Detailed information for compound 1187173

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1952.31 | Formula: C84H138N30O20S2
  • H donors: 29 H acceptors: 20 LogP: -9.11 Rotable bonds: 84
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CCCNC(=N)N)C(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@H](O)C)NC(=O)[C@@H](N)C)CCCCN)CS)Cc1ccccc1)CCC(=O)N)CCC(=O)N)CCCNC(=N)N)CC(=O)N)CCSC)CCCNC(=N)N
  • InChi: 1S/C84H138N30O20S2/c1-43(2)65(79(131)108-57(81(133)134)26-17-36-99-84(95)96)113-74(126)51(23-12-14-33-86)101-68(120)52(24-15-34-97-82(91)92)103-73(125)56(31-37-136-5)106-77(129)60(40-64(90)118)111-69(121)53(25-16-35-98-83(93)94)102-71(123)54(27-29-62(88)116)105-76(128)59(39-47-41-100-49-21-10-9-20-48(47)49)110-72(124)55(28-30-63(89)117)104-75(127)58(38-46-18-7-6-8-19-46)109-78(130)61(42-135)112-70(122)50(22-11-13-32-85)107-80(132)66(45(4)115)114-67(119)44(3)87/h6-10,18-21,41,43-45,50-61,65-66,100,115,135H,11-17,22-40,42,85-87H2,1-5H3,(H2,88,116)(H2,89,117)(H2,90,118)(H,101,120)(H,102,123)(H,103,125)(H,104,127)(H,105,128)(H,106,129)(H,107,132)(H,108,131)(H,109,130)(H,110,124)(H,111,121)(H,112,122)(H,113,126)(H,114,119)(H,133,134)(H4,91,92,97)(H4,93,94,98)(H4,95,96,99)/t44-,45+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,65-,66-/m0/s1
  • InChiKey: YDIPGIOADMYMDS-KNZUCTQWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus geminin 0.036 0.0762 0.4531
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0183 0.0368 0.4434
Loa Loa (eye worm) twinkle helicase 0.0111 0.0209 0.1241
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0059 0.0093 0.0733
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0014 0.0018
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0059 0.0093 0.0123
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0003 0.0003
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0003 0.0003
Onchocerca volvulus 0.0023 0.0014 0.027
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0133 0.0258 0.1535
Trypanosoma cruzi hypothetical protein, conserved 0.0084 0.0149 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0081 0.0142 0.151
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0003 0.0018
Schistosoma mansoni hypothetical protein 0.0104 0.0193 0.2059
Echinococcus granulosus lamin dm0 0.0027 0.0023 0.0135
Leishmania major hypothetical protein, conserved 0.0025 0.0019 0.0725
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0005 0.003
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0014 0.0081
Onchocerca volvulus Protein patched homolog 0.0026 0.0021 0.0409
Brugia malayi beta-lactamase family protein 0.0084 0.0149 0.0888
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0014 0.0055
Loa Loa (eye worm) hypothetical protein 0.0084 0.0149 0.0888
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0023 0.0014 0.0018
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0063 0.0102 0.2778
Echinococcus granulosus replication factor c subunit 1 0.0033 0.0035 0.0208
Brugia malayi AMP-binding enzyme family protein 0.0079 0.0137 0.0814
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0014 0.0223
Onchocerca volvulus 0.0158 0.0313 0.6171
Schistosoma mansoni hypothetical protein 0.0042 0.0055 0.0585
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Loa Loa (eye worm) patched family protein 0.0026 0.0021 0.0123
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0046 0.075
Schistosoma mansoni topbp1 0.0033 0.0035 0.0372
Loa Loa (eye worm) hypothetical protein 0.0059 0.0093 0.0552
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0014 0.0081
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0086 0.0114
Schistosoma mansoni lamin 0.0027 0.0023 0.0241
Onchocerca volvulus 0.0026 0.0021 0.0409
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0108 0.0203 0.2464
Plasmodium falciparum replication factor C subunit 1, putative 0.0033 0.0035 0.0948
Loa Loa (eye worm) hypothetical protein 0.0224 0.0461 0.274
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.0081
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0014 0.0081
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0023 0.0014 0.0018
Schistosoma mansoni Replicative DNA helicase 0.0388 0.0824 0.8787
Toxoplasma gondii patched family protein 0.0026 0.0021 0.0564
Loa Loa (eye worm) hypothetical protein 0.0033 0.0035 0.0208
Plasmodium vivax hypothetical protein, conserved 0.0084 0.0149 0.4055
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0186 0.0375 0.2229
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0035 0.0568
Loa Loa (eye worm) latrophilin receptor protein 2 0.0104 0.0193 0.1148
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.0614 1
Brugia malayi Patched protein homolog 1 0.0026 0.0021 0.0123
Brugia malayi beta-lactamase family protein 0.0084 0.0149 0.0888
Brugia malayi beta-lactamase 0.0084 0.0149 0.0888
Loa Loa (eye worm) patched family protein 0.0026 0.0021 0.0123
Brugia malayi intermediate filament protein 0.0027 0.0023 0.0135
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0023 0.0014 0.0372
Brugia malayi protein C24B5.3 0.0026 0.0021 0.0123
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0023 0.0014 0.0018
Chlamydia trachomatis recombinase RecA 0.0108 0.0203 0.2131
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.0614 0.6654
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Mycobacterium tuberculosis Conserved protein 0.0084 0.0149 0.0199
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0023 0.0014 0.0055
Chlamydia trachomatis replicative DNA helicase 0.0388 0.0824 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0019 0.0111
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0031 0.0332
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0014 0.0018
Toxoplasma gondii Alpha-galactosidase 0.0017 0.0001 0.0014
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0019 0.1253
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3124 0.6897 0.9174
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Loa Loa (eye worm) hypothetical protein 0.0079 0.0137 0.0814
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0102 0.2775
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0079 0.0137 0.166
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0005 0.0082
Leishmania major 4-coumarate:coa ligase-like protein 0.0079 0.0137 0.53
Brugia malayi AMP-binding enzyme family protein 0.0079 0.0137 0.0814
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0005 0.0136
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0023 0.0014 0.0917
Treponema pallidum replicative DNA helicase (dnaB) 0.0388 0.0824 1
Toxoplasma gondii propionate-CoA ligase 0.0023 0.0014 0.0372
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0072 0.0431
Loa Loa (eye worm) hypothetical protein 0.0033 0.0035 0.0208
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Schistosoma mansoni survival motor neuron protein 0.0158 0.0313 0.3338
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0046 0.0274
Brugia malayi Patched family protein 0.0026 0.0021 0.0123
Mycobacterium tuberculosis Probable hydrolase 0.0084 0.0149 0.0199
Loa Loa (eye worm) hypothetical protein 0.0079 0.0137 0.0814
Mycobacterium leprae Conserved hypothetical protein 0.1144 0.2503 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.012 0.0228 0.0304
Brugia malayi Patched family protein 0.0026 0.0021 0.0123
Treponema pallidum recombinase A 0.0108 0.0203 0.2418
Brugia malayi hypothetical protein 0.0026 0.0021 0.0123
Trypanosoma cruzi DNA repair protein, putative 0.0033 0.0037 0.245
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0072 0.0773
Onchocerca volvulus 0.0026 0.0021 0.0409
Mycobacterium ulcerans lipase LipD 0.0084 0.0149 0.1811
Schistosoma mansoni intermediate filament proteins 0.0027 0.0023 0.0241
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0046 0.0274
Plasmodium vivax acyl-CoA synthetase, putative 0.0059 0.0093 0.2519
Brugia malayi Patched family protein 0.0026 0.0021 0.0123
Trichomonas vaginalis D-aminoacylase, putative 0.0084 0.0149 0.2431
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0014 0.053
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0014 0.0917
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0121 0.0231 0.2464
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0023 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0017 0.0001 0.0006
Entamoeba histolytica hypothetical protein 0.0042 0.0055 0.0594
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0102 0.0608
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0033 0.0035 0.0139
Brugia malayi hypothetical protein 0.0033 0.0035 0.0208
Trypanosoma brucei hypothetical protein, conserved 0.0084 0.0149 1
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0108 0.0203 0.0811
Mycobacterium ulcerans hypothetical protein 0.0084 0.0149 0.1811
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0019 0.0508
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0014 0.0018
Mycobacterium ulcerans beta-lactamase 0.0084 0.0149 0.1811
Entamoeba histolytica acyl-CoA synthetase, putative 0.0079 0.0137 0.1482
Brugia malayi Probable ClpP-like protease 0.0183 0.0368 0.219
Loa Loa (eye worm) hypothetical protein 0.0033 0.0035 0.0208
Echinococcus multilocularis lamin dm0 0.0027 0.0023 0.0023
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0033 0.0035 0.2338
Brugia malayi Patched family protein 0.0026 0.0021 0.0123
Brugia malayi protein C24B5.3 0.0026 0.0021 0.0123
Loa Loa (eye worm) hypothetical protein 0.0059 0.0093 0.0552
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0033 0.0035 0.0948
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0095 0.0568
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0023 0.0014 0.0372
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0084 0.0149 0.0199
Echinococcus multilocularis protein patched 0.0186 0.0375 0.0375
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0046 0.0046
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0035 0.2338
Loa Loa (eye worm) hypothetical protein 0.0084 0.0149 0.0888
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0031 0.0332
Toxoplasma gondii patched family protein 0.0026 0.0021 0.0564
Brugia malayi Patched family protein 0.0026 0.0021 0.0123
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0005 0.0007
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0121 0.0231 0.2464
Brugia malayi hypothetical protein 0.0026 0.0021 0.0123
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0005 0.0336
Brugia malayi jmjC domain containing protein 0.006 0.0095 0.0568
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0023 0.0014 0.0081
Schistosoma mansoni hypothetical protein 0.036 0.0762 0.8123
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.0243 0.0243
Echinococcus granulosus Protein patched homolog 1 0.0186 0.0375 0.2229
Brugia malayi DKFZp564C0469 protein 0.0033 0.0035 0.0208
Schistosoma mansoni lamin 0.0027 0.0023 0.0241
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0003 0.0018
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0033 0.0035 0.0568
Plasmodium falciparum acyl-CoA synthetase 0.0059 0.0093 0.2519
Entamoeba histolytica hypothetical protein 0.0042 0.0055 0.0594
Mycobacterium tuberculosis Conserved protein 0.0084 0.0149 0.0199
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0014 0.0166
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0095 0.0095
Echinococcus granulosus Niemann Pick C1 protein 0.0433 0.0923 0.549
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0328 0.0691 0.4111
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0003 0.0082
Brugia malayi Patched related family protein 12 0.0026 0.0021 0.0123
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.0614 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0079 0.0137 0.1482
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0116 0.0221 0.1312
Schistosoma mansoni chromosome transmission fidelity factor 0.0033 0.0035 0.0372
Brugia malayi Latrophilin receptor protein 2 0.0104 0.0193 0.1148
Loa Loa (eye worm) hypothetical protein 0.0079 0.0137 0.0814
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0019 0.0508
Brugia malayi hypothetical protein 0.0774 0.1681 1
Loa Loa (eye worm) beta-lactamase 0.0084 0.0149 0.0888
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0046 0.0274
Brugia malayi Myosin head containing protein 0.0026 0.0021 0.0123
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0059 0.0093 0.1126
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0095 0.1017
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0033 0.0035 0.0568
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0014 0.0081
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0072 0.0431
Onchocerca volvulus 0.0245 0.0507 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0023 0.0014 0.0018
Brugia malayi Patched family protein 0.0026 0.0021 0.0123
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0023 0.0014 0.0166
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0121 0.0231 0.2464
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Toxoplasma gondii exonuclease III APE 0.0019 0.0005 0.0136
Echinococcus multilocularis Niemann Pick C1 protein 0.0433 0.0923 0.0923
Plasmodium vivax SET domain protein, putative 0.0031 0.0031 0.0847
Loa Loa (eye worm) patched family protein 0.0026 0.0021 0.0123
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0014 0.0166
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0084 0.0149 0.0888
Schistosoma mansoni hypothetical protein 0.0104 0.0193 0.2059
Echinococcus granulosus sterol regulatory element binding protein 0.0186 0.0375 0.2229
Onchocerca volvulus Protein patched homolog 0.0026 0.0021 0.0409
Entamoeba histolytica hypothetical protein 0.0042 0.0055 0.0594
Brugia malayi Patched family protein 0.0026 0.0021 0.0123
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0133 0.0258 1
Trypanosoma cruzi FHA domain containing protein, putative 0.0033 0.0035 0.2338
Schistosoma mansoni ap endonuclease 0.0019 0.0005 0.0053
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0095 0.0568
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.0614 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0023 0.0014 0.0166
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0023 0.0135
Echinococcus granulosus Niemann Pick C1 protein 0.0618 0.1335 0.7942
Trichomonas vaginalis penicillin-binding protein, putative 0.0084 0.0149 0.2431
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0019 0.1253
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0183 0.0368 0.4467
Loa Loa (eye worm) hypothetical protein 0.0084 0.0149 0.0888
Plasmodium falciparum lipid/sterol:H+ symporter 0.0026 0.0021 0.0564
Giardia lamblia Replication factor C, subunit 1 0.0033 0.0035 0.0568
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0019 0.0508
Mycobacterium ulcerans esterase/lipase LipP 0.0084 0.0149 0.1811
Schistosoma mansoni DNA ligase IV 0.0033 0.0035 0.0372
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0023 0.0014 0.0166
Entamoeba histolytica hypothetical protein 0.0042 0.0055 0.0594
Schistosoma mansoni hypothetical protein 0.0179 0.036 0.3837
Trypanosoma cruzi hypothetical protein, conserved 0.0084 0.0149 1
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0081 0.0142 0.2306
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0084 0.0149 0.1592
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0388 0.0824 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0014 0.0166
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0079 0.0137 0.0182
Mycobacterium tuberculosis Probable esterase LipL 0.0084 0.0149 0.0199
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0046 0.0046
Echinococcus granulosus nibrin 0.0033 0.0035 0.0208
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.0243 0.1446
Loa Loa (eye worm) hypothetical protein 0.0033 0.0035 0.0208
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0079 0.0137 0.166
Mycobacterium leprae Probable lipase LipE 0.0084 0.0149 0.0596
Trichomonas vaginalis penicillin-binding protein, putative 0.0084 0.0149 0.2431
Schistosoma mansoni hypothetical protein 0.0179 0.036 0.3837
Mycobacterium tuberculosis Probable lipase LipE 0.0084 0.0149 0.0199
Brugia malayi Melibiase family protein 0.0081 0.0142 0.0842
Onchocerca volvulus 0.0027 0.0023 0.0446
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0023 0.0014 0.0148
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0046 0.0499
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0014 0.0917
Onchocerca volvulus 0.0023 0.0014 0.027
Echinococcus multilocularis nibrin 0.0033 0.0035 0.0035
Echinococcus granulosus tumor protein p63 0.0391 0.083 0.4935
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0005 0.0136
Leishmania major hypothetical protein, conserved 0.0084 0.0149 0.5783
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0046 0.0491
Leishmania major 4-coumarate:coa ligase-like protein 0.0079 0.0137 0.53
Onchocerca volvulus 0.0033 0.0035 0.0688
Echinococcus granulosus GPCR family 2 0.0104 0.0193 0.1148
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.3404 0.7518 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.012 0.0228 0.0304
Brugia malayi Patched family protein 0.0026 0.0021 0.0123
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0033 0.0035 0.0378
Treponema pallidum DNA ligase (lig) 0.0033 0.0035 0.0365
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0102 0.124
Brugia malayi hypothetical protein 0.0025 0.0019 0.0111
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0046 0.3087
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0046 0.3087
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0003 0.0203
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0063 0.0102 0.2778
Onchocerca volvulus 0.0026 0.0021 0.0409
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0084 0.0149 0.0888
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0102 0.0102
Brugia malayi hypothetical protein 0.0033 0.0035 0.0208
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0005 0.0082
Loa Loa (eye worm) patched family protein 0.0026 0.0021 0.0123
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0023 0.0135
Echinococcus multilocularis peptidase Clp (S14 family) 0.012 0.0228 0.0228
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0014 0.0166
Brugia malayi Niemann-Pick C1 protein precursor 0.0433 0.0923 0.549
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0268 0.0557 0.331
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0183 0.0368 0.4467
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0031 0.0031
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0328 0.0691 0.4111
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.0081
Echinococcus multilocularis thyroid hormone receptor alpha 0.0137 0.0266 0.0266
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0046 0.0491
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0003 0.0018
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0023 0.0014 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0072 0.0773
Trypanosoma cruzi DNA repair protein, putative 0.0033 0.0037 0.245
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0014 0.0166
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0046 0.075
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0084 0.0149 0.1811
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0014 0.0166
Schistosoma mansoni hypothetical protein 0.0104 0.0193 0.2059
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0023 0.0135
Loa Loa (eye worm) hypothetical protein 0.0033 0.0035 0.0208
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0003 0.0082
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0183 0.0368 0.4223
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0005 0.0061
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0072 0.0431
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0104 0.0193 0.1148
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.0614 1
Loa Loa (eye worm) hypothetical protein 0.0227 0.0467 0.278
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0003 0.0082
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0084 0.0149 0.0199
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0388 0.0824 0.3293
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0104 0.0193 0.1148
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0014 0.0018
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0183 0.0368 1
Loa Loa (eye worm) oxidoreductase 0.0023 0.0014 0.0081
Echinococcus multilocularis tumor protein p63 0.0391 0.083 0.083
Brugia malayi isocitrate dehydrogenase 0.0018 0.0003 0.0018
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0003 0.0203
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.012 0.0228 0.0913
Loa Loa (eye worm) hypothetical protein 0.0057 0.0089 0.0532
Loa Loa (eye worm) hypothetical protein 0.0027 0.0022 0.0128
Loa Loa (eye worm) hypothetical protein 0.0084 0.0149 0.0888
Plasmodium vivax patched family protein, putative 0.0026 0.0021 0.0564
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0014 0.0081
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0121 0.0231 0.0231
Toxoplasma gondii ATPase, AAA family protein 0.0033 0.0035 0.0948
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0014 0.0917
Toxoplasma gondii melibiase subfamily protein 0.0121 0.0231 0.6278
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.0281 0.1122
Onchocerca volvulus 0.0079 0.0137 0.2697
Entamoeba histolytica acyl-CoA synthetase, putative 0.0079 0.0137 0.1482
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0014 0.0166
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.0614 1
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0095 0.0095
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.002 0.0007 0.0009
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0014 0.0917
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0104 0.0193 0.1148
Mycobacterium ulcerans acyl-CoA synthetase 0.0079 0.0137 0.166
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0031 0.0332
Echinococcus granulosus lamin 0.0027 0.0023 0.0135
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0055 0.0055
Brugia malayi Patched family protein 0.0026 0.0021 0.0123
Brugia malayi Patched family protein 0.0026 0.0021 0.0123
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0133 0.0258 0.2752
Mycobacterium ulcerans recombinase A 0.0108 0.0203 0.2464
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.0614 1
Schistosoma mansoni hypothetical protein 0.0179 0.036 0.3837
Brugia malayi follicle stimulating hormone receptor 0.0268 0.0557 0.331
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0005 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0035 0.0568
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0023 0.0014 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0035 0.0568
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0005 0.0336
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0081 0.0142 0.0842
Trichomonas vaginalis D-aminoacylase, putative 0.0084 0.0149 0.2431
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0439 0.0938 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0183 0.0368 0.1471
Onchocerca volvulus 0.0084 0.0149 0.2942
Brugia malayi hypothetical protein 0.0042 0.0055 0.0326
Leishmania major 4-coumarate:coa ligase-like protein 0.0079 0.0137 0.53
Trichomonas vaginalis set domain proteins, putative 0.0245 0.0507 0.8261
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0063 0.0102 0.0409
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0081 0.0142 0.151
Echinococcus multilocularis survival motor neuron protein 1 0.0774 0.1681 0.1681
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0084 0.0149 0.1592
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0183 0.0368 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0003 0.0032
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0046 0.1785
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0035 0.2338
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0003 0.0004
Toxoplasma gondii patched family protein 0.0026 0.0021 0.0564
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0019 0.0508
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Schistosoma mansoni hypothetical protein 0.0126 0.0243 0.2593
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.0281 0.0374
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0133 0.0258 0.1535
Trichomonas vaginalis esterase, putative 0.0084 0.0149 0.2431
Schistosoma mansoni hypothetical protein 0.0104 0.0193 0.2059
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0079 0.0137 0.166
Echinococcus multilocularis musashi 0.0027 0.0023 0.0023
Trichomonas vaginalis D-aminoacylase, putative 0.0084 0.0149 0.2431
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0433 0.0923 1
Brugia malayi Patched related family protein 4 0.0026 0.0021 0.0123
Brugia malayi Pre-SET motif family protein 0.0031 0.0031 0.0185
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0079 0.0137 0.0547
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0005 0.0194
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0003 0.0203
Echinococcus multilocularis sterol regulatory element binding protein 0.0186 0.0375 0.0375
Schistosoma mansoni topbp1 0.0033 0.0035 0.0372
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0104 0.0193 0.1148
Loa Loa (eye worm) hypothetical protein 0.0433 0.0923 0.549
Echinococcus multilocularis Niemann Pick C1 protein 0.0618 0.1335 0.1335
Loa Loa (eye worm) patched family protein 0.0026 0.0021 0.0123
Plasmodium vivax replication factor C subunit 1, putative 0.0033 0.0035 0.0948
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0121 0.0231 0.2464
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0014 0.0917
Trichomonas vaginalis conserved hypothetical protein 0.0186 0.0375 0.6101
Echinococcus granulosus intermediate filament protein 0.0027 0.0023 0.0135
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0133 0.0258 0.0343
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0023 0.0014 0.0166
Schistosoma mansoni thyroid hormone receptor 0.0137 0.0266 0.2833
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0003 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0035 0.0568
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0095 0.1017
Schistosoma mansoni ap endonuclease 0.0019 0.0005 0.0053
Loa Loa (eye worm) hypothetical protein 0.0084 0.0149 0.0888
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0003 0.0117
Brugia malayi AMP-binding enzyme family protein 0.0079 0.0137 0.0814
Brugia malayi Patched family protein 0.0026 0.0021 0.0123
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0005 0.0061
Schistosoma mansoni thyroid hormone receptor 0.0137 0.0266 0.2833
Brugia malayi Calcitonin receptor-like protein seb-1 0.0328 0.0691 0.4111
Loa Loa (eye worm) hypothetical protein 0.0084 0.0149 0.0888
Mycobacterium ulcerans acyl-CoA synthetase 0.0079 0.0137 0.166
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0003 0.0003
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0023 0.0014 0.0055
Mycobacterium tuberculosis Conserved protein 0.0084 0.0149 0.0199
Loa Loa (eye worm) hypothetical protein 0.0774 0.1681 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.0614 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0005 0.003
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0063 0.0102 0.1187
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0033 0.0037 0.245
Schistosoma mansoni hypothetical protein 0.0179 0.036 0.3837
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0121 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Echinococcus granulosus expressed conserved protein 0.0406 0.0865 0.5144
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0538 0.1156 0.1537
Toxoplasma gondii hypothetical protein 0.0063 0.0102 0.2778
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0079 0.0137 0.0182
Brugia malayi Patched family protein 0.0026 0.0021 0.0123
Brugia malayi hypothetical protein 0.0026 0.0021 0.0123
Onchocerca volvulus 0.0023 0.0014 0.027
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0121 0.0231 0.1375
Schistosoma mansoni hypothetical protein 0.0158 0.0313 0.3338
Echinococcus granulosus survival motor neuron protein 1 0.0774 0.1681 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0035 0.0208
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0003 0.0003
Toxoplasma gondii hypothetical protein 0.0026 0.0021 0.0564
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0079 0.0137 0.0547
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Mycobacterium tuberculosis Probable lipase LipD 0.0084 0.0149 0.0199
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0183 0.0368 0.219
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0055 0.0326
Brugia malayi latrophilin 2 splice variant baaae 0.0224 0.0461 0.274
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0185
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0005 0.0082
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0104 0.0193 0.0193
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.0281 0.3408
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0046 0.0046
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.0614 1
Brugia malayi topoisomerase 0.0033 0.0035 0.0208
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0086 0.0114
Loa Loa (eye worm) hypothetical protein 0.0059 0.0093 0.0552
Brugia malayi Pax transcription activation domain interacting protein 0.0033 0.0035 0.0208
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0023 0.0014 0.0166
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0072 0.0773
Mycobacterium ulcerans acyl-CoA synthetase 0.0079 0.0137 0.166
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0086 0.0114
Echinococcus multilocularis beta LACTamase domain containing family member 0.0084 0.0149 0.0149
Schistosoma mansoni acetyl-CoA synthetase 0.0023 0.0014 0.0146
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0158 0.0313 0.1862
Loa Loa (eye worm) hypothetical protein 0.0038 0.0046 0.0274
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0183 0.0368 0.4223
Loa Loa (eye worm) hypothetical protein 0.0186 0.0375 0.2229
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0072 0.0431
Schistosoma mansoni hypothetical protein 0.036 0.0762 0.8123
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0029 0.017
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0102 0.124
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0031 0.0847
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0133 0.0258 0.0258
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0084 0.0149 0.0199
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0014 0.053
Brugia malayi hypothetical protein 0.0026 0.0021 0.0123
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0133 0.0258 0.3132
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0086 0.0114
Mycobacterium leprae conserved hypothetical protein 0.0084 0.0149 0.0596
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0014 0.0166
Echinococcus multilocularis protein dispatched 1 0.0212 0.0433 0.0433
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0102 0.1089
Onchocerca volvulus 0.0026 0.0021 0.0409
Onchocerca volvulus 0.0084 0.0149 0.2942
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0005 0.0336
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0046 0.0274
Loa Loa (eye worm) hypothetical protein 0.0027 0.0023 0.0135
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0055 0.0585
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0033 0.0035 0.0208
Toxoplasma gondii ABC1 family protein 0.0084 0.0149 0.4055
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0005 0.0054
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0023 0.0014 0.0372
Loa Loa (eye worm) hypothetical protein 0.0328 0.0691 0.4111
Loa Loa (eye worm) hypothetical protein 0.0183 0.0368 0.219
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0388 0.0824 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0033 0.0035 0.0568
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0183 0.0368 1
Plasmodium vivax acetyl-CoA synthetase, putative 0.0023 0.0014 0.0372
Brugia malayi Patched family protein 0.0026 0.0021 0.0123
Loa Loa (eye worm) hypothetical protein 0.0059 0.0093 0.0552
Schistosoma mansoni patched 1 0.0186 0.0375 0.3995
Brugia malayi Patched family protein 0.0026 0.0021 0.0123
Onchocerca volvulus 0.0026 0.0021 0.0409
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0014 0.053
Schistosoma mansoni jumonji domain containing protein 0.006 0.0095 0.1017
Echinococcus granulosus beta LACTamase domain containing family member 0.0084 0.0149 0.0888
Mycobacterium ulcerans acetyl-CoA synthetase 0.0023 0.0014 0.0166
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0019 0.1253
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0023 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0133 0.0258 0.3132
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0035 0.0568
Trichomonas vaginalis replication factor C large subunit, putative 0.0033 0.0035 0.0568
Brugia malayi Patched related family protein 10 0.0026 0.0021 0.0123
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.0441 0.2624
Entamoeba histolytica hypothetical protein 0.0033 0.0035 0.0378
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0102 0.3958
Toxoplasma gondii patched family protein 0.0026 0.0021 0.0564
Echinococcus multilocularis geminin 0.036 0.0762 0.0762
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.0614 0.6654
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0102 0.1089
Onchocerca volvulus 0.004 0.0051 0.1009
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0014 0.0166
Giardia lamblia Fructose-bisphosphate aldolase 0.0294 0.0614 1
Onchocerca volvulus 0.0026 0.0021 0.0409
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0033 0.0035 0.0423
Brugia malayi Patched family protein 0.0026 0.0021 0.0123
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Brugia malayi jmjC domain containing protein 0.006 0.0095 0.0568
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0079 0.0137 0.166
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0023 0.0014 0.0166
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0072 0.0072
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0102 0.124
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0003 0.0003
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0089 0.0954
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0033 0.0035 0.0568
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0033 0.0035 0.2338
Brugia malayi Pre-SET motif family protein 0.0216 0.0441 0.2624
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0046 0.075
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0104 0.0193 0.0193
Brugia malayi CHE-14 protein 0.0186 0.0375 0.2229
Treponema pallidum fructose-bisphosphate aldolase 0.0294 0.0614 0.7437
Onchocerca volvulus 0.0084 0.0149 0.2942
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0183 0.0368 0.0368
Echinococcus multilocularis GPCR, family 2 0.0104 0.0193 0.0193
Echinococcus multilocularis lamin 0.0027 0.0023 0.0023
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0033 0.0035 0.0423
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0031 0.0031
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0023 0.0014 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0046 0.075
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Onchocerca volvulus 0.0057 0.0089 0.1763
Onchocerca volvulus 0.0027 0.0023 0.0446
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0014 0.0081
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0095 0.0568
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0046 0.3087
Echinococcus granulosus peptidase Clp S14 family 0.012 0.0228 0.1359
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0102 0.0136
Onchocerca volvulus 0.0031 0.0031 0.0614
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0014 0.0081
Echinococcus multilocularis replication factor c subunit 1 0.0033 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0224 0.0461 0.4911
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0014 0.0223
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0183 0.0368 0.4467
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0031 0.0332
Loa Loa (eye worm) hypothetical protein 0.0059 0.0093 0.0552
Mycobacterium ulcerans hypothetical protein 0.0079 0.0137 0.166
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0003 0.0082
Echinococcus multilocularis expressed conserved protein 0.0406 0.0865 0.0865
Schistosoma mansoni peptidase Clp (S14 family) 0.0183 0.0368 0.3926
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0123
Onchocerca volvulus 0.0026 0.0021 0.0409
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0183 0.0368 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0031 0.0185

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) >= 99 % Antimicrobial activity against Candida albicans ATCC 645499 using in brain heart infusion medium(dil) after 2 hrs at 10 ug/ml ChEMBL. 19917761
Activity (functional) >= 99 % Antimicrobial activity against Escherichia coli O14 using in brain heart infusion medium(dil) after 2 hrs at 25 ug/ml ChEMBL. 19917761

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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