Detailed information for compound 1186919

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 366.449 | Formula: C20H30O6
  • H donors: 5 H acceptors: 5 LogP: -0.64 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@]1(C)CCC[C@@]23[C@@H]1[C@H](O)[C@](O)(OC2)[C@]12[C@H]3[C@@H](O)C[C@H](C1)C(=C)C2O
  • InChi: 1S/C20H30O6/c1-10-11-6-12(22)13-18-5-3-4-17(2,8-21)14(18)16(24)20(25,26-9-18)19(13,7-11)15(10)23/h11-16,21-25H,1,3-9H2,2H3/t11-,12+,13+,14-,15?,16+,17+,18-,19+,20+/m1/s1
  • InChiKey: RIUMTXABLIPQRZ-BTOBVQBBSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0567 0.1272
Loa Loa (eye worm) hypothetical protein 0.0022 0.0418 0.0938
Loa Loa (eye worm) hypothetical protein 0.0037 0.0739 0.1659
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0567 0.1272
Loa Loa (eye worm) DR-78 0.0011 0.0152 0.0341
Onchocerca volvulus 0.0011 0.0152 0.0299
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0011 0.0152 0.0152
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0011 0.0152 0.0341
Echinococcus multilocularis cpg binding protein 0.0033 0.0649 0.0649
Schistosoma mansoni hypothetical protein 0.0197 0.4358 0.4442
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0072 0.00000000017798
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.4454 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0418 0.0938
Schistosoma mansoni smad1 5 8 and 0.0009 0.0106 0.0108
Loa Loa (eye worm) hypothetical protein 0.0022 0.0418 0.0938
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0418 0.0426
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0229 0.0229
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0111 0.0111
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0324 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0106 0.0106
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.013 0.013
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0296 0.0296
Echinococcus granulosus nuclear receptor nhr 48 0.0011 0.0152 0.0152
Brugia malayi steroid hormone receptor 0.0022 0.0418 0.0938
Brugia malayi nuclear receptor NHR-88 0.0022 0.0418 0.0938
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0418 0.0426
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0194 0.0244
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0418 0.0418
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.018 0.0405
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0418 0.0418
Schistosoma mansoni ferritin light chain 0.0009 0.0119 0.0122
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0418 0.0426
Brugia malayi nuclear receptor NHR-88 0.0011 0.0152 0.0341
Loa Loa (eye worm) hypothetical protein 0.0011 0.0152 0.0341
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0438 0.0438
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0418 0.0822
Onchocerca volvulus 0.0029 0.0567 0.1116
Schistosoma mansoni DNA helicase recq1 0.001 0.013 0.0133
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0578 0.4504
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0324 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0578 0.059
Echinococcus multilocularis dnaJ subfamily B 0.044 0.981 0.981
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.018 0.0405
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0578 0.059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0418 0.0938
Loa Loa (eye worm) hypothetical protein 0.0013 0.0217 0.0488
Loa Loa (eye worm) hypothetical protein 0.0029 0.0567 0.1272
Schistosoma mansoni cpg binding protein 0.0033 0.0649 0.0661
Loa Loa (eye worm) hypothetical protein 0.0014 0.0229 0.0514
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0418 0.0418
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0011 0.0152 0.0341
Echinococcus granulosus muscleblind protein 0.0174 0.3831 0.3831
Brugia malayi MH1 domain containing protein 0.0009 0.0106 0.0238
Echinococcus multilocularis lamin dm0 0.0029 0.0567 0.0567
Schistosoma mansoni blooms syndrome DNA helicase 0.0005 0.0024 0.0025
Echinococcus multilocularis expressed protein 0.0009 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0011 0.0152 0.0341
Brugia malayi MH1 domain containing protein 0.0005 0.002 0.0046
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.1412 0.1439
Echinococcus multilocularis Smad4 0.0009 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0011 0.0152 0.0341
Echinococcus granulosus thyroid hormone receptor alpha 0.0011 0.0152 0.0152
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0153 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0418 0.0938
Loa Loa (eye worm) hypothetical protein 0.0012 0.018 0.0405
Brugia malayi MH2 domain containing protein 0.0009 0.0106 0.0238
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.015 0.0338
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0418 0.0426
Brugia malayi MH2 domain containing protein 0.0125 0.273 0.613
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0418 0.0418
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0418 0.0418
Echinococcus multilocularis geminin 0.0197 0.4358 0.4358
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0268 0.4444
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1021 0.1041
Schistosoma mansoni apoferritin-2 0.0009 0.0119 0.0122
Schistosoma mansoni lamin 0.0029 0.0567 0.0578
Brugia malayi Smad1 0.0009 0.0106 0.0238
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0106 0.0106
Schistosoma mansoni ferritin 0.0009 0.0119 0.0122
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0438 0.0983
Schistosoma mansoni lamin 0.0029 0.0567 0.0578
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0106 0.0238
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0011 0.0152 0.0155
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0418 0.0418
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.013 0.013
Brugia malayi MH2 domain containing protein 0.0009 0.0106 0.0238
Brugia malayi MH1 domain containing protein 0.0005 0.002 0.0046
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0111 0.0113
Echinococcus granulosus Smad4 0.0009 0.0106 0.0106
Schistosoma mansoni nuclear receptor 0.0011 0.0152 0.0155
Schistosoma mansoni hypothetical protein 0.0017 0.0296 0.0302
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0418 0.0938
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0418 0.0938
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0418 0.0938
Brugia malayi nuclear hormone receptor 0.0011 0.0152 0.0341
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0418 0.0418
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.018 0.018
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0578 0.0578
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0106 0.0106
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0152 0.0155
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0324 0.545
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0989 0.1009
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0418 0.0418
Schistosoma mansoni ferritin 0.0009 0.0119 0.0122
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0152 0.0152
Echinococcus multilocularis nuclear receptor nhr 48 0.0011 0.0152 0.0152
Echinococcus granulosus cpg binding protein 0.0033 0.0649 0.0649
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0418 0.0426
Schistosoma mansoni ferritin 0.0009 0.0119 0.0122
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0418 0.0426
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0418 0.0938
Brugia malayi MH1 domain containing protein 0.0009 0.0106 0.0238
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0072 0.00000000017798
Schistosoma mansoni zinc finger protein 0.0011 0.0152 0.0155
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1021 0.1021
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.1254 1
Schistosoma mansoni hypothetical protein 0.0017 0.0296 0.0302
Schistosoma mansoni smad 0.0009 0.0106 0.0108
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.0011 0.0152 0.0341
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0038 0.0038
Brugia malayi nuclear hormone receptor 0.0022 0.0418 0.0938
Loa Loa (eye worm) hypothetical protein 0.0005 0.002 0.0046
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0106 0.0238
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0011 0.0152 0.0299
Echinococcus granulosus bloom syndrome protein 0.0023 0.0438 0.0438
Loa Loa (eye worm) nuclear factor I 0.0005 0.002 0.0046
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0578 0.0578
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.018 0.0184
Brugia malayi conserved hypotetical protein 0.0011 0.0152 0.0341
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0072 0.00000000017798
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0324 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0011 0.0152 0.0341
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0011 0.0152 0.0152
Entamoeba histolytica recQ family DNA helicase 0.0005 0.0024 0.0138
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0296 0.0296
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0296 0.0664
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.1021 0.2292
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0264 0.0592
Echinococcus granulosus geminin 0.0197 0.4358 0.4358
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0418 0.0938
Schistosoma mansoni hypothetical protein 0.0037 0.0739 0.0753
Loa Loa (eye worm) hypothetical protein 0.0174 0.3831 0.8603
Echinococcus multilocularis tumor protein p63 0.0326 0.726 0.726
Loa Loa (eye worm) hypothetical protein 0.0013 0.0217 0.0488
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0072 0.00000000017798
Schistosoma mansoni smad1 5 8 and 0.0009 0.0106 0.0108
Brugia malayi nuclear receptor RXR 0.0012 0.018 0.0405
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0578 0.0578
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0152 0.0341
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0418 0.0938
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0418 0.0938
Loa Loa (eye worm) hypothetical protein 0.0048 0.0989 0.2221
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0153 0.0153
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0324 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0152 0.0341
Brugia malayi Muscleblind-like protein 0.0174 0.3831 0.8603
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0578 0.059
Schistosoma mansoni coup transcription factor 0.0022 0.0418 0.0426
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.013 0.013
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0152 0.0152
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0418 0.0418
Brugia malayi intermediate filament protein 0.0029 0.0567 0.1272
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0438 0.0731
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0152 0.0152
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0022 0.0418 0.0938
Schistosoma mansoni intermediate filament proteins 0.0029 0.0567 0.0578
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0739 0.1659
Echinococcus granulosus tumor protein p63 0.0326 0.726 0.726
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0194 0.5711
Treponema pallidum bacterioferrin (TpF1) 0.0009 0.0119 0.3165
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0418 0.0938
Loa Loa (eye worm) hypothetical protein 0.0011 0.0152 0.0341
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0111 0.0111
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1021 0.1021
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.0011 0.0152 0.0341
Brugia malayi CXXC zinc finger family protein 0.0031 0.0609 0.1367
Schistosoma mansoni ferritin 0.0009 0.0119 0.0122
Brugia malayi tailless protein 0.0011 0.0152 0.0341
Toxoplasma gondii exonuclease III APE 0.0018 0.0324 0.2439
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0418 0.0938
Echinococcus granulosus lamin dm0 0.0029 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0152 0.0341
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0324 0.7958
Brugia malayi nuclear receptor RXR 0.0011 0.0152 0.0341
Loa Loa (eye worm) hypothetical protein 0.003 0.0578 0.1299
Schistosoma mansoni ferritin light chain 0.0009 0.0119 0.0122
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0324 0.0505
Onchocerca volvulus 0.0048 0.0989 0.1948
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0418 0.0938
Brugia malayi nuclear receptor NHR-67 0.0011 0.0152 0.0341
Schistosoma mansoni DNA helicase recq5 0.001 0.013 0.0133
Loa Loa (eye worm) hypothetical protein 0.0022 0.0418 0.0938
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.018 0.018
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.1021 0.2292
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0418 0.0426
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0418 0.0938
Loa Loa (eye worm) RecQ helicase 0.0023 0.0438 0.0983
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0111 0.0111
Brugia malayi nuclear hormone receptor family member odr-7 0.0011 0.0152 0.0341
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0264 0.1948
Loa Loa (eye worm) nuclear hormone receptor 0.0011 0.0152 0.0341
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0578 0.059
Trichomonas vaginalis set domain proteins, putative 0.023 0.5079 1
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.273 0.613
Echinococcus granulosus smad 0.0009 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0012 0.018 0.0405
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0418 0.0426
Onchocerca volvulus 0.0031 0.0609 0.1199
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.013 0.0861
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0324 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0418 0.0822
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0011 0.0152 0.0341
Loa Loa (eye worm) hypothetical protein 0.0174 0.3831 0.8603
Loa Loa (eye worm) hypothetical protein 0.0022 0.0418 0.0938
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0324 0.0324
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0418 0.0938
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.018 0.0405
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0324 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0152 0.0341
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0418 0.0938
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0072 0.00000000017798
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0324 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0024 0.0055
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.112 0.2515
Brugia malayi orphan nuclear receptor NR2E1 0.0011 0.0152 0.0341
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.018 0.0184
Schistosoma mansoni cpg binding protein 0.0031 0.0609 0.0621
Schistosoma mansoni cpg binding protein 0.0033 0.0649 0.0661
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0418 0.0418
Brugia malayi hypothetical protein 0.0011 0.0152 0.0341
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0072 0.00000000017798
Loa Loa (eye worm) hypothetical protein 0.0012 0.018 0.0405
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0438 0.0731
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0011 0.0152 0.0299
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0009 0.0119 0.5
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0418 0.0426
Brugia malayi Pre-SET motif family protein 0.003 0.0578 0.1299
Loa Loa (eye worm) hypothetical protein 0.0012 0.018 0.0405
Loa Loa (eye worm) hypothetical protein 0.0017 0.0296 0.0664
Brugia malayi Pre-SET motif family protein 0.0202 0.4454 1
Onchocerca volvulus 0.0029 0.0567 0.1116
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0011 0.0152 0.0341
Brugia malayi hypothetical protein 0.0012 0.018 0.0405
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0324 0.0324
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0152 0.0341
Echinococcus granulosus GPCR family 2 0.0017 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0054 0.112 0.2515
Loa Loa (eye worm) hypothetical protein 0.0022 0.0418 0.0938
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0324 0.0728
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1021 0.1021
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0418 0.0418
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0011 0.0152 0.0152
Echinococcus multilocularis smad 0.0009 0.0106 0.0106
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0324 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0418 0.0938
Plasmodium vivax SET domain protein, putative 0.003 0.0578 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.013 0.0293
Echinococcus granulosus intermediate filament protein 0.0029 0.0567 0.0567
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0418 0.0426
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0418 0.0938
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1021 0.1021
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0418 0.0938
Loa Loa (eye worm) hypothetical protein 0.001 0.013 0.0293
Schistosoma mansoni hypothetical protein 0.0017 0.0296 0.0302
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.273 0.613
Loa Loa (eye worm) hypothetical protein 0.0012 0.018 0.0405
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0011 0.0152 0.0155
Schistosoma mansoni Smad4 0.0009 0.0106 0.0108
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0152 0.0152
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0296 0.0664
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0106 0.0106
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0418 0.0418
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0418 0.0938
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.013 0.0293
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0418 0.0418
Brugia malayi ecdysone receptor 0.0011 0.0152 0.0341
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0022 0.0418 0.0938
Onchocerca volvulus 0.0011 0.0152 0.0299
Echinococcus granulosus dnaJ subfamily B 0.044 0.981 0.981
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0229 0.0229
Schistosoma mansoni nuclear receptor 0.0011 0.0152 0.0155
Schistosoma mansoni smad1 5 8 and 0.0009 0.0106 0.0108
Echinococcus multilocularis muscleblind protein 0.0174 0.3831 0.3831
Brugia malayi hypothetical protein 0.0011 0.0152 0.0341
Echinococcus granulosus expressed protein 0.0009 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0117 0.255 0.5725
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0418 0.0822
Schistosoma mansoni nuclear receptor nhr-48 0.0011 0.0152 0.0155
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0296 0.0664
Echinococcus granulosus lamin 0.0029 0.0567 0.0567
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0374 1
Schistosoma mansoni hypothetical protein 0.0197 0.4358 0.4442
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.112 0.2515
Echinococcus multilocularis muscleblind protein 1 0.0174 0.3831 0.3831
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0106 0.0108
Echinococcus granulosus ferritin 0.0009 0.0119 0.0119
Schistosoma mansoni hypothetical protein 0.0017 0.0296 0.0302
Onchocerca volvulus 0.0022 0.0418 0.0822
Echinococcus multilocularis GPCR, family 2 0.0017 0.0296 0.0296
Echinococcus multilocularis lamin 0.0029 0.0567 0.0567
Onchocerca volvulus 0.023 0.5079 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0194 0.5651
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0264 0.0592
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0609 0.1367
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0418 0.0418
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0418 0.0426
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0418 0.0938
Loa Loa (eye worm) Smad1 0.0009 0.0106 0.0238
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.013 0.0293
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0011 0.0152 0.0341
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0324 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0418 0.0426
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1021 0.1041
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0418 0.0938
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1021 0.1041
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0152 0.0155
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0418 0.0418
Brugia malayi hypothetical protein 0.0012 0.018 0.0405
Echinococcus multilocularis musashi 0.0029 0.0567 0.0567
Echinococcus multilocularis ferritin 0.0009 0.0119 0.0119
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0072 0.00000000017798
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0153 0.0344
Loa Loa (eye worm) hypothetical protein 0.0011 0.0152 0.0341
Brugia malayi ecdysteroid receptor 0.0022 0.0418 0.0938
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0539 0.0539
Loa Loa (eye worm) hypothetical protein 0.0028 0.0555 0.1246
Loa Loa (eye worm) nuclear receptor NHR-67 0.0011 0.0152 0.0341
Onchocerca volvulus 0.003 0.0578 0.1139
Trichomonas vaginalis ferritin, putative 0.0009 0.0119 0.0095
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.112 0.2515
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0072 0.00000000017798
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0418 0.0938
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0418 0.0938
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0296 0.0296
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.013 0.0861
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0324 1
Schistosoma mansoni ap endonuclease 0.0018 0.0324 0.0331
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0328 0.0334
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0418 0.0938
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0324 0.0728
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0567 0.1272
Schistosoma mansoni ap endonuclease 0.0018 0.0324 0.0331
Schistosoma mansoni hypothetical protein 0.044 0.981 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0418 0.0418
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0324 0.0505
Schistosoma mansoni apoferritin-2 0.0009 0.0119 0.0122

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 10 uM Cytotoxicity against human K562 cells after 48 hrs ChEMBL. 19697926
IC50 (functional) > 10 uM Cytotoxicity against human A549 cells after 48 hrs ChEMBL. 19697926
IC50 (functional) > 10 uM Cytotoxicity against human HepG2 cells after 48 hrs ChEMBL. 19697926

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 19697926

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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