Detailed information for compound 1285670

Basic information

Technical information
  • TDR Targets ID: 1285670
  • Name: N-[(2-pyridin-3-yl-1,3-thiazol-4-yl)methyl]th iophene-2-sulfonamide
  • MW: 337.44 | Formula: C13H11N3O2S3
  • H donors: 1 H acceptors: 4 LogP: 2.05 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=S(=O)(c1cccs1)NCc1csc(n1)c1cccnc1
  • InChi: 1S/C13H11N3O2S3/c17-21(18,12-4-2-6-19-12)15-8-11-9-20-13(16-11)10-3-1-5-14-7-10/h1-7,9,15H,8H2
  • InChiKey: FIAZGEDORHINTK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[[2-(3-pyridyl)thiazol-4-yl]methyl]thiophene-2-sulfonamide
  • N-[[2-(3-pyridyl)-4-thiazolyl]methyl]-2-thiophenesulfonamide
  • ZINC04166831
  • MLS000102702
  • SMR000018187

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens estrogen receptor 1 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0034 0.0416
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0034 0.0428
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1289 0.178
Loa Loa (eye worm) cysteine protease 0.002 0.0034 0.0088
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.2692 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2692 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0595 0.1545
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0796 0.2957
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0796 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0034 1
Brugia malayi hypothetical protein 0.0037 0.0819 0.2126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0034 0.0428
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0034 0.0428
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2692 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0595 0.1545
Loa Loa (eye worm) hypothetical protein 0.0037 0.0796 0.2067
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.2344 0.6087
Loa Loa (eye worm) beta-lactamase 0.0037 0.0796 0.2067
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0034 0.0428
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0034 0.0047
Loa Loa (eye worm) hypothetical protein 0.007 0.2344 0.6087
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0796 0.0796
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.3851 1
Leishmania major cathepsin L-like protease 0.002 0.0034 0.0126
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.1289 0.3346
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0796 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0796 0.2957
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0034 0.0428
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.3851 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0034 0.0428
Onchocerca volvulus 0.0037 0.0796 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0034 0.0428
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1289 0.178
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0034 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0796 0.11
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0796 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0595 0.0822
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0034 0.0428
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0796 0.11
Schistosoma mansoni hypothetical protein 0.0032 0.0595 0.0822
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0034 0.0047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2692 1
Echinococcus multilocularis GPCR, family 2 0.0032 0.0595 0.0822
Loa Loa (eye worm) hypothetical protein 0.0037 0.0796 0.2067
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0595 0.0822
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0796 1
Loa Loa (eye worm) fibroinase 0.002 0.0034 0.0088
Leishmania major hypothetical protein, conserved 0.0037 0.0796 0.2957
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0796 1
Onchocerca volvulus 0.0037 0.0796 1
Echinococcus multilocularis cysteine protease 0.002 0.0034 0.0047
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0796 0.5
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0034 0.0416
Onchocerca volvulus 0.0037 0.0796 1
Schistosoma mansoni hypothetical protein 0.007 0.2344 0.3238
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0034 1
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0595 0.1545
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0796 0.0796
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.2692 1
Toxoplasma gondii cathepsin CPL 0.002 0.0034 0.0428
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0796 0.11
Brugia malayi Cathepsin L-like precursor 0.002 0.0034 0.0088
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0034 0.0428
Loa Loa (eye worm) hypothetical protein 0.0037 0.0796 0.2067
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1289 0.178
Echinococcus multilocularis cysteine protease 0.002 0.0034 0.0047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2692 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1289 0.178
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0034 0.0088
Loa Loa (eye worm) hypothetical protein 0.0037 0.0796 0.2067
Brugia malayi Cathepsin L-like precursor 0.002 0.0034 0.0088
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0796 0.11
Schistosoma mansoni hypothetical protein 0.0037 0.0819 0.1131
Echinococcus multilocularis geminin 0.0174 0.724 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0034 0.0428
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0034 0.0047
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.3851 1
Entamoeba histolytica hypothetical protein 0.0037 0.0819 1
Entamoeba histolytica hypothetical protein 0.0037 0.0819 1
Trichomonas vaginalis esterase, putative 0.0037 0.0796 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0034 0.0428
Leishmania major cathepsin L-like protease 0.0077 0.2692 1
Plasmodium vivax vivapain-2 0.002 0.0034 0.0428
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.1289 0.3346
Brugia malayi Cathepsin L-like precursor 0.002 0.0034 0.0088
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0595 0.0822
Loa Loa (eye worm) ctsf protein 0.002 0.0034 0.0088
Loa Loa (eye worm) hypothetical protein 0.0037 0.0796 0.2067
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0819 0.1131
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0034 0.0047
Plasmodium vivax vivapain-2 0.002 0.0034 0.0428
Entamoeba histolytica hypothetical protein 0.0037 0.0819 1
Schistosoma mansoni hypothetical protein 0.0032 0.0595 0.0822
Leishmania major cathepsin L-like protease 0.0077 0.2692 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.2379 0.8838
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2692 1
Echinococcus granulosus cathepsin l1 0.002 0.0034 0.0047
Loa Loa (eye worm) hypothetical protein 0.0037 0.0796 0.2067
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0034 0.0428
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2692 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0034 0.0088
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0595 0.1545
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0034 0.0428
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0595 0.0822
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0034 0.0428
Schistosoma mansoni hypothetical protein 0.0032 0.0595 0.0822
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0819 0.1131
Echinococcus granulosus geminin 0.0174 0.724 1
Mycobacterium ulcerans lipase LipD 0.0037 0.0796 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0796 0.2067
Brugia malayi Cathepsin L-like precursor 0.002 0.0034 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0034 0.0428
Leishmania major cathepsin L-like protease 0.0077 0.2692 1
Leishmania major cathepsin L-like protease 0.002 0.0034 0.0126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0034 0.0428
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0796 0.0796
Schistosoma mansoni hypothetical protein 0.0174 0.724 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0034 0.0088
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0796 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0796 0.0796
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0088
Schistosoma mansoni hypothetical protein 0.0174 0.724 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0034 0.0428
Leishmania major cysteine peptidase A (CPA) 0.002 0.0034 0.0126
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0034 0.0428
Mycobacterium ulcerans hypothetical protein 0.0037 0.0796 1
Echinococcus granulosus GPCR family 2 0.0032 0.0595 0.0822
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2692 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1289 0.178
Brugia malayi beta-lactamase family protein 0.0037 0.0796 0.2067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2692 1
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.2692 1
Leishmania major cathepsin L-like protease 0.002 0.0034 0.0126
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0796 0.2957
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0034 0.0428
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0796 1
Brugia malayi beta-lactamase family protein 0.0037 0.0796 0.2067
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0819 0.1131
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.2692 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0034 0.0088
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0034 0.0047
Entamoeba histolytica hypothetical protein 0.0037 0.0819 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0034 0.0428
Loa Loa (eye worm) hypothetical protein 0.0102 0.3851 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0034 0.0428
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0034 0.0047
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.1921 0.7135
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0796 0.0796
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0034 0.0428
Entamoeba histolytica cysteine protease, putative 0.002 0.0034 0.0416
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0034 0.0428
Toxoplasma gondii ABC1 family protein 0.0037 0.0796 1
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0034 0.0047
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0796 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1289 0.178
Schistosoma mansoni hypothetical protein 0.0032 0.0595 0.0822
Mycobacterium tuberculosis Conserved protein 0.0037 0.0796 0.0796
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0034 0.0088
Mycobacterium leprae Probable lipase LipE 0.0037 0.0796 0.5
Leishmania major cathepsin L-like protease 0.002 0.0034 0.0126
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0034 0.0047
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0034 0.0428
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2692 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0796 0.2067
Brugia malayi beta-lactamase 0.0037 0.0796 0.2067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2692 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2692 1
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0796 0.0796
Mycobacterium tuberculosis Conserved protein 0.0037 0.0796 0.0796
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0034 0.0126
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0796 0.0796
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1289 0.178
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0034 0.0428
Leishmania major cathepsin L-like protease 0.002 0.0034 0.0126
Mycobacterium ulcerans beta-lactamase 0.0037 0.0796 1
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0796 0.0796

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 18.04536 um PUBCHEM_BIOASSAY: Estrogen Receptor-alpha Coactivator Binding Inhibitors Dose Response Confirmation. (Class of assay: confirmatory) [Related pubchem assays: 629 (Primary screen preceding this dose response confirmation assay.)] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 70.7946 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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