Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0018 | 0.0087 | 0.0103 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0641 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0066 | 0.0066 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0037 | 0.1385 | 0.1385 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.006 | 0.2887 | 0.8824 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.2316 | 0.2316 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0157 | 0.0691 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0066 | 0.0066 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.3263 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0037 | 0.1385 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0641 | 0.1799 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.1385 | 1 |
Brugia malayi | PHD-finger family protein | 0.0026 | 0.0621 | 0.0621 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0641 | 0.1799 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0017 | 0.0066 | 0.0066 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.046 | 0.0544 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0017 | 0.0066 | 0.0066 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0037 | 0.1385 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.0019 | 0.0157 | 0.0285 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0641 | 0.436 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.0258 | 0.0306 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0017 | 0.0066 | 0.0066 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0018 | 0.0087 | 0.0087 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0037 | 0.1385 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0066 | 0.0066 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0018 | 0.0087 | 0.0103 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.3263 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0037 | 0.1385 | 0.1385 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0037 | 0.1385 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.1385 | 0.4125 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0017 | 0.0066 | 0.0078 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3734 | 0.3734 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.1385 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0157 | 0.0691 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0037 | 0.1385 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0066 | 0.3263 | 1 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0052 | 0.2336 | 0.7098 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.038 | 0.038 |
Onchocerca volvulus | 0.0097 | 0.5332 | 1 | |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0018 | 0.0087 | 0.0087 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.046 | 0.046 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.1244 | 0.1244 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1826 | 0.1826 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0641 | 1 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0019 | 0.0157 | 0.0285 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0019 | 0.0157 | 0.0157 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.3263 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.3263 | 1 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0019 | 0.0157 | 0.0157 |
Schistosoma mansoni | phosphatidylinositol 3-and 4-kinase | 0.0019 | 0.0157 | 0.0186 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.3263 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.1385 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.3263 | 1 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0019 | 0.0157 | 0.0285 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0019 | 0.0157 | 0.0285 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.3263 | 1 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.0129 | 0.0129 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0157 | 0.0691 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0157 | 0.0691 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0026 | 0.0616 | 0.0616 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0641 | 0.1799 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0157 | 0.0691 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0018 | 0.0087 | 0.0087 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0017 | 0.0066 | 0.0066 |
Trypanosoma brucei | phosphatidylinositol kinase related protein, putative | 0.0026 | 0.0616 | 0.1478 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.2316 | 0.2316 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0157 | 0.0691 |
Schistosoma mansoni | bromodomain containing protein | 0.0065 | 0.3228 | 0.3817 |
Loa Loa (eye worm) | cysteine protease | 0.0017 | 0.0066 | 0.0066 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0066 | 0.3263 | 1 |
Leishmania major | cathepsin L-like protease | 0.0066 | 0.3263 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0077 | 0.4025 | 0.4025 |
Leishmania major | cathepsin L-like protease | 0.0066 | 0.3263 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0157 | 0.0691 |
Echinococcus granulosus | serine protein kinase ATM | 0.0026 | 0.0616 | 0.0616 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0157 | 0.0691 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0157 | 0.0691 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0066 | 0.3263 | 1 |
Leishmania major | phosphatidylinositol 3-kinase, putative | 0.0019 | 0.0157 | 0.0285 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0017 | 0.0066 | 0.0066 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0019 | 0.0157 | 0.0186 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0157 | 0.0691 |
Entamoeba histolytica | hypothetical protein | 0.0026 | 0.0616 | 0.4172 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0641 | 0.1558 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0066 | 0.3263 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0087 | 0.0087 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1244 | 0.1244 |
Echinococcus granulosus | zinc finger protein | 0.002 | 0.0258 | 0.0258 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0616 | 0.4172 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0066 | 0.0066 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0034 | 0.0034 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.3263 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.033 | 0.033 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0019 | 0.0157 | 0.0285 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0157 | 0.0691 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0157 | 0.0691 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0018 | 0.0087 | 0.0103 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.137 | 0.137 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0157 | 0.0691 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.137 | 0.137 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1536 | 0.1536 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.1385 | 0.4125 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0157 | 0.0691 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0062 | 0.2985 | 0.2985 |
Echinococcus granulosus | phosphatidylinositol 3 and 4 kinase | 0.0019 | 0.0157 | 0.0157 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0019 | 0.0159 | 0.0292 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0017 | 0.0066 | 0.0066 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0019 | 0.0157 | 0.0285 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.3263 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0017 | 0.0066 | 0.0066 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0037 | 0.1385 | 0.1385 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.2316 | 0.2316 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0157 | 0.0691 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0019 | 0.0157 | 0.0691 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1696 | 0.1696 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0066 | 0.0066 |
Echinococcus granulosus | cathepsin l1 | 0.0017 | 0.0066 | 0.0066 |
Loa Loa (eye worm) | ctsf protein | 0.0017 | 0.0066 | 0.0066 |
Schistosoma mansoni | alpha-glucosidase | 0.0144 | 0.8458 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0157 | 0.0691 |
Leishmania major | phosphatidylinositol 3-related kinase, putative | 0.0019 | 0.0157 | 0.0285 |
Leishmania major | phosphatidylinositol kinase related protein, putative | 0.0019 | 0.0159 | 0.0292 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.1385 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1244 | 0.1471 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.046 | 0.046 |
Echinococcus multilocularis | serine protein kinase ATM | 0.0026 | 0.0616 | 0.0616 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0019 | 0.0157 | 0.0157 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0157 | 0.0691 |
Schistosoma mansoni | alpha glucosidase | 0.0037 | 0.1385 | 0.1637 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0037 | 0.1385 | 0.4125 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0157 | 0.0691 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0017 | 0.0066 | 0.0066 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0641 | 1 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0019 | 0.0157 | 0.0285 |
Toxoplasma gondii | FATC domain-containing protein | 0.0026 | 0.0616 | 0.4172 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0062 | 0.2985 | 0.2985 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0641 | 0.0641 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0019 | 0.0157 | 0.0691 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0641 | 0.0641 |
Schistosoma mansoni | alpha-glucosidase | 0.0144 | 0.8458 | 1 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0037 | 0.1385 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0019 | 0.0157 | 0.0157 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0019 | 0.0157 | 0.0157 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.1531 | 0.1531 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0026 | 0.0616 | 0.1721 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.3263 | 1 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm) | 0.0026 | 0.0616 | 0.0728 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0066 | 0.0066 |
Loa Loa (eye worm) | fibroinase | 0.0017 | 0.0066 | 0.0066 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.3263 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0066 | 0.0066 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0157 | 0.0691 |
Echinococcus multilocularis | phosphatidylinositol 3 and 4 kinase | 0.0019 | 0.0157 | 0.0157 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0157 | 0.0691 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.033 | 0.039 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0157 | 0.0691 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0157 | 0.0691 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0157 | 0.0691 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0019 | 0.0157 | 0.0691 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0018 | 0.0087 | 0.0103 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0019 | 0.0157 | 0.0157 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0157 | 0.0691 |
Leishmania major | cathepsin L-like protease | 0.0066 | 0.3263 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0017 | 0.0066 | 0.0066 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.0019 | 0.0157 | 0.0285 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0017 | 0.0066 | 0.0078 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0037 | 0.1385 | 0.1385 |
Trypanosoma brucei | glucosidase, putative | 0.0037 | 0.1385 | 0.3953 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0018 | 0.0087 | 0.0087 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0017 | 0.0066 | 0.0066 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0157 | 0.0691 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0022 | 0.038 | 0.0981 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0037 | 0.1385 | 1 |
Giardia lamblia | GTOR | 0.0019 | 0.0157 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.1385 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0157 | 0.0691 |
Echinococcus multilocularis | cysteine protease | 0.0017 | 0.0066 | 0.0066 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0157 | 0.0691 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0157 | 0.0691 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0019 | 0.0157 | 0.0691 |
Echinococcus multilocularis | zinc finger protein | 0.002 | 0.0258 | 0.0258 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.2316 | 0.2316 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.