Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0042 | 0.0075 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0195 | 0.0195 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0609 | 0.1079 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.1 | 0.1772 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0628 | 0.0628 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0609 | 0.1242 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.1333 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.046 | 0.0814 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0028 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0609 | 0.1079 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0961 | 0.0961 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0035 | 0.0609 | 0.1242 |
Schistosoma mansoni | ferritin | 0.0008 | 0.0008 | 0.0008 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0035 | 0.0609 | 0.1242 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0609 | 0.1079 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0609 | 0.0348 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0609 | 0.4536 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0011 | 0.0068 | 0.0121 |
Schistosoma mansoni | apoferritin-2 | 0.0008 | 0.0008 | 0.0008 |
Brugia malayi | Pre-SET motif family protein | 0.0034 | 0.0583 | 0.1032 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0014 | 0.013 | 0.013 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0195 | 0.0346 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0195 | 0.0195 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0609 | 0.1047 |
Brugia malayi | MH2 domain containing protein | 0.0018 | 0.0219 | 0.0389 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0609 | 0.1242 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0068 | 0.1366 | 0.1366 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0195 | 0.0195 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0609 | 0.1079 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0628 | 0.1112 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0035 | 0.0609 | 0.1242 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0164 | 0.029 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0258 | 0.5647 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0609 | 0.1047 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0609 | 0.1047 |
Echinococcus multilocularis | musashi | 0.0028 | 0.046 | 0.046 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0609 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.1 | 0.1772 |
Brugia malayi | MH2 domain containing protein | 0.0258 | 0.5647 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0195 | 0.0346 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.3524 | 0.3524 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0609 | 0.1079 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0961 | 0.0961 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0035 | 0.0609 | 0.1242 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0195 | 0.0346 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.1333 | 0.1333 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0609 | 0.1047 |
Echinococcus multilocularis | Smad4 | 0.0018 | 0.0219 | 0.0219 |
Echinococcus granulosus | lamin | 0.0028 | 0.046 | 0.046 |
Schistosoma mansoni | lamin | 0.0028 | 0.046 | 0.046 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0067 | 0.1333 | 1 |
Echinococcus granulosus | geminin | 0.0164 | 0.3524 | 0.3524 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.1333 | 0.1333 |
Schistosoma mansoni | lamin | 0.0028 | 0.046 | 0.046 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0628 | 0.1112 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.046 | 0.046 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0067 | 0.1333 | 0.2739 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0448 | 0.0794 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0609 | 0.1079 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0195 | 0.0195 |
Brugia malayi | Smad1 | 0.0018 | 0.0219 | 0.0389 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0035 | 0.0609 | 0.1242 |
Echinococcus granulosus | expressed protein | 0.0008 | 0.0008 | 0.0008 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0195 | 0.0195 |
Onchocerca volvulus | 0.0028 | 0.046 | 0.08 | |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0609 | 0.0609 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0118 | 0.021 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0018 | 0.0219 | 0.0389 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0014 | 0.013 | 0.013 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0061 | 0.1204 | 0.8273 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0961 | 0.0961 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.3524 | 0.3524 |
Brugia malayi | Pre-SET motif family protein | 0.0231 | 0.5031 | 0.8909 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0231 | 0.5031 | 0.8909 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0258 | 0.5647 | 1 |
Schistosoma mansoni | ferritin light chain | 0.0008 | 0.0008 | 0.0008 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0609 | 0.0609 |
Onchocerca volvulus | 0.0028 | 0.046 | 0.08 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0583 | 0.0583 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.046 | 0.046 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.1333 | 1 |
Schistosoma mansoni | ferritin | 0.0008 | 0.0008 | 0.0008 |
Brugia malayi | MH2 domain containing protein | 0.0018 | 0.0219 | 0.0389 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0018 | 0.0219 | 0.0219 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0609 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0609 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0578 | 0.0578 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0195 | 0.0195 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0609 | 0.1242 |
Schistosoma mansoni | ferritin light chain | 0.0008 | 0.0008 | 0.0008 |
Echinococcus multilocularis | geminin | 0.0164 | 0.3524 | 0.3524 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0583 | 0.1032 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0609 | 0.1079 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0009 | 0.0028 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0195 | 0.0346 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0067 | 0.1333 | 0.1333 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0008 | 0.0008 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.0018 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0609 | 0.1079 |
Echinococcus granulosus | Smad4 | 0.0018 | 0.0219 | 0.0219 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0034 | 0.0583 | 0.0583 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.046 | 0.046 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0195 | 0.0195 |
Echinococcus multilocularis | smad | 0.0018 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0961 | 0.1702 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0609 | 0.4536 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0035 | 0.0609 | 0.1242 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.1 | 0.1772 |
Echinococcus multilocularis | lamin | 0.0028 | 0.046 | 0.046 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0583 | 0.0583 |
Schistosoma mansoni | smad1 5 8 and | 0.0018 | 0.0219 | 0.0219 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0015 | 0.0164 | 0.029 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0067 | 0.1333 | 0.1333 |
Schistosoma mansoni | smad | 0.0018 | 0.0219 | 0.0219 |
Onchocerca volvulus | 0.0035 | 0.0609 | 0.106 | |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0071 | 0.0071 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0018 | 0.0219 | 0.0219 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0961 | 0.1702 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0008 | 0.0008 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.0018 | 0.0219 | 0.0219 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0961 | 0.0961 |
Echinococcus multilocularis | ferritin | 0.0008 | 0.0008 | 0.0008 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0028 | 0.0028 |
Loa Loa (eye worm) | nuclear factor I | 0.001 | 0.0042 | 0.0075 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0018 | 0.0219 | 0.0219 |
Onchocerca volvulus | 0.0032 | 0.0537 | 0.0935 | |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0609 | 0.4536 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0609 | 0.4536 |
Schistosoma mansoni | apoferritin-2 | 0.0008 | 0.0008 | 0.0008 |
Trichomonas vaginalis | set domain proteins, putative | 0.0263 | 0.5748 | 1 |
Onchocerca volvulus | 0.0034 | 0.0583 | 0.1014 | |
Schistosoma mansoni | ferritin | 0.0008 | 0.0008 | 0.0008 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0609 | 0.1079 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0609 | 0.1047 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.0537 | 0.0537 |
Echinococcus granulosus | cpg binding protein | 0.0033 | 0.0578 | 0.0578 |
Onchocerca volvulus | 0.0035 | 0.0609 | 0.106 | |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.054 | 0.054 |
Onchocerca volvulus | 0.0035 | 0.0609 | 0.106 | |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.0042 | 0.0075 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0609 | 0.1079 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0018 | 0.0219 | 0.0389 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0609 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1 | 0.1772 |
Onchocerca volvulus | 0.0263 | 0.5748 | 1 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0609 | 0.5 |
Brugia malayi | MH1 domain containing protein | 0.0018 | 0.0219 | 0.0389 |
Echinococcus granulosus | ferritin | 0.0008 | 0.0008 | 0.0008 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0609 | 0.1079 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0195 | 0.0195 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0961 | 0.0961 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0609 | 0.0609 |
Brugia malayi | MH1 domain containing protein | 0.0018 | 0.0219 | 0.0389 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.1333 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0609 | 0.1047 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0009 | 0.0028 | 0.0028 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0067 | 0.1333 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0609 | 0.0609 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.013 | 0.023 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0032 | 0.0537 | 0.0951 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0578 | 0.0578 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0028 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.046 | 0.0814 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0034 | 0.0583 | 0.0583 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0583 | 0.0583 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0034 | 0.0583 | 0.0583 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.046 | 0.0814 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0018 | 0.0219 | 0.0219 |
Brugia malayi | CXXC zinc finger family protein | 0.0032 | 0.0537 | 0.0951 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0195 | 0.0195 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0118 | 0.021 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0223 | 0.4847 | 1 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.046 | 0.0814 |
Echinococcus granulosus | smad | 0.0018 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0609 | 0.1079 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0071 | 0.0071 |
Echinococcus multilocularis | expressed protein | 0.0008 | 0.0008 | 0.0008 |
Schistosoma mansoni | ferritin | 0.0008 | 0.0008 | 0.0008 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.0042 | 0.0075 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0195 | 0.0195 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0961 | 0.0961 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0609 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0033 | 0.0578 | 0.0578 |
Loa Loa (eye worm) | Smad1 | 0.0018 | 0.0219 | 0.0389 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0035 | 0.0609 | 0.1242 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0609 | 0.4536 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0034 | 0.0583 | 0.0583 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.046 | 0.0814 |
Schistosoma mansoni | Smad4 | 0.0018 | 0.0219 | 0.0219 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0961 | 0.0961 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.046 | 0.046 |
Loa Loa (eye worm) | histone methyltransferase | 0.0011 | 0.0071 | 0.0126 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0018 | 0.0219 | 0.0219 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.