Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0187 | 0.0187 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0187 | 0.0187 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0187 | 0.0187 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.1138 | 0.3289 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.0187 | 0.0541 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0187 | 0.0187 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0129 | 0.3461 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0698 | 0.2017 |
Echinococcus granulosus | GPCR family 2 | 0.0015 | 0.0187 | 0.0187 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.1138 | 0.3289 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.1138 | 0.3289 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1138 | 0.3289 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0187 | 0.0187 |
Brugia malayi | MH2 domain containing protein | 0.0129 | 0.3461 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.0187 | 0.0541 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.0187 | 0.0541 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0187 | 0.0187 |
Echinococcus multilocularis | GPCR, family 2 | 0.0015 | 0.0187 | 0.0187 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0187 | 0.0187 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0129 | 0.3461 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0698 | 0.2017 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0187 | 0.0187 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0187 | 0.0541 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | > 100 uM | Cytotoxicity against human MT4 cells after 96 hrs by MTT assay | ChEMBL. | 20359898 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.