Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | TAR-binding protein | 0.0076 | 0.3216 | 0.5049 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 0.637 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.2655 | 0.4168 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1412 | 0.1412 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1412 | 0.1412 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.2655 | 0.2655 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3216 | 0.5049 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3216 | 0.3216 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1412 | 0.1412 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3216 | 0.3216 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0069 | 0.2655 | 0.4168 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.1412 | 0.2216 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1412 | 0.1412 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3216 | 0.3216 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1412 | 0.1412 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.01 | 0.4942 | 0.7759 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3216 | 0.3216 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.4942 | 0.7759 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.01 | 0.4942 | 0.7759 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3216 | 0.3216 |
Brugia malayi | MH2 domain containing protein | 0.012 | 0.637 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.01 | 0.4942 | 0.7759 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3216 | 0.3216 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3216 | 0.5049 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1412 | 0.1412 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 0.637 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3216 | 0.5049 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3216 | 0.5049 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1412 | 0.1412 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3216 | 0.5049 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3216 | 0.3216 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.1412 | 0.2216 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.7865 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.