Detailed information for compound 1285654

Basic information

Technical information
  • TDR Targets ID: 1285654
  • Name: 3-cyclohexyl-1-(phenylmethyl)-1-propan-2-ylth iourea
  • MW: 290.467 | Formula: C17H26N2S
  • H donors: 0 H acceptors: 0 LogP: 4.49 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(N(C(=NC1CCCCC1)S)Cc1ccccc1)C
  • InChi: 1S/C17H26N2S/c1-14(2)19(13-15-9-5-3-6-10-15)17(20)18-16-11-7-4-8-12-16/h3,5-6,9-10,14,16H,4,7-8,11-13H2,1-2H3,(H,18,20)
  • InChiKey: VGUZGFGEFYFGFT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-cyclohexyl-1-isopropyl-1-(phenylmethyl)thiourea
  • 1-(benzyl)-3-cyclohexyl-1-isopropyl-thiourea
  • 3-cyclohexyl-1-(phenylmethyl)-1-propan-2-yl-thiourea
  • A3305/0140438
  • ZINC00110449
  • MLS001033857
  • SMR000385743

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.002 0.0063 0.0063
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0049 0.0502 0.0787
Trypanosoma cruzi phosphomannose isomerase, putative 0.0192 0.2667 0.4186
Leishmania major phosphomannomutase, putative 0.0043 0.0404 0.0634
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.4095 0.5077
Plasmodium falciparum hexokinase 0.024 0.3403 0.5138
Plasmodium falciparum mannose-6-phosphate isomerase, putative 0.0192 0.2667 0.4027
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0497 0.0616
Echinococcus multilocularis heat shock protein 90 0.0038 0.0339 0.0339
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.0339 0.0532
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0092 0.0092
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0737 0.178
Trypanosoma brucei heat shock protein, putative 0.0045 0.0437 0.0686
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0192 0.2667 0.3306
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0991 0.0991
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0169 0.2327 0.2327
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0092 0.0092
Echinococcus granulosus zinc finger protein 0.0023 0.01 0.01
Entamoeba histolytica hypothetical protein 0.0043 0.0416 0.0995
Leishmania major heat shock protein 83-1 0.0045 0.0437 0.0686
Toxoplasma gondii heat shock protein 90, putative 0.0045 0.0437 0.066
Schistosoma mansoni rab6-interacting 0.0039 0.0342 0.0342
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0276 0.0342
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0049 0.0502 0.0622
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0104 0.0157
Brugia malayi PHD-finger family protein 0.0028 0.0179 0.0222
Trypanosoma brucei hexokinase 0.024 0.3403 0.5342
Treponema pallidum heat shock protein 90 0.0042 0.0395 0.062
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0152 0.023
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0092 0.0114
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0459 0.121
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0193 0.0291
Plasmodium vivax endoplasmin, putative 0.0045 0.0437 0.066
Trypanosoma cruzi hexokinase, putative 0.024 0.3403 0.5342
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0092 0.0092
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0193 0.0291
Echinococcus granulosus RUN 0.0039 0.0342 0.0342
Brugia malayi Hexokinase family protein 0.0074 0.0885 0.1097
Mycobacterium ulcerans mannose-6-phosphate isomerase ManA 0.0192 0.2667 0.3306
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0193 0.0291
Loa Loa (eye worm) endoplasmin 0.0045 0.0437 0.0531
Trypanosoma cruzi phosphomannose isomerase, putative 0.0192 0.2667 0.4186
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0128 0.1693 0.4466
Echinococcus multilocularis caspase 0.0097 0.123 0.123
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0092 0.0092
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0092 0.0092
Brugia malayi Thioredoxin reductase 0.0046 0.0459 0.0569
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0281 0.0281
Echinococcus granulosus neuropeptide receptor A26 0.0453 0.6621 0.6621
Brugia malayi jmjC domain containing protein 0.0093 0.1174 0.1456
Loa Loa (eye worm) hypothetical protein 0.0022 0.0092 0.0103
Leishmania major hypothetical protein, conserved 0.0107 0.1386 0.2175
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0459 0.0459
Leishmania major hexokinase, putative 0.024 0.3403 0.5342
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0128 0.1693 0.902
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.02 0.0302
Entamoeba histolytica phosphomannomutase, putative 0.0043 0.0404 0.0966
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0092 0.0092
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0148 0.2 0.247
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0453 0.6623 0.8211
Leishmania major phosphomannose isomerase 0.0192 0.2667 0.4186
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0263 0.0326
Entamoeba histolytica mannose-6-phosphate isomerase, putative 0.0088 0.1089 0.2643
Schistosoma mansoni polycystin 1-related 0.0039 0.0342 0.0342
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0192 0.2667 0.3306
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0453 0.0453
Echinococcus multilocularis peregrin 0.0034 0.0277 0.0277
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0017 0.0009 0.0011
Leishmania major heat shock protein 83-1 0.0045 0.0437 0.0686
Brugia malayi steroid hormone receptor 0.0022 0.0092 0.0114
Chlamydia trachomatis 6-phosphogluconolactonase 0.0017 0.0009 0.0014
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0436 0.6371 0.6371
Loa Loa (eye worm) hypothetical protein 0.0076 0.0916 0.1126
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0109 0.0135
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.1174 0.1174
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0209 0.0209
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0497 0.0616
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0189 0.2628 0.325
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0285 0.4077 0.6155
Leishmania major heat shock protein 83-1 0.0045 0.0437 0.0686
Toxoplasma gondii phosphomannose isomerase type I protein 0.0192 0.2667 0.4027
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0092 0.0092
Brugia malayi Cell death protein 3 precursor 0.0026 0.0151 0.0187
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.1536 0.8181
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0991 0.1228
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0359 0.0359
Echinococcus multilocularis zinc finger protein 0.0023 0.01 0.01
Echinococcus multilocularis hexokinase 0.024 0.3403 0.3403
Trypanosoma cruzi metacaspase, putative 0.0026 0.0151 0.0237
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0151 0.0187
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.1358 0.3582
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0883 0.0883
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0497 0.0605
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0193 0.0291
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.019 0.0224
Echinococcus multilocularis endoplasmin 0.0042 0.0395 0.0395
Echinococcus multilocularis citrate lyase subunit beta protein 0.0049 0.0502 0.0502
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0436 0.6371 1
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.137 0.137
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0092 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0151 0.0187
Trypanosoma cruzi polo-like protein kinase, putative 0.0189 0.2628 0.4125
Plasmodium vivax heat shock protein 90, putative 0.003 0.0209 0.0315
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.4095 0.5077
Mycobacterium tuberculosis Probable reductase 0.0106 0.1358 0.3582
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0104 0.0163
Brugia malayi serine/threonine-protein kinase plk-2 0.0189 0.2628 0.3258
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0276 0.0342
Brugia malayi Hexokinase family protein 0.0151 0.2044 0.2534
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0092 0.0103
Echinococcus granulosus jumonji domain containing protein 0.004 0.0359 0.0359
Treponema pallidum hexokinase (hxk) 0.024 0.3403 0.5342
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0416 0.0416
Trypanosoma brucei hypothetical protein, conserved 0.0426 0.6224 0.9769
Trypanosoma brucei heat shock protein 84, putative 0.003 0.0209 0.0327
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.029 0.029
Plasmodium falciparum heat shock protein 90, putative 0.017 0.2335 0.3525
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0092 0.0092
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.2628 0.3258
Schistosoma mansoni coup transcription factor 0.0022 0.0092 0.0092
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0437 0.1047
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0696 0.0696
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0092 0.0092
Schistosoma mansoni heat shock protein 0.0045 0.0437 0.0437
Toxoplasma gondii thioredoxin reductase 0.0046 0.0459 0.0692
Trypanosoma brucei glucosamine-6-phosphate isomerase, putative 0.0017 0.0009 0.0014
Leishmania major heat shock protein 83-1 0.0045 0.0437 0.0686
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.137 0.2151
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0437 0.0686
Schistosoma mansoni 6-phosphogluconolactonase 0.0017 0.0009 0.0009
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0658 0.0658
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0144 0.1948 0.3058
Onchocerca volvulus 0.0039 0.0342 0.0756
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0658 0.0658
Leishmania major heat shock protein 83-1 0.0045 0.0437 0.0686
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0151 0.0187
Schistosoma mansoni serine/threonine protein kinase 0.0189 0.2628 0.2628
Loa Loa (eye worm) glutaminase 0.0548 0.8067 1
Echinococcus granulosus caspase 0.0097 0.123 0.123
Brugia malayi Endoplasmin precursor 0.0045 0.0437 0.0542
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0658 0.1033
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0104 0.0163
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.019 0.0286
Brugia malayi MH2 domain containing protein 0.0117 0.1529 0.1895
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0436 0.6371 1
Plasmodium vivax hypothetical protein, conserved 0.0029 0.019 0.0286
Loa Loa (eye worm) hypothetical protein 0.0022 0.0092 0.0103
Brugia malayi Bromodomain containing protein 0.0034 0.0277 0.0344
Echinococcus multilocularis neuropeptide s receptor 0.0453 0.6621 0.6621
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0005 0.0014
Trypanosoma cruzi Putative Phosphatase/Protein of unknown function DUF89, putative 0.0107 0.1386 0.2175
Echinococcus multilocularis hexokinase type 2 0.024 0.3403 0.3403
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.137 0.3331
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0453 0.6623 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0005 0.0014
Brugia malayi hexokinase 0.024 0.3403 0.4219
Trichomonas vaginalis glutaminase, putative 0.0548 0.8067 1
Plasmodium vivax hexokinase, putative 0.024 0.3403 0.5138
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.137 0.1689
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0092 0.0092
Trypanosoma brucei phosphomannose isomerase 0.0192 0.2667 0.4186
Schistosoma mansoni 6-phosphogluconolactonase 0.0017 0.0009 0.0009
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0309 0.0372
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0092 0.0103
Trypanosoma cruzi Putative Phosphatase/Protein of unknown function DUF89, putative 0.0107 0.1386 0.2175
Schistosoma mansoni transcription factor btf3 0.0034 0.0276 0.0276
Brugia malayi hexokinase type II 0.0076 0.0916 0.1136
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0337 0.0508
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0151 0.0187
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0104 0.0157
Onchocerca volvulus 0.024 0.3403 1
Plasmodium falciparum glutathione reductase 0.0046 0.0459 0.0692
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.2846 0.3521
Brugia malayi Pre-SET motif family protein 0.0204 0.2846 0.3528
Schistosoma mansoni hypothetical protein 0.0166 0.2272 0.2272
Schistosoma mansoni glucosamine-6-phosphate isomerase 0.0017 0.0009 0.0009
Echinococcus multilocularis RUN 0.0039 0.0342 0.0342
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0459 0.0558
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.137 0.2151
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0151 0.0228
Schistosoma mansoni mannose-6-phosphate isomerase 0.0192 0.2667 0.2667
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0092 0.0092
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0342 0.0342
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0193 0.0302
Leishmania major heat shock protein 83-1 0.0045 0.0437 0.0686
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.137 0.2151
Schistosoma mansoni glutaminase 0.0548 0.8067 0.8067
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0193 0.0449
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.137 0.1689
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0193 0.0291
Echinococcus multilocularis hexokinase 0.024 0.3403 0.3403
Echinococcus multilocularis phosphomannomutase 0.0043 0.0404 0.0404
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0151 0.0228
Giardia lamblia Grp94/Hsp90 0.0042 0.0395 0.0597
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.0342 0.0517
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0151 0.0187
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0453 0.6623 0.8211
Loa Loa (eye worm) hypothetical protein 0.0022 0.0092 0.0103
Entamoeba histolytica hypothetical protein 0.0034 0.0276 0.0652
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0097 0.123 0.123
Loa Loa (eye worm) hypothetical protein 0.0045 0.0443 0.0538
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0092 0.0114
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0013
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0276 0.0433
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0005 0.0014
Plasmodium falciparum thioredoxin reductase 0.0046 0.0459 0.0692
Brugia malayi 6-phosphofructokinase 0.0106 0.137 0.1699
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0991 0.0991
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0109 0.0244
Trypanosoma brucei polo-like protein kinase 0.0189 0.2628 0.4125
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0169 0.2327 0.2327
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0076 0.0916 0.1126
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0109 0.0135
Leishmania major glucosamine-6-phosphate isomerase, putative 0.0017 0.0009 0.0014
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0189 0.2628 0.4125
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0192 0.2667 0.3299
Loa Loa (eye worm) glutathione reductase 0.0046 0.0459 0.0558
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0309 0.0309
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0092 0.0103
Echinococcus granulosus hexokinase type 2 0.024 0.3403 0.3403
Brugia malayi Pre-SET motif family protein 0.0029 0.02 0.0248
Plasmodium vivax glutathione reductase, putative 0.0046 0.0459 0.0692
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0276 0.0342
Echinococcus granulosus geminin 0.0166 0.2272 0.2272
Trypanosoma brucei Metacaspase-4 0.0026 0.0151 0.0237
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.137 0.1699
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0092 0.0103
Trypanosoma cruzi hexokinase, putative 0.024 0.3403 0.5342
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0109 0.0135
Plasmodium vivax metacaspase 1, putative 0.0026 0.0151 0.0228
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.0342 0.0517
Plasmodium falciparum phosphomannomutase, putative 0.0043 0.0404 0.061
Plasmodium falciparum endoplasmin, putative 0.0033 0.025 0.0378
Trypanosoma brucei metacaspase MCA3 0.0026 0.0151 0.0237
Echinococcus granulosus heat shock protein 90 0.0038 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0013
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0309 0.0309
Brugia malayi glutaminase DH11.1 0.0548 0.8067 1
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1178 0.1461
Plasmodium vivax mannose-6-phosphate isomerase, putative 0.0192 0.2667 0.4027
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0193 0.0291
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0266 0.3791 0.4699
Echinococcus multilocularis hexokinase 0.024 0.3403 0.3403
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0416 0.0416
Mycobacterium ulcerans hypothetical protein 0.0023 0.0109 0.0135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0092 0.0103
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0453 0.6623 1
Trypanosoma brucei phosphomannomutase 0.0043 0.0404 0.0634
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0092 0.0103
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0425 0.0641
Trichomonas vaginalis set domain proteins, putative 0.0232 0.3273 0.4057
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0151 0.0187
Schistosoma mansoni rab6-interacting 0.0039 0.0342 0.0342
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0151 0.0228
Loa Loa (eye worm) hypothetical protein 0.0026 0.0151 0.0176
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0013
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0425 0.0425
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0017 0.0009 0.0014
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0026 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0039 0.0342 0.0413
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0091 0.0091
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0342 0.0342
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0737 0.0737
Trypanosoma brucei heat shock protein, putative 0.0045 0.0437 0.0686
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0109 0.0287
Leishmania major metacaspase, putative 0.0026 0.0151 0.0237
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0436 0.6371 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0092 0.0103
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0042 0.0065
Toxoplasma gondii Hsp90 domain-containing protein 0.017 0.2335 0.3525
Schistosoma mansoni caspase-3 (C14 family) 0.0097 0.123 0.123
Entamoeba histolytica hexokinase 2 0.024 0.3403 0.8307
Giardia lamblia Heat shock protein HSP 90-alpha 0.0045 0.0437 0.066
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0342 0.0342
Toxoplasma gondii hexokinase 0.024 0.3403 0.5138
Schistosoma mansoni caspase-7 (C14 family) 0.0026 0.0151 0.0151
Entamoeba histolytica phosphomannose isomerase, putative 0.0192 0.2667 0.6505
Trypanosoma brucei Heat shock protein 83, putative 0.0045 0.0437 0.0686
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0193 0.0291
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.002 0.0024
Loa Loa (eye worm) heat shock protein 75 0.003 0.0209 0.0248
Loa Loa (eye worm) phosphomannomutase 2 0.0043 0.0404 0.049
Loa Loa (eye worm) heat shock protein 90 0.0045 0.0437 0.0531
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0184 0.0184
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.2628 0.3258
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.1848 0.1848
Mycobacterium tuberculosis Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho 0.0104 0.1334 0.352
Loa Loa (eye worm) hypothetical protein 0.0033 0.0263 0.0315
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0658 0.0658
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0042 0.0395 0.062
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0151 0.0187
Loa Loa (eye worm) hexokinase type II 0.024 0.3403 0.4212
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.1174 0.1174
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0109 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0092 0.0114
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.4095 0.5077
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.1358 0.3582
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0737 0.0913
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0109 0.0244
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0437 0.0686
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.02 0.02
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0092 0.0092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.02 0.02
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0189 0.2628 0.2628
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0151 0.0187
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0017 0.0009 0.0014
Mycobacterium ulcerans heat shock protein 90 0.0042 0.0395 0.049
Leishmania major heat shock protein 83-1 0.0045 0.0437 0.0686
Trypanosoma brucei heat shock protein, putative 0.0045 0.0437 0.0686
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.4095 0.5077
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0193 0.0239
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0425 0.0641
Brugia malayi hypothetical protein 0.0043 0.0416 0.0515
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0092 0.0092
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0737 0.0737
Trypanosoma cruzi Heat shock protein 83, putative 0.0045 0.0437 0.0686
Trypanosoma brucei heat shock protein, putative 0.0045 0.0437 0.0686
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0425 0.0641
Giardia lamblia Glucosamine-6-phosphate deaminase 0.0017 0.0009 0.0014
Loa Loa (eye worm) hypothetical protein 0.0022 0.0092 0.0103
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0658 0.0658
Brugia malayi hypothetical protein 0.0039 0.0342 0.0424
Echinococcus granulosus mannose 6 phosphate isomerase 0.0192 0.2667 0.2667
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0092 0.0092
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.001 0.001
Echinococcus granulosus citrate lyase subunit beta protein 0.0049 0.0502 0.0502
Mycobacterium ulcerans hypothetical protein 0.0049 0.0502 0.0622
Plasmodium falciparum metacaspase 1 0.0026 0.0151 0.0228
Trypanosoma cruzi metacaspase, putative 0.0026 0.0151 0.0237
Echinococcus granulosus caspase 8 0.0026 0.0151 0.0151
Entamoeba histolytica hypothetical protein 0.0043 0.0416 0.0995
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1178 0.1461
Plasmodium falciparum metacaspase-like protein 0.0026 0.0151 0.0228
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0436 0.6371 0.7898
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0453 0.6623 1
Echinococcus multilocularis transcription factor btf3 0.0034 0.0276 0.0276
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0425 0.0526
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0022 0.0092 0.0103
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.1876 0.2326
Leishmania major basic transcription factor 3a, putative 0.0034 0.0276 0.0433
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.4095 1
Brugia malayi Doublecortin family protein 0.0039 0.0342 0.0424
Schistosoma mansoni zinc finger protein 0.0023 0.01 0.01
Echinococcus granulosus neuropeptide s receptor 0.0453 0.6621 0.6621
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.137 0.1699
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0091 0.0091
Onchocerca volvulus Serine\/threonine kinase homolog 0.0189 0.2628 0.766
Loa Loa (eye worm) hypothetical protein 0.0038 0.0326 0.0394
Loa Loa (eye worm) hypothetical protein 0.0023 0.0109 0.0124
Plasmodium vivax SET domain protein, putative 0.0029 0.02 0.0302
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0092 0.0114
Entamoeba histolytica hexokinase 1 0.024 0.3403 0.8307
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.1536 0.4053
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0092 0.0092
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0658 0.0816
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0109 0.0171
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0193 0.0239
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0092 0.0092
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0017 0.0009 0.0014
Trypanosoma brucei metacaspase MCA2 0.0026 0.0151 0.0237
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0395 0.049
Loa Loa (eye worm) glutaminase 2 0.0548 0.8067 1
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0342 0.0342
Trypanosoma cruzi hypothetical protein, conserved 0.0426 0.6224 0.9769
Trichomonas vaginalis heat shock protein, putative 0.0033 0.025 0.031
Giardia lamblia Glucosamine-6-phosphate deaminase 0.0017 0.0009 0.0014
Leishmania major hexokinase, putative 0.024 0.3403 0.5342
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0459 0.0692
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.001 0.001
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0092 0.0092
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0092 0.0114
Echinococcus multilocularis caspase 2 0.0026 0.0151 0.0151
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.137 0.137
Onchocerca volvulus Alhambra homolog 0.0029 0.019 0.0295
Brugia malayi ecdysteroid receptor 0.0022 0.0092 0.0114
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.014 0.1885 0.2959
Loa Loa (eye worm) hypothetical protein 0.0049 0.0499 0.0608
Loa Loa (eye worm) hypothetical protein 0.0022 0.0092 0.0103
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.137 0.1699
Echinococcus granulosus endoplasmin 0.0042 0.0395 0.0395
Schistosoma mansoni heat shock protein 0.003 0.0209 0.0209
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0092 0.0114
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0017 0.0009 0.0014
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0276 0.0416
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.0209 0.0488
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.137 0.7291
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0416 0.0416
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.1943 0.2409
Treponema pallidum fructose-bisphosphate aldolase 0.0286 0.4095 0.6428
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0658 0.1736
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.4095 0.5077
Leishmania major heat shock protein 83-1 0.0045 0.0437 0.0686
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.2628 0.3258
Brugia malayi nuclear receptor NHR-88 0.0022 0.0092 0.0114
Brugia malayi PHD-finger family protein 0.0029 0.019 0.0235
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0337 0.0508
Plasmodium falciparum phd finger protein, putative 0.0029 0.019 0.0286
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0309 0.0309
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0049 0.0502 0.0622
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0152 0.0189
Schistosoma mansoni hexokinase 0.024 0.3403 0.3403
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0193 0.0302
Leishmania major heat shock protein, putative 0.003 0.0209 0.0327
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.019 0.019
Brugia malayi Bromodomain containing protein 0.0041 0.0378 0.0469
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0151 0.0237
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0436 0.6371 0.6371
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.019 0.0286
Leishmania major heat shock protein 83-1 0.0045 0.0437 0.0686
Onchocerca volvulus Putative phosphomannomutase 0.0043 0.0404 0.0943
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.065 0.0796
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.1876 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0092 0.0114
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0092 0.0092
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0092 0.0092
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.137 0.3331
Loa Loa (eye worm) hypothetical protein 0.0023 0.0109 0.0124
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0342 0.0413
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.1358 0.3582
Loa Loa (eye worm) hypothetical protein 0.0023 0.0109 0.0124
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0151 0.0228
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0193 0.0291
Trypanosoma brucei metacaspase 5, putative 0.0026 0.0151 0.0237
Loa Loa (eye worm) hypothetical protein 0.0026 0.0151 0.0176
Loa Loa (eye worm) phosphofructokinase 0.0106 0.137 0.1689
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0046 0.0453 0.0551
Loa Loa (eye worm) hypothetical protein 0.0043 0.0414 0.0503
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0109 0.0135
Toxoplasma gondii phosphomannomutase 0.0043 0.0404 0.061
Loa Loa (eye worm) hexokinase 0.024 0.3403 0.4212
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.002 0.0031
Schistosoma mansoni heat shock protein 0.0045 0.0437 0.0437
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0104 0.0129
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0658 0.0816
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0013
Schistosoma mansoni hypothetical protein 0.0029 0.019 0.019
Schistosoma mansoni hypothetical protein 0.0039 0.0342 0.0342
Trichomonas vaginalis heat shock protein, putative 0.0038 0.0339 0.042
Echinococcus granulosus hexokinase 0.024 0.3403 0.3403
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0453 0.6623 0.8211
Leishmania major 6-phosphogluconolactonase 0.0017 0.0009 0.0014
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.02 0.02
Trypanosoma brucei heat shock protein, putative 0.0045 0.0437 0.0686
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.1358 0.3582
Echinococcus granulosus peregrin 0.0034 0.0277 0.0277
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0049 0.0502 0.0622
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0276 0.0416
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.1358 0.7224
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0151 0.0187
Echinococcus granulosus heat shock protein 90 0.0045 0.0437 0.0437
Brugia malayi beta-NAC-like protein 0.0034 0.0276 0.0342
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.019 0.019
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.001 0.001
Trypanosoma cruzi metacaspase, putative 0.0026 0.0151 0.0237
Loa Loa (eye worm) hypothetical protein 0.0022 0.0092 0.0103
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0437 0.1047
Brugia malayi Hexokinase family protein 0.024 0.3403 0.4219
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0151 0.0187
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0151 0.2051 0.5411
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0151 0.0187
Echinococcus multilocularis 6 phosphogluconolactonase 0.0017 0.0009 0.0009
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0193 0.0239
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0092 0.0092
Brugia malayi nuclear hormone receptor 0.0022 0.0092 0.0114
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.137 0.3331
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0436 0.6371 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0342 0.0342
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0104 0.2629
Schistosoma mansoni loxhd1 0.0039 0.0342 0.0342
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0209 0.0209
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0276 0.0433
Onchocerca volvulus 0.0081 0.0991 0.2715
Leishmania major trypanothione reductase 0.0046 0.0459 0.072
Loa Loa (eye worm) hexokinase 0.0151 0.2044 0.2526
Schistosoma mansoni hypothetical protein 0.0033 0.0263 0.0263
Trypanosoma cruzi polo-like protein kinase, putative 0.0189 0.2628 0.4125
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0276 0.0416
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0193 0.0302
Trichomonas vaginalis phosphomannomutase, putative 0.0043 0.0404 0.0501
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0049 0.0502 0.0787
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0151 0.0187
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0092 0.0092
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.002 0.003
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0436 0.6371 0.7896
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0342 0.0342
Echinococcus granulosus 6 phosphogluconolactonase 0.0017 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0069 0.0807 0.099
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0339 0.0532
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0436 0.6371 1
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0092 0.0092
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0104 0.0507
Mycobacterium leprae probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO 0.0104 0.1334 0.7099
Loa Loa (eye worm) hypothetical protein 0.0039 0.0342 0.0413
Leishmania major heat shock protein 83-1 0.0045 0.0437 0.0686
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0437 0.0686
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0109 0.0287
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0097 0.123 0.123
Echinococcus multilocularis caspase 3 0.0071 0.0836 0.0836
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.1943 0.1943
Leishmania major heat shock protein 83-1 0.0045 0.0437 0.0686
Trichomonas vaginalis mannose-6-phosphate isomerase, putative 0.0192 0.2667 0.3306
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.2628 0.3258
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.029 0.029
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0459 0.0459
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0276 0.0652
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0104 0.0163
Mycobacterium ulcerans lipoprotein LpqF 0.0128 0.1693 0.2099
Mycobacterium ulcerans hypothetical protein 0.0049 0.0502 0.0622
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.2628 0.3258
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0737 0.0737
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.4095 0.5077
Schistosoma mansoni hypothetical protein 0.0166 0.2272 0.2272
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.4095 0.5077
Brugia malayi glutathione reductase 0.0046 0.0459 0.0569
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0425 0.0526
Trypanosoma cruzi heat shock protein 90, putative 0.0045 0.0437 0.0686
Onchocerca volvulus 0.0232 0.3273 0.9606
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0459 0.072
Loa Loa (eye worm) hypothetical protein 0.0164 0.2244 0.2773
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0092 0.0114
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0109 0.0135
Plasmodium vivax heat shock protein, putative 0.017 0.2335 0.3525
Plasmodium falciparum heat shock protein 90 0.0045 0.0437 0.066
Echinococcus multilocularis heat shock protein 0.0045 0.0437 0.0437
Leishmania major hypothetical protein, conserved 0.0426 0.6224 0.9769
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.137 0.1699
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.137 0.1699
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.137 0.137
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0276 0.0433
Trichomonas vaginalis endoplasmin, putative 0.0033 0.025 0.031
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.001 0.001
Onchocerca volvulus 0.0151 0.2044 0.5896
Echinococcus granulosus hexokinase 0.024 0.3403 0.3403
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.002 0.0052
Brugia malayi 6-phosphofructokinase 0.0106 0.137 0.1699
Entamoeba histolytica hypothetical protein 0.0043 0.0416 0.0995
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.4095 0.5077
Echinococcus granulosus caspase 3 0.0071 0.0836 0.0836
Plasmodium vivax phosphomannomutase, putative 0.0043 0.0404 0.061
Echinococcus multilocularis mannose 6 phosphate isomerase 0.0192 0.2667 0.2667
Trypanosoma brucei hexokinase 0.024 0.3403 0.5342
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0737 0.1156
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0658 0.0816
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0453 0.0453
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0049 0.0502 0.1323
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0092 0.0114
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0285 0.4077 0.5054
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1529 0.1886
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1529 0.1886
Leishmania major heat shock protein 83-1 0.0045 0.0437 0.0686
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0192 0.2667 0.3299
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0092 0.0103
Echinococcus multilocularis caspase 8 0.0026 0.0151 0.0151
Toxoplasma gondii heat shock protein HSP90 0.0045 0.0437 0.066
Echinococcus multilocularis neuropeptide receptor A26 0.0453 0.6621 0.6621
Leishmania major heat shock protein 83-1 0.0045 0.0437 0.0686
Brugia malayi Hsp90 protein 0.003 0.0209 0.0259
Giardia lamblia PHD finger protein 15 0.0029 0.019 0.0286
Echinococcus multilocularis heat shock protein 90 0.0045 0.0437 0.0437
Brugia malayi phosphofructokinase 0.0106 0.137 0.1699
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0337 0.0802
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.1876 0.4949
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0109 0.0135
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0395 0.049
Brugia malayi heat shock protein 90 0.0045 0.0437 0.0542
Giardia lamblia Kinase, PLK 0.0189 0.2628 0.3968
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0092 0.0092
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.1943 0.1943
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0658 0.0994
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0324 0.0324
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0109 0.0244
Schistosoma mansoni hypothetical protein 0.0043 0.0416 0.0416
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0038 0.0339 0.0339
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0029 0.019 0.0224
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0193 0.0239
Trypanosoma brucei metacaspase 0.0026 0.0151 0.0237
Onchocerca volvulus 0.024 0.3403 1
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0324 0.0324
Trypanosoma cruzi phosphomannomutase, putative 0.0043 0.0404 0.0634
Trypanosoma cruzi heat shock protein, putative 0.003 0.0209 0.0327
Onchocerca volvulus 0.024 0.3403 1
Loa Loa (eye worm) hexokinase 0.0074 0.0885 0.1087
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0109 0.0135
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0026 0.0151 0.0187
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.1358 0.3582
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0072 0.0078
Loa Loa (eye worm) acetyltransferase 0.0144 0.1943 0.24
Onchocerca volvulus 0.0029 0.02 0.0326
Schistosoma mansoni kinase 0.0096 0.1216 0.1216
Brugia malayi hypothetical protein 0.0039 0.0342 0.0424
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0696 0.0696
Trypanosoma brucei heat shock protein, putative 0.0045 0.0437 0.0686
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0437 0.0686
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0042 0.0395 1
Brugia malayi glucose-6-phosphate dehydrogenase 0.0436 0.6371 0.7898
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0193 0.0239
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0737 0.1156
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.1536 0.4053
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0049 0.0502 0.0787
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0453 0.0453
Leishmania major heat shock protein 83-1 0.0045 0.0437 0.0686
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0991 0.0991
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.2628 0.3258
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0193 0.0239
Echinococcus granulosus transcription factor btf3 0.0034 0.0276 0.0276
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0109 0.0171
Trypanosoma brucei heat shock protein, putative 0.0045 0.0437 0.0686
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0109 0.0135
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0092 0.0114
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0453 0.6623 1
Brugia malayi hypothetical protein 0.0148 0.2 0.2479
Giardia lamblia Heat shock protein HSP 90-alpha 0.0038 0.0339 0.0511
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0092 0.0114
Leishmania major heat shock protein 83-1 0.0045 0.0437 0.0686
Giardia lamblia Fructose-bisphosphate aldolase 0.0286 0.4095 0.6183
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0092 0.0114
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.0209 0.0352
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0104 0.0157
Echinococcus granulosus heat shock protein 0.0045 0.0437 0.0437
Plasmodium vivax heat shock protein 86, putative 0.0045 0.0437 0.066
Schistosoma mansoni endoplasmin 0.0045 0.0437 0.0437
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0017 0.0009 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0092 0.0114
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.2628 0.3258
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0737 0.0903
Leishmania major heat shock protein 83-1 0.0045 0.0437 0.0686
Echinococcus granulosus phosphomannomutase 0.0043 0.0404 0.0404
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0042 0.0395 0.2067
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0737 0.1156
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0104 0.0129
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0437 0.0686
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0092 0.0103
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0092 0.0092
Onchocerca volvulus 0.0148 0.2 0.5762
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0276 0.0331
Onchocerca volvulus Hexokinase homolog 0.0151 0.2044 0.5896
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.1536 0.4053
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0109 0.0533
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.002 0.003
Trypanosoma brucei 6-phosphogluconolactonase 0.0017 0.0009 0.0014
Leishmania major heat shock protein 83-1 0.0045 0.0437 0.0686
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0109 0.0533
Onchocerca volvulus 0.0023 0.0109 0.0051
Echinococcus granulosus caspase 2 0.0026 0.0151 0.0151
Mycobacterium tuberculosis Conserved protein 0.0049 0.0502 0.1323
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0109 0.0135
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0266 0.3791 1
Schistosoma mansoni bromodomain containing protein 0.0065 0.0749 0.0749
Entamoeba histolytica serine/threonine protein kinase, putative 0.0189 0.2628 0.641
Onchocerca volvulus 0.0039 0.0342 0.0756
Schistosoma mansoni lipoxygenase 0.0169 0.2327 0.2327
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0737 0.1156
Schistosoma mansoni lipoxygenase 0.01 0.1273 0.1273
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0436 0.6371 0.6371
Brugia malayi jmjC domain containing protein 0.0036 0.0309 0.0383
Brugia malayi phosphomannomutase 2 0.0043 0.0404 0.0501
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0151 0.0187
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0189 0.2628 0.2628
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0092 0.0114
Trypanosoma brucei beta lactamase 0.0128 0.1693 0.2658
Loa Loa (eye worm) hypothetical protein 0.0081 0.0991 0.1218
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0151 0.0187
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0151 0.0237
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0092 0.0092
Trypanosoma brucei hexokinase, putative 0.024 0.3403 0.5342
Entamoeba histolytica hypothetical protein 0.0043 0.0416 0.0995
Schistosoma mansoni endoplasmin 0.0045 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0049 0.0497 0.0605
Toxoplasma gondii heat shock protein 75, putative 0.003 0.0209 0.0315
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.137 0.2151
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.137 0.3614
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.137 0.137
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0092 0.0092
Trypanosoma cruzi hypothetical protein, conserved 0.0426 0.6224 0.9769
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0104 0.0163
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.019 0.019
Mycobacterium ulcerans glutaminase 0.0548 0.8067 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.4095 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0092 0.0092
Trypanosoma brucei Putative Phosphatase/Protein of unknown function DUF89, putative 0.0107 0.1386 0.2175
Schistosoma mansoni caspase-7 (C14 family) 0.0097 0.123 0.123
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0042 0.0395 0.1042
Brugia malayi Bromodomain containing protein 0.0077 0.0923 0.1144
Trypanosoma brucei heat shock protein, putative 0.0045 0.0437 0.0686
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0151 0.0187
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0013
Loa Loa (eye worm) hexokinase 0.024 0.3403 0.4212
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0049 0.0502 0.0622
Echinococcus multilocularis geminin 0.0166 0.2272 0.2272
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0104 0.0274
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0193 0.0239
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0063 0.0067
Entamoeba histolytica hypothetical protein 0.0023 0.0104 0.0232
Onchocerca volvulus Cell death protein 3 homolog 0.0026 0.0151 0.0178
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0453 0.0453
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0104 0.0157
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0109 0.0135
Trypanosoma cruzi metacaspase, putative 0.0026 0.0151 0.0237
Trypanosoma brucei trypanothione reductase 0.0046 0.0459 0.072
Schistosoma mansoni phosphomannomutase 0.0043 0.0404 0.0404
Echinococcus granulosus hexokinase 0.024 0.3403 0.3403
Mycobacterium ulcerans 6-phosphogluconolactonase 0.0017 0.0009 0.0011
Brugia malayi 6-phosphogluconolactonase family protein 0.0017 0.0009 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0092 0.0114
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0437 0.0542

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 50 uM PUBCHEM_BIOASSAY: Factor XIIa 1536 HTS Dose Response Confirmation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID800] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.581 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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