Detailed information for compound 1187490

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 419.985 | Formula: C24H34ClNO3
  • H donors: 2 H acceptors: 1 LogP: 5.41 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2C[C@H](NCCC(c3ccccc3)C(C)C)[C@H](Cc2cc1OC)O.Cl
  • InChi: 1S/C24H33NO3.ClH/c1-16(2)20(17-8-6-5-7-9-17)10-11-25-21-12-18-14-23(27-3)24(28-4)15-19(18)13-22(21)26;/h5-9,14-16,20-22,25-26H,10-13H2,1-4H3;1H/t20?,21-,22-;/m0./s1
  • InChiKey: NBVDZMCVUHKBKM-HGDDKUDHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.003 0.0491 0.4874
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0124 0.0666
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0052 0.0052
Schistosoma mansoni alpha-glucosidase 0.014 0.2864 0.3262
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0097
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0052 0.0052
Brugia malayi nuclear receptor NHR-88 0.001 0.0052 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0052 0.0097
Brugia malayi MH1 domain containing protein 0.0009 0.004 0.0074
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0052 0.0059
Brugia malayi Cytochrome P450 family protein 0.003 0.0491 0.0917
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0959 0.0959
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.003 0.0491 0.4874
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.004 0.0704 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.003 0.0491 1
Echinococcus granulosus dnaJ subfamily B 0.0412 0.878 0.878
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.003 0.0491 0.6334
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0289 0.2222
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.003 0.0491 1
Echinococcus multilocularis survival motor neuron protein 1 0.0255 0.5358 0.5358
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0959 0.0959
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0615 0.0615
Onchocerca volvulus 0.0094 0.187 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0143 0.2928 0.5465
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0781 1
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.003 0.0491 1
Echinococcus multilocularis smad 0.0017 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0013 0.0124 0.0232
Brugia malayi Smad1 0.0017 0.0206 0.0385
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.003 0.0491 0.4874
Schistosoma mansoni hypothetical protein 0.0016 0.0178 0.0203
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.003 0.0491 1
Loa Loa (eye worm) RNA binding protein 0.0143 0.2928 0.5465
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0615 0.6605
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0289 0.2847
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0615 0.6605
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0615 0.6605
Schistosoma mansoni thyroid hormone receptor 0.001 0.0052 0.0059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0052 0.0097
Echinococcus granulosus FTZ F1 alpha 0.001 0.0052 0.0052
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0615 0.8463
Schistosoma mansoni hypothetical protein 0.003 0.0491 0.056
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0206 0.0385
Schistosoma mansoni tar DNA-binding protein 0.0143 0.2928 0.3335
Schistosoma mansoni hypothetical protein 0.0412 0.878 1
Loa Loa (eye worm) nuclear factor I 0.0009 0.004 0.0074
Trypanosoma cruzi cytochrome p450-like protein, putative 0.003 0.0491 0.6334
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0162 0.3354 0.626
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0178 0.0333
Leishmania major lanosterol 14-alpha-demethylase, putative 0.003 0.0491 0.6334
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0052 0.0097
Brugia malayi MH1 domain containing protein 0.0017 0.0206 0.0385
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.1652 0.1652
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0162 0.3347 0.3812
Loa Loa (eye worm) MH2 domain-containing protein 0.0252 0.5302 0.9895
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0052 0.0097
Schistosoma mansoni smad1 5 8 and 0.0017 0.0206 0.0235
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.003 0.0491 0.4874
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0345 0.0677
Leishmania major cytochrome p450-like protein 0.003 0.0491 0.6334
Brugia malayi nuclear hormone receptor 0.001 0.0052 0.0097
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0206 0.0206
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0052 0.0052
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0052 0.0059
Brugia malayi Cytochrome P450 family protein 0.0111 0.224 0.4179
Brugia malayi Glycosyl hydrolases family 31 protein 0.0162 0.3354 0.626
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0959 0.1093
Trypanosoma brucei glucosidase, putative 0.0036 0.0615 0.8463
Schistosoma mansoni smad1 5 8 and 0.0017 0.0206 0.0235
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.003 0.0491 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.003 0.0491 0.4874
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0052 0.0059
Brugia malayi MH2 domain containing protein 0.0017 0.0206 0.0385
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.003 0.0491 0.6334
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.111 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0178 0.0333
Brugia malayi MH1 domain containing protein 0.0017 0.0206 0.0385
Toxoplasma gondii cytochrome p450 superfamily protein 0.003 0.0491 0.2463
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0924 0.1724
Echinococcus granulosus survival motor neuron protein 1 0.0255 0.5358 0.5358
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0052 0.0052
Schistosoma mansoni tar DNA-binding protein 0.0143 0.2928 0.3335
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.003 0.0491 1
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.003 0.0491 0.4874
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0289 0.0289
Loa Loa (eye worm) cytochrome P450 family protein 0.0111 0.224 0.4179
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.003 0.0491 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0052 0.0052
Schistosoma mansoni tar DNA-binding protein 0.0143 0.2928 0.3335
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0781 1
Onchocerca volvulus 0.0084 0.1652 0.8834
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.003 0.0491 1
Loa Loa (eye worm) Smad1 0.0017 0.0206 0.0385
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0704 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0781 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0052 0.0097
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0025 0.0047
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0615 0.1147
Brugia malayi cytochrome P450 0.003 0.0491 0.0917
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0924 0.1724
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0615 0.8463
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0959 0.0959
Schistosoma mansoni smad 0.0017 0.0206 0.0235
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.1652 0.1882
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.003 0.0491 1
Echinococcus granulosus Smad4 0.0017 0.0206 0.0206
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.003 0.0491 1
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0345 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0579 0.108
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0178 0.0333
Loa Loa (eye worm) transcription factor SMAD2 0.0252 0.5302 0.9895
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.003 0.0491 0.4874
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0178 0.0178
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0704 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.003 0.0491 0.6334
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.003 0.0491 0.4874
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0052 0.0052
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0052 0.0097
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0052 0.0059
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0028 0.0052
Echinococcus multilocularis Smad4 0.0017 0.0206 0.0206
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0345 0.3806
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0052 0.0097
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0704 0.1313
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0704 0.1313
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.003 0.0491 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0097
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.003 0.0491 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.003 0.0491 0.4874
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0345 0.2749
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.003 0.0491 0.4874
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0052 0.0097
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0097
Schistosoma mansoni cpg binding protein 0.0029 0.0462 0.0526
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0052 0.0059
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0052 0.0052
Schistosoma mansoni cpg binding protein 0.0031 0.0497 0.0567
Schistosoma mansoni hypothetical protein 0.0016 0.0178 0.0203
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0052 0.0052
Schistosoma mansoni survival motor neuron protein 0.0052 0.096 0.1094
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0289 0.2847
Schistosoma mansoni hypothetical protein 0.0016 0.0178 0.0203
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0615 0.3967
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0028 0.0028
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.003 0.0491 1
Schistosoma mansoni cpg binding protein 0.0031 0.0497 0.0567
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0615 0.6605
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0097
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0615 0.7472
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0124 0.0232
Brugia malayi RNA recognition motif domain containing protein 0.0143 0.2928 0.5465
Echinococcus granulosus lysosomal alpha glucosidase 0.0162 0.3354 0.3354
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0206 0.0385
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0052 0.0097
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0867 0.7039
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0052 0.0052
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0615 0.8463
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0178 0.0178
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0959 0.1093
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0052 0.0059
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0206 0.0206
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.003 0.0491 0.4874
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0345 0.134
Loa Loa (eye worm) acetyltransferase 0.0162 0.3347 0.6247
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0289 0.2847
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.003 0.0491 0.4874
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0289 0.2847
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0052 0.0277
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0345 0.3806
Schistosoma mansoni thyroid hormone receptor 0.001 0.0052 0.0059
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0052 0.0052
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0867 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0345 0.113
Echinococcus granulosus smad 0.0017 0.0206 0.0206
Loa Loa (eye worm) cytochrome P450 0.003 0.0491 0.0917
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.003 0.0491 1
Brugia malayi MH2 domain containing protein 0.0252 0.5302 0.9895
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0867 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0052 0.0052
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.3354 0.3354
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0615 0.1147
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.003 0.0491 0.4874
Schistosoma mansoni nuclear hormone receptor 0.001 0.0052 0.0059
Echinococcus granulosus histone acetyltransferase KAT2B 0.0157 0.3249 0.3249
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.003 0.0491 1
Echinococcus granulosus cpg binding protein 0.0031 0.0497 0.0497
Loa Loa (eye worm) CYP4Cod1 0.004 0.0704 0.1313
Brugia malayi acetyltransferase, GNAT family protein 0.0162 0.3347 0.6247
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0959 0.179
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.1652 0.1652
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0959 0.179
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0052 0.0052
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0462 0.0861
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.003 0.0491 1
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.003 0.0491 0.4874
Schistosoma mansoni tar DNA-binding protein 0.0143 0.2928 0.3335
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0097
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0162 0.3347 0.3347
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0028 0.0028
Echinococcus granulosus cytochrome P450 2K1 0.003 0.0491 0.0491
Loa Loa (eye worm) hypothetical protein 0.005 0.0924 0.1724
Schistosoma mansoni hypothetical protein 0.0052 0.096 0.1094
Brugia malayi MH2 domain containing protein 0.0017 0.0206 0.0385
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.003 0.0491 0.4874
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.003 0.0491 1
Onchocerca volvulus 0.001 0.0052 0.0277
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0052 0.0097
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0615 0.6605
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0867 1
Schistosoma mansoni Smad4 0.0017 0.0206 0.0235
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0867 0.0867
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0206 0.0206
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0924 0.1724
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0052 0.0052
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0052 0.0277
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0052 0.0097
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0289 0.054
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0052 0.0097
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0345 0.0677
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0345 1
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0289 0.054
Onchocerca volvulus 0.0052 0.096 0.5136
Schistosoma mansoni hypothetical protein 0.0034 0.0579 0.0659
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0052 0.0059
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.003 0.0491 0.4874
Leishmania major cytochrome p450-like protein 0.004 0.0704 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0579 0.108
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0052 0.0052
Schistosoma mansoni coup transcription factor 0.001 0.0052 0.0059
Echinococcus granulosus tar DNA binding protein 0.0143 0.2928 0.2928
Schistosoma mansoni tar DNA-binding protein 0.0143 0.2928 0.3335
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0867 0.7039
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0345 0.134
Brugia malayi hypothetical protein 0.0255 0.5358 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.1652 0.3083
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0097
Onchocerca volvulus 0.0029 0.0462 0.2469
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0345 0.5
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0615 0.7472
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0097
Mycobacterium leprae putative cytochrome p450 0.003 0.0491 1
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0052 0.0097
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0052 0.0097
Schistosoma mansoni hypothetical protein 0.0016 0.0178 0.0203
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0052 0.0059
Brugia malayi CXXC zinc finger family protein 0.0029 0.0462 0.0861
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0052 0.0097
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.003 0.0491 1
Schistosoma mansoni smad1 5 8 and 0.0017 0.0206 0.0235
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0289 0.0289
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.3354 0.3354
Trypanosoma brucei cytochrome P450, putative 0.004 0.0704 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0959 0.0959
Loa Loa (eye worm) hypothetical protein 0.0009 0.004 0.0074
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.003 0.0491 1
Echinococcus multilocularis 0.003 0.0491 0.0491
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0615 0.6605
Brugia malayi Cytochrome P450 family protein 0.004 0.0704 0.1313
Schistosoma mansoni alpha glucosidase 0.0036 0.0615 0.07
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0206 0.0235
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0615 0.6605
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0959 0.1093
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.096 0.1792
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0206 0.0206
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0052 0.0097
Brugia malayi RNA binding protein 0.0143 0.2928 0.5465
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.003 0.0491 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0615 0.6605
Echinococcus multilocularis tar DNA binding protein 0.0143 0.2928 0.2928
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.003 0.0491 0.4874
Loa Loa (eye worm) hypothetical protein 0.001 0.0046 0.0086
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0052 0.0052
Schistosoma mansoni ap endonuclease 0.0021 0.0289 0.033
Mycobacterium leprae Conserved hypothetical protein 0.003 0.0491 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1166 0.1328
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0289 0.2222
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0052 0.0097
Brugia malayi MH1 domain containing protein 0.0009 0.004 0.0074
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0097
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0052 0.0059
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0052 0.0052
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0052 0.0097
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0289 0.2513
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0178 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0052 0.0097
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0615 0.0615
Brugia malayi TAR-binding protein 0.0143 0.2928 0.5465
Loa Loa (eye worm) hypothetical protein 0.0255 0.5358 1
Loa Loa (eye worm) TAR-binding protein 0.0143 0.2928 0.5465
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0052 0.0097
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0615 0.6605
Schistosoma mansoni ap endonuclease 0.0021 0.0289 0.033
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0052 0.0277
Echinococcus granulosus GPCR family 2 0.0016 0.0178 0.0178
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0345 0.0962
Entamoeba histolytica hypothetical protein 0.0024 0.0345 0.336
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0016 0.0178 0.0333
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0052 0.0097
Brugia malayi ecdysteroid receptor 0.001 0.0052 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0052 0.0097
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.003 0.0491 0.4874
Brugia malayi steroid hormone receptor 0.001 0.0052 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0052 0.0097
Schistosoma mansoni cytochrome P450 0.003 0.0491 0.056
Leishmania major cytochrome p450-like protein 0.003 0.0491 0.6334
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0052 0.0097
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0052 0.0052
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.003 0.0491 0.4874
Echinococcus multilocularis cpg binding protein 0.0031 0.0497 0.0497
Schistosoma mansoni alpha-glucosidase 0.014 0.2864 0.3262
Echinococcus multilocularis GPCR, family 2 0.0016 0.0178 0.0178
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.003 0.0491 0.4874
Brugia malayi Cytochrome P450 family protein 0.004 0.0704 0.1313
Echinococcus multilocularis dnaJ subfamily B 0.0412 0.878 0.878
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.1652 0.3083

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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