Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D3 | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04588 secretin receptor, putative | Get druggable targets OG5_139196 | All targets in OG5_139196 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | hypothetical protein | dopamine receptor D3 | 400 aa | 392 aa | 19.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.1252 | 0.1506 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0706 | 0.185 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.1252 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2225 | 0.5835 |
Brugia malayi | TAR-binding protein | 0.007 | 0.2225 | 0.2677 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0233 | 0.8313 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1252 | 0.1506 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0706 | 0.0849 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0052 | 0.1566 | 0.1884 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2225 | 0.5835 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.1566 | 0.4106 |
Onchocerca volvulus | 0.0047 | 0.14 | 0.1713 | |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 0.2225 | 0.2677 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0112 | 0.3814 | 0.4588 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.1252 | 0.3283 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.3814 | 0.4588 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.1252 | 0.3283 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.1252 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.1252 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.1252 | 0.1506 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0706 | 0.185 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1252 | 0.1506 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1252 | 0.1506 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.14 | 0.1684 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0164 | 0.5751 | 0.6918 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0706 | 0.0849 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0052 | 0.1566 | 0.1884 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0706 | 0.0849 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.1252 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.5751 | 0.6918 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0201 | 0.7136 | 0.8584 |
Brugia malayi | Pre-SET motif family protein | 0.0201 | 0.7136 | 0.8584 |
Onchocerca volvulus | 0.0229 | 0.8173 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.8313 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.1252 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1252 | 0.1506 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2225 | 0.5835 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0052 | 0.1566 | 0.1884 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.14 | 0.3671 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2225 | 0.5835 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0666 | 0.0801 |
Onchocerca volvulus | 0.0043 | 0.1252 | 0.1532 | |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1566 | 0.1884 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1252 | 0.1506 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.4013 | 0.4828 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.1566 | 0.4106 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 0.2225 | 0.2677 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.4013 | 0.4828 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.1252 | 0.1506 |
Onchocerca volvulus | 0.0043 | 0.1252 | 0.1532 | |
Echinococcus multilocularis | GPCR, family 2 | 0.0052 | 0.1566 | 0.1884 |
Brugia malayi | RNA binding protein | 0.007 | 0.2225 | 0.2677 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0706 | 0.0849 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.1252 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2225 | 0.5835 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0052 | 0.1566 | 0.1884 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.1252 | 0.1506 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.1252 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 0.2225 | 0.2677 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0.1252 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 0.2225 | 0.2677 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.1252 | 0.1506 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0706 | 0.0849 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.14 | 0.3671 |
Brugia malayi | beta-lactamase | 0.0043 | 0.1252 | 0.1506 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0706 | 0.185 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 0.2225 | 0.2677 |
Brugia malayi | hypothetical protein | 0.0233 | 0.8313 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0164 | 0.5751 | 0.6918 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.1252 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0052 | 0.1566 | 0.1884 |
Echinococcus granulosus | GPCR family 2 | 0.0052 | 0.1566 | 0.1884 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0706 | 0.185 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0052 | 0.1566 | 0.1884 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.3814 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.1252 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.1252 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.1252 | 0.1506 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 0.2225 | 0.2677 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.4013 | 0.4828 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0164 | 0.5751 | 0.6918 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.1252 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0052 | 0.1566 | 0.1884 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.1252 | 0.1506 |
Onchocerca volvulus | 0.0043 | 0.1252 | 0.1532 | |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.1566 | 0.4106 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0233 | 0.8313 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.1252 | 1 |
Onchocerca volvulus | 0.0029 | 0.0706 | 0.0863 | |
Trichomonas vaginalis | set domain proteins, putative | 0.0229 | 0.8173 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.1566 | 0.4106 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1252 | 0.1506 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.2589 uM | PubChem BioAssay. qHTS of D3 Dopamine Receptor Agonist: D3 Dopamine Receptor B-arrestin Agonist Confirmatory Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 4.4668 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.