TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 521.341 | Formula: C18H19F3N5O8P
H donors: 6 H acceptors: 6 LogP: -1.77 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: O[C@@H]1[C@H](O)[C@H](O[C@H]1n1c[n+](c2c1nc(N)[nH]c2=O)Cc1cccc(c1)C(F)(F)F)COP(=O)(O)[O-]
InChi: 1S/C18H19F3N5O8P/c19-18(20,21)9-3-1-2-8(4-9)5-25-7-26(14-11(25)15(29)24-17(22)23-14)16-13(28)12(27)10(34-16)6-33-35(30,31)32/h1-4,7,10,12-13,16,27-28H,5-6H2,(H4-,22,23,24,29,30,31,32)/t10-,12-,13-,16-/m1/s1
InChiKey: MYLXMDVAWFAVEE-XNIJJKJLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	eukaryotic translation initiation factor 4E	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania donovani	Eukaryotic translation initiation factor 4E-1	Get druggable targets OG5_127278	All targets in OG5_127278
Leishmania mexicana	eukaryotic translation initiation factor-like protein	Get druggable targets OG5_127278	All targets in OG5_127278
Neospora caninum	hypothetical protein	Get druggable targets OG5_127278	All targets in OG5_127278
Leishmania donovani	Eukaryotic translation initiation factor 4E-2	Get druggable targets OG5_127278	All targets in OG5_127278
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-1	Get druggable targets OG5_127278	All targets in OG5_127278
Leishmania major	eukaryotic translation initiation factor eIF-4E, putative	Get druggable targets OG5_127278	All targets in OG5_127278
Leishmania braziliensis	eukaryotic translation initiation factor eIF-4E, putative	Get druggable targets OG5_127278	All targets in OG5_127278
Theileria parva	translation initiation factor E4, putative	Get druggable targets OG5_127278	All targets in OG5_127278
Cryptosporidium hominis	initiation factor e4	Get druggable targets OG5_127278	All targets in OG5_127278
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-1	Get druggable targets OG5_127278	All targets in OG5_127278
Echinococcus multilocularis	eukaryotic translation initiation factor 4E	Get druggable targets OG5_127278	All targets in OG5_127278
Leishmania mexicana	eukaryotic translation initiation factor eIF-4E, putative	Get druggable targets OG5_127278	All targets in OG5_127278
Cryptosporidium parvum	translation initiation factor if-4E	Get druggable targets OG5_127278	All targets in OG5_127278
Brugia malayi	translation initiation factor 4E	Get druggable targets OG5_127278	All targets in OG5_127278
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	Get druggable targets OG5_127278	All targets in OG5_127278
Schistosoma japonicum	ko:K03259 translation initiation factor eIF-4E, putative	Get druggable targets OG5_127278	All targets in OG5_127278
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	Get druggable targets OG5_127278	All targets in OG5_127278
Leishmania major	eukaryotic translation initiation factor-like protein	Get druggable targets OG5_127278	All targets in OG5_127278
Trypanosoma congolense	Eukaryotic translation initiation factor 4E-1	Get druggable targets OG5_127278	All targets in OG5_127278
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	Get druggable targets OG5_127278	All targets in OG5_127278
Candida albicans	mRNA cap-binding protein eIF4E, translation initiation	Get druggable targets OG5_127278	All targets in OG5_127278
Trypanosoma brucei gambiense	eukaryotic translation initiation factor 4e, putative	Get druggable targets OG5_127278	All targets in OG5_127278
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	Get druggable targets OG5_127278	All targets in OG5_127278
Schistosoma mansoni	eukaryotic translation initiation factor 4e	Get druggable targets OG5_127278	All targets in OG5_127278
Toxoplasma gondii	eukaryotic initiation factor-4E, putative	Get druggable targets OG5_127278	All targets in OG5_127278
Leishmania infantum	eukaryotic translation initiation factor eIF-4E, putative	Get druggable targets OG5_127278	All targets in OG5_127278
Leishmania infantum	eukaryotic translation initiation factor-like protein	Get druggable targets OG5_127278	All targets in OG5_127278
Trypanosoma brucei	Eukaryotic translation initiation factor 4E-1	Get druggable targets OG5_127278	All targets in OG5_127278
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	Get druggable targets OG5_127278	All targets in OG5_127278
Leishmania major	eukaryotic translation initiation factor-like	Get druggable targets OG5_127278	All targets in OG5_127278
Echinococcus granulosus	eukaryotic translation initiation factor 4E	Get druggable targets OG5_127278	All targets in OG5_127278
Loa Loa (eye worm)	translation initiation factor 4E	Get druggable targets OG5_127278	All targets in OG5_127278
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	Get druggable targets OG5_127278	All targets in OG5_127278

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	eukaryotic translation initiation factor 4E	eukaryotic translation initiation factor 4E	217 aa	188 aa	25.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.003	0.0188	0.0589
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0022	0.0088	0.1886
Schistosoma mansoni	Smad4	0.0018	0.0028	0.0115
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0032	0.008
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0022	0.0088	0.0452
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.008	0.1643
Onchocerca volvulus		0.003	0.0188	0.1628
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.0088	1
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0022	0.0088	0.029
Echinococcus granulosus	survival motor neuron protein 1	0.0237	0.2778	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.0022	0.0088	0.0878
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.026	0.7685
Schistosoma mansoni	transcription factor LCR-F1	0.0076	0.076	0.4228
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0032	0.0138
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0042	0.0328	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.003	0.0188	0.0651
Schistosoma mansoni	smad	0.0018	0.0028	0.0115
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0076	0.076	0.2717
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0163	0.1853	0.6024
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0955	0.5324
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0018	0.0032	0.0025
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0412	0.2271
Brugia malayi	photoreceptor-specific nuclear receptor	0.003	0.0188	0.0589
Schistosoma mansoni	nuclear hormone receptor	0.003	0.0188	0.1014
Echinococcus granulosus	Smad4	0.0018	0.0028	0.0074
Leishmania major	cathepsin L-like protease	0.0069	0.0668	1
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0032	0.008
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0022	0.008	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0088	0.1312
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.0668	1
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0036	0.026	0.7685
Echinococcus multilocularis	survival motor neuron protein 1	0.0237	0.2778	0.2773
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.0042	0.0328	0.4073
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0022	0.0088	0.0452
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0955	0.5324
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0088	0.0262
Schistosoma mansoni	hypothetical protein	0.0063	0.0598	0.332
Brugia malayi	steroid hormone receptor	0.003	0.0188	0.0589
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.0955	0.3421
Schistosoma mansoni	hypothetical protein	0.0136	0.1519	0.849
Schistosoma mansoni	hypothetical protein	0.0063	0.0598	0.332
Schistosoma mansoni	retinoic acid receptor RXR	0.003	0.0188	0.1014
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.003	0.0188	0.0589
Brugia malayi	Calcitonin receptor-like protein seb-1	0.02	0.2312	0.752
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.003	0.0188	0.0181
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0063	0.0598	0.0592
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0018	0.0028	0.0115
Brugia malayi	hypothetical protein	0.0076	0.076	0.2456
Echinococcus multilocularis	cathepsin L cysteine protease	0.0018	0.0032	0.0025
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.008	0.5197
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0088	0.1312
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0668	1
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-1	0.0042	0.0328	0.4658
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.003	0.0188	0.1014
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0018	0.0028	0.0074
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.003	0.0188	0.0589
Schistosoma mansoni	eukaryotic translation initiation factor 4e	0.0042	0.0328	0.1803
Leishmania major	cathepsin L-like protease	0.0069	0.0668	1
Giardia lamblia	DINP protein human, muc B family	0.0022	0.0088	1
Leishmania major	eukaryotic translation initiation factor-like protein	0.0042	0.0328	0.4658
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.003	0.0188	0.1014
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0018	0.0028	0.002
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0042	0.0328	1
Schistosoma mansoni	smad1 5 8 and	0.0018	0.0028	0.0115
Onchocerca volvulus		0.0094	0.099	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.003	0.0188	0.0589
Brugia malayi	Latrophilin receptor protein 2	0.0063	0.0598	0.1929
Schistosoma mansoni	hypothetical protein	0.0048	0.0412	0.2271
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.0088	0.0262
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0022	0.008	0.0765
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.003	0.0188	0.0651
Echinococcus granulosus	lysosomal alpha glucosidase	0.0163	0.1853	0.6663
Loa Loa (eye worm)	ctsf protein	0.0018	0.0032	0.008
Echinococcus multilocularis	Smad4	0.0018	0.0028	0.002
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0088	0.1312
Schistosoma mansoni	ap endonuclease	0.0022	0.008	0.0411
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.026	0.7685
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0668	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0188	0.0589
Echinococcus granulosus	smad	0.0018	0.0028	0.0074
Leishmania major	cathepsin L-like protease	0.0069	0.0668	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.003	0.0188	0.0651
Schistosoma mansoni	smad1 5 8 and	0.0018	0.0028	0.0115
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0088	0.1312
Echinococcus multilocularis	cysteine protease	0.0018	0.0032	0.0025
Loa Loa (eye worm)	MH2 domain-containing protein	0.026	0.3072	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0036	0.026	0.0824
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0022	0.0088	0.0878
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0032	0.008
Toxoplasma gondii	exonuclease III APE	0.0022	0.008	0.1643
Schistosoma mansoni	alpha-glucosidase	0.014	0.1568	0.8767
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.003	0.0188	0.0181
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0022	0.0088	0.0262
Loa Loa (eye worm)	Smad1	0.0018	0.0028	0.0067
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.003	0.0188	0.0589
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0126	0.0386
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0022	0.0088	0.008
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.003	0.0188	0.0589
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.0042	0.0328	0.4073
Brugia malayi	hypothetical protein	0.0026	0.0126	0.0386
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0022	0.0088	1
Brugia malayi	MH2 domain containing protein	0.0018	0.0028	0.0067
Schistosoma mansoni	smad1 5 8 and	0.0018	0.0028	0.0115
Schistosoma mansoni	hypothetical protein	0.0076	0.076	0.4228
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0032	0.0138
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0092	0.0955	0.3093
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0088	0.0878
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.026	0.7685
Loa Loa (eye worm)	fibroinase	0.0018	0.0032	0.008
Entamoeba histolytica	hypothetical protein	0.0076	0.076	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.003	0.0188	0.0181
Brugia malayi	ecdysteroid receptor	0.003	0.0188	0.0589
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0022	0.008	0.0765
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.003	0.0188	0.0589
Trypanosoma cruzi	cruzipain precursor, putative	0.0069	0.0668	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0022	0.008	0.1204
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.003	0.0188	0.0589
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0088	0.1312
Brugia malayi	Steroid receptor seven-up type 2	0.003	0.0188	0.0589
Echinococcus granulosus	neutral alpha glucosidase AB	0.0036	0.026	0.0911
Schistosoma mansoni	alpha-glucosidase	0.014	0.1568	0.8767
Echinococcus multilocularis	FTZ F1 alpha	0.003	0.0188	0.0181
Leishmania major	eukaryotic translation initiation factor eIF-4E, putative	0.0042	0.0328	0.4658
Brugia malayi	MH2 domain containing protein	0.0018	0.0028	0.0067
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0022	0.0088	0.0768
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0668	1
Leishmania major	hypothetical protein, conserved	0.0026	0.0126	0.1473
Trypanosoma cruzi	major cysteine proteinase, putative	0.0054	0.0484	0.7098
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0063	0.0598	0.0592
Echinococcus multilocularis	smad	0.0018	0.0028	0.002
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0018	0.0032	0.008
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0126	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0063	0.0598	0.1929
Schistosoma mansoni	RAR-like nuclear receptor	0.003	0.0188	0.1014
Schistosoma mansoni	thyroid hormone receptor	0.0158	0.1788	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.003	0.0188	0.1628
Echinococcus granulosus	mothers against decapentaplegic 5	0.0018	0.0028	0.0074
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.0088	0.0262
Brugia malayi	MH1 domain containing protein	0.0018	0.0028	0.0067
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0063	0.0598	0.2133
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0668	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.0955	0.3421
Loa Loa (eye worm)	translation initiation factor 4E	0.0042	0.0328	0.1048
Echinococcus multilocularis	GPCR, family 2	0.0063	0.0598	0.0592
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0036	0.026	0.0253
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0088	0.1312
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.026	0.7685
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0163	0.1853	0.6024
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0668	1
Leishmania major	DNA polymerase eta, putative	0.0022	0.0088	0.0878
Trichomonas vaginalis	DNA polymerase eta, putative	0.0022	0.0088	0.1886
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0088	0.1312
Echinococcus multilocularis	cathepsin L cysteine protease	0.0018	0.0032	0.0025
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0022	0.008	0.0073
Brugia malayi	nuclear receptor NHR-88	0.003	0.0188	0.0589
Loa Loa (eye worm)	cysteine protease	0.0018	0.0032	0.008
Loa Loa (eye worm)	MH2 domain-containing protein	0.0018	0.0028	0.0067
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.0955	0.0949
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0668	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.003	0.0188	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0598	0.1929
Schistosoma mansoni	steroid hormone receptor ad4bp	0.003	0.0188	0.1014
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0018	0.0032	0.0025
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0042	0.0328	1
Schistosoma mansoni	ap endonuclease	0.0022	0.008	0.0411
Echinococcus granulosus	dna polymerase eta	0.0022	0.0088	0.029
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0042	0.0328	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0088	0.0878
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0022	0.008	0.5
Onchocerca volvulus	Bile acid receptor homolog	0.003	0.0188	0.1628
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0022	0.008	0.0239
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.003	0.0188	0.0589
Entamoeba histolytica	hypothetical protein	0.0076	0.076	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.003	0.0188	0.0589
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0036	0.026	0.7685
Trypanosoma brucei	glucosidase, putative	0.0036	0.026	0.3885
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0036	0.026	0.0824
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.003	0.0188	0.1014
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.003	0.0188	0.0589
Brugia malayi	exodeoxyribonuclease III family protein	0.0022	0.008	0.0239
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.003	0.0188	0.1014
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.003	0.0188	0.1628
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0063	0.0594	0.8824
Echinococcus granulosus	eukaryotic translation initiation factor 4E	0.0042	0.0328	0.1159
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0158	0.1788	0.1782
Schistosoma mansoni	DNA polymerase eta	0.0022	0.0088	0.0452
Schistosoma mansoni	hypothetical protein	0.0127	0.1405	0.7851
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0088	0.1312
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0668	1
Entamoeba histolytica	hypothetical protein	0.0076	0.076	1
Echinococcus granulosus	ecdysone induced protein 78C	0.003	0.0188	0.0651
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.026	0.7685
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.003	0.0188	0.0589
Schistosoma mansoni	hypothetical protein	0.0063	0.0598	0.332
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0127	0.1405	0.5045
Brugia malayi	MH1 domain containing protein	0.0018	0.0028	0.0067
Loa Loa (eye worm)	hypothetical protein	0.003	0.0188	0.0589
Echinococcus granulosus	cathepsin l1	0.0018	0.0032	0.0088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0955	0.5324
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.003	0.0188	0.1014
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.003	0.0188	0.0651
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0088	0.1312
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.003	0.0188	0.0589
Loa Loa (eye worm)	hypothetical protein	0.0237	0.2778	0.9041
Echinococcus granulosus	GPCR family 2	0.0063	0.0598	0.2133
Loa Loa (eye worm)	hypothetical protein	0.003	0.0188	0.0589
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0126	0.1473
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0063	0.0598	0.1929
Brugia malayi	Papain family cysteine protease containing protein	0.0018	0.0032	0.008
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.003	0.0188	0.0589
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0668	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.003	0.0188	0.0181
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0063	0.0598	0.2133
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.003	0.0188	0.0589
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0092	0.0955	0.3093
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0126	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.003	0.0188	0.0651
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.02	0.2312	0.752
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0668	1
Loa Loa (eye worm)	hypothetical protein	0.0136	0.1519	0.4932
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.026	0.358
Echinococcus granulosus	FTZ F1 alpha	0.003	0.0188	0.0651
Entamoeba histolytica	hypothetical protein	0.0076	0.076	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.0668	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0412	0.1319
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0036	0.026	0.7685
Trypanosoma brucei	unspecified product	0.0022	0.0088	0.1312
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0032	0.008
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.008	0.5197
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0032	0.008
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.003	0.0188	0.0651
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0126	0.1473
Brugia malayi	Smad1	0.0018	0.0028	0.0067
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-1	0.0042	0.0328	0.4658
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0126	1
Brugia malayi	MH2 domain containing protein	0.026	0.3072	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.026	0.7685
Loa Loa (eye worm)	hypothetical protein	0.003	0.0188	0.0589
Brugia malayi	Nuclear hormone receptor-like 1	0.003	0.0188	0.0589
Echinococcus multilocularis	eukaryotic translation initiation factor 4E	0.0042	0.0328	0.0321
Schistosoma mansoni	alpha glucosidase	0.0036	0.026	0.1418
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.0668	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0032	0.008
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0668	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.003	0.0188	0.0181
Loa Loa (eye worm)	hypothetical protein	0.02	0.2312	0.752
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0163	0.1853	0.1848
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0088	0.1312
Trypanosoma brucei	Eukaryotic translation initiation factor 4E-1	0.0042	0.0328	0.4912
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0127	0.1405	0.1399
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0163	0.1853	0.1848
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0126	0.1878
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0022	0.008	0.0264
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0088	0.0878
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.0088	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.003	0.0188	0.0181
Leishmania major	eukaryotic translation initiation factor-like	0.0042	0.0328	0.4658
Echinococcus granulosus	dna polymerase kappa	0.0022	0.0088	0.029
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0088	0.1312
Loa Loa (eye worm)	hypothetical protein	0.003	0.0188	0.0589
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.003	0.0188	0.0589
Echinococcus multilocularis	dna polymerase eta	0.0022	0.0088	0.008
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0018	0.0028	0.002
Brugia malayi	latrophilin 2 splice variant baaae	0.0136	0.1519	0.4932
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.003	0.0188	0.0589
Loa Loa (eye worm)	transcription factor SMAD2	0.026	0.3072	1
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0036	0.026	0.313
Toxoplasma gondii	eukaryotic initiation factor-4E, putative	0.0042	0.0328	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.026	0.7685
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.026	0.358
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0088	0.1312
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0668	1
Schistosoma mansoni	coup transcription factor	0.003	0.0188	0.1014
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0018	0.0032	0.008
Echinococcus multilocularis	cysteine protease	0.0018	0.0032	0.0025
Loa Loa (eye worm)	hypothetical protein	0.003	0.0188	0.0589
Echinococcus multilocularis	dna polymerase kappa	0.0022	0.0088	0.008
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.003	0.0188	0.1014
Schistosoma mansoni	hypothetical protein	0.0063	0.0598	0.332
Schistosoma mansoni	thyroid hormone receptor	0.0158	0.1788	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.02	0.2312	0.752
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0022	0.008	0.0669
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0022	0.008	0.0765
Leishmania major	DNA polymerase kappa, putative	0.0022	0.0088	0.0878
Loa Loa (eye worm)	steroid hormone receptor	0.003	0.0188	0.0589
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.003	0.0188	0.0589
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.003	0.0188	0.0181
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0036	0.026	0.313
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0076	0.076	0.0753
Loa Loa (eye worm)	MH1 domain-containing protein	0.0018	0.0028	0.0067
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0022	0.0088	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0018	0.0032	0.0088
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0088	0.1312
Onchocerca volvulus		0.0048	0.0412	0.3964
Leishmania major	alpha glucosidase II subunit, putative	0.0036	0.026	0.358
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.003	0.0188	0.0589
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0088	0.0878
Brugia malayi	hypothetical protein	0.0237	0.2778	0.9041
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.003	0.0188	0.0589
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0126	0.3162
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0032	0.008
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.008	0.1643
Brugia malayi	translation initiation factor 4E	0.0042	0.0328	0.1048
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.0955	0.0949
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.003	0.0188	0.0589
Trypanosoma brucei	DNA polymerase eta, putative	0.0022	0.0088	0.1312
Loa Loa (eye worm)	hypothetical protein	0.003	0.0188	0.0589
Brugia malayi	hypothetical protein	0.0016	0.0012	0.0015
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0018	0.0032	0.0088
Brugia malayi	nuclear hormone receptor	0.003	0.0188	0.0589

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	= 32.1 %	Binding affinity to mouse eIF4E expressed in Escherichia coli assessed as fluorescence quenching by time-synchronized fluorescence titration assay in presence of KKRYDREFLLGFQFIFA	ChEMBL.	20060622
Kd (binding)	= 7.56 uM	Binding affinity to mouse eIF4E expressed in Escherichia coli by fluorescence time-synchronized titration method in presence of KKRYDREFLLGFQFIFA	ChEMBL.	20060622

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1097637

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1187215