Detailed information for compound 1188773

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 386.446 | Formula: C23H22N4O2
  • H donors: 1 H acceptors: 2 LogP: 2.88 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1C)[C@@]1(N=C(N(C1=O)C)N)c1cccc(c1)c1cccnc1
  • InChi: 1S/C23H22N4O2/c1-15-12-19(9-10-20(15)29-3)23(21(28)27(2)22(24)26-23)18-8-4-6-16(13-18)17-7-5-11-25-14-17/h4-14H,1-3H3,(H2,24,26)/t23-/m0/s1
  • InChiKey: TWVGNKMRZLBNOD-QHCPKHFHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0077
Echinococcus granulosus smad 0.0041 0.0117 0.0116
Brugia malayi Cytochrome P450 family protein 0.0017 0.001 0.0034
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0033 0.0079 0.0078
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.019 0.0793 0.0791
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0079 0.0078
Echinococcus granulosus neuropeptide FF receptor 2 0.0033 0.0079 0.0078
Onchocerca volvulus 0.0033 0.0079 0.031
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0018 0.0045
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0085 0.0957
Trichomonas vaginalis set domain proteins, putative 0.0479 0.2106 0.5118
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0079 0.0078
Echinococcus granulosus Nuclear hormone receptor HR96 0.0021 0.0024 0.0023
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.002 0.0021 0.0057
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0085 0.034
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0289 0.0287
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0033 0.0079 0.0078
Schistosoma mansoni DNA ligase IV 0.002 0.0021 0.002
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0033 0.0079 0.0292
Echinococcus multilocularis neuropeptide receptor A26 0.0033 0.0079 0.0078
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0093 0.0091
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0155 0.0576
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0032 0.0279
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.002 0.0021 0.0076
Schistosoma mansoni zinc finger protein 0.0021 0.0028 0.0026
Echinococcus granulosus SAM and MBT domain containing protein 0.0102 0.0395 0.0394
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0023 0.0036 0.0034
Schistosoma mansoni hypothetical protein 0.0033 0.0079 0.0078
Echinococcus granulosus fmrfamide receptor 0.0033 0.0079 0.0078
Schistosoma mansoni hypothetical protein 0.0033 0.0079 0.0078
Echinococcus granulosus sex peptide receptor 0.0033 0.0079 0.0078
Echinococcus granulosus chromobox protein 1 0.0072 0.0256 0.0255
Schistosoma mansoni lamin 0.0027 0.0054 0.0052
Echinococcus multilocularis lamin 0.0027 0.0054 0.0052
Schistosoma mansoni neuropeptide f receptor 76f 0.0033 0.0079 0.0078
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0115 0.0113
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.019 0.0793 0.297
Brugia malayi Importin beta-1 subunit 0.003 0.0069 0.0252
Schistosoma mansoni Smad4 0.0041 0.0117 0.0116
Schistosoma mansoni amine GPCR 0.0033 0.0079 0.0078
Onchocerca volvulus 0.0021 0.0024 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0021 0.0052
Brugia malayi G protein-coupled receptor F59B2.13 0.0033 0.0079 0.0292
Onchocerca volvulus 0.0033 0.0079 0.031
Brugia malayi RNA, U transporter 1 0.0086 0.0322 0.1204
Schistosoma mansoni biogenic amine receptor 0.0033 0.0079 0.0078
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0019 0.0047
Onchocerca volvulus Bile acid receptor homolog 0.0044 0.0129 0.055
Brugia malayi MH2 domain containing protein 0.0041 0.0117 0.0435
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0033 0.0079 0.0292
Mycobacterium ulcerans hypothetical protein 0.019 0.0793 0.3982
Treponema pallidum fructose-bisphosphate aldolase 0.092 0.4116 1
Brugia malayi hypothetical protein 0.002 0.0021 0.0076
Plasmodium falciparum importin beta, putative 0.003 0.0069 0.1541
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0053 0.0193
Loa Loa (eye worm) hypothetical protein 0.0047 0.0146 0.0542
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0069 0.0743
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0079 0.0078
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0085 0.0207
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0079 0.0078
Brugia malayi PHD-finger family protein 0.0027 0.0052 0.0189
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0085 0.0957
Giardia lamblia Fructose-bisphosphate aldolase 0.092 0.4116 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0033 0.0079 0.0078
Onchocerca volvulus Neuropeptide F receptor homolog 0.0033 0.0079 0.031
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0048
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0079 0.0078
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0079 0.0078
Echinococcus multilocularis mothers against decapentaplegic 2 0.0018 0.0014 0.0013
Trypanosoma cruzi FHA domain containing protein, putative 0.002 0.0021 0.0142
Onchocerca volvulus 0.0033 0.0079 0.031
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0085 0.0315
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0053 0.0193
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0407 0.178 0.1778
Loa Loa (eye worm) G-protein coupled receptor 0.0033 0.0079 0.0292
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0068 0.0745
Mycobacterium leprae Probable lipase LipE 0.019 0.0793 0.3982
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0077
Brugia malayi ecdysteroid receptor 0.0044 0.0129 0.048
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0053 0.0215
Echinococcus granulosus GPCR family 2 0.0047 0.0146 0.0144
Loa Loa (eye worm) nuclear receptor NHR-67 0.0021 0.0024 0.0086
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Schistosoma mansoni myosin xvIII 0.0033 0.0079 0.0078
Echinococcus multilocularis pyruvate kinase 0.0034 0.0085 0.0084
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.0381 0.038
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0079 0.0078
Brugia malayi hypothetical protein 0.0033 0.0079 0.0292
Brugia malayi neuropeptide F receptor 0.0033 0.0079 0.0292
Echinococcus granulosus lamin 0.0027 0.0054 0.0052
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0078 0.0285 0.0283
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0073 0.0261 0.026
Schistosoma mansoni hypothetical protein 0.002 0.0024 0.0022
Echinococcus granulosus peregrin 0.0033 0.0079 0.0078
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0079 0.0078
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0053 0.0541
Echinococcus multilocularis SAM and MBT domain containing protein 0.0102 0.0395 0.0394
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0122 0.0121
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0033 0.0079 0.0078
Echinococcus multilocularis neuropeptide FF receptor 2 0.0033 0.0079 0.0078
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.061 0.2284
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0024 0.0084
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Echinococcus multilocularis orexin receptor type 2 0.0033 0.0079 0.0078
Schistosoma mansoni nuclear receptor nhr-48 0.0021 0.0024 0.0023
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Brugia malayi Cytochrome P450 family protein 0.0026 0.0049 0.018
Schistosoma mansoni hypothetical protein 0.0047 0.0146 0.0144
Echinococcus granulosus cpg binding protein 0.0037 0.0099 0.0098
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0146 0.0144
Schistosoma mansoni thyroid hormone receptor 0.0309 0.1336 0.1335
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0102 0.0395 0.0394
Echinococcus multilocularis snurportin 1 0.0323 0.14 0.1399
Schistosoma mansoni pyruvate kinase 0.0034 0.0085 0.0084
Brugia malayi nuclear receptor NHR-88 0.0021 0.0024 0.0086
Loa Loa (eye worm) hypothetical protein 0.0044 0.0129 0.048
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0044 0.0129 0.048
Schistosoma mansoni biogenic amine (5HT) receptor 0.0033 0.0079 0.0078
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0053 0.0078
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0019 0.0068
Toxoplasma gondii aspartyl protease 0.0056 0.0184 0.2228
Trichomonas vaginalis ran, putative 0.0022 0.0032 0.0078
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0184 0.0183
Schistosoma mansoni sex comb on midleg homolog 0.0102 0.0395 0.0394
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0193
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0085 0.0381
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.002 0.0021 0.0057
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0021 0.0142
Brugia malayi Pepsin A precursor 0.0056 0.0184 0.0687
Brugia malayi follicle stimulating hormone receptor 0.0033 0.0079 0.0292
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0049 0.05
Brugia malayi Pre-SET motif family protein 0.0421 0.1843 0.691
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0033 0.0079 0.0078
Echinococcus granulosus neuropeptides capa receptor 0.0033 0.0079 0.0078
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0208 0.0207
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0053 0.0078
Plasmodium falciparum plasmepsin IV 0.0101 0.0389 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0044 0.0129 0.048
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0021 0.0052
Brugia malayi DKFZp564C0469 protein 0.002 0.0021 0.0076
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0023 0.0036 0.0034
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0049 0.018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0044 0.0129 0.048
Mycobacterium tuberculosis Probable lipase LipD 0.019 0.0793 0.1442
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.0559 0.2092
Brugia malayi hypothetical protein 0.0033 0.0079 0.0292
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0044 0.0129 0.0128
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0077
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.0079 0.0078
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Echinococcus multilocularis FTZ F1 alpha 0.0044 0.0129 0.0128
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.0432 0.0431
Schistosoma mansoni biogenic amine (5HT) receptor 0.0033 0.0079 0.0078
Schistosoma mansoni myelin transcription factor 1 myt1 0.0116 0.046 0.0458
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0079 0.0078
Echinococcus multilocularis Smad4 0.0041 0.0117 0.0116
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0008 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0044 0.0129 0.048
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0023 0.0022
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0049 0.1039
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0421 0.1843 0.691
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0559 0.0557
Loa Loa (eye worm) hypothetical protein 0.0051 0.0164 0.0611
Schistosoma mansoni hypothetical protein 0.0323 0.14 0.1399
Echinococcus multilocularis tumor protein p63 0.035 0.1524 0.1523
Schistosoma mansoni transcription factor LCR-F1 0.011 0.0432 0.0431
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0044 0.0129 0.0128
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0041 0.0117 0.0116
Trypanosoma cruzi hypothetical protein, conserved 0.019 0.0793 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0041 0.0117 0.0116
Brugia malayi hypothetical protein 0.0033 0.0079 0.0292
Onchocerca volvulus 0.002 0.0021 0.0035
Echinococcus granulosus somatostatin receptor 0.0033 0.0079 0.0078
Echinococcus granulosus importin subunit beta 1 0.003 0.0069 0.0067
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0019 0.0068
Entamoeba histolytica hypothetical protein 0.011 0.0432 0.1007
Schistosoma mansoni chromobox protein 0.0072 0.0256 0.0255
Loa Loa (eye worm) hypothetical protein 0.019 0.0793 0.297
Schistosoma mansoni intermediate filament proteins 0.0027 0.0054 0.0052
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0097 0.0096
Echinococcus granulosus replication factor c subunit 1 0.002 0.0021 0.002
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.0238 0.2917
Echinococcus multilocularis chromobox protein 1 0.0072 0.0256 0.0255
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.0381 0.038
Brugia malayi hypothetical protein 0.0026 0.0049 0.0181
Schistosoma mansoni nuclear hormone receptor 0.0044 0.0129 0.0128
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0003 0.0006
Onchocerca volvulus 0.0033 0.0079 0.031
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0017 0.0012
Schistosoma mansoni chromobox protein 0.0072 0.0256 0.0255
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0021 0.0024 0.0049
Onchocerca volvulus 0.0033 0.0079 0.031
Brugia malayi CXXC zinc finger family protein 0.0033 0.0082 0.0304
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0069 0.0747
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0049 0.0503
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0008 0.0006
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0033 0.0079 0.0078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0044 0.0129 0.048
Loa Loa (eye worm) hypothetical protein 0.019 0.0793 0.297
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0146 0.0542
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0086
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0018 0.0045
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0054 0.0196
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0078 0.0285 0.0283
Onchocerca volvulus 0.0033 0.0079 0.031
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0044 0.0129 0.048
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0023 0.0036 0.0034
Echinococcus multilocularis musashi 0.0027 0.0054 0.0052
Brugia malayi Eukaryotic aspartyl protease family protein 0.0056 0.0184 0.0687
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0024 0.0023
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0044 0.0129 0.0128
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0036 0.0034
Entamoeba histolytica hypothetical protein 0.011 0.0432 0.1007
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.0079 0.0078
Loa Loa (eye worm) G-protein coupled receptor 0.0033 0.0079 0.0292
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0053 0.0081
Echinococcus multilocularis neuropeptide s receptor 0.0033 0.0079 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.006 0.0146
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0079 0.0078
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0014 0.0048
Schistosoma mansoni neuropeptide receptor 0.0033 0.0079 0.0078
Onchocerca volvulus 0.0479 0.2106 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0209 0.0207
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Echinococcus granulosus peptide allatostatin:somatostatin 0.0033 0.0079 0.0078
Brugia malayi hypothetical protein 0.0033 0.0079 0.0292
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0085 0.0207
Brugia malayi Dopamine receptor protein 2 0.0033 0.0079 0.0292
Schistosoma mansoni cpg binding protein 0.0037 0.0099 0.0098
Echinococcus multilocularis GPCR, family 2 0.0047 0.0146 0.0144
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0049 0.05
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0039 0.0047
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0033 0.0079 0.0078
Echinococcus granulosus serotonin receptor 0.0033 0.0079 0.0078
Schistosoma mansoni hypothetical protein 0.003 0.0068 0.0067
Schistosoma mansoni memapsin-2 (A01 family) 0.0556 0.2458 0.2457
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0008 0.0006
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.0395 0.1478
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0559 0.0557
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0086
Loa Loa (eye worm) melatonin receptor type 1A 0.0033 0.0079 0.0292
Echinococcus multilocularis serotonin receptor 0.0033 0.0079 0.0078
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0021 0.0024 0.0023
Brugia malayi nuclear hormone receptor 0.0021 0.0024 0.0086
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.019 0.0793 0.3982
Echinococcus multilocularis pyruvate kinase 0.0017 0.001 0.0009
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0184 0.0183
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0079 0.0078
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0032 0.0116
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0076
Brugia malayi Bromodomain containing protein 0.0038 0.0103 0.0383
Brugia malayi Bromodomain containing protein 0.0033 0.0079 0.0292
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0018 0.0045
Brugia malayi hypothetical protein 0.0021 0.0024 0.0086
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0049 0.05
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0049 0.0498
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0164 0.0163
Brugia malayi Steroid receptor seven-up type 2 0.0044 0.0129 0.048
Echinococcus multilocularis neuropeptide receptor 0.0033 0.0079 0.0078
Brugia malayi PHD-finger family protein 0.003 0.0068 0.0252
Loa Loa (eye worm) hypothetical protein 0.007 0.025 0.0932
Plasmodium falciparum plasmepsin VII 0.0056 0.0184 0.4599
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0102 0.0395 0.1822
Echinococcus multilocularis g protein coupled receptor 0.0033 0.0079 0.0078
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0017 0.0012
Brugia malayi GnHR receptor homolog 0.0033 0.0079 0.0292
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0018 0.0045
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0086
Schistosoma mansoni hypothetical protein 0.0017 0.001 0.0009
Echinococcus granulosus Nuclear hormone receptor HR96 0.0021 0.0024 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0044 0.0129 0.048
Schistosoma mansoni hypothetical protein 0.0047 0.0146 0.0144
Toxoplasma gondii aspartyl protease ASP1 0.0101 0.0389 0.4845
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0122 0.0121
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0086
Plasmodium vivax aspartyl proteinase, putative 0.0056 0.0184 0.2228
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0036 0.0129
Brugia malayi Smad1 0.0041 0.0117 0.0435
Echinococcus granulosus pyruvate kinase 0.0034 0.0085 0.0084
Schistosoma mansoni hypothetical protein 0.0474 0.2087 0.2086
Echinococcus multilocularis neuropeptide Y receptor 0.0033 0.0079 0.0078
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0184 0.0183
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0079 0.0078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0044 0.0129 0.048
Loa Loa (eye worm) hypothetical protein 0.0031 0.0074 0.0272
Schistosoma mansoni thyroid hormone receptor 0.0309 0.1336 0.1335
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Echinococcus granulosus hypothetical protein 0.0033 0.0079 0.0078
Onchocerca volvulus 0.0027 0.0054 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0044 0.0129 0.048
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0559 0.0557
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0033 0.0079 0.0078
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0033 0.0079 0.0292
Echinococcus granulosus neuropeptide s receptor 0.0033 0.0079 0.0078
Loa Loa (eye worm) hypothetical protein 0.0044 0.0129 0.048
Brugia malayi Serotonin receptor 0.0033 0.0079 0.0292
Brugia malayi hypothetical protein 0.0017 0.0007 0.0023
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0008 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.092 0.4116 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Schistosoma mansoni sex comb on midleg homolog 0.0102 0.0395 0.0394
Onchocerca volvulus Protein ultraspiracle homolog 0.0044 0.0129 0.055
Echinococcus multilocularis zinc finger protein 0.0021 0.0028 0.0026
Echinococcus multilocularis pyruvate kinase 0.0017 0.001 0.0009
Brugia malayi nuclear hormone receptor 0.0044 0.0129 0.048
Schistosoma mansoni zinc finger protein 0.0021 0.0024 0.0023
Echinococcus multilocularis pyruvate kinase 0.0017 0.001 0.0009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0018 0.0045
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0033 0.0079 0.0078
Loa Loa (eye worm) hypothetical protein 0.0242 0.1029 0.3858
Brugia malayi hypothetical protein 0.0242 0.1029 0.3858
Plasmodium falciparum plasmepsin IX 0.0056 0.0184 0.4599
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0032 0.0582
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0113 0.0474
Echinococcus granulosus pyruvate kinase 0.0017 0.001 0.0009
Echinococcus granulosus geminin 0.0168 0.0695 0.0693
Echinococcus granulosus pyruvate kinase 0.0017 0.001 0.0009
Brugia malayi beta-lactamase family protein 0.019 0.0793 0.297
Onchocerca volvulus 0.0056 0.0184 0.0814
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0021 0.0024 0.0049
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.002 0.0021 0.0005
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0146 0.0542
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0049 0.1039
Brugia malayi Heterochromatin protein 1 0.0072 0.0256 0.0957
Loa Loa (eye worm) steroid hormone receptor 0.0044 0.0129 0.048
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Brugia malayi mbt repeat family protein 0.0102 0.0395 0.1479
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0019 0.0115
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0023 0.0036 0.0129
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0101 0.0389 0.4845
Plasmodium falciparum plasmepsin II 0.0101 0.0389 1
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0127 0.0309
Brugia malayi putative neuropeptide receptor NPR1 0.0033 0.0079 0.0292
Leishmania major hypothetical protein, conserved 0.019 0.0793 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.092 0.4116 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0041 0.0117 0.0116
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0044 0.0129 0.0128
Entamoeba histolytica hypothetical protein 0.0025 0.0042 0.0056
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Onchocerca volvulus 0.0033 0.0079 0.031
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0146 0.0542
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0018 0.0045
Echinococcus granulosus orexin receptor type 2 0.0033 0.0079 0.0078
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0115 0.0113
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0086
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0021 0.0024 0.0023
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0033 0.0079 0.0078
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0039 0.0139
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0085 0.0315
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.002 0.0021 0.0146
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0044 0.0129 0.0128
Schistosoma mansoni hypothetical protein 0.0168 0.0695 0.0693
Brugia malayi mbt repeat family protein 0.0102 0.0395 0.1479
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0033 0.0079 0.0078
Brugia malayi MH1 domain containing protein 0.0023 0.0034 0.0122
Schistosoma mansoni ran 0.0022 0.0032 0.0031
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0033 0.0079 0.031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0079 0.0078
Brugia malayi G-protein coupled receptor 0.0033 0.0079 0.0292
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0019 0.0018
Mycobacterium ulcerans lipase LipD 0.019 0.0793 0.3982
Brugia malayi sulfakinin receptor protein 0.0033 0.0079 0.0292
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0076
Schistosoma mansoni ap endonuclease 0.0019 0.0019 0.0018
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0033 0.0079 0.0292
Onchocerca volvulus 0.0021 0.0024 0.0049
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0068 0.0745
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0022 0.0311
Echinococcus granulosus pyruvate kinase 0.0017 0.001 0.0009
Schistosoma mansoni neuropeptide F-like receptor 0.0033 0.0079 0.0078
Plasmodium vivax plasmepsin IV, putative 0.0101 0.0389 0.4845
Echinococcus multilocularis g protein coupled receptor 0.0033 0.0079 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0021 0.0052
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0056 0.0184 0.0687
Toxoplasma gondii ABC1 family protein 0.019 0.0793 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0068 0.0067
Brugia malayi jmjC domain containing protein 0.004 0.0115 0.0425
Plasmodium vivax SET domain protein, putative 0.0061 0.0208 0.2528
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.045 0.1975 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0033 0.0079 0.0292
Brugia malayi tailless protein 0.0021 0.0024 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0003 0.0006
Schistosoma mansoni smad1 5 8 and 0.0041 0.0117 0.0116
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0079 0.0078
Loa Loa (eye worm) hypothetical protein 0.0149 0.061 0.2284
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0041 0.004
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0032 0.0031
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0209 0.0207
Plasmodium vivax replication factor C subunit 1, putative 0.002 0.0021 0.0146
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0208 0.0207
Schistosoma mansoni opsin-like receptor 0.0033 0.0079 0.0078
Leishmania major GTP-binding protein, putative 0.0022 0.0032 0.0279
Echinococcus granulosus tumor protein p63 0.035 0.1524 0.1523
Schistosoma mansoni hypothetical protein 0.0033 0.0079 0.0078
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0021 0.0024 0.0086
Schistosoma mansoni smad 0.0041 0.0117 0.0116
Brugia malayi nuclear receptor NHR-88 0.0044 0.0129 0.048
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0078 0.0285 0.0283
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0033 0.0079 0.0292
Mycobacterium ulcerans hypothetical protein 0.0027 0.0053 0.0215
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0086
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0019 0.0115
Mycobacterium ulcerans beta-lactamase 0.019 0.0793 0.3982
Schistosoma mansoni retinoic acid receptor RXR 0.0044 0.0129 0.0128
Giardia lamblia Replication factor C, subunit 1 0.002 0.0021 0.0028
Brugia malayi MH1 domain containing protein 0.0023 0.0034 0.0122
Entamoeba histolytica hypothetical protein 0.011 0.0432 0.1007
Echinococcus granulosus G protein coupled receptor 139 0.0033 0.0079 0.0078
Echinococcus multilocularis G protein coupled receptor 139 0.0033 0.0079 0.0078
Onchocerca volvulus 0.0033 0.0079 0.031
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.092 0.4116 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0033 0.0079 0.0078
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0265 0.1138 0.1136
Plasmodium falciparum plasmepsin VI 0.0101 0.0389 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0195 0.0193
Schistosoma mansoni pyruvate kinase 0.0034 0.0085 0.0084
Loa Loa (eye worm) nuclear hormone receptor 0.0021 0.0024 0.0086
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0184 0.0183
Loa Loa (eye worm) hypothetical protein 0.0044 0.0129 0.048
Echinococcus multilocularis dro:myosuppressin receptor 0.0033 0.0079 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0113 0.0275
Mycobacterium ulcerans esterase/lipase LipP 0.019 0.0793 0.3982
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0068 0.0252
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0053 0.0215
Schistosoma mansoni hypothetical protein 0.0033 0.0079 0.0078
Onchocerca volvulus 0.0027 0.0054 0.0189
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0044 0.0129 0.048
Onchocerca volvulus Alhambra homolog 0.003 0.0068 0.0259
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Echinococcus multilocularis neuropeptide Y receptor 0.0033 0.0079 0.0078
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0044 0.0129 0.0128
Echinococcus granulosus biogenic amine 5HT receptor 0.0033 0.0079 0.0078
Echinococcus granulosus neuropeptide receptor 0.0033 0.0079 0.0078
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0044 0.0129 0.0128
Brugia malayi neuropeptide F receptor 0.0033 0.0079 0.0292
Echinococcus multilocularis smad 0.0041 0.0117 0.0116
Echinococcus multilocularis mothers against decapentaplegic 6 0.0018 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0086
Schistosoma mansoni nuclear receptor 0.0021 0.0024 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0044 0.0129 0.048
Echinococcus granulosus FTZ F1 alpha 0.0044 0.0129 0.0128
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0053 0.0215
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0033 0.0079 0.0078
Schistosoma mansoni hypothetical protein 0.0168 0.0695 0.0693
Brugia malayi Cytochrome P450 family protein 0.0055 0.0182 0.0679
Schistosoma mansoni nuclear receptor 0.0021 0.0024 0.0023
Echinococcus granulosus neuropeptide receptor 0.0033 0.0079 0.0078
Echinococcus multilocularis polycomb protein SCMH1 0.0102 0.0395 0.0394
Echinococcus granulosus polycomb protein SCMH1 0.0102 0.0395 0.0394
Brugia malayi Tachykinin-like peptides receptor 99D 0.0033 0.0079 0.0292
Brugia malayi topoisomerase 0.002 0.0021 0.0076
Brugia malayi chromobox protein homolog 3 0.004 0.0113 0.042
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0085 0.0315
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0182 0.0679
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0021 0.0024 0.0023
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0041 0.004
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0033 0.0079 0.0078
Schistosoma mansoni coup transcription factor 0.0044 0.0129 0.0128
Schistosoma mansoni Smad4 0.0018 0.0014 0.0013
Echinococcus granulosus g protein coupled receptor 0.0033 0.0079 0.0078
Brugia malayi ecdysone receptor 0.0021 0.0024 0.0086
Brugia malayi photoreceptor-specific nuclear receptor 0.0044 0.0129 0.048
Echinococcus granulosus nuclear receptor nhr 48 0.0021 0.0024 0.0023
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0101 0.0389 0.1456
Echinococcus granulosus dro:myosuppressin receptor 0.0033 0.0079 0.0078
Plasmodium vivax importin-beta 2, putative 0.003 0.0069 0.0747
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0193
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0044 0.0129 0.048
Echinococcus granulosus neuropeptide receptor A26 0.0033 0.0079 0.0078
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0053 0.0215
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0033 0.0079 0.0078
Brugia malayi hypothetical protein 0.011 0.0432 0.1615
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0032 0.0279
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0042 0.0103
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0049 0.0503
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0184 0.0183
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0024 0.0023
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.0079 0.0078
Schistosoma mansoni cathepsin D (A01 family) 0.0216 0.0912 0.0911
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0184 0.0183
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0559 0.0557
Schistosoma mansoni topbp1 0.002 0.0021 0.002
Loa Loa (eye worm) TYRA-2 protein 0.0033 0.0079 0.0292
Plasmodium vivax aspartyl protease, putative 0.0056 0.0184 0.2228
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0033 0.0079 0.0078
Brugia malayi jmjC domain containing protein 0.0099 0.0381 0.1426
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0044 0.0129 0.0128
Schistosoma mansoni cathepsin D (A01 family) 0.0216 0.0912 0.0911
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0101 0.0389 0.0946
Brugia malayi hypothetical protein 0.0023 0.0036 0.0129
Schistosoma mansoni amine GPCR 0.0033 0.0079 0.0078
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0079 0.0078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0044 0.0129 0.048
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.092 0.4116 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Brugia malayi aspartic protease BmAsp-2, identical 0.0056 0.0184 0.0687
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0086
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0019 0.0047
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0022 0.0059
Brugia malayi Melatonin receptor type 1A 0.0033 0.0079 0.0292
Echinococcus granulosus mothers against decapentaplegic 2 0.0018 0.0014 0.0013
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.019 0.0793 0.0791
Onchocerca volvulus 0.0044 0.0129 0.055
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Schistosoma mansoni cpg binding protein 0.0037 0.0099 0.0098
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0033 0.0079 0.0078
Echinococcus granulosus allatostatin A receptor 0.0033 0.0079 0.0078
Schistosoma mansoni growth hormone secretagogue receptor 0.0033 0.0079 0.0078
Loa Loa (eye worm) mbt repeat family protein 0.0102 0.0395 0.1479
Echinococcus multilocularis geminin 0.0168 0.0695 0.0693
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Schistosoma mansoni hypothetical protein 0.0625 0.2773 0.2772
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0019 0.0046
Plasmodium vivax aspartyl protease, putative 0.0056 0.0184 0.2228
Echinococcus granulosus nibrin 0.002 0.0021 0.002
Echinococcus granulosus alpha 1A adrenergic receptor 0.0033 0.0079 0.0078
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0184 0.0183
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0033 0.0079 0.0292
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0076
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0044 0.0129 0.0128
Loa Loa (eye worm) hypothetical protein 0.0116 0.046 0.172
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.1029 0.1028
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0036 0.0129
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0018 0.0045
Echinococcus multilocularis importin subunit beta 1 0.003 0.0069 0.0067
Loa Loa (eye worm) Smad1 0.0041 0.0117 0.0435
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0032 0.0282
Schistosoma mansoni importin beta-1 0.003 0.0069 0.0067
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0022 0.0021
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0079 0.0078
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.045 0.1975 0.362
Toxoplasma gondii aspartyl protease ASP3 0.0056 0.0184 0.2228
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0085 0.0957
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.0079 0.0078
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0032 0.0031
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0082 0.0304
Trichomonas vaginalis D-aminoacylase, putative 0.019 0.0793 0.1926
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0256 0.0623
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Brugia malayi MH2 domain containing protein 0.0041 0.0117 0.0435
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0086
Echinococcus granulosus g protein coupled receptor 0.0033 0.0079 0.0078
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.019 0.0793 0.1442
Echinococcus multilocularis fmrfamide receptor 0.0033 0.0079 0.0078
Brugia malayi conserved hypotetical protein 0.0021 0.0024 0.0086
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0101 0.0389 0.0388
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0019 0.0023
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Brugia malayi Dopamine receptor protein 1 0.0033 0.0079 0.0292
Echinococcus granulosus 7tm_1 domain containing protein 0.0033 0.0079 0.0078
Loa Loa (eye worm) hypothetical protein 0.0052 0.0167 0.062
Onchocerca volvulus 0.019 0.0793 0.3721
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0044 0.0129 0.0128
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0076
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0042 0.0103
Brugia malayi hypothetical protein 0.0056 0.0184 0.0687
Echinococcus multilocularis replication factor c subunit 1 0.002 0.0021 0.002
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0068 0.0067
Loa Loa (eye worm) hypothetical protein 0.0044 0.0129 0.048
Loa Loa (eye worm) DR-78 0.0021 0.0024 0.0086
Schistosoma mansoni lamin 0.0027 0.0054 0.0052
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.019 0.0793 0.1442
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0093 0.0091
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0265 0.1138 0.1136
Loa Loa (eye worm) nuclear factor I 0.0023 0.0034 0.0122
Loa Loa (eye worm) hypothetical protein 0.019 0.0793 0.297
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0024 0.0023
Mycobacterium tuberculosis Conserved protein 0.019 0.0793 0.1442
Schistosoma mansoni steroid hormone receptor ad4bp 0.0044 0.0129 0.0128
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0044 0.0129 0.0128
Echinococcus granulosus neuropeptide Y receptor 0.0033 0.0079 0.0078
Onchocerca volvulus 0.0033 0.0079 0.031
Brugia malayi nuclear receptor RXR 0.0023 0.0036 0.0129
Echinococcus granulosus g-protein coupled receptor 0.0033 0.0079 0.0078
Schistosoma mansoni histamine h1 receptor 0.0033 0.0079 0.0078
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.0432 0.0431
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0044 0.0129 0.0128
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0115 0.0113
Brugia malayi MH2 domain containing protein 0.0018 0.0014 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0044 0.0129 0.048
Chlamydia trachomatis pyruvate kinase 0.0034 0.0085 1
Schistosoma mansoni topbp1 0.002 0.0021 0.002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0044 0.0129 0.0128
Onchocerca volvulus 0.0033 0.0079 0.031
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0021 0.0142
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0044 0.0129 0.048
Loa Loa (eye worm) hypothetical protein 0.019 0.0793 0.297
Trichomonas vaginalis penicillin-binding protein, putative 0.019 0.0793 0.1926
Toxoplasma gondii cytochrome p450 superfamily protein 0.0017 0.001 0.0003
Toxoplasma gondii ATPase, AAA family protein 0.002 0.0021 0.0146
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0085 0.096
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0033 0.0079 0.0292
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0033 0.0079 0.0078
Mycobacterium tuberculosis Conserved protein 0.019 0.0793 0.1442
Plasmodium vivax aspartyl proteinase, putative 0.0101 0.0389 0.4845
Onchocerca volvulus 0.0056 0.0184 0.0814
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0021 0.0024 0.0023
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.0079 0.0078
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0017 0.0012
Onchocerca volvulus 0.0033 0.0082 0.0325
Brugia malayi hypothetical protein 0.0056 0.0184 0.0687
Loa Loa (eye worm) neuropeptide F receptor 0.0033 0.0079 0.0292
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0053 0.0081
Loa Loa (eye worm) hypothetical protein 0.0044 0.0129 0.048
Onchocerca volvulus 0.019 0.0793 0.3721
Echinococcus multilocularis G-protein coupled receptor, putative 0.0033 0.0079 0.0078
Schistosoma mansoni bromodomain containing protein 0.0065 0.0225 0.0223
Loa Loa (eye worm) hypothetical protein 0.0027 0.0051 0.0188
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0793 0.3538 0.3537
Mycobacterium leprae conserved hypothetical protein 0.019 0.0793 0.3982
Trichomonas vaginalis penicillin-binding protein, putative 0.019 0.0793 0.1926
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.092 0.4116 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0129
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0049 0.0498
Brugia malayi Pre-SET motif family protein 0.0061 0.0208 0.0775
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0041 0.004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0079 0.0078
Echinococcus multilocularis dnaJ subfamily B 0.0474 0.2087 0.2086
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0033 0.0079 0.0078
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0101 0.0389 0.0388
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0086
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.092 0.4116 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0069 0.0252
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0077
Brugia malayi larval opioid receptor 0.0033 0.0079 0.0292
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0129
Echinococcus granulosus lamin dm0 0.0027 0.0054 0.0052
Loa Loa (eye worm) hypothetical protein 0.0101 0.0389 0.1456
Trichomonas vaginalis D-aminoacylase, putative 0.019 0.0793 0.1926
Schistosoma mansoni amine GPCR 0.0033 0.0079 0.0078
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0101 0.0389 0.0388
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Echinococcus multilocularis pyruvate kinase 0.0027 0.0053 0.0051
Echinococcus granulosus g protein coupled receptor 0.0033 0.0079 0.0078
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0049 0.0498
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.002 0.0021 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.019 0.0793 0.0791
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0049 0.018
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0053 0.0215
Brugia malayi G protein-coupled receptor 0.0033 0.0079 0.0292
Onchocerca volvulus 0.019 0.0793 0.3721
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.019 0.0793 0.297
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0044 0.0129 0.048
Echinococcus multilocularis nibrin 0.002 0.0021 0.002
Mycobacterium tuberculosis Probable lipase LipE 0.019 0.0793 0.1442
Echinococcus multilocularis nuclear receptor nhr 48 0.0021 0.0024 0.0023
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0076
Schistosoma mansoni hypothetical protein 0.011 0.0432 0.0431
Plasmodium vivax hypothetical protein, conserved 0.003 0.0068 0.0745
Brugia malayi nuclear hormone receptor family member nhr-6 0.0021 0.0024 0.0086
Echinococcus granulosus zinc finger protein 0.0021 0.0028 0.0026
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0184 0.0183
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Echinococcus multilocularis fmrfamide receptor 0.0033 0.0079 0.0078
Schistosoma mansoni amine GPCR 0.0033 0.0079 0.0078
Brugia malayi nuclear hormone receptor family member odr-7 0.0021 0.0024 0.0086
Mycobacterium tuberculosis Probable esterase LipL 0.019 0.0793 0.1442
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0079 0.0078
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0085 0.0138
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0127 0.054
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0079 0.0078
Brugia malayi Bromodomain containing protein 0.0076 0.0278 0.1036
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.092 0.4116 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0033 0.0079 0.0078
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0042 0.0411
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.0079 0.0078
Echinococcus granulosus histone lysine methyltransferase setb 0.0078 0.0285 0.0283
Toxoplasma gondii exonuclease III APE 0.0019 0.0019 0.0118
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0019 0.0017
Brugia malayi mothers against decapentaplegic homolog 3 0.0018 0.0014 0.0048
Plasmodium falciparum pyruvate kinase 0.0034 0.0085 0.1981
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0256 0.0623
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0044 0.0129 0.0128
Onchocerca volvulus 0.0033 0.0079 0.031
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0054 0.0196
Schistosoma mansoni biogenic amine receptor 0.0033 0.0079 0.0078
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.0559 0.2092
Brugia malayi hypothetical protein 0.0033 0.0079 0.0292
Echinococcus granulosus snurportin 1 0.0323 0.14 0.1399
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0073 0.0262 0.0261
Loa Loa (eye worm) aspartyl protease 6 0.0056 0.0184 0.0687
Brugia malayi Pax transcription activation domain interacting protein 0.002 0.0021 0.0076
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0044 0.0129 0.0128
Echinococcus multilocularis sex peptide receptor 0.0033 0.0079 0.0078
Echinococcus multilocularis neuropeptides capa receptor 0.0033 0.0079 0.0078
Loa Loa (eye worm) hypothetical protein 0.0034 0.0085 0.0315
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.045 0.1975 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0129 0.048
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0256 0.0957
Onchocerca volvulus 0.0102 0.0395 0.1822
Schistosoma mansoni opsin-like receptor 0.0033 0.0079 0.0078
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0085 0.034
Loa Loa (eye worm) hypothetical protein 0.019 0.0793 0.297
Echinococcus multilocularis cpg binding protein 0.0037 0.0099 0.0098
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0079 0.0078
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0559 0.0557
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.001 0.0009
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.001 0.0034
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0033 0.0079 0.0292
Schistosoma mansoni hypothetical protein 0.0049 0.0155 0.0154
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0019 0.0118
Brugia malayi hypothetical protein 0.0021 0.0024 0.0086
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0032 0.0116
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0033 0.0079 0.0078
Loa Loa (eye worm) MH2 domain-containing protein 0.0041 0.0117 0.0435
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0021 0.0024 0.0023
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0407 0.178 0.1778
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0129
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0116 0.046 0.172
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0042 0.0103
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0033 0.0079 0.0078
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0559 0.0557
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0033 0.0079 0.0078
Brugia malayi steroid hormone receptor 0.0044 0.0129 0.048
Echinococcus multilocularis pyruvate kinase 0.0034 0.0085 0.0084
Onchocerca volvulus 0.0049 0.0155 0.0673
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0127 0.0309
Echinococcus multilocularis somatostatin receptor 0.0033 0.0079 0.0078
Loa Loa (eye worm) hypothetical protein 0.0056 0.0184 0.0687
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0116 0.046 0.0458
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1211 0.5437 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0129 0.048
Leishmania major cytochrome p450-like protein 0.0026 0.0049 0.0498
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0146 0.0144
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0018 0.0045
Schistosoma mansoni adenoreceptor 0.0033 0.0079 0.0078
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0053 0.0215
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0044 0.0129 0.0128
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0044 0.0129 0.048
Echinococcus granulosus chromobox protein 1 0.0072 0.0256 0.0255
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0053 0.0193
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0044 0.0129 0.0128
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0054 0.0196
Schistosoma mansoni hypothetical protein 0.0047 0.0146 0.0144
Schistosoma mansoni hypothetical protein 0.0102 0.0395 0.0394
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.092 0.4116 1
Trypanosoma brucei hypothetical protein, conserved 0.019 0.0793 1
Plasmodium falciparum plasmepsin V 0.0056 0.0184 0.4599
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0021 0.0142
Echinococcus multilocularis g-protein coupled receptor 0.0033 0.0079 0.0078
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0085 0.0957
Loa Loa (eye worm) neuropeptide F receptor 0.0033 0.0079 0.0292
Echinococcus granulosus biogenic amine 5HT receptor 0.0033 0.0079 0.0078
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0113 0.0275
Brugia malayi hypothetical protein 0.0033 0.0079 0.0292
Brugia malayi RE15519p 0.0033 0.0079 0.0292
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0053 0.0215
Loa Loa (eye worm) hypothetical protein 0.0038 0.0104 0.0384
Brugia malayi MH2 domain containing protein 0.0602 0.2666 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0076
Echinococcus granulosus thyroid hormone receptor alpha 0.0021 0.0024 0.0023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0079 0.0078
Echinococcus granulosus mothers against decapentaplegic 5 0.0041 0.0117 0.0116
Mycobacterium tuberculosis Probable hydrolase 0.019 0.0793 0.1442
Brugia malayi nuclear receptor RXR 0.0021 0.0024 0.0086
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0032 0.0282
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.1029 0.1028
Loa Loa (eye worm) hypothetical protein 0.019 0.0793 0.297
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0085 0.0381
Brugia malayi hypothetical protein 0.0033 0.0079 0.0292
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0033 0.0079 0.0078
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0033 0.0079 0.0292
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.006 0.0146
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.0079 0.0078
Giardia lamblia Pyruvate kinase 0.0034 0.0085 0.0183
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0085 0.0315
Loa Loa (eye worm) hypothetical protein 0.0023 0.0034 0.0122
Entamoeba histolytica Ran family GTPase 0.0022 0.0032 0.0031
Plasmodium falciparum plasmepsin VIII, putative 0.0056 0.0184 0.4599
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0044 0.0129 0.0128
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0032 0.0054
Brugia malayi orphan nuclear receptor NR2E1 0.0021 0.0024 0.0086
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0033 0.0079 0.0078
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0033 0.0079 0.0078
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0049 0.0198
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0086
Leishmania major pyruvate kinase 0.0034 0.0085 0.0957
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.0079 0.0078
Onchocerca volvulus 0.0027 0.0053 0.0184
Schistosoma mansoni cytochrome P450 0.0017 0.001 0.0009
Onchocerca volvulus 0.0033 0.0079 0.031
Brugia malayi MH1 domain containing protein 0.0041 0.0117 0.0435
Loa Loa (eye worm) hypothetical protein 0.0027 0.0054 0.0196
Brugia malayi Nuclear hormone receptor E75 0.0021 0.0024 0.0086
Plasmodium vivax hypothetical protein, conserved 0.019 0.0793 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0017 0.0012
Echinococcus granulosus ecdysone induced protein 78C 0.0044 0.0129 0.0128
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Brugia malayi putative neuropeptide receptor 0.0033 0.0079 0.0292
Echinococcus granulosus mothers against decapentaplegic 6 0.0018 0.0014 0.0013
Onchocerca volvulus 0.0031 0.0074 0.0285
Echinococcus granulosus dnaJ subfamily B 0.0474 0.2087 0.2086
Plasmodium falciparum phd finger protein, putative 0.003 0.0068 0.1538
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0116 0.046 0.0458
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0129
Plasmodium vivax aspartyl protease, putative 0.0056 0.0184 0.2228
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0129
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0049 0.018
Brugia malayi Dopamine receptor 0.0033 0.0079 0.0292
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.092 0.4116 1
Brugia malayi ORL1-like opioid receptor 0.0033 0.0079 0.0292
Schistosoma mansoni smad 0.0018 0.0014 0.0013
Loa Loa (eye worm) beta-lactamase 0.019 0.0793 0.297
Loa Loa (eye worm) hypothetical protein 0.004 0.0113 0.042
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0019 0.0244
Echinococcus multilocularis allatostatin A receptor 0.0033 0.0079 0.0078
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0024 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0021 0.0052
Loa Loa (eye worm) hypothetical protein 0.0026 0.0049 0.0181
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0085 0.096
Brugia malayi hypothetical protein 0.0023 0.0036 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0044 0.0129 0.048
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0021 0.0052
Brugia malayi Serotonin receptor 0.0033 0.0079 0.0292
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0193
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0053 0.0081
Echinococcus multilocularis ecdysone induced protein 78C 0.0044 0.0129 0.0128
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0215 0.0801
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0021 0.0024 0.0023
Schistosoma mansoni biogenic amine receptor 0.0033 0.0079 0.0078
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Plasmodium falciparum plasmepsin X 0.0056 0.0184 0.4599
Giardia lamblia PHD finger protein 15 0.003 0.0068 0.0142
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0559 0.0557
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0021 0.0052
Trypanosoma cruzi hypothetical protein, conserved 0.019 0.0793 1
Brugia malayi intermediate filament protein 0.0027 0.0054 0.0196
Schistosoma mansoni neuropeptide receptor 0.0033 0.0079 0.0078
Schistosoma mansoni RAR-like nuclear receptor 0.0044 0.0129 0.0128
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Plasmodium falciparum plasmepsin III 0.0056 0.0184 0.4599
Echinococcus multilocularis serotonin receptor 0.0033 0.0079 0.0078
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.061 0.2284
Loa Loa (eye worm) MBCTL1 0.0116 0.046 0.172
Echinococcus granulosus neuropeptides capa receptor 0.0033 0.0079 0.0078
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0022 0.0151
Loa Loa (eye worm) hypothetical protein 0.0056 0.0184 0.0687
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0021 0.0052
Echinococcus granulosus neuropeptide Y receptor 0.0033 0.0079 0.0078
Schistosoma mansoni Smad4 0.0018 0.0014 0.0013
Onchocerca volvulus 0.0073 0.0261 0.1181
Echinococcus granulosus tachykinin peptides receptor 99D 0.0033 0.0079 0.0078
Brugia malayi beta-lactamase family protein 0.019 0.0793 0.297
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0044 0.0129 0.055
Onchocerca volvulus 0.0033 0.0079 0.031
Brugia malayi beta-lactamase 0.019 0.0793 0.297
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Entamoeba histolytica hypothetical protein 0.011 0.0432 0.1007
Onchocerca volvulus 0.0033 0.0079 0.031
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0041 0.0148
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0019 0.0115
Loa Loa (eye worm) hypothetical protein 0.0044 0.0129 0.048
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0053 0.0541
Brugia malayi MH1 domain containing protein 0.0041 0.0117 0.0435
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0068 0.0067
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0053 0.0215
Mycobacterium tuberculosis Probable conserved lipoprotein 0.019 0.0793 0.1442
Leishmania major pyruvate kinase 0.0034 0.0085 0.0957
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0146 0.0144
Schistosoma mansoni amine GPCR 0.0033 0.0079 0.0078
Schistosoma mansoni neuropeptide F-like receptor 0.0033 0.0079 0.0078
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0021 0.0024 0.0023
Brugia malayi Nuclear hormone receptor E75 0.0021 0.0024 0.0086
Schistosoma mansoni ran 0.0022 0.0032 0.0031
Schistosoma mansoni neuropeptide receptor 0.0033 0.0079 0.0078
Onchocerca volvulus 0.0051 0.0164 0.0716
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0044 0.0129 0.0128
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Echinococcus multilocularis peregrin 0.0033 0.0079 0.0078
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0115 0.0425
Loa Loa (eye worm) hypothetical protein 0.003 0.0068 0.0252
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0146 0.0144
Treponema pallidum DNA ligase (lig) 0.002 0.0021 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0044 0.0129 0.048
Echinococcus multilocularis neuropeptides capa receptor 0.0033 0.0079 0.0078
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0021 0.0142
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0053 0.0541
Loa Loa (eye worm) cytochrome P450 0.0017 0.001 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0079 0.0078
Loa Loa (eye worm) hypothetical protein 0.0102 0.0395 0.1478
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0019 0.0018
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0056 0.0184 0.2228
Loa Loa (eye worm) transcription factor SMAD2 0.0602 0.2666 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.092 0.4116 1
Brugia malayi nuclear receptor NHR-67 0.0021 0.0024 0.0086
Brugia malayi hypothetical protein 0.0033 0.0079 0.0292
Schistosoma mansoni pyruvate kinase 0.0017 0.001 0.0009
Echinococcus granulosus Smad4 0.0041 0.0117 0.0116
Entamoeba histolytica hypothetical protein 0.002 0.0021 0.0005
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.061 0.2284
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0079 0.0078
Brugia malayi AKH receptor 0.0033 0.0079 0.0292
Brugia malayi cytochrome P450 0.0017 0.001 0.0034
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0032 0.0279
Onchocerca volvulus 0.0033 0.0079 0.031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0079 0.0078
Trichomonas vaginalis esterase, putative 0.019 0.0793 0.1926
Plasmodium falciparum plasmepsin I 0.0101 0.0389 1
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0021 0.0052
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.0079 0.0078
Schistosoma mansoni hypothetical protein 0.0047 0.0146 0.0144
Schistosoma mansoni chromosome transmission fidelity factor 0.002 0.0021 0.002
Schistosoma mansoni hypothetical protein 0.0265 0.1138 0.1136
Trichomonas vaginalis replication factor C large subunit, putative 0.002 0.0021 0.0052
Brugia malayi G-protein coupled receptor 0.0033 0.0079 0.0292
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0085 0.034
Loa Loa (eye worm) MH2 domain-containing protein 0.0602 0.2666 1
Echinococcus multilocularis 0.0017 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0078 0.0285 0.1063
Echinococcus granulosus intermediate filament protein 0.0027 0.0054 0.0052
Schistosoma mansoni opsin-like receptor 0.0033 0.0079 0.0078
Brugia malayi hypothetical protein 0.002 0.0021 0.0076
Loa Loa (eye worm) MH1 domain-containing protein 0.0041 0.0117 0.0435
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0069 0.0743
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0129 0.048
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0014 0.0048
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0077
Trichomonas vaginalis D-aminoacylase, putative 0.019 0.0793 0.1926
Onchocerca volvulus 0.0033 0.0079 0.031
Mycobacterium tuberculosis Conserved protein 0.019 0.0793 0.1442
Echinococcus multilocularis mothers against decapentaplegic 5 0.0041 0.0117 0.0116
Onchocerca volvulus 0.0033 0.0079 0.031
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Brugia malayi Cytochrome P450 family protein 0.0026 0.0049 0.018
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0085 0.0315
Schistosoma mansoni survival motor neuron protein 0.0049 0.0155 0.0154
Echinococcus granulosus beta LACTamase domain containing family member 0.019 0.0793 0.0791
Brugia malayi hypothetical protein 0.0033 0.0079 0.0292
Schistosoma mansoni ap endonuclease 0.0019 0.0019 0.0018
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0033 0.0079 0.0078
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0021 0.0052
Plasmodium vivax plasmepsin V, putative 0.0056 0.0184 0.2228
Schistosoma mansoni cpg binding protein 0.0033 0.0082 0.0081
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0086
Echinococcus multilocularis neuropeptide receptor 0.0033 0.0079 0.0078
Echinococcus granulosus histone acetyltransferase MYST2 0.0116 0.046 0.0458
Echinococcus multilocularis lamin dm0 0.0027 0.0054 0.0052
Loa Loa (eye worm) hypothetical protein 0.0102 0.0395 0.1479
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0208 0.2528
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0044 0.0129 0.048
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0139
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0292
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0033 0.0079 0.0078
Schistosoma mansoni neuropeptide receptor 0.0033 0.0079 0.0078
Leishmania major importin beta-1 subunit, putative 0.0025 0.0042 0.0411
Plasmodium falciparum replication factor C subunit 1, putative 0.002 0.0021 0.0301
Echinococcus multilocularis chromobox protein 1 0.0072 0.0256 0.0255
Echinococcus multilocularis thyroid hormone receptor alpha 0.0309 0.1336 0.1335
Brugia malayi aspartic protease BmAsp-1, identical 0.0056 0.0184 0.0687
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0022 0.006
Echinococcus granulosus 7TM GPCR rhodopsin 0.0033 0.0079 0.0078
Loa Loa (eye worm) hypothetical protein 0.0044 0.0132 0.0489
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0323 0.14 0.525
Loa Loa (eye worm) hypothetical protein 0.004 0.0114 0.0424
Schistosoma mansoni smad1 5 8 and 0.0041 0.0117 0.0116
Echinococcus multilocularis g protein coupled receptor 0.0033 0.0079 0.0078
Echinococcus multilocularis histone acetyltransferase MYST2 0.0116 0.046 0.0458
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0021 0.0024 0.0086
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0053 0.0215
Brugia malayi hypothetical protein 0.0033 0.0079 0.0292
Echinococcus granulosus pyruvate kinase 0.0034 0.0085 0.0084
Leishmania major hypothetical protein, conserved 0.0026 0.0049 0.05
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0019 0.0115
Schistosoma mansoni smad1 5 8 and 0.0041 0.0117 0.0116

Activities

Activity type Activity value Assay description Source Reference
permeability (ADMET) = 15 % Permeability across brain in Tg2576 mouse at 100 mg/kg, po ChEMBL. 20880704

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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