Detailed information for compound 1185967

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 324.375 | Formula: C15H24N4O4
  • H donors: 4 H acceptors: 2 LogP: -2.25 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(CN[C@@H](C(=O)O)CCCN=C(N)N)ccc1OC
  • InChi: 1S/C15H24N4O4/c1-22-12-6-5-10(8-13(12)23-2)9-19-11(14(20)21)4-3-7-18-15(16)17/h5-6,8,11,19H,3-4,7,9H2,1-2H3,(H,20,21)(H4,16,17,18)/t11-/m1/s1
  • InChiKey: QHQBLLAISBIVRN-LLVKDONJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens melanocortin 3 receptor Starlite/ChEMBL References
Homo sapiens melanocortin 4 receptor Starlite/ChEMBL References
Homo sapiens melanocortin 5 receptor Starlite/ChEMBL References
Homo sapiens melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium falciparum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Theileria parva tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin, beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium parvum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi beta tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-7 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-4 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-2A chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-4 chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi beta-tubulin, identical Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium hominis beta-catenin-like repeat protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-1 tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Babesia bovis tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein melanocortin 5 receptor 325 aa 311 aa 20.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni inositol monophosphatase 0.0036 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0026 0.2282
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0034 0.0823
Loa Loa (eye worm) hypothetical protein 0.0065 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0065 0.0045 0.0045
Onchocerca volvulus 0.0042 0.0015 0.0154
Onchocerca volvulus 0.0592 0.0738 0.7582
Schistosoma mansoni cercarial elastase (S01 family) 0.012 0.0118 0.0118
Loa Loa (eye worm) neuropeptide F receptor 0.0592 0.0738 0.0738
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0592 0.0738 0.0738
Loa Loa (eye worm) pyruvate kinase-PB 0.0068 0.005 0.005
Trichomonas vaginalis penicillin-binding protein, putative 0.0082 0.0068 0.74
Entamoeba histolytica hypothetical protein 0.0116 0.0113 1
Echinococcus multilocularis g protein coupled receptor 0.0592 0.0738 0.0738
Echinococcus multilocularis neurogenic locus protein delta 0.0065 0.0045 0.0045
Entamoeba histolytica pyruvate kinase, putative 0.0068 0.005 0.4017
Schistosoma mansoni hypothetical protein 0.0116 0.0113 0.0113
Onchocerca volvulus 0.0651 0.0815 0.8373
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0082 0.0082
Echinococcus multilocularis neurogenic locus notch protein 0.0065 0.0045 0.0045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0592 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0082 0.0068 0.0068
Onchocerca volvulus 0.0082 0.0068 0.0696
Onchocerca volvulus Deterin homolog 0.0093 0.0083 0.0849
Brugia malayi MH2 domain containing protein 0.0133 0.0135 0.024
Mycobacterium ulcerans esterase/lipase LipP 0.0082 0.0068 0.5436
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0106 0.0099 1
Toxoplasma gondii PAN domain-containing protein 0.0042 0.0015 0.0229
Echinococcus multilocularis g protein coupled receptor 0.0592 0.0738 0.0738
Onchocerca volvulus 0.0049 0.0024 0.0244
Schistosoma mansoni biogenic amine (5HT) receptor 0.2457 0.3188 0.3188
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0024 0.0024
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0101 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Mycobacterium tuberculosis Hypothetical protein 0.005 0.0026 0.0365
Schistosoma mansoni hypothetical protein 0.0401 0.0487 0.0487
Loa Loa (eye worm) hypothetical protein 0.012 0.0118 0.0118
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0082 0.0068 0.0068
Mycobacterium tuberculosis Probable lipase LipE 0.0082 0.0068 0.101
Onchocerca volvulus 0.0592 0.0738 0.7582
Echinococcus multilocularis protein dispatched 1 0.0047 0.0022 0.0022
Echinococcus multilocularis enteropeptidase 0.012 0.0118 0.0118
Brugia malayi Cadherin domain containing protein 0.0065 0.0045 0.008
Schistosoma mansoni cercarial elastase (S01 family) 0.012 0.0118 0.0118
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0043 0.0017 0.0219
Echinococcus granulosus neural cadherin 0.0065 0.0045 0.0045
Schistosoma mansoni opsin-like receptor 0.0592 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0093 0.0083 0.0083
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0024 0.0024
Schistosoma mansoni neuropeptide F-like receptor 0.0592 0.0738 0.0738
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0017 0.0656
Schistosoma mansoni hypothetical protein 0.0286 0.0336 0.0336
Entamoeba histolytica hypothetical protein 0.0116 0.0113 1
Onchocerca volvulus 0.0042 0.0015 0.0154
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0082 0.0068 0.0068
Echinococcus granulosus neurogenic locus notch protein 0.0065 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0055 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0065 0.0045 0.0045
Mycobacterium tuberculosis Conserved protein 0.0082 0.0068 0.101
Loa Loa (eye worm) hypothetical protein 0.0082 0.0068 0.0068
Schistosoma mansoni cercarial elastase (S01 family) 0.012 0.0118 0.0118
Echinococcus granulosus tm gpcr rhodopsin 0.4694 0.6128 0.6128
Schistosoma mansoni hypothetical protein 0.0065 0.0045 0.0045
Echinococcus granulosus ubiquitin specific protease 41 0.0044 0.0017 0.0017
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0592 0.0738 0.0738
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.012 0.0118 0.0118
Onchocerca volvulus 0.0592 0.0738 0.7582
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Schistosoma mansoni hypothetical protein 0.0592 0.0738 0.0738
Mycobacterium ulcerans beta-lactamase 0.0082 0.0068 0.5436
Toxoplasma gondii pyruvate kinase PyK1 0.0098 0.0089 0.248
Toxoplasma gondii PAN domain-containing protein 0.0042 0.0015 0.0229
Brugia malayi Dopamine receptor protein 1 0.0592 0.0738 0.1316
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.0141 0.0141
Echinococcus granulosus g protein coupled receptor 0.0592 0.0738 0.0738
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0033 0.0033
Onchocerca volvulus 0.0082 0.0068 0.0696
Loa Loa (eye worm) hypothetical protein 0.0101 0.0093 0.0093
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0034 0.0823
Brugia malayi Dihydrofolate reductase 0.0043 0.0017 0.003
Leishmania major hypothetical protein, conserved 0.0082 0.0068 0.1835
Schistosoma mansoni adenoreceptor 0.0592 0.0738 0.0738
Echinococcus multilocularis neuropeptide s receptor 0.0592 0.0738 0.0738
Trypanosoma cruzi pyruvate kinase 2, putative 0.0098 0.0089 0.248
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0093 0.0083 0.0147
Loa Loa (eye worm) hypothetical protein 0.0044 0.0017 0.0017
Onchocerca volvulus 0.0592 0.0738 0.7582
Brugia malayi Dopamine receptor 0.0592 0.0738 0.1316
Schistosoma mansoni hypothetical protein 0.0054 0.0031 0.0031
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0033 0.0033
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0093 0.0083 0.0147
Schistosoma mansoni cercarial elastase (S01 family) 0.012 0.0118 0.0118
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0592 0.0738 0.0738
Echinococcus multilocularis pyruvate kinase 0.0098 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0286 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0065 0.0045 0.0045
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0087 0.0155
Loa Loa (eye worm) PAN domain-containing protein 0.0042 0.0015 0.0015
Toxoplasma gondii calcium binding egf domain-containing protein 0.017 0.0183 0.5348
Echinococcus granulosus somatostatin receptor 0.0592 0.0738 0.0738
Echinococcus granulosus 7TM GPCR rhodopsin 0.0592 0.0738 0.0738
Echinococcus multilocularis protein patched 0.0041 0.0014 0.0014
Onchocerca volvulus 0.0042 0.0015 0.0154
Echinococcus granulosus neuropeptide receptor A26 0.0592 0.0738 0.0738
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0592 0.0738 0.0738
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0592 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0065 0.0045 0.0045
Echinococcus granulosus neurogenic locus protein delta 0.0065 0.0045 0.0045
Brugia malayi G-protein coupled receptor 0.0592 0.0738 0.1316
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0106 0.0099 0.0099
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0044 0.0017 0.1192
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0592 0.0738 0.0738
Echinococcus multilocularis pyruvate kinase 0.0098 0.0089 0.0089
Brugia malayi PAN domain containing protein 0.0042 0.0015 0.0027
Toxoplasma gondii PAN domain-containing protein 0.0042 0.0015 0.0229
Echinococcus multilocularis neuropeptide Y receptor 0.0592 0.0738 0.0738
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0592 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Entamoeba histolytica hypothetical protein 0.0116 0.0113 1
Brugia malayi Fibulin-1 precursor 0.017 0.0183 0.0327
Giardia lamblia High cysteine protein 0.0065 0.0045 0.3895
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.017 0.0183 0.0183
Echinococcus multilocularis g protein coupled receptor 0.0592 0.0738 0.0738
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0592 0.0738 0.1316
Brugia malayi hypothetical protein 0.0592 0.0738 0.1316
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Echinococcus multilocularis rhodopsin orphan GPCR 0.0592 0.0738 0.0738
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0017 0.1192
Schistosoma mansoni cercarial elastase (S01 family) 0.012 0.0118 0.0118
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0098 0.0089 0.1338
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0087 0.0087
Brugia malayi mbt repeat family protein 0.0049 0.0024 0.0042
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.032 0.038 0.0678
Loa Loa (eye worm) hypothetical protein 0.012 0.0118 0.0118
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.0135 0.0135
Schistosoma mansoni neuropeptide receptor 0.0592 0.0738 0.0738
Echinococcus granulosus tachykinin peptides receptor 99D 0.0592 0.0738 0.0738
Echinococcus multilocularis g-protein coupled receptor 0.0592 0.0738 0.0738
Schistosoma mansoni hypothetical protein 0.0592 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0592 0.0738 0.0738
Echinococcus granulosus 7tm_1 domain containing protein 0.0592 0.0738 0.0738
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.0034 0.0823
Brugia malayi EGF-like domain containing protein 0.0065 0.0045 0.008
Onchocerca volvulus 0.012 0.0118 0.1216
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0195 0.0217 0.0217
Loa Loa (eye worm) G-protein coupled receptor 0.0592 0.0738 0.0738
Toxoplasma gondii microneme protein MIC17C 0.0042 0.0015 0.0229
Loa Loa (eye worm) hypothetical protein 0.032 0.038 0.038
Loa Loa (eye worm) beta-lactamase 0.0082 0.0068 0.0068
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0592 0.0738 0.0738
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0195 0.0217 0.0217
Onchocerca volvulus Pyruvate kinase homolog 0.0098 0.0089 0.0913
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0014 0.0852
Onchocerca volvulus 0.0592 0.0738 0.7582
Brugia malayi Pyruvate kinase, M2 isozyme 0.0098 0.0089 0.0159
Onchocerca volvulus 0.0042 0.0015 0.0154
Loa Loa (eye worm) PAN domain-containing protein 0.0042 0.0015 0.0015
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.003 0.0688
Brugia malayi hypothetical protein 0.0263 0.0306 0.0545
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Echinococcus granulosus beta LACTamase domain containing family member 0.0082 0.0068 0.0068
Echinococcus multilocularis beta LACTamase domain containing family member 0.0082 0.0068 0.0068
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0024 0.0024
Brugia malayi neuropeptide F receptor 0.0592 0.0738 0.1316
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0082 0.0068 0.0068
Echinococcus multilocularis Tolloid protein 1 0.017 0.0183 0.0183
Toxoplasma gondii microneme protein, putative 0.0042 0.0015 0.0229
Loa Loa (eye worm) pyruvate kinase 0.0098 0.0089 0.0089
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0082 0.0068 0.5436
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0087 0.751
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0592 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0065 0.0045 0.0045
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0771 0.0973 0.0973
Brugia malayi Trypsin family protein 0.012 0.0118 0.0211
Brugia malayi Tachykinin-like peptides receptor 99D 0.0592 0.0738 0.1316
Loa Loa (eye worm) PAN domain-containing protein 0.0042 0.0015 0.0015
Echinococcus multilocularis neurogenic locus notch protein 4 0.0065 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0015 0.0015
Onchocerca volvulus 0.0054 0.0031 0.0313
Echinococcus granulosus protein jagged 1 0.0065 0.0045 0.0045
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0771 0.0973 0.0973
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0592 0.0738 0.0738
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0101 0.0093 0.0093
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0116 0.0113 0.0113
Echinococcus granulosus protein jagged 2 0.0065 0.0045 0.0045
Trypanosoma cruzi pyruvate kinase 2, putative 0.0098 0.0089 0.248
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0093 0.0083 0.0083
Echinococcus granulosus g protein coupled receptor 0.0592 0.0738 0.0738
Brugia malayi Calcium binding EGF domain containing protein 0.0065 0.0045 0.008
Echinococcus granulosus dihydrofolate reductase 0.0043 0.0017 0.0017
Toxoplasma gondii EGF family domain-containing protein 0.0065 0.0045 0.1146
Mycobacterium tuberculosis Conserved protein 0.0082 0.0068 0.101
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0044 0.0017 0.0296
Echinococcus granulosus tissue type plasminogen activator 0.0286 0.0336 0.0336
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0014 0.0014
Brugia malayi dihydrofolate reductase family protein 0.0043 0.0017 0.003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0592 0.0738 0.0738
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.005 0.0026 0.0566
Brugia malayi larval opioid receptor 0.0592 0.0738 0.1316
Echinococcus multilocularis fat cadherin tumor suppressor 0.0065 0.0045 0.0045
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0068 0.1835
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0592 0.0738 0.0738
Echinococcus multilocularis rhodopsin orphan GPCR 0.0592 0.0738 0.0738
Echinococcus granulosus GPCR family 2 0.0101 0.0093 0.0093
Echinococcus granulosus Tolloid protein 1 0.017 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0042 0.0015 0.0015
Toxoplasma gondii PAN domain-containing protein 0.0042 0.0015 0.0229
Onchocerca volvulus Neuropeptide F receptor homolog 0.0592 0.0738 0.7582
Schistosoma mansoni cercarial elastase (S01 family) 0.012 0.0118 0.0118
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0082 0.0082
Brugia malayi EGF-like domain containing protein 0.0065 0.0045 0.008
Brugia malayi Serotonin receptor 0.0592 0.0738 0.1316
Loa Loa (eye worm) TYRA-2 protein 0.0592 0.0738 0.0738
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0033 0.0033
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0848 0.1074 0.1074
Schistosoma mansoni amine GPCR 0.0592 0.0738 0.0738
Brugia malayi Muscle positioning protein 4 0.0099 0.009 0.016
Echinococcus granulosus rhodopsin orphan GPCR 0.0592 0.0738 0.0738
Onchocerca volvulus Pyruvate kinase homolog 0.0098 0.0089 0.0913
Echinococcus multilocularis inhibitor of apoptosis protein 0.0093 0.0083 0.0083
Echinococcus multilocularis protein jagged 1 0.0065 0.0045 0.0045
Schistosoma mansoni notch 0.0065 0.0045 0.0045
Echinococcus multilocularis tissue type plasminogen activator 0.0286 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0065 0.0045 0.0045
Toxoplasma gondii microneme protein MIC4 0.0042 0.0015 0.0229
Loa Loa (eye worm) hypothetical protein 0.0219 0.0247 0.0247
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0033 0.0033
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0149 0.0155 1
Schistosoma mansoni biogenic amine receptor 0.0592 0.0738 0.0738
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0082 0.0082
Echinococcus multilocularis pyruvate kinase 0.005 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Mycobacterium tuberculosis Conserved protein 0.0082 0.0068 0.101
Echinococcus multilocularis rhodopsin orphan GPCR 0.0592 0.0738 0.0738
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.012 0.0118 0.0118
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.012 0.0118 0.0118
Onchocerca volvulus 0.0592 0.0738 0.7582
Schistosoma mansoni hypothetical protein 0.004 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0414 0.0504 0.0504
Onchocerca volvulus 0.0592 0.0738 0.7582
Echinococcus granulosus alpha 1A adrenergic receptor 0.0592 0.0738 0.0738
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.0141 0.0141
Toxoplasma gondii hypothetical protein 0.0042 0.0015 0.0229
Echinococcus multilocularis fibrillin 1 0.017 0.0183 0.0183
Schistosoma mansoni hypothetical protein 0.0093 0.0083 0.0083
Mycobacterium tuberculosis Probable lipase LipD 0.0082 0.0068 0.101
Echinococcus granulosus G protein coupled receptor 139 0.0592 0.0738 0.0738
Echinococcus granulosus rhodopsin orphan GPCR 0.0592 0.0738 0.0738
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0149 0.0155 0.4175
Echinococcus granulosus neuropeptide FF receptor 2 0.0592 0.0738 0.0738
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.0034 0.0034
Echinococcus granulosus biogenic amine 5HT receptor 0.2457 0.3188 0.3188
Loa Loa (eye worm) hypothetical protein 0.0068 0.005 0.005
Echinococcus granulosus enteropeptidase 0.012 0.0118 0.0118
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0592 0.0738 0.0738
Schistosoma mansoni hypothetical protein 0.004 0.0012 0.0012
Toxoplasma gondii PAN domain-containing protein 0.0042 0.0015 0.0229
Brugia malayi Dopamine receptor protein 2 0.0592 0.0738 0.1316
Loa Loa (eye worm) hypothetical protein 0.017 0.0183 0.0183
Onchocerca volvulus 0.0099 0.009 0.0923
Brugia malayi Melatonin receptor type 1A 0.0592 0.0738 0.1316
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0592 0.0738 0.0738
Echinococcus multilocularis fmrfamide receptor 0.0592 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Echinococcus granulosus Mastin 0.012 0.0118 0.0118
Schistosoma mansoni histamine h1 receptor 0.0592 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0034 0.3318
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.0487 0.0487
Onchocerca volvulus Huntingtin homolog 0.0414 0.0504 0.5175
Brugia malayi hypothetical protein 0.005 0.0026 0.0046
Echinococcus granulosus pyruvate kinase 0.0098 0.0089 0.0089
Schistosoma mansoni amine GPCR 0.0592 0.0738 0.0738
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0089 0.0089
Loa Loa (eye worm) DOMON domain-containing protein 0.0034 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0093 0.0083 0.0083
Plasmodium vivax hypothetical protein, conserved 0.0082 0.0068 0.1342
Echinococcus multilocularis pyruvate kinase 0.0077 0.0062 0.0062
Echinococcus multilocularis laminin 0.017 0.0183 0.0183
Schistosoma mansoni opsin-like receptor 0.0592 0.0738 0.0738
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0592 0.0738 0.0738
Echinococcus granulosus neurogenic locus notch protein 0.0065 0.0045 0.0045
Brugia malayi SEA domain containing protein 0.0034 0.0005 0.0008
Echinococcus multilocularis fibropellin Ia 0.0065 0.0045 0.0045
Onchocerca volvulus 0.0042 0.0015 0.0154
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.012 0.0118 0.0118
Schistosoma mansoni cercarial elastase (S01 family) 0.012 0.0118 0.0118
Schistosoma mansoni notch 0.0065 0.0045 0.0045
Echinococcus multilocularis neuropeptide receptor 0.0592 0.0738 0.0738
Mycobacterium ulcerans pyruvate kinase 0.0098 0.0089 0.7346
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0524 0.0648 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0592 0.0738 0.1316
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0093 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.012 0.0118 0.0118
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0592 0.0738 0.0738
Schistosoma mansoni slit 0.0065 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0041 0.0014 0.0014
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0592 0.0738 0.0738
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0592 0.0738 0.1316
Schistosoma mansoni hypothetical protein 0.0065 0.0045 0.0045
Mycobacterium ulcerans hypothetical protein 0.012 0.0118 1
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0065 0.0045 0.0463
Echinococcus granulosus sex peptide receptor 0.0592 0.0738 0.0738
Brugia malayi hypothetical protein 0.0592 0.0738 0.1316
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Plasmodium vivax pyruvate kinase, putative 0.0098 0.0089 0.2026
Loa Loa (eye worm) hypothetical protein 0.0065 0.0045 0.0045
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0592 0.0738 0.1316
Brugia malayi GCC2 and GCC3 family protein 0.0065 0.0045 0.008
Giardia lamblia Pyruvate kinase 0.005 0.0026 0.1252
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0592 0.0738 0.0738
Onchocerca volvulus 0.012 0.0118 0.1216
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.0034 0.0823
Echinococcus granulosus neuropeptide Y receptor 0.0592 0.0738 0.0738
Brugia malayi Cadherin domain containing protein 0.0065 0.0045 0.008
Schistosoma mansoni hypothetical protein 0.0065 0.0045 0.0045
Loa Loa (eye worm) pigment dispersing factor receptor c 0.032 0.038 0.038
Echinococcus multilocularis protein jagged 1 0.0065 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.0299 0.0353 0.0353
Loa Loa (eye worm) hypothetical protein 0.0065 0.0045 0.0045
Echinococcus granulosus pyruvate kinase 0.005 0.0026 0.0026
Echinococcus multilocularis protein jagged 2 0.0065 0.0045 0.0045
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.0034 0.0034
Onchocerca volvulus 0.0042 0.0015 0.0154
Echinococcus multilocularis survival motor neuron protein 1 0.0263 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Schistosoma mansoni cercarial elastase (S01 family) 0.012 0.0118 0.0118
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0024 0.0024
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0044 0.0017 0.0017
Entamoeba histolytica hypothetical protein 0.0116 0.0113 1
Brugia malayi hypothetical protein 0.0592 0.0738 0.1316
Onchocerca volvulus Arrow homolog 0.017 0.0183 0.1881
Brugia malayi EGF-like domain containing protein 0.0065 0.0045 0.008
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0082 0.0068 0.101
Brugia malayi Serotonin receptor 0.4297 0.5607 1
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Echinococcus multilocularis orexin receptor type 2 0.0592 0.0738 0.0738
Echinococcus granulosus neurogenic locus notch protein 4 0.0065 0.0045 0.0045
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Mycobacterium ulcerans lipase LipD 0.0082 0.0068 0.5436
Loa Loa (eye worm) notch protein 0.0065 0.0045 0.0045
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0017 0.0296
Schistosoma mansoni hypothetical protein 0.0533 0.0661 0.0661
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0034 0.3318
Schistosoma mansoni cercarial elastase (S01 family) 0.012 0.0118 0.0118
Schistosoma mansoni hypothetical protein 0.012 0.0118 0.0118
Onchocerca volvulus 0.0592 0.0738 0.7582
Echinococcus multilocularis neural cadherin 0.0065 0.0045 0.0045
Onchocerca volvulus 0.0042 0.0015 0.0154
Brugia malayi Calcium binding EGF domain containing protein 0.017 0.0183 0.0327
Loa Loa (eye worm) hypothetical protein 0.0065 0.0045 0.0045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0592 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Trypanosoma brucei pyruvate kinase 1, putative 0.0098 0.0089 0.5502
Plasmodium falciparum cysteine repeat modular protein 1 0.0286 0.0336 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0044 0.0017 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0034 0.0034
Schistosoma mansoni amine GPCR 0.0592 0.0738 0.0738
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0592 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.017 0.0183 0.0183
Echinococcus multilocularis glycoprotein Antigen 5 0.012 0.0118 0.0118
Echinococcus granulosus neuropeptide s receptor 0.0592 0.0738 0.0738
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0101 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0065 0.0045 0.0045
Schistosoma mansoni neuropeptide receptor 0.0592 0.0738 0.0738
Brugia malayi AKH receptor 0.0592 0.0738 0.1316
Toxoplasma gondii PAN domain-containing protein 0.0042 0.0015 0.0229
Brugia malayi PAN domain containing protein 0.0042 0.0015 0.0027
Echinococcus multilocularis allatostatin A receptor 0.0592 0.0738 0.0738
Onchocerca volvulus 0.0034 0.0005 0.0048
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0592 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0042 0.0015 0.0015
Schistosoma mansoni septate junction protein 0.0065 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0065 0.0045 0.0045
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0065 0.0045 0.0045
Schistosoma mansoni neuropeptide receptor 0.0592 0.0738 0.0738
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0044 0.0017 0.0017
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0024 0.0244
Loa Loa (eye worm) hypothetical protein 0.017 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0065 0.0045 0.0045
Brugia malayi hypothetical protein 0.0414 0.0504 0.0898
Echinococcus granulosus slit 2 protein 0.0065 0.0045 0.0045
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0061 0.0041 0.0041
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0592 0.0738 0.0738
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0592 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0771 0.0973 0.0973
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0082 0.0145
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.012 0.0118 0.0211
Echinococcus granulosus expressed conserved protein 0.0091 0.0079 0.0079
Schistosoma mansoni hypothetical protein 0.0101 0.0093 0.0093
Echinococcus granulosus rhodopsin orphan GPCR 0.0592 0.0738 0.0738
Mycobacterium leprae Probable pyruvate kinase PykA 0.0098 0.0089 0.8968
Echinococcus granulosus dnaJ subfamily B 0.0401 0.0487 0.0487
Brugia malayi putative neuropeptide receptor 0.0592 0.0738 0.1316
Brugia malayi Pyruvate kinase, muscle isozyme 0.0098 0.0089 0.0159
Echinococcus multilocularis biogenic amine (5HT) receptor 0.2457 0.3188 0.3188
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0014 0.0014
Echinococcus granulosus protein jagged 1 0.0065 0.0045 0.0045
Schistosoma mansoni notch 0.0065 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0414 0.0504 0.0504
Echinococcus multilocularis G-protein coupled receptor, putative 0.0592 0.0738 0.0738
Onchocerca volvulus 0.0286 0.0336 0.3451
Schistosoma mansoni alpha-1 adrenergic receptor 0.0592 0.0738 0.0738
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0592 0.0738 0.0738
Echinococcus multilocularis rhodopsin orphan GPCR 0.0592 0.0738 0.0738
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0034 0.3318
Echinococcus multilocularis neurogenic locus protein delta 0.0065 0.0045 0.0045
Echinococcus granulosus rhodopsin orphan GPCR 0.0592 0.0738 0.0738
Onchocerca volvulus 0.012 0.0118 0.1216
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0592 0.0738 0.0738
Echinococcus granulosus fibropellin Ia 0.0065 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Brugia malayi beta-lactamase 0.0082 0.0068 0.0121
Onchocerca volvulus Putative cubilin 0.0065 0.0045 0.0463
Echinococcus multilocularis rhodopsin orphan GPCR 0.0592 0.0738 0.0738
Brugia malayi neuropeptide F receptor 0.0592 0.0738 0.1316
Loa Loa (eye worm) hypothetical protein 0.0065 0.0045 0.0045
Onchocerca volvulus 0.0034 0.0005 0.0048
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0116 0.0113 0.0113
Schistosoma mansoni hypothetical protein 0.0034 0.0005 0.0005
Echinococcus multilocularis pyruvate kinase 0.005 0.0026 0.0026
Trypanosoma brucei protein kinase, putative 0.0057 0.0034 0.1826
Schistosoma mansoni neuropeptide f receptor 76f 0.0592 0.0738 0.0738
Toxoplasma gondii pyruvate kinase PyKII 0.005 0.0026 0.0569
Echinococcus granulosus glycoprotein Antigen 5 0.012 0.0118 0.0118
Echinococcus multilocularis neuropeptides capa receptor 0.0592 0.0738 0.0738
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0082 0.0082
Brugia malayi G protein-coupled receptor 0.0592 0.0738 0.1316
Schistosoma mansoni hypothetical protein 0.004 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Echinococcus granulosus peptide allatostatin:somatostatin 0.0592 0.0738 0.0738
Echinococcus multilocularis notch 0.0065 0.0045 0.0045
Echinococcus multilocularis neuropeptide FF receptor 2 0.0592 0.0738 0.0738
Toxoplasma gondii calcium binding egf domain-containing protein 0.017 0.0183 0.5348
Schistosoma mansoni hypothetical protein 0.0101 0.0093 0.0093
Schistosoma mansoni notch 0.0065 0.0045 0.0045
Echinococcus granulosus protein jagged 2 0.0065 0.0045 0.0045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0592 0.0738 0.0738
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.012 0.0118 0.0118
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0149 0.0155 0.4175
Brugia malayi Inositol-1 0.0036 0.0007 0.0013
Trypanosoma brucei pyruvate kinase 1 0.0098 0.0089 0.5502
Brugia malayi EGF-like domain containing protein 0.0065 0.0045 0.008
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0592 0.0738 0.7582
Trichomonas vaginalis esterase, putative 0.0082 0.0068 0.74
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Brugia malayi Trypsin family protein 0.012 0.0118 0.0211
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Schistosoma mansoni hypothetical protein 0.0592 0.0738 0.0738
Schistosoma mansoni hypothetical protein 0.0533 0.0661 0.0661
Echinococcus granulosus pyruvate kinase 0.005 0.0026 0.0026
Echinococcus multilocularis somatostatin receptor 0.0592 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Onchocerca volvulus 0.0042 0.0015 0.0154
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Echinococcus granulosus delta-like protein 1 0.0065 0.0045 0.0045
Echinococcus granulosus neuropeptides capa receptor 0.0592 0.0738 0.0738
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.017 0.0183 0.0183
Brugia malayi hypothetical protein 0.0592 0.0738 0.1316
Toxoplasma gondii PAN/Apple domain-containing protein 0.0042 0.0015 0.0229
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0101 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0099 0.009 0.009
Mycobacterium leprae conserved hypothetical protein 0.0082 0.0068 0.6771
Schistosoma mansoni hypothetical protein 0.0101 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0042 0.0015 0.0015
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0592 0.0738 0.0738
Echinococcus granulosus survival motor neuron protein 1 0.0263 0.0306 0.0306
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0592 0.0738 0.0738
Mycobacterium tuberculosis Probable esterase LipL 0.0082 0.0068 0.101
Loa Loa (eye worm) hypothetical protein 0.0065 0.0045 0.0045
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0592 0.0738 0.1316
Schistosoma mansoni neuropeptide receptor 0.0592 0.0738 0.0738
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0592 0.0738 0.0738
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0592 0.0738 0.0738
Schistosoma mansoni cercarial elastase (S01 family) 0.012 0.0118 0.0118
Onchocerca volvulus 0.0065 0.0045 0.0463
Loa Loa (eye worm) MBCTL1 0.0055 0.0033 0.0033
Mycobacterium leprae Probable lipase LipE 0.0082 0.0068 0.6771
Loa Loa (eye worm) hypothetical protein 0.017 0.0183 0.0183
Loa Loa (eye worm) G-protein coupled receptor 0.0592 0.0738 0.0738
Toxoplasma gondii kringle domain-containing protein 0.0286 0.0336 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0017 0.0296
Schistosoma mansoni pyruvate kinase 0.0098 0.0089 0.0089
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0061 0.0041 0.0041
Toxoplasma gondii microneme protein MIC17B 0.0042 0.0015 0.0229
Echinococcus granulosus tm gpcr rhodopsin 0.0592 0.0738 0.0738
Brugia malayi PAN domain containing protein 0.0042 0.0015 0.0027
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0042 0.0015 0.0229
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.0034 0.0034
Onchocerca volvulus Pyruvate kinase homolog 0.0098 0.0089 0.0913
Onchocerca volvulus 0.0592 0.0738 0.7582
Schistosoma mansoni pyruvate kinase 0.0098 0.0089 0.0089
Schistosoma mansoni pyruvate kinase 0.005 0.0026 0.0026
Schistosoma mansoni microtubule-associated protein tau 0.1457 0.1875 0.1875
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0007 0.5
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0043 0.0017 0.0825
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0592 0.0738 0.0738
Loa Loa (eye worm) neuropeptide F receptor 0.0592 0.0738 0.0738
Echinococcus granulosus inhibitor of apoptosis protein 0.0093 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Trypanosoma brucei hypothetical protein, conserved 0.0082 0.0068 0.4072
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Loa Loa (eye worm) inositol-1 0.0036 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2528 0.3282 0.3282
Brugia malayi PAN domain containing protein 0.0042 0.0015 0.0027
Echinococcus multilocularis neuropeptide receptor A26 0.0592 0.0738 0.0738
Brugia malayi PAN domain containing protein 0.0042 0.0015 0.0027
Brugia malayi G protein-coupled receptor F59B2.13 0.0592 0.0738 0.1316
Schistosoma mansoni dihydrofolate reductase 0.0043 0.0017 0.0017
Brugia malayi follicle stimulating hormone receptor 0.0848 0.1074 0.1916
Echinococcus multilocularis thymidylate synthase 0.0106 0.0099 0.0099
Echinococcus multilocularis rhodopsin orphan GPCR 0.0592 0.0738 0.0738
Leishmania major hypothetical protein, conserved 0.0286 0.0336 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0082 0.0068 0.0068
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0149 0.0155 0.4506
Trichomonas vaginalis penicillin-binding protein, putative 0.0082 0.0068 0.74
Onchocerca volvulus 0.0592 0.0738 0.7582
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.4694 0.6128 0.6128
Brugia malayi PAN domain containing protein 0.0042 0.0015 0.0027
Loa Loa (eye worm) hypothetical protein 0.0082 0.0068 0.0068
Brugia malayi beta-lactamase family protein 0.0082 0.0068 0.0121
Onchocerca volvulus 0.0592 0.0738 0.7582
Echinococcus granulosus neuropeptide receptor 0.0592 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0065 0.0045 0.0045
Brugia malayi thymidylate synthase 0.0106 0.0099 0.0176
Schistosoma mansoni laminin gamma-3 chain 0.0065 0.0045 0.0045
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0592 0.0738 0.0738
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0101 0.0093 0.0166
Echinococcus multilocularis slit 2 protein 0.0065 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Onchocerca volvulus Huntingtin homolog 0.0414 0.0504 0.5175
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0592 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Brugia malayi mbt repeat family protein 0.0049 0.0024 0.0042
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0592 0.0738 0.0738
Leishmania major pyruvate kinase 0.0098 0.0089 0.248
Schistosoma mansoni notch 0.0065 0.0045 0.0045
Echinococcus granulosus neuropeptide receptor 0.0592 0.0738 0.0738
Schistosoma mansoni transcription factor LCR-F1 0.0116 0.0113 0.0113
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0592 0.0738 0.0738
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.012 0.0118 0.0118
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0034 0.3318
Loa Loa (eye worm) melatonin receptor type 1A 0.0592 0.0738 0.0738
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0082 0.0082
Echinococcus multilocularis expressed conserved protein 0.0091 0.0079 0.0079
Brugia malayi hypothetical protein 0.0116 0.0113 0.0202
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Echinococcus multilocularis neuropeptide Y receptor 0.0592 0.0738 0.0738
Brugia malayi hypothetical protein 0.0592 0.0738 0.1316
Brugia malayi putative neuropeptide receptor NPR1 0.0592 0.0738 0.1316
Echinococcus multilocularis geminin 0.0533 0.0661 0.0661
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0592 0.0738 0.0738
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0082 0.0082
Brugia malayi hypothetical protein 0.0592 0.0738 0.1316
Loa Loa (eye worm) hypothetical protein 0.0042 0.0015 0.0015
Echinococcus granulosus rhodopsin orphan GPCR 0.0592 0.0738 0.0738
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.0034 0.0823
Loa Loa (eye worm) hypothetical protein 0.0065 0.0045 0.0045
Brugia malayi Kringle domain containing protein 0.0286 0.0336 0.0599
Brugia malayi hypothetical protein 0.0592 0.0738 0.1316
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0044 0.0017 0.0017
Schistosoma mansoni biogenic amine receptor 0.0592 0.0738 0.0738
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0044 0.0017 0.0031
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0286 0.0336 1
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.017 0.0183 0.0183
Onchocerca volvulus 0.0042 0.0015 0.0154
Brugia malayi sulfakinin receptor protein 0.0592 0.0738 0.1316
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.017 0.0183 0.0327
Echinococcus multilocularis fmrfamide receptor 0.0592 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0042 0.0015 0.0015
Onchocerca volvulus Neurogenic locus notch homolog 0.0065 0.0045 0.0463
Schistosoma mansoni hypothetical protein 0.0101 0.0093 0.0093
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0149 0.0155 0.4506
Onchocerca volvulus 0.0592 0.0738 0.7582
Brugia malayi EGF-like domain containing protein 0.0065 0.0045 0.008
Echinococcus granulosus hypothetical protein 0.615 0.8042 0.8042
Echinococcus granulosus g protein coupled receptor 0.0592 0.0738 0.0738
Echinococcus multilocularis rhodopsin orphan GPCR 0.0592 0.0738 0.0738
Schistosoma mansoni lipoxygenase 0.0061 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0263 0.0306 0.0306
Schistosoma mansoni myosin xvIII 0.0592 0.0738 0.0738
Loa Loa (eye worm) pyruvate kinase 0.0098 0.0089 0.0089
Onchocerca volvulus 0.0034 0.0005 0.0048
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0082 0.0082
Echinococcus granulosus orexin receptor type 2 0.0592 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0065 0.0045 0.0045
Echinococcus granulosus rhodopsin orphan GPCR 0.0592 0.0738 0.0738
Loa Loa (eye worm) PAN domain-containing protein 0.0042 0.0015 0.0015
Loa Loa (eye worm) trypsin family protein 0.012 0.0118 0.0118
Onchocerca volvulus 0.0592 0.0738 0.7582
Onchocerca volvulus 0.0034 0.0005 0.0048
Echinococcus granulosus notch 0.0065 0.0045 0.0045
Onchocerca volvulus 0.0065 0.0045 0.0463
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.0034 0.2414
Schistosoma mansoni biogenic amine receptor 0.0592 0.0738 0.0738
Schistosoma mansoni growth hormone secretagogue receptor 0.0592 0.0738 0.0738
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.012 0.0118 0.0118
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.0034 0.0823
Echinococcus multilocularis Mastin 0.012 0.0118 0.0118
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0592 0.0738 0.0738
Brugia malayi hypothetical protein 0.012 0.0118 0.0211
Onchocerca volvulus 0.0771 0.0973 1
Loa Loa (eye worm) pyruvate kinase 0.0098 0.0089 0.0089
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0044 0.0017 0.1192
Trichomonas vaginalis pyruvate kinase, putative 0.0098 0.0089 1
Loa Loa (eye worm) thymidylate synthase 0.0106 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0082 0.0068 0.0068
Loa Loa (eye worm) Notch2 0.0065 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0096 0.0087 0.0087
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.012 0.0118 0.0118
Brugia malayi beta-lactamase family protein 0.0082 0.0068 0.0121
Brugia malayi RE15519p 0.0592 0.0738 0.1316
Echinococcus granulosus allatostatin A receptor 0.0592 0.0738 0.0738
Onchocerca volvulus 0.0093 0.0083 0.0849
Echinococcus multilocularis conserved hypothetical protein 0.5558 0.7264 0.7264
Brugia malayi G-protein coupled receptor 0.0592 0.0738 0.1316
Brugia malayi CHE-14 protein 0.0041 0.0014 0.0026
Schistosoma mansoni inositol monophosphatase 0.0036 0.0007 0.0007
Trichomonas vaginalis D-aminoacylase, putative 0.0082 0.0068 0.74
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Echinococcus multilocularis pyruvate kinase 0.005 0.0026 0.0026
Echinococcus granulosus pyruvate kinase 0.005 0.0026 0.0026
Echinococcus granulosus fmrfamide receptor 0.0592 0.0738 0.0738
Brugia malayi latrophilin 2 splice variant baaae 0.0219 0.0247 0.0441
Loa Loa (eye worm) latrophilin receptor protein 2 0.0101 0.0093 0.0093
Schistosoma mansoni amine GPCR 0.0592 0.0738 0.0738
Loa Loa (eye worm) PAN domain-containing protein 0.0042 0.0015 0.0015
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0106 0.0099 0.1492
Brugia malayi Delta serrate ligand family protein 0.0065 0.0045 0.008
Trichomonas vaginalis D-aminoacylase, putative 0.0082 0.0068 0.74
Loa Loa (eye worm) hypothetical protein 0.012 0.0118 0.0118
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0044 0.0017 0.0017
Brugia malayi Calcium binding EGF domain containing protein 0.0065 0.0045 0.008
Toxoplasma gondii subtilisin SUB12 0.0042 0.0015 0.0229
Loa Loa (eye worm) hypothetical protein 0.017 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0034 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0065 0.0045 0.0045
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0082 0.0068 0.101
Echinococcus multilocularis ubiquitin specific protease 41 0.0044 0.0017 0.0017
Echinococcus granulosus thymidylate synthase 0.0106 0.0099 0.0099
Schistosoma mansoni survival motor neuron protein 0.0054 0.0031 0.0031
Brugia malayi Latrophilin receptor protein 2 0.0101 0.0093 0.0166
Schistosoma mansoni hypothetical protein 0.004 0.0012 0.0012
Onchocerca volvulus 0.0592 0.0738 0.7582
Giardia lamblia Pyruvate kinase 0.0098 0.0089 1
Echinococcus multilocularis sex peptide receptor 0.0592 0.0738 0.0738
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.0034 0.0823
Loa Loa (eye worm) dihydrofolate reductase 0.0043 0.0017 0.0017
Brugia malayi Protein kinase domain containing protein 0.0286 0.0336 0.0599
Brugia malayi hypothetical protein 0.0592 0.0738 0.1316
Trypanosoma cruzi hypothetical protein, conserved 0.0286 0.0336 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0044 0.0017 0.0919
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0033 0.0058
Trichomonas vaginalis pyruvate kinase, putative 0.0098 0.0089 1
Toxoplasma gondii microneme protein MIC17A 0.0042 0.0015 0.0229
Schistosoma mansoni cercarial elastase (S01 family) 0.012 0.0118 0.0118
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Echinococcus granulosus transmembrane protease serine 3 0.012 0.0118 0.0118
Brugia malayi EGF-like domain containing protein 0.0065 0.0045 0.008
Onchocerca volvulus Slit protein homolog 0.0065 0.0045 0.0463
Echinococcus multilocularis microtubule associated protein 2 0.1457 0.1875 0.1875
Loa Loa (eye worm) hypothetical protein 0.0042 0.0015 0.0015
Echinococcus multilocularis GPCR, family 2 0.0101 0.0093 0.0093
Schistosoma mansoni patched 1 0.0041 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Loa Loa (eye worm) TK/ROR protein kinase 0.0286 0.0336 0.0336
Mycobacterium tuberculosis Probable hydrolase 0.0082 0.0068 0.101
Loa Loa (eye worm) hypothetical protein 0.0098 0.0089 0.0089
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0082 0.0068 0.101
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0592 0.0738 0.0738
Brugia malayi MAP kinase sur-1 0.0057 0.0034 0.0061
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Brugia malayi GnHR receptor homolog 0.0592 0.0738 0.1316
Schistosoma mansoni hypothetical protein 0.0065 0.0045 0.0045
Brugia malayi hypothetical protein 0.0592 0.0738 0.1316
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0065 0.0045 0.008
Echinococcus granulosus dro:myosuppressin receptor 0.0592 0.0738 0.0738
Echinococcus granulosus rhodopsin orphan GPCR 0.0592 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0065 0.0045 0.0045
Echinococcus granulosus neuropeptide Y receptor 0.0592 0.0738 0.0738
Brugia malayi PAN domain containing protein 0.0042 0.0015 0.0027
Plasmodium falciparum pyruvate kinase 0.0098 0.0089 0.2026
Brugia malayi Calcitonin receptor-like protein seb-1 0.032 0.038 0.0678
Loa Loa (eye worm) hypothetical protein 0.0051 0.0027 0.0027
Echinococcus granulosus serotonin receptor 0.0592 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0049 0.0024 0.0024
Echinococcus granulosus geminin 0.0533 0.0661 0.0661
Echinococcus multilocularis neurogenic locus notch protein 0.0065 0.0045 0.0045
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0024 0.0024
Echinococcus multilocularis neuropeptides capa receptor 0.0592 0.0738 0.0738
Trichomonas vaginalis D-aminoacylase, putative 0.0082 0.0068 0.74
Brugia malayi EGF-like domain containing protein 0.0065 0.0045 0.008
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.012 0.0118 0.0118
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0031 0.0054
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0149 0.0155 0.4506
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0592 0.0738 0.0738
Echinococcus multilocularis dro:myosuppressin receptor 0.0592 0.0738 0.0738
Mycobacterium ulcerans thymidylate synthase 0.0106 0.0099 0.8243
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.0034 0.1826
Schistosoma mansoni hypothetical protein 0.0065 0.0045 0.0045
Echinococcus granulosus laminin 0.017 0.0183 0.0183
Brugia malayi PAN domain containing protein 0.0042 0.0015 0.0027
Onchocerca volvulus 0.012 0.0118 0.1216
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0024 0.0024
Onchocerca volvulus 0.0042 0.0015 0.0154
Brugia malayi Trypsin family protein 0.0771 0.0973 0.1736
Onchocerca volvulus 0.0592 0.0738 0.7582
Echinococcus multilocularis dihydrofolate reductase 0.0043 0.0017 0.0017
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0038 0.0038
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0592 0.0738 0.0738
Onchocerca volvulus 0.0106 0.0099 0.1016
Brugia malayi Calcium binding EGF domain containing protein 0.0065 0.0045 0.008
Schistosoma mansoni hypothetical protein 0.0592 0.0738 0.0738
Schistosoma mansoni opsin-like receptor 0.0592 0.0738 0.0738
Onchocerca volvulus 0.0592 0.0738 0.7582
Schistosoma mansoni hypothetical protein 0.0065 0.0045 0.0045
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0592 0.0738 0.0738
Chlamydia trachomatis pyruvate kinase 0.0098 0.0089 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0045 0.0045
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0082 0.0068 0.0121
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.0034 0.0034
Echinococcus granulosus pyruvate kinase 0.0098 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.012 0.0118 0.0118
Echinococcus multilocularis neuropeptide receptor 0.0592 0.0738 0.0738
Schistosoma mansoni hypothetical protein 0.0065 0.0045 0.0045
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0771 0.0973 0.0973
Echinococcus granulosus microtubule associated protein 2 0.1457 0.1875 0.1875
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.0034 0.0034
Echinococcus granulosus neuropeptides capa receptor 0.0592 0.0738 0.0738
Leishmania major pyruvate kinase 0.0098 0.0089 0.248
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0043 0.0017 0.1466
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0592 0.0738 0.0738
Schistosoma mansoni amine GPCR 0.0592 0.0738 0.0738
Toxoplasma gondii hypothetical protein 0.0042 0.0015 0.0229
Brugia malayi ORL1-like opioid receptor 0.0592 0.0738 0.1316
Loa Loa (eye worm) hypothetical protein 0.0082 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Onchocerca volvulus 0.0065 0.0045 0.0463
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0592 0.0738 0.0738
Onchocerca volvulus 0.0065 0.0045 0.0463
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0033 0.0033
Onchocerca volvulus 0.0042 0.0015 0.0154
Schistosoma mansoni inhibitor of apoptosis protein 0.0093 0.0083 0.0083
Onchocerca volvulus 0.0592 0.0738 0.7582
Brugia malayi Trypsin-like protease protein 5 0.012 0.0118 0.0211
Onchocerca volvulus 0.0082 0.0068 0.0696
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Toxoplasma gondii ABC1 family protein 0.0082 0.0068 0.1835
Echinococcus granulosus g-protein coupled receptor 0.0592 0.0738 0.0738
Onchocerca volvulus 0.012 0.0118 0.1216
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0082 0.0082
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0024 0.0024
Echinococcus multilocularis transmembrane protease serine 3 0.012 0.0118 0.0118
Schistosoma mansoni hypothetical protein 0.0219 0.0247 0.0247
Brugia malayi PAN domain containing protein 0.0042 0.0015 0.0027
Schistosoma mansoni hypothetical protein 0.012 0.0118 0.0118
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.0135 0.0135
Echinococcus granulosus tm gpcr rhodopsin 0.0592 0.0738 0.0738
Brugia malayi notch-like transmembrane receptor 0.0065 0.0045 0.008
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0044 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0592 0.0738 0.0738
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.012 0.0118 0.0118
Brugia malayi Trypsin family protein 0.012 0.0118 0.0211
Mycobacterium ulcerans hypothetical protein 0.0082 0.0068 0.5436
Loa Loa (eye worm) bone morphogenetic protein 1b 0.017 0.0183 0.0183
Echinococcus multilocularis G protein coupled receptor 139 0.0592 0.0738 0.0738
Schistosoma mansoni neuropeptide F-like receptor 0.0592 0.0738 0.0738
Brugia malayi hypothetical protein 0.0592 0.0738 0.1316
Schistosoma mansoni notch 0.0065 0.0045 0.0045
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0093 0.0083 0.0083
Schistosoma mansoni cell polarity protein 0.0065 0.0045 0.0045
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0068 0.1835
Brugia malayi PAN domain containing protein 0.0042 0.0015 0.0027
Schistosoma mansoni egf-like domain protein 0.017 0.0183 0.0183
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0014 0.0014

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) > 1 uM Binding affinity in competition with [125I]-NDP-MSH on recombinant melanocortin 1 receptor ChEMBL. 11909712
Ki (binding) > 1 uM Binding affinity in competition with [125I]-NDP-MSH on recombinant melanocortin 3 receptor ChEMBL. 11909712
Ki (binding) > 1 uM Binding affinity in competition with [125I]-NDP-MSH on recombinant melanocortin 4 receptor ChEMBL. 11909712
Ki (binding) > 1 uM Binding affinity in competition with [125I]-NDP-MSH on recombinant melanocortin 5 receptor ChEMBL. 11909712

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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