Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bacillus subtilis (strain 168) | ATP-dependent Clp protease proteolytic subunit | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Probable ClpP-like protease | 0.0094 | 0.2651 | 0.2838 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0609 | 0.0652 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.2651 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0609 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0609 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.0609 | 0.5 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0609 | 0.5 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0062 | 0.1347 | 0.2674 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0094 | 0.2651 | 1 |
Onchocerca volvulus | 0.0043 | 0.0609 | 0.5 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0609 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0033 | 0.017 | 0.0643 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.2651 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0609 | 0.0652 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0094 | 0.2651 | 0.7397 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0062 | 0.1347 | 0.0786 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0609 | 0.0652 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0609 | 0.0652 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0094 | 0.2651 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0609 | 0.0652 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0609 | 0.0652 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0609 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0112 | 0.337 | 1 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0609 | 0.0652 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.0609 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.0609 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0261 | 0.9343 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.0609 | 0.2297 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0609 | 0.0652 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.2651 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.2651 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0112 | 0.337 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.2651 | 0.2838 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0062 | 0.1347 | 0.4744 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0609 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0609 | 0.0652 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0609 | 0.0652 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0261 | 0.9343 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0094 | 0.2651 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0112 | 0.337 | 0.5 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0033 | 0.017 | 0.0643 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0094 | 0.2651 | 0.7397 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.2651 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0094 | 0.2651 | 0.7397 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0033 | 0.017 | 0.0643 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0609 | 0.0652 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0094 | 0.2651 | 1 |
Onchocerca volvulus | 0.0043 | 0.0609 | 0.5 | |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.0609 | 0.1768 |
Brugia malayi | MH2 domain containing protein | 0.0261 | 0.9343 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.2651 | 0.5 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0062 | 0.1347 | 0.0786 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0609 | 0.0652 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.2651 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0609 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0112 | 0.337 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0112 | 0.337 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.337 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0112 | 0.337 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0112 | 0.337 | 1 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0062 | 0.1347 | 0.2674 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.0609 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.0609 | 0.2297 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.0609 | 0.1768 |
Brugia malayi | hypothetical protein | 0.0112 | 0.337 | 0.3607 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 4.4668 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.