Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.5337 | 0.5271 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0114 | 0.5337 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.5337 | 0.5 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0114 | 0.5337 | 0.5 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 0.5337 | 0.5 |
Giardia lamblia | Kinase, PLK | 0.0114 | 0.5337 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5337 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0114 | 0.5337 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5337 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0114 | 0.5337 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.5337 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5337 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5337 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5337 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5337 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0114 | 0.5337 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5337 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 66 uM | PUBCHEM_BIOASSAY: Dose-response secondary confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay using Cy5 labeled peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | > 66 uM | PUBCHEM_BIOASSAY: Dose-response confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.6213 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.