Detailed information for compound 1186680

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 151.123 | Formula: C6H5N3O2
  • H donors: 3 H acceptors: 3 LogP: 0.29 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1[nH]c2c(c1)[nH]nc2
  • InChi: 1S/C6H5N3O2/c10-6(11)4-1-3-5(8-4)2-7-9-3/h1-2,8H,(H,7,9)(H,10,11)
  • InChiKey: JESHBAKAUQDDRC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens D-amino-acid oxidase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans D-amino acid oxidase Aao Get druggable targets OG5_127583 All targets in OG5_127583
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao Get druggable targets OG5_127583 All targets in OG5_127583
Candida albicans D-amino acid oxidase Get druggable targets OG5_127583 All targets in OG5_127583
Candida albicans putative d-amino acid oxidase Get druggable targets OG5_127583 All targets in OG5_127583
Schistosoma japonicum ko:K00272 D-aspartate oxidase [EC1.4.3.1], putative Get druggable targets OG5_127583 All targets in OG5_127583
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO Get druggable targets OG5_127583 All targets in OG5_127583
Candida albicans putative d-amino acid oxidase Get druggable targets OG5_127583 All targets in OG5_127583
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127583 All targets in OG5_127583
Candida albicans D-amino acid oxidase Get druggable targets OG5_127583 All targets in OG5_127583
Schistosoma mansoni d-amino acid oxidase Get druggable targets OG5_127583 All targets in OG5_127583
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium ulcerans D-amino acid oxidase Aao D-amino-acid oxidase 347 aa 378 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0115 0.1301 0.4355
Loa Loa (eye worm) Smad1 0.0017 0.0091 0.0306
Schistosoma mansoni coup transcription factor 0.0011 0.0016 0.0025
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0016 0.0083 0.0362
Loa Loa (eye worm) beta-lactamase 0.0115 0.1301 0.4355
Toxoplasma gondii exonuclease III APE 0.0042 0.0399 0.2905
Leishmania major hypothetical protein, conserved 0.0016 0.0083 0.0634
Toxoplasma gondii t-complex protein beta subunit 0.0023 0.0171 0.1113
Schistosoma mansoni smad1 5 8 and 0.0017 0.0091 0.0143
Echinococcus granulosus smad 0.0017 0.0091 0.0118
Brugia malayi latrophilin 2 splice variant baaae 0.0108 0.1217 0.4073
Echinococcus granulosus Protein patched homolog 1 0.0085 0.0925 0.143
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0016 0.0054
Echinococcus granulosus sterol regulatory element binding protein 0.0085 0.0925 0.143
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.05 0.0485
Brugia malayi T-complex protein 1, beta subunit 0.0023 0.0171 0.0574
Brugia malayi nuclear receptor NHR-88 0.0011 0.0016 0.0054
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.05 0.0762
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0068 0.0052
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0042 0.0399 0.1749
Schistosoma mansoni hypothetical protein 0.0082 0.0888 0.1393
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.106 0.1046
Loa Loa (eye worm) hypothetical protein 0.0197 0.2313 0.7739
Onchocerca volvulus 0.0115 0.1301 0.7439
Brugia malayi Latrophilin receptor protein 2 0.005 0.05 0.1674
Brugia malayi RE18450p 0.0016 0.0083 0.0276
Loa Loa (eye worm) hypothetical protein 0.0195 0.2282 0.7636
Brugia malayi cDNA sequence BC016226 0.0016 0.0083 0.0276
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.0195 0.2282 1
Onchocerca volvulus 0.0115 0.1301 0.7439
Echinococcus multilocularis cpg binding protein 0.0064 0.0672 0.0657
Entamoeba histolytica hypothetical protein 0.0041 0.0391 0.1385
Schistosoma mansoni hypothetical protein 0.0051 0.0516 0.081
Onchocerca volvulus Huntingtin homolog 0.0131 0.1492 0.8527
Trichomonas vaginalis esterase, putative 0.0115 0.1301 1
Brugia malayi hypothetical protein 0.0152 0.1749 0.5854
Brugia malayi Patched family protein 0.0012 0.003 0.01
Onchocerca volvulus 0.0061 0.0629 0.3597
Brugia malayi Patched related family protein 4 0.0012 0.003 0.01
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0042 0.0399 0.3068
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0115 0.1301 0.1454
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0054
Schistosoma mansoni hypothetical protein 0.0527 0.6374 1
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0399 0.2781
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0023 0.0171 0.0156
Echinococcus multilocularis glycerol 3 phosphate dehydrogenase 0.0016 0.0083 0.0067
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0023 0.0171 0.0399
Toxoplasma gondii ABC1 family protein 0.0115 0.1301 1
Brugia malayi ecdysteroid receptor 0.0011 0.0016 0.0054
Onchocerca volvulus 0.0012 0.003 0.0171
Mycobacterium tuberculosis Conserved protein 0.0115 0.1301 0.1454
Brugia malayi exodeoxyribonuclease III family protein 0.0042 0.0399 0.1336
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0091 0.0075
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0042 0.0399 0.5
Plasmodium falciparum T-complex protein 1 subunit beta 0.0023 0.0171 0.3833
Brugia malayi hypothetical protein 0.0252 0.2988 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.1749 0.5854
Onchocerca volvulus 0.0051 0.0516 0.295
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0016 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.0115 0.1301 1
Brugia malayi Patched related family protein 10 0.0012 0.003 0.01
Schistosoma mansoni ap endonuclease 0.0042 0.0399 0.0626
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0195 0.2282 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0115 0.1301 0.4355
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Loa Loa (eye worm) hypothetical protein 0.0131 0.1492 0.4991
Plasmodium vivax hypothetical protein, conserved 0.0115 0.1301 1
Schistosoma mansoni cpg binding protein 0.0064 0.0672 0.1054
Loa Loa (eye worm) hypothetical protein 0.0115 0.1301 0.4355
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.106 0.1642
Schistosoma mansoni cpg binding protein 0.0061 0.0629 0.0987
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0016 0.0054
Onchocerca volvulus Protein patched homolog 0.0012 0.003 0.0171
Onchocerca volvulus 0.0012 0.003 0.0171
Toxoplasma gondii hypothetical protein 0.0016 0.0083 0.0414
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0016 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0016 0.0054
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.05 0.1674
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0114 0.0098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0016 0.0054
Brugia malayi Myosin head containing protein 0.0012 0.003 0.01
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0629 0.2105
Schistosoma mansoni hypothetical protein 0.0082 0.0888 0.1393
Schistosoma mansoni hypothetical protein 0.0527 0.6374 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0091 0.0306
Loa Loa (eye worm) hypothetical protein 0.0108 0.1217 0.4073
Echinococcus multilocularis protein dispatched 1 0.0097 0.1073 0.1058
Schistosoma mansoni hypothetical protein 0.0041 0.0391 0.0614
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0016 0.0054
Brugia malayi Patched family protein 0.0012 0.003 0.01
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.1301 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0016 0.0025
Echinococcus multilocularis sterol regulatory element binding protein 0.0085 0.0925 0.0911
Mycobacterium ulcerans lipase LipD 0.0115 0.1301 0.5703
Brugia malayi Patched family protein 0.0012 0.003 0.01
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0016 0.0025
Brugia malayi MH2 domain containing protein 0.0249 0.2948 0.9865
Echinococcus multilocularis Niemann Pick C1 protein 0.0282 0.3355 0.3345
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0516 0.1727
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0016 0.0054
Loa Loa (eye worm) hypothetical protein 0.0115 0.1301 0.4355
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0016 0.0054
Schistosoma mansoni Smad4 0.0017 0.0091 0.0143
Echinococcus multilocularis survival motor neuron protein 1 0.0252 0.2988 0.2977
Schistosoma mansoni d-amino acid oxidase 0.0195 0.2282 0.358
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0042 0.0399 0.2598
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0054
Brugia malayi MH1 domain containing protein 0.0017 0.0091 0.0306
Echinococcus multilocularis Smad4 0.0017 0.0091 0.0075
Brugia malayi MH2 domain containing protein 0.0017 0.0091 0.0306
Schistosoma mansoni hypothetical protein 0.005 0.05 0.0785
Schistosoma mansoni smad1 5 8 and 0.0017 0.0091 0.0143
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0091 0.0306
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase GlpD2 0.0016 0.0083 0.0362
Schistosoma mansoni hypothetical protein 0.005 0.05 0.0785
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.106 0.3547
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.106 0.1663
Loa Loa (eye worm) hypothetical protein 0.0115 0.1301 0.4355
Echinococcus multilocularis geminin 0.0527 0.6374 0.6368
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0016 0.0025
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0391 0.059
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Echinococcus granulosus Niemann Pick C1 protein 0.0197 0.2313 0.3612
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0085 0.0925 0.3097
Loa Loa (eye worm) hypothetical protein 0.0085 0.0925 0.3097
Brugia malayi steroid hormone receptor 0.0011 0.0016 0.0054
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Treponema pallidum exodeoxyribonuclease (exoA) 0.0042 0.0399 0.5
Brugia malayi Patched related family protein 12 0.0012 0.003 0.01
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0042 0.0399 0.0446
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.1301 1
Onchocerca volvulus Putative fad oxidoreductase 0.0016 0.0083 0.0472
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Mycobacterium ulcerans thiamine biosynthesis oxidoreductase ThiO 0.0016 0.0083 0.0362
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0068 0.0107
Echinococcus granulosus Smad4 0.0017 0.0091 0.0118
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0054
Echinococcus granulosus Niemann Pick C1 protein 0.0282 0.3355 0.5252
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Loa Loa (eye worm) MH2 domain-containing protein 0.0249 0.2948 0.9865
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0016 0.0025
Leishmania major hypothetical protein, conserved 0.0115 0.1301 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0091 0.0143
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0023 0.0171 0.1113
Echinococcus multilocularis protein patched 0.0085 0.0925 0.0911
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0042 0.0399 1
Brugia malayi CXXC zinc finger family protein 0.0061 0.0629 0.2105
Brugia malayi T-complex protein 1, beta subunit 0.0023 0.0171 0.0574
Mycobacterium ulcerans hypothetical protein 0.0115 0.1301 0.5703
Schistosoma mansoni fad oxidoreductase 0.0016 0.0083 0.0129
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Schistosoma mansoni ATP:guanidino kinase (Smc74) 0.0016 0.0083 0.0129
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Brugia malayi Patched family protein 0.0012 0.003 0.01
Loa Loa (eye worm) patched family protein 0.0012 0.003 0.01
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0115 0.1301 0.2042
Brugia malayi hypothetical protein 0.0041 0.0391 0.131
Echinococcus granulosus geminin 0.0527 0.6374 1
Echinococcus multilocularis smad 0.0017 0.0091 0.0075
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0391 0.0614
Brugia malayi CHE-14 protein 0.0085 0.0925 0.3097
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0042 0.0399 0.142
Loa Loa (eye worm) hypothetical protein 0.0104 0.116 0.3882
Loa Loa (eye worm) hypothetical protein 0.0159 0.1835 0.614
Chlamydia trachomatis D-amino acid dehydrogenase 0.0016 0.0083 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0016 0.0054
Brugia malayi hypothetical protein 0.0012 0.003 0.01
Schistosoma mansoni smad1 5 8 and 0.0017 0.0091 0.0143
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0023 0.0171 0.073
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0042 0.0399 0.0603
Brugia malayi hypothetical protein 0.0012 0.003 0.01
Plasmodium vivax FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0016 0.0083 0.0414
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0016 0.0092
Echinococcus granulosus glycerol 3 phosphate dehydrogenase 0.0016 0.0083 0.0105
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Onchocerca volvulus Protein patched homolog 0.0012 0.003 0.0171
Brugia malayi dimethylglycine dehydrogenase, mitochondrial precursor, putative 0.0016 0.0083 0.0276
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0016 0.0025
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0042 0.0399 0.2598
Schistosoma mansoni hypothetical protein 0.0458 0.5518 0.8658
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0016 0.0025
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.05 0.1674
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0068 0.0082
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0091 0.0118
Echinococcus granulosus cpg binding protein 0.0064 0.0672 0.1031
Brugia malayi Patched family protein 0.0012 0.003 0.01
Onchocerca volvulus Huntingtin homolog 0.0131 0.1492 0.8527
Schistosoma mansoni smad 0.0017 0.0091 0.0143
Onchocerca volvulus 0.0012 0.003 0.0171
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.1466 0.23
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0115 0.1301 0.4355
Echinococcus multilocularis GPCR, family 2 0.005 0.05 0.0485
Brugia malayi Calcitonin receptor-like protein seb-1 0.0159 0.1835 0.614
Loa Loa (eye worm) transcription factor SMAD2 0.0249 0.2948 0.9865
Onchocerca volvulus Dimethylglycine dehydrogenase, mitochondrial homolog 0.0016 0.0083 0.0472
Loa Loa (eye worm) patched family protein 0.0012 0.003 0.01
Leishmania major hypothetical protein, conserved 0.0016 0.0083 0.0634
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0115 0.1301 0.2042
Brugia malayi Patched family protein 0.0012 0.003 0.01
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0016 0.0025
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0171 0.0269
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0016 0.0054
Entamoeba histolytica hypothetical protein 0.0041 0.0391 0.1385
Mycobacterium ulcerans beta-lactamase 0.0115 0.1301 0.5703
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.106 0.1642
Echinococcus multilocularis beta LACTamase domain containing family member 0.0115 0.1301 0.1287
Brugia malayi Smad1 0.0017 0.0091 0.0306
Brugia malayi Patched family protein 0.0012 0.003 0.01
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.0179 0.2082 0.2327
Plasmodium falciparum FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0016 0.0083 0.1425
Echinococcus multilocularis dnaJ subfamily B 0.0458 0.5518 0.5511
Mycobacterium ulcerans esterase/lipase LipP 0.0115 0.1301 0.5703
Giardia lamblia TCP-1 chaperonin subunit beta 0.0023 0.0171 0.2808
Trypanosoma brucei hypothetical protein, conserved 0.0115 0.1301 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0016 0.0054
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0016 0.0025
Echinococcus multilocularis Niemann Pick C1 protein 0.0197 0.2313 0.23
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0159 0.1835 0.614
Entamoeba histolytica hypothetical protein 0.0041 0.0391 0.1385
Mycobacterium tuberculosis Conserved protein 0.0115 0.1301 0.1454
Mycobacterium tuberculosis Conserved protein 0.0115 0.1301 0.1454
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0399 0.2781
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0016 0.0054
Echinococcus granulosus dnaJ subfamily B 0.0458 0.5518 0.8654
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0171 0.0269
Schistosoma mansoni fad oxidoreductase 0.0016 0.0083 0.0129
Brugia malayi Patched family protein 0.0012 0.003 0.01
Mycobacterium leprae Probable lipase LipE 0.0115 0.1301 0.5541
Loa Loa (eye worm) patched family protein 0.0012 0.003 0.01
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0016 0.0054
Brugia malayi Patched family protein 0.0012 0.003 0.01
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0399 0.2905
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.106 0.1046
Echinococcus multilocularis FAD dependent oxidoreductase domain containing protein 0.0016 0.0083 0.0067
Mycobacterium leprae conserved hypothetical protein 0.0115 0.1301 0.5541
Onchocerca volvulus 0.0012 0.003 0.0171
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0023 0.0171 0.073
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.106 0.1663
Onchocerca volvulus 0.0115 0.1301 0.7439
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.106 0.1663
Loa Loa (eye worm) T-complex protein 1 0.0023 0.0171 0.0574
Loa Loa (eye worm) hypothetical protein 0.005 0.05 0.1674
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0016 0.0054
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase 0.0016 0.0083 0.0362
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0016 0.0054
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0115 0.1301 0.5703
Trypanosoma cruzi hypothetical protein, conserved 0.0115 0.1301 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0042 0.0399 0.0384
Echinococcus granulosus expressed conserved protein 0.0185 0.2165 0.338
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Brugia malayi beta-lactamase family protein 0.0115 0.1301 0.4355
Echinococcus granulosus survival motor neuron protein 1 0.0252 0.2988 0.4675
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0054
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0399 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.1301 0.4355
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0925 0.6992
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0054
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0091 0.0118
Loa Loa (eye worm) patched family protein 0.0012 0.003 0.01
Brugia malayi Patched family protein 0.0012 0.003 0.01
Loa Loa (eye worm) glycerol-3-phosphate dehydrogenase 0.0016 0.0083 0.0276
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0054
Echinococcus granulosus GPCR family 2 0.005 0.05 0.0762
Brugia malayi beta-lactamase family protein 0.0115 0.1301 0.4355
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0016 0.0054
Brugia malayi hypothetical protein 0.0012 0.003 0.01
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0068 0.0052
Brugia malayi protein C24B5.3 0.0012 0.003 0.01
Mycobacterium tuberculosis Possible thiamine biosynthesis oxidoreductase ThiO 0.0016 0.0083 0.0092
Schistosoma mansoni hypothetical protein 0.0082 0.0888 0.1393
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0736 0.8947 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0091 0.0075
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0114 0.0153
Schistosoma mansoni survival motor neuron protein 0.0051 0.0516 0.081
Brugia malayi Patched family protein 0.0012 0.003 0.01
Schistosoma mansoni hypothetical protein 0.005 0.05 0.0785
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Echinococcus granulosus FAD dependent oxidoreductase domain containing protein 0.0016 0.0083 0.0105
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0016 0.0025
Brugia malayi Niemann-Pick C1 protein precursor 0.0197 0.2313 0.7739
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Brugia malayi hypothetical protein 0.0131 0.1492 0.4991
Brugia malayi Patched family protein 0.0012 0.003 0.01
Onchocerca volvulus 0.0012 0.003 0.0171
Leishmania major T-complex protein 1, beta subunit, putative 0.0023 0.0171 0.1317
Loa Loa (eye worm) hypothetical protein 0.0016 0.0083 0.0276
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0016 0.0054
Brugia malayi beta-lactamase 0.0115 0.1301 0.4355
Schistosoma mansoni ap endonuclease 0.0042 0.0399 0.0626
Trichomonas vaginalis chaperonin, putative 0.0023 0.0171 0.0958
Loa Loa (eye worm) hypothetical protein 0.0131 0.1492 0.4991
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0042 0.0399 0.2598
Schistosoma mansoni patched 1 0.0085 0.0925 0.1452
Brugia malayi Patched family protein 0.0012 0.003 0.01
Brugia malayi MH2 domain containing protein 0.0017 0.0091 0.0306
Echinococcus multilocularis expressed conserved protein 0.0185 0.2165 0.2153
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0016 0.0025
Brugia malayi hypothetical protein 0.0012 0.003 0.01
Onchocerca volvulus 0.0011 0.0016 0.0092
Loa Loa (eye worm) hypothetical protein 0.0016 0.0083 0.0276
Trichomonas vaginalis penicillin-binding protein, putative 0.0115 0.1301 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0391 0.0376
Brugia malayi MH1 domain containing protein 0.0017 0.0091 0.0306
Brugia malayi protein C24B5.3 0.0012 0.003 0.01
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0197 0.2313 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.106 0.3547
Brugia malayi Patched family protein 0.0012 0.003 0.01
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0171 0.0269
Brugia malayi pyruvate dehydrogenase phosphatase regulatory subunit precursor 0.0016 0.0083 0.0276
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0042 0.0399 0.1336
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0114 0.038
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.1301 1
Schistosoma mansoni NAD dehydrogenase 0.0016 0.0083 0.0129
Onchocerca volvulus 0.0012 0.003 0.0171
Loa Loa (eye worm) hypothetical protein 0.0115 0.1301 0.4355
Schistosoma mansoni hypothetical protein 0.005 0.05 0.0785
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0016 0.0092
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0115 0.1301 0.1454
Mycobacterium tuberculosis Probable hydrolase 0.0115 0.1301 0.1454
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.05 0.0485
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0016 0.0054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0016 0.0054
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0023 0.0171 0.0244
Schistosoma mansoni niemann-pick C1 (NPC1) 0.02 0.235 0.3687
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0115 0.1301 0.1454
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0111 0.037
Onchocerca volvulus 0.0012 0.003 0.0171
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Leishmania major glycerol-3-phosphate dehydrogenase-like protein 0.0016 0.0083 0.0634
Brugia malayi Patched family protein 0.0012 0.003 0.01
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Mycobacterium tuberculosis Probable esterase LipL 0.0115 0.1301 0.1454
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0016 0.0054
Schistosoma mansoni hypothetical protein 0.0108 0.1217 0.191
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0054
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0159 0.1835 0.614
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.1297 0.9967
Mycobacterium tuberculosis Probable lipase LipD 0.0115 0.1301 0.1454
Echinococcus granulosus beta LACTamase domain containing family member 0.0115 0.1301 0.2021
Loa Loa (eye worm) hypothetical protein 0.0252 0.2988 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0016 0.0025
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0016 0.0092
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0054
Schistosoma mansoni hypothetical protein 0.0082 0.0888 0.1393
Loa Loa (eye worm) hypothetical protein 0.0016 0.0083 0.0276
Schistosoma mansoni cpg binding protein 0.0064 0.0672 0.1054
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Toxoplasma gondii FAD-dependent glycerol-3-phosphate dehydrogenase 0.0016 0.0083 0.0414
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0016 0.0025
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0068 0.0082
Brugia malayi nuclear hormone receptor 0.0011 0.0016 0.0054
Schistosoma mansoni glycerol-3-phosphate dehydrogenase 0.0016 0.0083 0.0129
Brugia malayi Patched protein homolog 1 0.0012 0.003 0.01
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0023 0.0171 0.0958
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0016 0.0054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0016 0.0054
Onchocerca volvulus Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog 0.0016 0.0083 0.0472
Loa Loa (eye worm) patched family protein 0.0012 0.003 0.01
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Mycobacterium tuberculosis Probable lipase LipE 0.0115 0.1301 0.1454
Entamoeba histolytica hypothetical protein 0.0041 0.0391 0.1385
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0016 0.0054
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.05 0.0762
Trichomonas vaginalis penicillin-binding protein, putative 0.0115 0.1301 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.01
Onchocerca volvulus 0.0152 0.1749 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 5000 nM Inhibition of human DAO ChEMBL. 18455394

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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