TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 546.743 | Formula: C33H46N4O3
H donors: 1 H acceptors: 4 LogP: 4.64 Rotable bonds: 13
Rule of 5 violations (Lipinski): 2
SMILES: O=C(CC1CC(=C(N(C1=O)Cc1ccc(cc1)C(C)(C)C)C)C(=O)N(C(C)C)C(C)C)NCCc1ccccn1
InChi: 1S/C33H46N4O3/c1-22(2)37(23(3)4)32(40)29-19-26(20-30(38)35-18-16-28-11-9-10-17-34-28)31(39)36(24(29)5)21-25-12-14-27(15-13-25)33(6,7)8/h9-15,17,22-23,26H,16,18-21H2,1-8H3,(H,35,38)
InChiKey: DKJKYPASTOOWKX-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Babesia bovis	heat shock protein 70 precursor, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis		Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Onchocerca volvulus		Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania mexicana	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Neospora caninum	Heat shock protein 70 (Precursor), related	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 71 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein 70 (HSP70)-4, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma mansoni	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium falciparum	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein 70kD, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium knowlesi	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70 related	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Cryptosporidium hominis	heat shock protein	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma mansoni	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma cruzi	glucose-regulated protein 78, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Neospora caninum	Heat shock protein 70, related	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania braziliensis	heat shock protein 70-related protein	Get druggable targets OG5_126588	All targets in OG5_126588
Babesia bovis	dnaK protein	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	microsomal stress 70 protein ATPase core precursor, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania mexicana	heat shock protein 70-related protein	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania braziliensis	glucose-regulated protein 78, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Echinococcus granulosus	heat shock protein 71 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70 related	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium yoelii	heat shock protein	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania mexicana	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70 related	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	3'partial\|5'partial\|heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70b	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_126588	All targets in OG5_126588
Brugia malayi	heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein 70 (HSP70)-4, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	heat shock protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock protein 70 (HSP70)	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania donovani	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70b	Get druggable targets OG5_126588	All targets in OG5_126588
Giardia lamblia	Bip	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock 70 kDa protein 1A:1B	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei gambiense	glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	heat shock protein 70-related protein	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma japonicum	ko:K09490 heat shock 70kDa protein 5, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	HSP70	Get druggable targets OG5_126588	All targets in OG5_126588
Cryptosporidium parvum	heat shock protein, Hsp70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei gambiense	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium knowlesi	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania mexicana	glucose-regulated protein 78, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma mansoni	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis		Get druggable targets OG5_126588	All targets in OG5_126588
Giardia lamblia	Cytosolic HSP70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock kda protein	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania donovani	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock kda protein	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania major	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein kDa heat shock kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis		Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	70 kDa heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 71 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat Shock protein family member hsp 3	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein 70kD, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Theileria parva	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium berghei	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania braziliensis	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Cryptosporidium parvum	heat shock 70 (HSP70) protein	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein 70 family	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Loa Loa (eye worm)	heat shock 70kDa protein 5	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania major	heat shock protein 70-related protein	Get druggable targets OG5_126588	All targets in OG5_126588
Toxoplasma gondii	heat shock protein HSP70	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania donovani	luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	Cytoplasmic chaperone	Get druggable targets OG5_126588	All targets in OG5_126588
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Echinococcus multilocularis	heat shock protein kDa heat shock kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma japonicum	similar to Heat shock 70 kDa protein homolog, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium berghei	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma cruzi	heat shock protein 70 (hsp70), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Cryptosporidium hominis	heat shock protein 70 precursor	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania major	glucose-regulated protein 78, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock 70 kDa protein 1	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania donovani	heat shock protein 70-related protein	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein 70 family	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	glucose-regulated protein 78, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein kDa	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium vivax	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei	luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70 related	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium falciparum	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	Cytoplasmic chaperone	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania major	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Toxoplasma gondii	chaperonin protein BiP	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium falciparum	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 71 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma cruzi	heat shock protein 70 (hsp70), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Theileria parva	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock 70 kda protein 1a	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat Shock protein family member (hsp 3)	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma japonicum	similar to Heat shock 70 kDa protein cognate 4, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Brugia malayi	heat shock 70 kDa protein C precursor	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium vivax	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium yoelii	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei gambiense	glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei	luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	HSP70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei	heat shock protein 70 (hsp70), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein 70 (HSP70)-4, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein	Get druggable targets OG5_126588	All targets in OG5_126588

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %
Plasmodium falciparum	heat shock protein 70	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	654 aa	613 aa	51.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	lipoxygenase	0.0119	0.0628	0.0628
Loa Loa (eye worm)	hypothetical protein	0.0229	0.1327	0.1327
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0073	0.0336	0.0206
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0073	0.0336	0.0206
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0073	0.0336	0.0206
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0229	0.1327	0.3306
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0073	0.0336	0.0206
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0073	0.0336	0.0206
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0073	0.0336	0.0206
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0073	0.0336	0.0233
Echinococcus granulosus	cytochrome P450 2K1	0.0073	0.0336	0.0336
Brugia malayi	Cytochrome P450 family protein	0.0127	0.0681	0.0681
Echinococcus multilocularis		0.0073	0.0336	0.0336
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0229	0.1327	0.1327
Trypanosoma cruzi	cytochrome P450, putative	0.0127	0.0681	0.1519
Mycobacterium leprae	putative cytochrome p450	0.0073	0.0336	0.0233
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0229	0.1327	0.1327
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0073	0.0336	0.0233
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0073	0.0336	0.0206
Brugia malayi	MH2 domain containing protein	0.0144	0.0788	0.0788
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0041	0.0133	0.5
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0073	0.0336	0.0206
Leishmania major	cytochrome p450-like protein	0.0073	0.0336	0.0563
Brugia malayi	Cytochrome P450 family protein	0.0127	0.0681	0.0681
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0461	0.2797	0.2797
Leishmania major	cytochrome p450-like protein	0.0073	0.0336	0.0563
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0073	0.0336	0.0233
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0073	0.0336	0.0206
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0073	0.0336	0.0563
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0229	0.1327	1
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0611	0.3746	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.0788	0.0788
Schistosoma mansoni	cytochrome P450	0.0073	0.0336	0.0336
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0229	0.1327	0.1327
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0073	0.0336	0.0563
Trypanosoma brucei	cytochrome P450, putative	0.0127	0.0681	0.1519
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0073	0.0336	0.0206
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0073	0.0336	0.0233
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0073	0.0336	0.0206
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0073	0.0336	0.0233
Schistosoma mansoni	lipoxygenase	0.0083	0.0401	0.0401
Mycobacterium leprae	Conserved hypothetical protein	0.0073	0.0336	0.0233
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0229	0.1327	0.3306
Echinococcus multilocularis	ubiquitin specific protease 41	0.0229	0.1327	0.1327
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0073	0.0336	0.0233
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0073	0.0336	0.0233
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0073	0.0336	0.0563
Brugia malayi	Cytochrome P450 family protein	0.015	0.0824	0.0824
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0219	0.0219
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0073	0.0336	0.0233
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0073	0.0336	0.0206
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0073	0.0336	0.0233
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0611	0.3746	1
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0073	0.0336	0.0233
Loa Loa (eye worm)	cytochrome P450 family protein	0.0127	0.0681	0.0681
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0073	0.0336	0.0206
Echinococcus granulosus	inositol monophosphatase 1	0.0041	0.0133	0.0133
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0229	0.1327	1
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0073	0.0336	0.0563
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0127	0.0681	0.0556
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0119	0.0628	0.0628
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0073	0.0336	0.0206
Echinococcus multilocularis	inositol monophosphatase 1	0.0041	0.0133	0.0133
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0073	0.0336	0.0206
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0073	0.0336	0.0233
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0073	0.0336	0.0233
Loa Loa (eye worm)	CYP4Cod1	0.0127	0.0681	0.0681
Loa Loa (eye worm)	inositol-1	0.0041	0.0133	0.0133
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0119	0.0628	0.0628
Echinococcus granulosus	ubiquitin specific protease 41	0.0229	0.1327	0.1327
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0229	0.1327	0.3306
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0073	0.0336	0.0233
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0073	0.0336	0.0233
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0611	0.3746	1
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0073	0.0336	0.0206
Loa Loa (eye worm)	cytochrome P450	0.0073	0.0336	0.0336
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0611	0.3746	1
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0611	0.3746	1
Schistosoma mansoni	hypothetical protein	0.0073	0.0336	0.0336
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0073	0.0336	0.0206
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0073	0.0336	0.0563
Schistosoma mansoni	inositol monophosphatase	0.0041	0.0133	0.0133
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0229	0.1327	1
Brugia malayi	cytochrome P450	0.0073	0.0336	0.0336
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0229	0.1327	0.1327
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0073	0.0336	0.0233
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0229	0.1327	0.1327
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0073	0.0336	0.0233
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0073	0.0336	0.0233
Trypanosoma cruzi	cytochrome P450, putative	0.0127	0.0681	0.1519
Brugia malayi	follicle stimulating hormone receptor	0.0461	0.2797	0.2797
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0073	0.0336	0.0206
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0073	0.0336	0.0206
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0611	0.3746	1
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0229	0.1327	0.3306
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0073	0.0336	0.0563
Schistosoma mansoni	inositol monophosphatase	0.0041	0.0133	0.0133
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.0788	0.0788
Leishmania major	cytochrome p450-like protein	0.0127	0.0681	0.1519
Loa Loa (eye worm)	cytochrome P450 family protein	0.015	0.0824	0.0824
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0229	0.1327	0.1327
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0229	0.1327	0.1327
Loa Loa (eye worm)	cytochrome P450 family protein	0.0127	0.0681	0.0681
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0229	0.1327	0.5
Brugia malayi	Inositol-1	0.0041	0.0133	0.0133
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0073	0.0336	0.0233
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0073	0.0336	0.0233
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0073	0.0336	0.0233
Brugia malayi	Cytochrome P450 family protein	0.0073	0.0336	0.0336
Trichomonas vaginalis	conserved hypothetical protein	0.0229	0.1327	1
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0073	0.0336	0.0206

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	8.9125 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1874116

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1186637