
Trichomonas vaginalis glutathione reductase, putative 0.0042 0.0074 0.0114
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0129 0.0278
Mycobacterium ulcerans glutaminase 0.0265 0.1389 0.8784
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0186 0.0921 0.5895
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.0471 0.043
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0208 0.0479
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0042 0.0074 0.0031
Mycobacterium leprae Conserved hypothetical protein 0.0613 0.345 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0186 0.0921 0.5895
Trypanosoma cruzi metacaspase, putative 0.0051 0.0127 0.0739
Loa Loa (eye worm) hypothetical protein 0.0088 0.0343 0.1337
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.0162 0.0775
Trypanosoma brucei pyruvate kinase 1 0.0037 0.0043 0.0192
Loa Loa (eye worm) hypothetical protein 0.0136 0.0625 0.244
Trypanosoma brucei metacaspase 0.0051 0.0127 0.0739
Leishmania major metacaspase, putative 0.0051 0.0127 0.0602
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0607 0.3411 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0127 0.0496
Echinococcus multilocularis serotonin transporter 0.0088 0.0343 0.0766
Loa Loa (eye worm) hypothetical protein 0.0088 0.0343 0.1337
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0607 0.3411 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0642 0.4082
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0042 0.0074 0.0254
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0281 0.1482 0.5787
Entamoeba histolytica protein kinase, putative 0.0186 0.0921 0.2624
Trichomonas vaginalis DNA polymerase eta, putative 0.008 0.0295 0.0769
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.0162 0.0374
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0105 0.0441 1
Mycobacterium tuberculosis Conserved protein 0.011 0.0471 0.043
Trypanosoma brucei heat shock protein 90, putative 0.0036 0.0036 0.0146
Echinococcus multilocularis lamin 0.011 0.0473 0.1058
Schistosoma mansoni microtubule-associated protein tau 0.0764 0.434 1
Schistosoma mansoni hypothetical protein 0.0033 0.0018 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0075 0.0398
Trichomonas vaginalis esterase, putative 0.011 0.0471 0.129
Loa Loa (eye worm) hypothetical protein 0.0429 0.2361 0.9219
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0823 0.2334
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0018 0.0071
Mycobacterium ulcerans DNA polymerase IV 0.008 0.0295 0.1646
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0129 0.029
Toxoplasma gondii ABC1 family protein 0.011 0.0471 0.85
Trypanosoma brucei glucosidase, putative 0.0036 0.0036 0.015
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0823 0.2334
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0042 0.0074 0.0752
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0122 0.0281
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0823 0.2334
Echinococcus multilocularis Protein lozenge 0.0054 0.0141 0.0316
Mycobacterium ulcerans hypothetical protein 0.0154 0.0735 0.4512
Echinococcus granulosus heat shock protein 90 0.0036 0.0036 0.0082
Loa Loa (eye worm) glutaminase 2 0.0265 0.1389 0.5425
Loa Loa (eye worm) glutathione reductase 0.0123 0.0548 0.2141
Entamoeba histolytica deoxycytidyl transferase, putative 0.0054 0.0143 0.0317
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1348 0.3887
Plasmodium falciparum thioredoxin reductase 0.0042 0.0074 0.0752
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0607 0.3411 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0607 0.3411 1
Trypanosoma brucei protein kinase, putative 0.0052 0.0129 0.0754
Brugia malayi polk-prov protein 0.0043 0.0075 0.0291
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0607 0.3411 1
Trypanosoma brucei hypothetical protein, conserved 0.011 0.0471 0.2973
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0105 0.0441 0.1169
Onchocerca volvulus 0.011 0.0471 0.1996
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0051 0.0127 0.1784
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0823 0.2334
Echinococcus granulosus caspase 0.0122 0.0544 0.1253
Mycobacterium leprae Probable lipase LipE 0.011 0.0471 0.1257
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0042 0.0074 0.0752
Brugia malayi prolyl oligopeptidase family protein 0.007 0.0239 0.0933
Loa Loa (eye worm) hypothetical protein 0.0184 0.0913 0.3565
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.0785 0.1808
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0074 0.0396
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0042 0.0074 0.0786
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0177 0.0876
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0042 0.0074 0.0396
Schistosoma mansoni ap endonuclease 0.0057 0.0162 0.0373
Schistosoma mansoni caspase-7 (C14 family) 0.0081 0.0304 0.0701
Loa Loa (eye worm) hypothetical protein 0.011 0.0473 0.1847
Schistosoma mansoni intermediate filament proteins 0.011 0.0473 0.109
Brugia malayi prolyl oligopeptidase family protein 0.0209 0.106 0.414
Echinococcus multilocularis microtubule associated protein 2 0.0764 0.434 0.9711
Brugia malayi MH2 domain containing protein 0.0248 0.1289 0.5032
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0208 0.0812
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0471 0.1086
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.0471 0.184
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0281 0.1482 0.3316
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0129 0.0505
Echinococcus multilocularis heat shock protein 90 0.0036 0.0036 0.008
Schistosoma mansoni endoplasmin 0.0036 0.0036 0.0082
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.011 0.0473 0.1847
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0607 0.3411 1
Echinococcus granulosus lamin 0.011 0.0473 0.109
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.0036 0.0146
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.0162 0.0831
Echinococcus granulosus thioredoxin glutathione reductase 0.0123 0.0548 0.1263
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.0785 0.3065
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0031 0.0008 0.0029
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0281 0.1482 0.3415
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.1554 1
Entamoeba histolytica protein kinase domain containing protein 0.0186 0.0921 0.2624
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.007 0.0239 0.3966
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0127 0.0271
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0051 0.0127 0.0271
Leishmania major hypothetical protein, conserved 0.011 0.0471 0.287
Brugia malayi intermediate filament protein 0.011 0.0473 0.1847
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0129 0.0754
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0051 0.0127 0.0293
Trypanosoma cruzi heat shock protein 90, putative 0.0036 0.0036 0.0146
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0043 0.0021
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0088 0.0343 0.0789
Treponema pallidum sodium- and chloride- dependent transporter 0.0088 0.0343 0.0804
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0036 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0877 0.2493
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.1554 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.0295 0.183
Schistosoma mansoni alpha-glucosidase 0.014 0.0651 0.15
Echinococcus granulosus dna polymerase eta 0.0054 0.0143 0.0329
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0642 0.3994
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0043 0.0141
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0129 0.0278
Entamoeba histolytica hypothetical protein 0.0072 0.0247 0.0626
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.0471 0.1054
Onchocerca volvulus Huntingtin homolog 0.0136 0.0625 0.2647
Echinococcus granulosus heat shock protein 0.0036 0.0036 0.0082
Plasmodium falciparum metacaspase 1 0.0051 0.0127 0.1784
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0186 0.0921 0.3598
Schistosoma mansoni caspase-7 (C14 family) 0.0122 0.0544 0.1253
Echinococcus multilocularis pyruvate kinase 0.0037 0.0043 0.0096
Plasmodium falciparum pyruvate kinase 0.0037 0.0043 0.0141
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0607 0.3411 1
Echinococcus multilocularis muscleblind protein 0.0463 0.2559 0.5726
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0296 0.1576 0.4499
Echinococcus multilocularis thioredoxin glutathione reductase 0.0123 0.0548 0.1226
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0043 0.0192
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0281 0.1482 0.3415
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.0471 0.043

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 8 nM In vitro inhibition of porcine Dipeptidylpeptidase IV. ChEMBL. 15115400

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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