Detailed information for compound 1286106

Basic information

Technical information
  • TDR Targets ID: 1286106
  • Name: ethyl 2-[[2-(2-cyanophenoxy)acetyl]amino]-5,5 ,7,7-tetramethyl-4,6-dihydrothieno[5,4-c]pyri dine-3-carboxylate
  • MW: 441.543 | Formula: C23H27N3O4S
  • H donors: 2 H acceptors: 3 LogP: 3.95 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1c(NC(=O)COc2ccccc2C#N)sc2c1CC(C)(C)NC2(C)C
  • InChi: 1S/C23H27N3O4S/c1-6-29-21(28)18-15-11-22(2,3)26-23(4,5)19(15)31-20(18)25-17(27)13-30-16-10-8-7-9-14(16)12-24/h7-10,26H,6,11,13H2,1-5H3,(H,25,27)
  • InChiKey: FKOCGWKIXOGBBA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[2-(2-cyanophenoxy)-1-oxoethyl]amino]-5,5,7,7-tetramethyl-4,6-dihydrothieno[5,4-c]pyridine-3-carboxylic acid ethyl ester
  • 2-[[2-(2-cyanophenoxy)acetyl]amino]-5,5,7,7-tetramethyl-4,6-dihydrothieno[5,4-c]pyridine-3-carboxylic acid ethyl ester
  • ethyl 2-[2-(2-cyanophenoxy)ethanoylamino]-5,5,7,7-tetramethyl-4,6-dihydrothieno[5,4-c]pyridine-3-carboxylate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens plasminogen activator, urokinase Starlite/ChEMBL No references
Homo sapiens _UBC13, UbcH-ben, UbcH13 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K10580 ubiquitin-conjugating enzyme E2 N, putative Get druggable targets OG5_127739 All targets in OG5_127739
Plasmodium knowlesi ubiquitin-conjugating enzyme E2 N, putative Get druggable targets OG5_127739 All targets in OG5_127739
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein Get druggable targets OG5_127739 All targets in OG5_127739
Theileria parva ubiquitin-protein ligase, putative Get druggable targets OG5_127739 All targets in OG5_127739
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N Get druggable targets OG5_127739 All targets in OG5_127739
Plasmodium berghei ubiquitin-conjugating enzyme E2 N, putative Get druggable targets OG5_127739 All targets in OG5_127739
Cryptosporidium hominis ubiquitin-conjugating enzyme Get druggable targets OG5_127739 All targets in OG5_127739
Leishmania donovani ubiquitin-conjugating enzyme E2, putative Get druggable targets OG5_127739 All targets in OG5_127739
Brugia malayi Ubiquitin conjugating enzyme protein 13 Get druggable targets OG5_127739 All targets in OG5_127739
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative Get druggable targets OG5_127739 All targets in OG5_127739
Candida albicans post-replication repair Get druggable targets OG5_127739 All targets in OG5_127739
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Candida albicans ubiquitin-conjugating enzyme Get druggable targets OG5_127739 All targets in OG5_127739
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative Get druggable targets OG5_127739 All targets in OG5_127739
Cryptosporidium parvum ubiquitin-conjugating enzyme Get druggable targets OG5_127739 All targets in OG5_127739
Leishmania infantum ubiquitin-conjugating enzyme e2, putative Get druggable targets OG5_127739 All targets in OG5_127739
Leishmania mexicana ubiquitin-conjugating enzyme e2, putative Get druggable targets OG5_127739 All targets in OG5_127739
Trypanosoma brucei gambiense ubiquitin-conjugating enzyme e2, putative,ubiquitin carrier protein, putative,ubiquitin-protein ligase, putative Get druggable targets OG5_127739 All targets in OG5_127739
Trypanosoma brucei ubiquitin-protein ligase, putative Get druggable targets OG5_127739 All targets in OG5_127739
Candida albicans ubiquitin conjugating enzyme Get druggable targets OG5_127739 All targets in OG5_127739
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 Get druggable targets OG5_127739 All targets in OG5_127739
Entamoeba histolytica ubiquitin-conjugating enzyme family protein Get druggable targets OG5_127739 All targets in OG5_127739
Trypanosoma congolense ubiquitin-protein ligase, putative Get druggable targets OG5_127739 All targets in OG5_127739
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative Get druggable targets OG5_127739 All targets in OG5_127739
Neospora caninum Ubiquitin carrier protein (EC 6.3.2.-), related Get druggable targets OG5_127739 All targets in OG5_127739
Schistosoma mansoni ubiquitin conjugating enzyme 13 Get druggable targets OG5_127739 All targets in OG5_127739
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative Get druggable targets OG5_127739 All targets in OG5_127739
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative Get druggable targets OG5_127739 All targets in OG5_127739
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative Get druggable targets OG5_127739 All targets in OG5_127739
Leishmania major ubiquitin-conjugating enzyme e2, putative Get druggable targets OG5_127739 All targets in OG5_127739
Leishmania braziliensis ubiquitin-conjugating enzyme e2, putative Get druggable targets OG5_127739 All targets in OG5_127739
Babesia bovis ubiquitin-conjugating enzyme E2, putative Get druggable targets OG5_127739 All targets in OG5_127739
Brugia malayi ubiquitin conjugating enzyme protein 13 Get druggable targets OG5_127739 All targets in OG5_127739
Echinococcus granulosus ubiquitin conjugating enzyme E2 N Get druggable targets OG5_127739 All targets in OG5_127739
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 Get druggable targets OG5_127739 All targets in OG5_127739
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus Mastin plasminogen activator, urokinase 414 aa 340 aa 24.4 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Plasmodium falciparum ubiquitin-conjugating enzyme E2, putative _UBC13, UbcH-ben, UbcH13 152 aa 153 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0196 0.0745
Leishmania major hypothetical protein, conserved 0.0273 0.0907 1
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0022 0.0022 0.0924
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0033 0.0366
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0046 0.0107 0.0365
Brugia malayi beta-lactamase family protein 0.0071 0.0196 0.0668
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0022 0.0022 0.0022
Onchocerca volvulus 0.0019 0.001 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0195 0.2151
Plasmodium vivax SET domain protein, putative 0.0121 0.0373 0.3243
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.001 0.0031
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0083 0.0236 0.2602
Onchocerca volvulus 0.0071 0.0196 0.0586
Brugia malayi Kringle domain containing protein 0.0035 0.007 0.0237
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0068 0.0185 0.0185
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0195 0.2151
Giardia lamblia NADH oxidase lateral transfer candidate 0.0083 0.0236 1
Mycobacterium ulcerans lipase LipD 0.0071 0.0196 0.1543
Onchocerca volvulus 0.0019 0.001 0.0031
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0341 0.1149 1
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0023 0.0026 0.0078
Onchocerca volvulus 0.0035 0.007 0.0208
Echinococcus granulosus Smad4 0.0052 0.0127 0.0127
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0022 0.0022 0.0074
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0341 0.1149 0.1149
Loa Loa (eye worm) hypothetical protein 0.0039 0.0083 0.0283
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0122 0.0376 0.0376
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0022 0.0022 0.0022
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0544 0.1864 0.8958
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0006 0.0023
Loa Loa (eye worm) MH2 domain-containing protein 0.0052 0.0127 0.0434
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0022 0.0022 0.0245
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0022 0.0022 0.0065
Schistosoma mansoni ferritin light chain 0.0151 0.0477 0.1814
Schistosoma mansoni tar DNA-binding protein 0.0328 0.11 0.4188
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0068 0.0185 0.0185
Schistosoma mansoni hypothetical protein 0.0068 0.0185 0.0703
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0196 0.0846
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0196 0.0668
Brugia malayi Thioredoxin reductase 0.0238 0.0786 0.2682
Echinococcus granulosus geminin 0.0205 0.0666 0.0666
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0033 0.0289
Schistosoma mansoni tar DNA-binding protein 0.0328 0.11 0.4188
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0195 0.2151
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0121 0.0373 0.0373
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0022 0.0022 0.024
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0046 0.0107 0.0407
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0083 0.0236 0.2054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.001 0.0031
Plasmodium vivax ferrodoxin reductase, putative 0.0022 0.0022 0.019
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0046 0.0107 0.118
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0038 0.013
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.001 0.0031
Loa Loa (eye worm) transcription factor SMAD2 0.076 0.2628 0.897
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0215 0.0704 0.2402
Brugia malayi Protein kinase domain containing protein 0.0035 0.007 0.0237
Toxoplasma gondii NADPH-glutathione reductase 0.0083 0.0236 0.2054
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0083 0.0236 0.19
Echinococcus granulosus lamin dm0 0.0027 0.0038 0.0038
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0022 0.0022 0.024
Loa Loa (eye worm) hypothetical protein 0.0071 0.0196 0.0668
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0121 0.0373 0.1418
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0151 0.0477 0.2213
Loa Loa (eye worm) hypothetical protein 0.0042 0.0091 0.0312
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0026 0.0026
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0006 0.0023
Leishmania major hypothetical protein, conserved 0.0022 0.0022 0.024
Loa Loa (eye worm) hypothetical protein 0.0273 0.0907 0.3096
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.001 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.001 0.0031
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0022 0.0022 0.019
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0022 0.0022 0.0022
Schistosoma mansoni intermediate filament proteins 0.0027 0.0038 0.0145
Trypanosoma cruzi PAB1-binding protein , putative 0.0273 0.0907 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.001 0.0031
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0196 0.2158
Brugia malayi Cathepsin L-like precursor 0.0019 0.001 0.0035
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0117 0.0357 0.0357
Mycobacterium ulcerans bacterioferritin BfrB 0.0151 0.0477 0.4035
Brugia malayi Cathepsin L-like precursor 0.0019 0.001 0.0035
Brugia malayi intermediate filament protein 0.0027 0.0038 0.013
Schistosoma mansoni disulfide oxidoreductase 0.0022 0.0022 0.0083
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0341 0.1149 1
Leishmania major cathepsin L-like protease 0.0071 0.0195 0.2151
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0341 0.1149 0.5483
Brugia malayi Bromodomain containing protein 0.0077 0.0215 0.0734
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0083 0.0236 0.2054
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0083 0.0236 0.19
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0022 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0068 0.0185 0.0703
Brugia malayi MH1 domain containing protein 0.0029 0.0046 0.0155
Onchocerca volvulus Cathepsin L homolog 0.0019 0.001 0.0031
Loa Loa (eye worm) hypothetical protein 0.0139 0.0434 0.1482
Trypanosoma brucei PAB1-binding protein , putative 0.0273 0.0907 1
Schistosoma mansoni hypothetical protein 0.0068 0.0185 0.0703
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.001 0.0031
Echinococcus multilocularis Smad4 0.0052 0.0127 0.0127
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0195 0.2151
Echinococcus granulosus mothers against decapentaplegic 2 0.0023 0.0026 0.0026
Leishmania major cathepsin L-like protease 0.0071 0.0195 0.2151
Echinococcus multilocularis tar DNA binding protein 0.0328 0.11 0.11
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0083 0.0236 0.0898
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0846 0.293 1
Echinococcus granulosus cathepsin l1 0.0019 0.001 0.001
Schistosoma mansoni smad1 5 8 and 0.0052 0.0127 0.0484
Onchocerca volvulus 0.0027 0.0038 0.0114
Plasmodium falciparum ataxin-2 like protein, putative 0.0273 0.0907 0.7893
Leishmania major cathepsin L-like protease 0.0019 0.001 0.0113
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0061 0.0159 0.0541
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.016 0.016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.001 0.0031
Schistosoma mansoni hypothetical protein 0.0035 0.007 0.0265
Loa Loa (eye worm) hypothetical protein 0.0071 0.0196 0.0668
Brugia malayi hypothetical protein 0.0176 0.0566 0.1931
Schistosoma mansoni smad1 5 8 and 0.0052 0.0127 0.0484
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0046 0.0107 0.118
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0022 0.0022 0.019
Schistosoma mansoni hypothetical protein 0.0133 0.0414 0.1577
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0122 0.0376 0.0376
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0046 0.0107 0.0107
Echinococcus granulosus mothers against decapentaplegic 6 0.0023 0.0026 0.0026
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0196 0.0586
Echinococcus multilocularis lamin dm0 0.0027 0.0038 0.0038
Loa Loa (eye worm) fibroinase 0.0019 0.001 0.0035
Loa Loa (eye worm) hypothetical protein 0.0068 0.0185 0.063
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0046 0.0107 0.0365
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0083 0.0236 0.2054
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0196 0.1543
Loa Loa (eye worm) hypothetical protein 0.0147 0.0463 0.1582
Echinococcus multilocularis glutamate synthase 0.0022 0.0022 0.0022
Schistosoma mansoni ferritin 0.0151 0.0477 0.1814
Trichomonas vaginalis esterase, putative 0.0071 0.0196 0.0586
Brugia malayi RNA binding protein 0.0328 0.11 0.3756
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0035 0.007 0.0605
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0019 0.0064
Loa Loa (eye worm) hypothetical protein 0.0417 0.1416 0.4834
Echinococcus multilocularis mothers against decapentaplegic 2 0.0023 0.0026 0.0026
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.001 0.0031
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0022 0.0022 0.0065
Onchocerca volvulus 0.0019 0.001 0.0031
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.001 0.0035
Onchocerca volvulus 0.0019 0.001 0.0031
Trypanosoma cruzi PAB1-binding protein , putative 0.0273 0.0907 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.001 0.0031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.001 0.0031
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0083 0.0236 0.2602
Loa Loa (eye worm) MH2 domain-containing protein 0.0023 0.0026 0.0089
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0083 0.0236 0.0805
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0118 0.0359 0.3128
Loa Loa (eye worm) hypothetical protein 0.0071 0.0196 0.0668
Plasmodium falciparum flap endonuclease 1 0.0025 0.0033 0.0289
Brugia malayi MH1 domain containing protein 0.0029 0.0046 0.0155
Schistosoma mansoni tar DNA-binding protein 0.0328 0.11 0.4188
Echinococcus granulosus intermediate filament protein 0.0027 0.0038 0.0038
Schistosoma mansoni lamin 0.0027 0.0038 0.0145
Brugia malayi Latrophilin receptor protein 2 0.0068 0.0185 0.063
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0083 0.0236 0.2602
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.001 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.001 0.0031
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0605 0.2078 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0273 0.0907 0.7893
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0022 0.0022 0.0022
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0022 0.0022 0.024
Onchocerca volvulus 0.0019 0.001 0.0031
Toxoplasma gondii ABC1 family protein 0.0071 0.0196 0.1704
Brugia malayi Pre-SET motif family protein 0.0846 0.293 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0023 0.0026 0.0089
Entamoeba histolytica cysteine protease, putative 0.0019 0.001 0.0115
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.001 0.0031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.001 0.0031
Brugia malayi Smad1 0.0052 0.0127 0.0434
Loa Loa (eye worm) TAR-binding protein 0.0328 0.11 0.3756
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0022 0.0022 0.019
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0341 0.1149 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0026 0.0098
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0083 0.0236 0.2602
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0022 0.0022 0.0022
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0022 0.0022 0.024
Schistosoma mansoni smad 0.0023 0.0026 0.0099
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0083 0.0236 0.2602
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0022 0.0022 0.019
Mycobacterium ulcerans beta-lactamase 0.0071 0.0196 0.1543
Brugia malayi Pre-SET motif family protein 0.0121 0.0373 0.1272
Onchocerca volvulus 0.0019 0.001 0.0031
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0083 0.0236 0.2602
Mycobacterium ulcerans hypothetical protein 0.0071 0.0196 0.1543
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0022 0.0022 0.024
Schistosoma mansoni zinc finger protein 0.002 0.0015 0.0057
Trypanosoma cruzi NADH dehydrogenase, putative 0.0022 0.0022 0.024
Echinococcus granulosus ferritin 0.0151 0.0477 0.0477
Leishmania major cathepsin L-like protease 0.0019 0.001 0.0113
Leishmania major hypothetical protein, conserved 0.0035 0.007 0.0767
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0341 0.1149 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0121 0.0373 0.1418
Schistosoma mansoni tar DNA-binding protein 0.0328 0.11 0.4188
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0196 0.0586
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0033 0.0366
Onchocerca volvulus 0.0121 0.0373 0.1115
Mycobacterium tuberculosis Conserved protein 0.0071 0.0196 0.0846
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0195 0.2151
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0046 0.0107 0.032
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0022 0.0022 0.0022
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0046 0.0107 0.0931
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0196 0.0745
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0341 0.1149 1
Schistosoma mansoni sulfide quinone reductase 0.0022 0.0022 0.0083
Onchocerca volvulus 0.0071 0.0196 0.0586
Schistosoma mansoni glutamate synthase 0.0022 0.0022 0.0083
Loa Loa (eye worm) latrophilin receptor protein 2 0.0068 0.0185 0.063
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0118 0.0359 0.2995
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0022 0.0022 0.024
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0022 0.024
Echinococcus granulosus TGF beta signal transducer SmadC 0.0052 0.0127 0.0127
Schistosoma mansoni apoferritin-2 0.0151 0.0477 0.1814
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0215 0.0704 0.2402
Loa Loa (eye worm) hypothetical protein 0.0044 0.0098 0.0335
Echinococcus multilocularis smad 0.0052 0.0127 0.0127
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0341 0.1149 1
Loa Loa (eye worm) nuclear factor I 0.0029 0.0046 0.0155
Brugia malayi latrophilin 2 splice variant baaae 0.0147 0.0463 0.1582
Echinococcus granulosus histone lysine methyltransferase setb 0.0139 0.0434 0.0434
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.016 0.016
Loa Loa (eye worm) thioredoxin reductase 0.0238 0.0786 0.2682
Loa Loa (eye worm) TK/ROR protein kinase 0.0035 0.007 0.0237
Onchocerca volvulus 0.0027 0.0038 0.0114
Schistosoma mansoni bromodomain containing protein 0.0065 0.0173 0.0657
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0341 0.1149 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0144 0.0452 0.0452
Brugia malayi Probable ClpP-like protease 0.0341 0.1149 0.3922
Brugia malayi beta-lactamase 0.0071 0.0196 0.0668
Echinococcus granulosus expressed protein 0.0151 0.0477 0.0477
Brugia malayi PHD-finger family protein 0.0025 0.0034 0.0117
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0268 0.0892 0.0892
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0083 0.0236 0.19
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0139 0.0434 0.1652
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0022 0.0022 0.0065
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0022 0.0022 0.019
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0083 0.0236 0.1042
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0083 0.0236 0.2602
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0083 0.0236 0.2602
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0022 0.0022 0.0065
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0083 0.0236 0.2602
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0046 0.0107 0.118
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.001 0.0089
Entamoeba histolytica hypothetical protein 0.0268 0.0892 1
Brugia malayi MH1 domain containing protein 0.0052 0.0127 0.0434
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.001 0.0031
Echinococcus multilocularis cysteine protease 0.0019 0.001 0.001
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0022 0.0022 0.019
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0052 0.0127 0.0484
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0083 0.0236 0.19
Toxoplasma gondii cathepsin CPL 0.0019 0.001 0.0089
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0195 0.2151
Trichomonas vaginalis glutamate synthase, putative 0.0022 0.0022 0.0065
Echinococcus granulosus smad 0.0052 0.0127 0.0127
Onchocerca volvulus 0.0071 0.0196 0.0586
Schistosoma mansoni glutamate synthase 0.0022 0.0022 0.0083
Trichomonas vaginalis apoptosis inducing factor, putative 0.0022 0.0022 0.0065
Brugia malayi MH2 domain containing protein 0.0023 0.0026 0.0089
Giardia lamblia Thioredoxin reductase 0.0022 0.0022 0.0924
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0195 0.2151
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0455 0.155 0.7433
Leishmania major cathepsin L-like protease 0.0019 0.001 0.0113
Loa Loa (eye worm) ctsf protein 0.0019 0.001 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0139 0.0434 0.1652
Brugia malayi Cathepsin L-like precursor 0.0019 0.001 0.0035
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0544 0.1864 0.8958
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.001 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0196 0.2158
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0033 0.1407
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.001 0.0089
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0022 0.0022 0.0065
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0151 0.0477 0.2213
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0022 0.0022 0.024
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0133 0.0414 0.0414
Entamoeba histolytica thioredoxin reductase, putative 0.0022 0.0022 0.0245
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0224 0.0734 0.3464
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0196 0.0846
Trichomonas vaginalis set domain proteins, putative 0.0963 0.3342 1
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0022 0.024
Brugia malayi glutamate synthase 0.0022 0.0022 0.0074
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.001 0.0039
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0022 0.0022 0.0074
Brugia malayi Flap endonuclease-1 0.0025 0.0033 0.0113
Entamoeba histolytica disulphide oxidoreductase, putative 0.0022 0.0022 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.001 0.0031
Loa Loa (eye worm) glutathione reductase 0.0238 0.0786 0.2682
Schistosoma mansoni lamin 0.0027 0.0038 0.0145
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0033 0.0113
Mycobacterium tuberculosis Probable reductase 0.0544 0.1864 0.8958
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0033 0.0372
Schistosoma mansoni hypothetical protein 0.0268 0.0892 0.3394
Brugia malayi RNA recognition motif domain containing protein 0.0328 0.11 0.3756
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0046 0.0107 0.0931
Loa Loa (eye worm) hypothetical protein 0.0071 0.0196 0.0668
Echinococcus granulosus glutamate synthase 0.0022 0.0022 0.0022
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0022 0.0022 0.0245
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.001 0.0115
Echinococcus multilocularis lamin 0.0027 0.0038 0.0038
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.001 0.0031
Loa Loa (eye worm) programmed cell death 8 0.0022 0.0022 0.0074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.001 0.0031
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0035
Schistosoma mansoni smad 0.0052 0.0127 0.0484
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0022 0.0022 0.024
Schistosoma mansoni transcription factor LCR-F1 0.0268 0.0892 0.3394
Leishmania major hypothetical protein, conserved 0.0071 0.0196 0.2158
Echinococcus multilocularis ferritin 0.0151 0.0477 0.0477
Schistosoma mansoni cellular tumor antigen P53 0.0417 0.1416 0.539
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.001 0.001
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0605 0.2078 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.001 0.001
Schistosoma mansoni glutamate synthase 0.0022 0.0022 0.0083
Schistosoma mansoni Smad4 0.0023 0.0026 0.0099
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0006 0.0006
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0033 0.0366
Entamoeba histolytica hypothetical protein 0.0268 0.0892 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0052 0.0127 0.0127
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0083 0.0236 0.0236
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0022 0.0022 0.024
Schistosoma mansoni Smad4 0.0052 0.0127 0.0484
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0196 0.0196
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0022 0.0022 0.0065
Leishmania major hypothetical protein, conserved 0.0022 0.0022 0.024
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0061 0.0159 0.0541
Echinococcus granulosus peptidase Clp S14 family 0.0224 0.0734 0.0734
Schistosoma mansoni apoferritin-2 0.0151 0.0477 0.1814
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0195 0.2151
Schistosoma mansoni hypothetical protein 0.0147 0.0463 0.1764
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0006 0.0006
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0151 0.0477 0.4035
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0196 0.0196
Plasmodium vivax ataxin-2 like protein, putative 0.0273 0.0907 0.7893
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0083 0.0236 0.2602
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.001 0.0031
Schistosoma mansoni thyroid hormone receptor 0.0144 0.0452 0.172
Leishmania major hypothetical protein, conserved 0.0022 0.0022 0.024
Brugia malayi glutathione reductase 0.0238 0.0786 0.2682
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.001 0.0031
Brugia malayi MH1 domain containing protein 0.0052 0.0127 0.0434
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0196 0.2158
Echinococcus granulosus thioredoxin glutathione reductase 0.0238 0.0786 0.0786
Schistosoma mansoni hypothetical protein 0.0022 0.0022 0.0083
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.013
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0046 0.0107 0.12
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0074 0.0074
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0196 0.0586
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0038 0.013
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0008 0.0028
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.001 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.001 0.0031
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0068 0.0185 0.063
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0195 0.2151
Trichomonas vaginalis glutamate synthase, putative 0.0022 0.0022 0.0065
Toxoplasma gondii hypothetical protein 0.0118 0.0359 0.3128
Echinococcus granulosus lamin 0.0027 0.0038 0.0038
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0022 0.0022 0.0065
Mycobacterium tuberculosis Probable oxidoreductase 0.0605 0.2078 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0544 0.1864 0.8958
Brugia malayi Cathepsin L-like precursor 0.0019 0.001 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0195 0.2151
Loa Loa (eye worm) hypothetical protein 0.0071 0.0196 0.0668
Trichomonas vaginalis glutathione reductase, putative 0.0083 0.0236 0.0706
Entamoeba histolytica hypothetical protein 0.0268 0.0892 1
Leishmania major cysteine peptidase A (CPA) 0.0019 0.001 0.0113
Trypanosoma cruzi NADH dehydrogenase, putative 0.0022 0.0022 0.024
Trichomonas vaginalis ferritin, putative 0.0151 0.0477 0.1426
Trypanosoma cruzi trypanothione reductase, putative 0.0083 0.0236 0.2602
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0544 0.1864 0.8958
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0022 0.0022 0.0074
Schistosoma mansoni tar DNA-binding protein 0.0328 0.11 0.4188
Echinococcus multilocularis mothers against decapentaplegic 5 0.0052 0.0127 0.0127
Giardia lamblia Glutamate synthase 0.0022 0.0022 0.0924
Echinococcus multilocularis musashi 0.0027 0.0038 0.0038
Plasmodium vivax vivapain-2 0.0019 0.001 0.0089
Echinococcus multilocularis tissue type plasminogen activator 0.0035 0.007 0.007
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0224 0.0734 0.3464
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0268 0.0892 0.0892
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.001 0.0031
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0196 0.0846
Brugia malayi Cathepsin L-like precursor 0.0019 0.001 0.0035
Toxoplasma gondii LsmAD domain-containing protein 0.0273 0.0907 0.7893
Brugia malayi beta-lactamase family protein 0.0071 0.0196 0.0668
Brugia malayi mothers against decapentaplegic homolog 3 0.0023 0.0026 0.0089
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0022 0.0022 0.0022
Trypanosoma cruzi cruzipain precursor, putative 0.0071 0.0195 0.2151
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0118 0.0359 0.3128
Schistosoma mansoni ferritin 0.0151 0.0477 0.1814
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.001 0.0031
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.001 0.001
Schistosoma mansoni sulfide quinone reductase 0.0022 0.0022 0.0083
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0046 0.0107 0.032
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0196 0.1704
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0083 0.0236 0.19
Loa Loa (eye worm) hypothetical protein 0.0341 0.1149 0.3922
Onchocerca volvulus Cathepsin L homolog 0.0019 0.001 0.0031
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0038 0.013
Loa Loa (eye worm) hypothetical protein 0.0026 0.0036 0.0124
Schistosoma mansoni peptidase Clp (S14 family) 0.0341 0.1149 0.4373
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0046 0.0107 0.0365
Loa Loa (eye worm) hypothetical protein 0.0035 0.007 0.0237
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0026 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.001 0.0031
Schistosoma mansoni ferritin light chain 0.0151 0.0477 0.1814
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0118 0.0359 0.1642
Echinococcus granulosus tar DNA binding protein 0.0328 0.11 0.11
Schistosoma mansoni smad1 5 8 and 0.0052 0.0127 0.0484
Plasmodium falciparum glutathione reductase 0.0083 0.0236 0.2054
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0196 0.0846
Brugia malayi MH2 domain containing protein 0.076 0.2628 0.897
Trypanosoma brucei NADH dehydrogenase 0.0022 0.0022 0.024
Schistosoma mansoni hypothetical protein 0.0068 0.0185 0.0703
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0065 0.0173 0.1911
Onchocerca volvulus 0.0022 0.0022 0.0065
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0022 0.0022 0.0022
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0224 0.0734 0.3464
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0196 0.0846
Echinococcus multilocularis geminin 0.0205 0.0666 0.0666
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0022 0.0022 0.0065
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0544 0.1864 0.8958
Schistosoma mansoni hypothetical protein 0.0122 0.0376 0.1431
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0033 0.0099
Echinococcus multilocularis zinc finger protein 0.002 0.0015 0.0015
Echinococcus multilocularis expressed protein 0.0151 0.0477 0.0477
Brugia malayi TAR-binding protein 0.0328 0.11 0.3756
Echinococcus granulosus GPCR family 2 0.0068 0.0185 0.0185
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0022 0.0022 0.019
Mycobacterium tuberculosis Conserved protein 0.0071 0.0196 0.0846
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0195 0.2151
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0341 0.1149 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0046 0.0155
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0083 0.0236 0.2602
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.001 0.001
Echinococcus multilocularis thioredoxin glutathione reductase 0.0238 0.0786 0.0786
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.001 0.0115
Echinococcus multilocularis mothers against decapentaplegic 6 0.0023 0.0026 0.0026
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0196 0.0846
Trichomonas vaginalis mercuric reductase, putative 0.0083 0.0236 0.0706
Loa Loa (eye worm) cysteine protease 0.0019 0.001 0.0035
Plasmodium falciparum glutathione reductase 0.0238 0.0786 0.6838
Toxoplasma gondii kringle domain-containing protein 0.0035 0.007 0.0605
Mycobacterium tuberculosis Conserved protein 0.0071 0.0196 0.0846
Echinococcus multilocularis peptidase Clp (S14 family) 0.0224 0.0734 0.0734
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0046 0.0107 0.0107
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0196 0.0586
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0022 0.0022 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0022 0.024
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0068 0.0185 0.0185
Schistosoma mansoni hypothetical protein 0.0205 0.0666 0.2537
Brugia malayi hypothetical protein 0.0268 0.0892 0.3044
Echinococcus granulosus flap endonuclease 1 0.0025 0.0033 0.0033
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0328 0.11 0.3756
Leishmania major trypanothione reductase 0.0238 0.0786 0.8664
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0196 0.0586
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.001 0.0031
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0196 0.1543
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0022 0.0022 0.0065
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0022 0.0022 0.0022
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0046 0.0107 0.0365
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0074 0.0074
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0033 0.0289
Schistosoma mansoni thyroid hormone receptor 0.0144 0.0452 0.172
Entamoeba histolytica hypothetical protein 0.0268 0.0892 1
Brugia malayi Bromodomain containing protein 0.0039 0.0083 0.0282
Onchocerca volvulus Cathepsin F homolog 0.0019 0.001 0.0031
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.0141 0.156
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.001 0.0113
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0089
Plasmodium vivax glutathione reductase, putative 0.0238 0.0786 0.6838
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0196 0.0846
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0083 0.0236 0.2054
Plasmodium falciparum thioredoxin reductase 0.0238 0.0786 0.6838
Loa Loa (eye worm) hypothetical protein 0.0215 0.0704 0.2402
Loa Loa (eye worm) MH1 domain-containing protein 0.0052 0.0127 0.0434
Leishmania major cathepsin L-like protease 0.0019 0.001 0.0113
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0022 0.0022 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0195 0.2151
Leishmania major cathepsin L-like protease 0.0019 0.001 0.0113
Loa Loa (eye worm) hypothetical protein 0.0072 0.02 0.0681
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0238 0.0786 0.3716
Loa Loa (eye worm) MH2 domain-containing protein 0.076 0.2628 0.897
Loa Loa (eye worm) RNA binding protein 0.0328 0.11 0.3756
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0544 0.1864 0.8958
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0083 0.0236 0.2602
Plasmodium vivax thioredoxin reductase, putative 0.0238 0.0786 0.6838
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0083 0.0236 0.2054
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0022 0.0022 0.0065
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0605 0.2078 1
Treponema pallidum NADH oxidase 0.0083 0.0236 0.19
Onchocerca volvulus 0.0417 0.1416 0.4238
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.001 0.0089
Toxoplasma gondii selenide, water dikinase 0.0022 0.0022 0.019
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0083 0.0236 0.0236
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0022 0.0022 0.024
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0022 0.0022 0.024
Schistosoma mansoni hypothetical protein 0.0205 0.0666 0.2537
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0139 0.0434 0.0434
Trypanosoma brucei trypanothione reductase 0.0238 0.0786 0.8664
Trypanosoma cruzi trypanothione reductase, putative 0.0238 0.0786 0.8664
Brugia malayi hypothetical protein 0.0273 0.0907 0.3096
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0068 0.0185 0.0185
Echinococcus multilocularis cysteine protease 0.0019 0.001 0.001
Plasmodium falciparum ferrodoxin reductase-like protein 0.0022 0.0022 0.019
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0196 0.0846
Onchocerca volvulus 0.0019 0.001 0.0031
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0083 0.0236 0.19
Echinococcus granulosus zinc finger protein 0.002 0.0015 0.0015
Onchocerca volvulus 0.0963 0.3342 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0083 0.0236 0.2602
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.001 0.001
Plasmodium falciparum cysteine repeat modular protein 1 0.0035 0.007 0.0605
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0022 0.0022 0.0245
Brugia malayi Calcitonin receptor-like protein seb-1 0.0215 0.0704 0.2402
Plasmodium vivax vivapain-2 0.0019 0.001 0.0089
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0083 0.0236 0.2602
Brugia malayi MH2 domain containing protein 0.0052 0.0127 0.0434
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0074
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0083 0.0236 0.2602
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0022 0.0022 0.019
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0341 0.1149 0.1149
Mycobacterium ulcerans bacterioferritin BfrA 0.0151 0.0477 0.4035
Brugia malayi Cathepsin L-like precursor 0.0019 0.001 0.0035
Plasmodium falciparum thioredoxin reductase 0.0083 0.0236 0.2054
Leishmania major cathepsin L-like protease 0.0071 0.0195 0.2151
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0341 0.1149 1
Schistosoma mansoni Smad4 0.0023 0.0026 0.0099
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0022 0.0022 0.0245
Schistosoma mansoni hypothetical protein 0.0021 0.0019 0.0072
Echinococcus multilocularis GPCR, family 2 0.0068 0.0185 0.0185
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0195 0.2151
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0033 0.0033
Toxoplasma gondii thioredoxin reductase 0.0238 0.0786 0.6838
Schistosoma mansoni flap endonuclease-1 0.0023 0.0025 0.0094
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0133 0.0414 0.0414
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0022 0.0022 0.019
Schistosoma mansoni ferritin 0.0151 0.0477 0.1814
Echinococcus granulosus tissue type plasminogen activator 0.0035 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0071 0.0196 0.0668
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0052 0.0127 0.0127
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0151 0.0477 0.2213
Treponema pallidum bacterioferrin (TpF1) 0.0151 0.0477 0.4035
Leishmania major NADH dehydrogenase, putative 0.0022 0.0022 0.024
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0022 0.0022 0.0245
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0341 0.1149 1
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0046 0.0107 0.118
Loa Loa (eye worm) beta-lactamase 0.0071 0.0196 0.0668
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.34 0.34
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0195 0.2151
Schistosoma mansoni ferritin 0.0151 0.0477 0.1814
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.007 0.0767
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0196 0.0668
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.001 0.0035
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0022 0.0022 0.0074
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0121 0.0373 0.3243
Mycobacterium leprae Probable lipase LipE 0.0071 0.0196 0.0846
Brugia malayi MH2 domain containing protein 0.0052 0.0127 0.0434
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0083 0.0236 0.2602
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0046 0.0107 0.0931
Loa Loa (eye worm) Smad1 0.0052 0.0127 0.0434

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 4.909 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay reconfirm. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485273, AID485343, AID493155] ChEMBL. No reference
IC50 (functional) = 5.945 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485273, AID485343, AID493182] ChEMBL. No reference
IC50 (functional) > 20 uM PUBCHEM_BIOASSAY: Dose Response confirmation of UBC13 Polyubiquitin Inhibitors using a Bfl-1 counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485273, AID485343] ChEMBL. No reference
Potency (functional) 2.0749 uM PubChem BioAssay. qHTS for Inhibitors of Cell Surface uPA Generation: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.9081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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