Detailed information for compound 1286100

Basic information

Technical information
  • TDR Targets ID: 1286100
  • Name: 2-(3-methyl-5-oxo-4-phenyldiazenyl-4H-pyrazol -1-yl)benzoic acid
  • MW: 322.318 | Formula: C17H14N4O3
  • H donors: 1 H acceptors: 3 LogP: 2.84 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1=NN(C(=O)C1N=Nc1ccccc1)c1ccccc1C(=O)O
  • InChi: 1S/C17H14N4O3/c1-11-15(19-18-12-7-3-2-4-8-12)16(22)21(20-11)14-10-6-5-9-13(14)17(23)24/h2-10,15H,1H3,(H,23,24)
  • InChiKey: OGFXKWDLRDEHMI-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-(3-methyl-5-oxo-4-phenylazo-4H-pyrazol-1-yl)benzoic acid
  • 2-(5-keto-3-methyl-4-phenylazo-4H-pyrazol-1-yl)benzoic acid
  • AG-690/36924015
  • 2-(3-Methyl-5-oxo-4-phenylazo-4,5-dihydro-pyrazol-1-yl)-benzoic acid
  • BAS 00472249

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens flap structure-specific endonuclease 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma brucei gambiense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania infantum flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Giardia lamblia Flap structure-specific endonuclease Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum ko:K04799 flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii flap structure-specific endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Neospora caninum flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica Flap nuclease, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii flap endonuclease-1-related Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Cryptosporidium hominis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma congolense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium knowlesi flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Trichomonas vaginalis flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Babesia bovis XPG N-terminal domain and XPG I-region domain containing protein Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trypanosoma brucei exonuclease, putative flap structure-specific endonuclease 1 380 aa 322 aa 24.5 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0029 0.048 0.7697
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0055 0.0975
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0067 0.1185
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family member 0.0006 0.0025 0.0022
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.1061 0.1761
Onchocerca volvulus 0.0009 0.0073 0.0118
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0264 0.0981
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0335 0.6198
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0264 0.5063
Loa Loa (eye worm) hypothetical protein 0.0029 0.048 0.0797
Echinococcus granulosus flap endonuclease GEN 1 0.0006 0.0025 0.0022
Brugia malayi CXXC zinc finger family protein 0.0035 0.0604 0.2248
Echinococcus multilocularis GPCR, family 2 0.0018 0.0264 0.0261
Echinococcus granulosus importin subunit beta 1 0.0028 0.0469 0.0466
Echinococcus granulosus flap endonuclease 1 0.0031 0.0538 0.0535
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.03 0.6025 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0073 0.0121
Entamoeba histolytica DNA-repair protein, putative 0.0006 0.0025 0.0302
Schistosoma mansoni exonuclease 0.0006 0.0025 0.0022
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0067 0.1116
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0067 0.1185
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0055 0.0975
Brugia malayi AMP-binding enzyme family protein 0.0029 0.048 0.1787
Schistosoma mansoni hypothetical protein 0.0039 0.0692 0.0689
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0335 0.6198
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0264 0.0261
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.14 0.1397
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0396 0.7342
Onchocerca volvulus 0.0024 0.0396 0.6125
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0073 0.1236
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1025 0.1022
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0067 0.1116
Schistosoma mansoni hypothetical protein 0.0018 0.0264 0.0261
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0067 0.0546
Loa Loa (eye worm) hypothetical protein 0.0009 0.0073 0.0121
Trichomonas vaginalis ran, putative 0.0021 0.0317 0.5872
Toxoplasma gondii ran binding protein 0.0009 0.0073 0.0564
Echinococcus granulosus ring and YY1 binding protein 0.0009 0.0073 0.007
Brugia malayi kap beta 3 protein 0.0005 0.0003 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1025 0.1022
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0085 0.0082
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0067 0.0546
Echinococcus multilocularis flap endonuclease GEN 1 0.0006 0.0025 0.0022
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0067 0.0546
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0264 0.0439
Echinococcus granulosus smad 0.0009 0.0085 0.0082
Schistosoma mansoni ap endonuclease 0.0022 0.0335 0.0332
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0009 0.0073 0.1236
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0067 0.0248
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0264 0.4882
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.0067 0.0864
Loa Loa (eye worm) hypothetical protein 0.0018 0.0264 0.0438
Trichomonas vaginalis helicase, putative 0.0008 0.0055 0.0975
Loa Loa (eye worm) hypothetical protein 0.0021 0.0332 0.0552
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0317 0.584
Schistosoma mansoni hypothetical protein 0.0194 0.386 0.3858
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0055 0.0975
Brugia malayi Importin beta-1 subunit 0.0028 0.0469 0.1745
Schistosoma mansoni cpg binding protein 0.0035 0.0604 0.0601
Brugia malayi MH2 domain containing protein 0.0137 0.2688 1
Echinococcus granulosus zinc finger protein Ran binding 0.0009 0.0073 0.007
Schistosoma mansoni TRABID protein (C64 family) 0.0009 0.0073 0.007
Echinococcus multilocularis DNA repair protein complementing XP G cells 0.0006 0.0025 0.0022
Echinococcus multilocularis ring and YY1 binding protein 0.0009 0.0073 0.007
Leishmania major hypothetical protein, conserved 0.0009 0.0073 0.1303
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family 0.0006 0.0025 0.0022
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0006 0.0025 0.034
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0604 0.1003
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.048 1
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0009 0.0073 0.007
Loa Loa (eye worm) hypothetical protein 0.0029 0.048 0.0797
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0024 0.0396 0.7342
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0317 0.5694
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.0538 1
Plasmodium falciparum flap endonuclease 1 0.0031 0.0538 1
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0009 0.0073 0.1303
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.048 0.8922
Leishmania major importin beta-1 subunit, putative 0.0023 0.036 0.6677
Leishmania major pantothenate kinase subunit, putative 0.0006 0.0007 0.0077
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0469 0.8708
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0085 0.0082
Schistosoma mansoni Smad4 0.0009 0.0085 0.0082
Schistosoma mansoni hypothetical protein 0.0024 0.0396 0.0393
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0024 0.0396 0.0393
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0071 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0055 0.0975
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0335 0.5
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0006 0.0025 0.0179
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0024 0.0396 0.0657
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0114 0.0111
Trichomonas vaginalis importin beta-1, putative 0.0023 0.036 0.6677
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0737 0.0733
Schistosoma mansoni hypothetical protein 0.0018 0.0264 0.0261
Trypanosoma brucei exonuclease, putative 0.0006 0.0025 0.0414
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0264 0.4842
Schistosoma mansoni smad1 5 8 and 0.0009 0.0085 0.0082
Schistosoma mansoni smad1 5 8 and 0.0009 0.0085 0.0082
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0317 0.2542
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0067 0.0546
Schistosoma mansoni hypothetical protein 0.0009 0.0073 0.007
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.0538 0.0893
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0111 0.0415
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0469 0.3769
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.0067 0.1185
Brugia malayi MH2 domain containing protein 0.0009 0.0085 0.0316
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0067 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0055 0.0975
Loa Loa (eye worm) hypothetical protein 0.0021 0.0332 0.0552
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0067 0.0546
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0055 0.0975
Echinococcus multilocularis SWI:SNF matrix associated 0.0024 0.0396 0.0393
Onchocerca volvulus 0.0009 0.0073 0.0118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1025 0.1022
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0264 0.2113
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.048 1
Leishmania major hypothetical protein, conserved 0.0009 0.0073 0.1303
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0067 0.0248
Leishmania major GTP-binding protein, putative 0.0021 0.0317 0.5872
Giardia lamblia Flap structure-specific endonuclease 0.0031 0.0538 1
Plasmodium falciparum DNA repair protein RAD2, putative 0.0006 0.0025 0.0414
Schistosoma mansoni hypothetical protein 0.0024 0.0396 0.0393
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0317 0.5872
Echinococcus granulosus Smad4 0.0009 0.0085 0.0082
Loa Loa (eye worm) hypothetical protein 0.0057 0.1061 0.1761
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0009 0.0073 0.1303
Echinococcus granulosus cpg binding protein 0.0037 0.0645 0.0642
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0335 0.6168
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0335 0.0332
Echinococcus multilocularis flap endonuclease 1 0.0031 0.0538 0.0535
Schistosoma mansoni RNA binding protein 0.0009 0.0073 0.007
Echinococcus multilocularis zinc finger protein Ran binding 0.0009 0.0073 0.007
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0006 0.0025 0.034
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0055 0.0975
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0067 0.1116
Schistosoma mansoni hypothetical protein 0.0018 0.0264 0.0261
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0317 0.5872
Echinococcus multilocularis cpg binding protein 0.0037 0.0645 0.0642
Brugia malayi isocitrate dehydrogenase 0.0018 0.0264 0.0984
Brugia malayi RNA, U transporter 1 0.008 0.1528 0.5683
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.1061 0.3948
Echinococcus granulosus geminin 0.0194 0.386 0.3858
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.048 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0264 0.4882
Schistosoma mansoni zinc finger protein 0.0009 0.0073 0.007
Plasmodium vivax DNA repair protein RAD2, putative 0.0006 0.0025 0.0414
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0335 0.0556
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0335 0.6198
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0335 0.0332
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0024 0.0396 0.7342
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0264 0.0438
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0071 0.0068
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0006 0.0025 0.0179
Trypanosoma brucei DNA repair protein RAD2, putative 0.0006 0.0025 0.0414
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0067 0.0546
Toxoplasma gondii propionate-CoA ligase 0.0008 0.0067 0.0513
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0055 0.0975
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0067 0.0111
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0073 0.1236
Loa Loa (eye worm) hypothetical protein 0.0009 0.0073 0.0121
Schistosoma mansoni hypothetical protein 0.0024 0.0396 0.0393
Schistosoma mansoni flap endonuclease-1 0.0028 0.0476 0.0473
Mycobacterium ulcerans hypothetical protein 0.0029 0.048 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0067 0.0248
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0067 0.1185
Loa Loa (eye worm) hypothetical protein 0.0039 0.0692 0.1149
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0067 0.0546
Echinococcus multilocularis exonuclease 1 0.0006 0.0025 0.0022
Loa Loa (eye worm) Smad1 0.0009 0.0085 0.0141
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0067 0.1116
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.036 0.6651
Plasmodium vivax exonuclease I, putative 0.0006 0.0025 0.0414
Chlamydia trachomatis DNA topoisomerase I 0.0024 0.0396 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0055 0.0975
Echinococcus multilocularis SWI:SNF matrix associated 0.0024 0.0396 0.0393
Echinococcus multilocularis smad 0.0009 0.0085 0.0082
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 0.0538 0.4328
Schistosoma mansoni smad 0.0009 0.0085 0.0082
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0055 0.0975
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0264 0.0261
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0692 0.2575
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0317 0.5872
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0067 0.1185
Loa Loa (eye worm) hypothetical protein 0.0009 0.0073 0.0121
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0009 0.0073 0.1236
Plasmodium falciparum importin beta, putative 0.0028 0.0469 0.8708
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0264 0.0261
Entamoeba histolytica Ran family GTPase 0.0021 0.0317 0.4283
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0006 0.0025 0.0179
Toxoplasma gondii exonuclease III APE 0.0022 0.0335 0.2682
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0024 0.0396 0.3178
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.1061 0.3948
Echinococcus granulosus GPCR family 2 0.0018 0.0264 0.0261
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0009 0.0073 0.1303
Trichomonas vaginalis flap endonuclease-1, putative 0.0006 0.0025 0.0414
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0335 0.6198
Trichomonas vaginalis flap endonuclease-1, putative 0.0006 0.0025 0.0414
Echinococcus granulosus Zinc finger RanBP2 type 0.0009 0.0073 0.007
Schistosoma mansoni ran 0.0021 0.0317 0.0314
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0335 0.5
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.0538 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0264 0.0261
Loa Loa (eye worm) hypothetical protein 0.0008 0.0067 0.0111
Loa Loa (eye worm) hypothetical protein 0.0006 0.0025 0.0042
Schistosoma mansoni hypothetical protein 0.0194 0.386 0.3858
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1025 0.1022
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.0538 1
Brugia malayi MH1 domain containing protein 0.0009 0.0085 0.0316
Loa Loa (eye worm) transcription factor SMAD2 0.0137 0.2688 0.4462
Loa Loa (eye worm) hypothetical protein 0.0029 0.048 0.0797
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0264 0.0261
Schistosoma mansoni hypothetical protein 0.0018 0.0264 0.0261
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 0.0538 1
Loa Loa (eye worm) XPG I-region family protein 0.0006 0.0025 0.0042
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0317 0.0314
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0085 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0055 0.0975
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.048 0.6507
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0264 0.4882
Brugia malayi SWIB/MDM2 domain containing protein 0.0024 0.0396 0.1473
Onchocerca volvulus 0.0035 0.0604 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0071 0.0068
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0055 0.0975
Leishmania major hypothetical protein, conserved 0.0006 0.0025 0.0414
Entamoeba histolytica Flap nuclease, putative 0.0031 0.0538 0.7294
Onchocerca volvulus 0.0009 0.0073 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0055 0.0975
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1025 0.1022
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0009 0.0073 0.1236
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0317 0.0527
Loa Loa (eye worm) oxidoreductase 0.0008 0.0067 0.0111
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0009 0.0073 0.0564
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0067 0.0546
Brugia malayi Flap endonuclease-1 0.0031 0.0538 0.2002
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0009 0.0073 0.1236
Schistosoma mansoni hypothetical protein 0.0041 0.0737 0.0733
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.036 0.6677
Echinococcus granulosus exonuclease 1 0.0006 0.0025 0.0022
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0008 0.0067 0.1185
Loa Loa (eye worm) hypothetical protein 0.0006 0.0025 0.0042
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0469 0.8708
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0067 0.0063
Entamoeba histolytica exonuclease, putative 0.0006 0.0025 0.0302
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0085 0.0141
Echinococcus multilocularis snurportin 1 0.03 0.6025 0.6024
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0114 0.019
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.048 1
Echinococcus granulosus DNA repair protein complementing XP G cells 0.0006 0.0025 0.0022
Schistosoma mansoni cpg binding protein 0.0037 0.0645 0.0642
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0009 0.0073 0.0272
Plasmodium vivax importin-beta 2, putative 0.0028 0.0469 0.8708
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.048 0.8922
Trypanosoma brucei hypothetical protein, conserved 0.0009 0.0073 0.1303
Brugia malayi YY1-associated factor 2 0.0009 0.0073 0.0272
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0264 0.0261
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.048 1
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0024 0.0396 0.3178
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0055 0.0975
Loa Loa (eye worm) hypothetical protein 0.0021 0.0332 0.0552
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0085 0.0141
Entamoeba histolytica hypothetical protein 0.0041 0.0737 1
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.0067 0.0513
Schistosoma mansoni importin beta-1 0.0028 0.0469 0.0466
Trichomonas vaginalis exonuclease%2C+putative 0.0006 0.0025 0.0414
Brugia malayi MH1 domain containing protein 0.0009 0.0085 0.0316
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0335 0.1245
Schistosoma mansoni cpg binding protein 0.0037 0.0645 0.0642
Loa Loa (eye worm) hypothetical protein 0.0021 0.0332 0.0552
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.048 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0067 0.0546
Leishmania major hypothetical protein, conserved 0.0009 0.0073 0.1303
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0317 0.1181
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0009 0.0073 0.007
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0025 0.034
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.048 0.8922
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0025 0.034
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0335 0.6168
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0308 0.6071
Schistosoma mansoni fusion 0.0009 0.0073 0.007
Schistosoma mansoni ran 0.0021 0.0317 0.0314
Loa Loa (eye worm) hypothetical protein 0.0021 0.0332 0.0552
Trypanosoma cruzi WLM domain containing protein, putative 0.0009 0.0073 0.1236
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0067 0.1185
Schistosoma mansoni brg-1 associated factor 0.0024 0.0396 0.0393
Loa Loa (eye worm) hypothetical protein 0.0028 0.0469 0.0778
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0396 0.7342
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0264 0.0981
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.0538 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0264 0.4842
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0335 0.6479
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0009 0.0073 0.007
Echinococcus multilocularis geminin 0.0194 0.386 0.3858
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.048 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.0067 0.0513
Loa Loa (eye worm) kap beta 3 protein 0.0005 0.0003 0.0006
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0264 0.0261
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1239 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0067 0.0546
Loa Loa (eye worm) MH2 domain-containing protein 0.0137 0.2688 0.4462
Entamoeba histolytica hypothetical protein 0.0041 0.0737 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0264 0.0261
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.048 1
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0332 0.6153
Echinococcus multilocularis Smad4 0.0009 0.0085 0.0082
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1025 0.3812
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0332 0.6421
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0335 0.6671
Echinococcus granulosus snurportin 1 0.03 0.6025 0.6024
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0317 0.584
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0067 0.0063
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0006 0.0025 0.0179
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0332 0.6617
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0308 0.6071
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.048 1
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0469 0.0466
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0308 0.6071
Loa Loa (eye worm) importin-beta domain-containing protein 0.0005 0.0003 0.0006
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0264 0.0261
Leishmania major hypothetical protein, conserved 0.0009 0.0073 0.1303
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0317 0.0314
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0264 0.0261
Brugia malayi brahma associated protein 60 kDa 0.0024 0.0396 0.1473
Schistosoma mansoni ap endonuclease 0.0022 0.0335 0.0332
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0067 0.0248
Brugia malayi hypothetical protein 0.0041 0.0737 0.274
Loa Loa (eye worm) hypothetical protein 0.0008 0.0067 0.0111
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.048 0.6507
Brugia malayi Smad1 0.0009 0.0085 0.0316
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.048 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.048 0.6507
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0085 0.0082
Entamoeba histolytica hypothetical protein 0.0023 0.036 0.487
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0055 0.0975
Trypanosoma cruzi WLM domain containing protein, putative 0.0009 0.0073 0.1236
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.048 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0067 0.0546
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0009 0.0073 0.0118
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0085 0.0082
Loa Loa (eye worm) brahma associated protein 0.0024 0.0396 0.0657
Entamoeba histolytica hypothetical protein 0.0041 0.0737 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.036 0.6677
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0737 0.0733
Brugia malayi AMP-binding enzyme family protein 0.0029 0.048 0.1787
Brugia malayi XPG I-region family protein 0.0006 0.0025 0.0095
Trichomonas vaginalis flap endonuclease-1, putative 0.0006 0.0025 0.0414
Brugia malayi AMP-binding enzyme family protein 0.0029 0.048 0.1787
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0073 0.1236
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0335 0.6198
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0067 0.0248
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0332 0.6153
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0071 0.0068
Chlamydia trachomatis SWIB complex protein 0.0024 0.0396 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0308 0.6071
Entamoeba histolytica hypothetical protein 0.0041 0.0737 1
Echinococcus multilocularis SWI:SNF matrix associated 0.0024 0.0396 0.0393
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1025 0.1022
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0264 0.0261
Plasmodium falciparum exonuclease I, putative 0.0006 0.0025 0.0414
Trypanosoma brucei hypothetical protein, conserved 0.0009 0.0073 0.1303
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0264 0.4882
Schistosoma mansoni smad1 5 8 and 0.0009 0.0085 0.0082
Onchocerca volvulus 0.0009 0.0073 0.0118
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0067 0.1185
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0055 0.0975
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0009 0.0073 0.0272
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1025 0.1022
Trichomonas vaginalis flap endonuclease-1, putative 0.0006 0.0025 0.0414
Schistosoma mansoni hypothetical protein 0.03 0.6025 0.6024
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0024 0.0396 0.7342
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0264 0.0984
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0009 0.0073 0.0272
Brugia malayi MH2 domain containing protein 0.0009 0.0085 0.0316
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0055 0.0975
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0009 0.0073 0.0272
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0009 0.0073 0.1236
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0335 0.452
Leishmania major hypothetical protein, conserved 0.0009 0.0073 0.1303
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0335 0.6198
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0264 0.2113
Echinococcus granulosus SWI:SNF matrix associated 0.0024 0.0396 0.0393
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0008 0.0067 0.1185
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0067 0.0063
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0071 0.0068
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0114 0.0111
Loa Loa (eye worm) hypothetical protein 0.0009 0.0073 0.0121
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1025 0.1701
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0264 0.4882
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0067 0.0248
Entamoeba histolytica exonuclease, putative 0.0006 0.0025 0.0302
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0335 0.6034
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0737 0.0733
Brugia malayi brahma associated protein 60 kDa 0.0024 0.0396 0.1473
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0024 0.0396 0.0393

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.1014 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 29.9349 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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