Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | cytidine deaminase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.7807 | 0.9912 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.1873 | 0.2314 | 0.2335 |
Brugia malayi | hypothetical protein | 0.1873 | 0.2314 | 0.2314 |
Loa Loa (eye worm) | thymidylate synthase | 0.3936 | 0.4956 | 0.4923 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.7807 | 0.9912 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0159 | 0.0121 | 0.0055 |
Echinococcus multilocularis | thymidylate synthase | 0.3936 | 0.4956 | 0.4956 |
Brugia malayi | thymidylate synthase | 0.3936 | 0.4956 | 0.4956 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.3936 | 0.4956 | 0.4956 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1873 | 0.2314 | 1 |
Onchocerca volvulus | 0.3936 | 0.4956 | 1 | |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.7807 | 0.9912 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.3936 | 0.4956 | 0.4956 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.7807 | 0.9912 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.7807 | 0.9912 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.7807 | 0.9912 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0159 | 0.0121 | 0.0121 |
Mycobacterium tuberculosis | Hypothetical protein | 0.1873 | 0.2314 | 0.2314 |
Mycobacterium ulcerans | thymidylate synthase | 0.3936 | 0.4956 | 0.4956 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.0066 | 0.0066 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0159 | 0.0121 | 0.0121 |
Onchocerca volvulus | 0.0092 | 0.0035 | 0.0071 | |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.3936 | 0.4956 | 0.4956 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0159 | 0.0121 | 0.0121 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0159 | 0.0121 | 0.0121 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3936 | 0.4956 | 0.4909 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.000004 M | Compound was tested for the inhibitory constant for mouse kidney cytidine deaminase | ChEMBL. | 3735306 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.