Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0093 | 0.222 | 1 | |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0057 | 0.1191 | 0.1558 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0042 | 0.0785 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0042 | 0.0785 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.1191 | 0.0795 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.043 | 0.0581 |
Echinococcus multilocularis | lamin dm0 | 0.003 | 0.043 | 0.043 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0093 | 0.222 | 0.2955 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0042 | 0.0785 | 1 |
Brugia malayi | intermediate filament protein | 0.003 | 0.043 | 0.0524 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0093 | 0.222 | 0.222 |
Brugia malayi | hypothetical protein | 0.0277 | 0.7407 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0042 | 0.0785 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0042 | 0.0785 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0042 | 0.0785 | 0.1059 |
Mycobacterium leprae | conserved hypothetical protein | 0.0026 | 0.0336 | 0.5 |
Echinococcus granulosus | lamin | 0.003 | 0.043 | 0.043 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.3659 | 0.494 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0277 | 0.7407 | 0.7407 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 0.043 | 0.043 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0044 | 0.006 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0042 | 0.0785 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.7407 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.3659 | 0.494 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0093 | 0.222 | 0.187 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.3659 | 0.4909 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.222 | 0.2997 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0042 | 0.0785 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0042 | 0.0785 | 0.1006 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0042 | 0.0785 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0042 | 0.0785 | 0.037 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0093 | 0.222 | 0.222 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.043 | 0.0581 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0415 | 0.056 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0042 | 0.0785 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.043 | 0.0524 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.043 | 0.0581 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0042 | 0.0785 | 0.0785 |
Onchocerca volvulus | 0.0057 | 0.1191 | 0.4253 | |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0042 | 0.0785 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0042 | 0.0785 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0042 | 0.0785 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0042 | 0.0785 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0042 | 0.0785 | 0.037 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0026 | 0.0336 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0042 | 0.0785 | 1 |
Echinococcus multilocularis | lamin | 0.003 | 0.043 | 0.043 |
Echinococcus granulosus | lamin dm0 | 0.003 | 0.043 | 0.043 |
Echinococcus multilocularis | musashi | 0.003 | 0.043 | 0.043 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0042 | 0.0785 | 0.0785 |
Toxoplasma gondii | exonuclease III APE | 0.0042 | 0.0785 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0057 | 0.1191 | 0.0795 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0277 | 0.7407 | 0.7407 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 54 um | PUBCHEM_BIOASSAY: Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors. (Class of assay: confirmatory) [Related pubchem assays: 1022 (Primary screen preceding this dose-response assay.)] | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 20.7865 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.