Detailed information for compound 1286515

Basic information

Technical information
  • TDR Targets ID: 1286515
  • Name: 6-(propan-2-ylcarbamoyl)cyclohex-3-ene-1-carb oxylic acid
  • MW: 211.258 | Formula: C11H17NO3
  • H donors: 2 H acceptors: 3 LogP: 0.99 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(NC(=O)C1CC=CCC1C(=O)O)C
  • InChi: 1S/C11H17NO3/c1-7(2)12-10(13)8-5-3-4-6-9(8)11(14)15/h3-4,7-9H,5-6H2,1-2H3,(H,12,13)(H,14,15)
  • InChiKey: JCMHNFKSHATAGJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-(isopropylcarbamoyl)cyclohex-3-ene-1-carboxylic acid
  • 6-[(isopropylamino)-oxomethyl]-1-cyclohex-3-enecarboxylic acid
  • 6-[(isopropylamino)carbonyl]cyclohex-3-ene-1-carboxylic acid
  • MLS000699031
  • SMR000231286
  • AK-968/40709512
  • IVK/9156375

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0055 0.0035
Onchocerca volvulus Huntingtin homolog 0.0119 0.1114 0.1072
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0019 0.0047 0.0162
Schistosoma mansoni intermediate filament proteins 0.0027 0.0128 0.0392
Trichomonas vaginalis glutaminase, putative 0.0272 0.2754 0.272
Mycobacterium ulcerans lipase LipD 0.0071 0.0599 0.2041
Loa Loa (eye worm) glutaminase 2 0.0272 0.2754 0.3122
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0236 0.0719
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0047 0.0143
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0235 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0599 0.1191
Trichomonas vaginalis CAMK family protein kinase 0.0285 0.2886 0.2852
Entamoeba histolytica hypothetical protein 0.0024 0.0102 0.0195
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0019 0.0047 0.0162
Mycobacterium ulcerans beta-lactamase 0.0071 0.0599 0.2041
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0599 0.2077
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0599 0.0555
Echinococcus granulosus lamin 0.0027 0.0128 0.0338
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0115 0.1074 0.3239
Loa Loa (eye worm) hypothetical protein 0.0119 0.1114 0.1246
Trichomonas vaginalis CAMK family protein kinase 0.0141 0.1348 0.1307
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0136 0.0089
Echinococcus multilocularis Polycystic kidney disease protein 0.0058 0.0466 0.1375
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0432 0.1318
Loa Loa (eye worm) hypothetical protein 0.0027 0.0128 0.0119
Leishmania major short chain dehydrogenase/reductase, putative 0.0019 0.0047 0.0162
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0432 0.1269
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0372 0.1289
Trypanosoma brucei oxidoreductase-like protein 0.0019 0.0047 0.0162
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0047 0.0043
Brugia malayi hypothetical protein 0.0058 0.0466 0.0522
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0019 0.0047 0.0162
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0432 0.1269
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0136 0.1298 0.3927
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0453 0.4687 1
Schistosoma mansoni rab6-interacting 0.0058 0.0466 0.1423
Loa Loa (eye worm) hypothetical protein 0.0071 0.0599 0.0658
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0047 0.0043
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0075 0.023
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0047 0.0162
Echinococcus granulosus carbonyl reductase 1 0.0019 0.0047 0.0088
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0047 0.0143
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0599 0.0674
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0372 0.7749
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.012 0.1121 0.6245
Schistosoma mansoni hypothetical protein 0.0058 0.0466 0.1423
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0047 0.0143
Loa Loa (eye worm) hypothetical protein 0.0294 0.2985 0.3386
Trichomonas vaginalis CAMK family protein kinase 0.0285 0.2886 0.2852
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0047 0.0143
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0019 0.0047 0.0043
Loa Loa (eye worm) inositol-1 0.0037 0.0235 0.024
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0285 0.2886 0.8796
Echinococcus multilocularis RUN 0.0058 0.0466 0.1375
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0019 0.0047 0.0162
Leishmania major oxidoreductase-like protein 0.0019 0.0047 0.0162
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0372 0.1289
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0583 0.0539
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.1121 0.3421
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0236 0.019
Schistosoma mansoni hypothetical protein 0.0321 0.3278 1
Brugia malayi chromobox protein homolog 3 0.0039 0.0257 0.0283
Toxoplasma gondii aldehyde dehydrogenase 0.018 0.1767 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0285 0.2886 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0075 0.0175
Trichomonas vaginalis ran, putative 0.0022 0.0078 0.0031
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0019 0.0047 0.0088
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0372 0.3026
Echinococcus granulosus carbonyl reductase 1 0.0019 0.0047 0.0088
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0047 0.0143
Onchocerca volvulus 0.0027 0.0128 0.0082
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0047 0.0143
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0599 0.1829
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0599 0.1191
Brugia malayi beta-lactamase family protein 0.0071 0.0599 0.0674
Entamoeba histolytica Ran family GTPase 0.0022 0.0078 0.011
Brugia malayi Importin beta-1 subunit 0.003 0.0163 0.0175
Echinococcus granulosus WW domain containing oxidoreductase 0.0019 0.0047 0.0088
Echinococcus multilocularis lipoxygenase domain containing protein 0.0058 0.0466 0.1375
Loa Loa (eye worm) hypothetical protein 0.0069 0.0576 0.0631
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0102 0.5
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0025
Echinococcus multilocularis retinol dehydrogenase 11 0.0019 0.0047 0.0088
Brugia malayi Dehydrogenases, short chain protein 30 0.0019 0.0047 0.0043
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0019 0.0047 0.0143
Trypanosoma cruzi polo-like protein kinase, putative 0.0285 0.2886 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0372 0.0397
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0599 0.1191
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0047 0.0043
Loa Loa (eye worm) hypothetical protein 0.0071 0.0599 0.0658
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0025
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0047 0.0143
Giardia lamblia Kinase, PLK 0.0285 0.2886 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0599 0.1783
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0019 0.0047 0.0162
Echinococcus multilocularis lamin 0.0027 0.0128 0.0338
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0235 0.0664
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0236 0.0667
Loa Loa (eye worm) oxidoreductase 0.0019 0.0047 0.0025
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0583 0.0539
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0225 0.0634
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0047 0.0143
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0102 0.0321
Brugia malayi hypothetical protein 0.005 0.0372 0.0414
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0078 0.0181
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0599 0.1191
Loa Loa (eye worm) hypothetical protein 0.0026 0.0123 0.0113
Leishmania major hypothetical protein, conserved 0.0071 0.0599 0.2077
Echinococcus granulosus retinol dehydrogenase 11 0.0019 0.0047 0.0088
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0285 0.2886 0.3273
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0225 0.0634
Schistosoma mansoni hypothetical protein 0.0022 0.0079 0.0242
Entamoeba histolytica hypothetical protein 0.0036 0.0225 0.0628
Mycobacterium tuberculosis Conserved protein 0.0071 0.0599 0.1191
Brugia malayi Pre-SET motif family protein 0.0834 0.8767 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0257 0.0211
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0078 0.0078
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0235 0.0813
Echinococcus multilocularis transient receptor potential cation channel 0.0019 0.0047 0.0088
Leishmania major hypothetical protein, conserved 0.0019 0.0047 0.0162
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0432 0.0466
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0047 0.0143
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0432 0.0482
Echinococcus multilocularis oxidoreductase 0.0019 0.0047 0.0088
Brugia malayi hypothetical protein 0.0032 0.0184 0.0199
Trichomonas vaginalis CAMK family protein kinase 0.0285 0.2886 0.2852
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0019 0.0047 0.0162
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0047 0.0162
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0102 0.1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0047 0.0043
Echinococcus granulosus importin subunit beta 1 0.003 0.0163 0.0444
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0235 0.1091
Schistosoma mansoni loxhd1 0.0058 0.0466 0.1423
Brugia malayi glutaminase DH11.1 0.0272 0.2754 0.3134
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0047 0.0043
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0599 0.2077
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0047 0.0143
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0047 0.0143
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0102 0.5
Echinococcus granulosus lipoxygenase domain containing protein 0.0058 0.0466 0.1375
Mycobacterium tuberculosis Conserved protein 0.0071 0.0599 0.1191
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0214 0.0602
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0047 0.0143
Echinococcus granulosus histone lysine methyltransferase setb 0.0136 0.1298 0.3927
Echinococcus multilocularis carbonyl reductase 1 0.0019 0.0047 0.0088
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0102 0.0321
Plasmodium vivax SET domain protein, putative 0.012 0.1121 1
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0019 0.0047 0.0162
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0599 0.0555
Brugia malayi dehydrogenases, short chain protein 2 0.0019 0.0047 0.0043
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0047 0.0162
Brugia malayi intermediate filament protein 0.0027 0.0128 0.0136
Trypanosoma cruzi polo-like protein kinase, putative 0.0285 0.2886 1
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0047 0.0162
Loa Loa (eye worm) hypothetical protein 0.0058 0.0466 0.0505
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.018 0.1771 0.5404
Loa Loa (eye worm) hypothetical protein 0.0071 0.0599 0.0658
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0163 0.0565
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0019 0.0047 0.0162
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0047 0.0043
Schistosoma mansoni inositol monophosphatase 0.0037 0.0235 0.0716
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.018 0.1771 0.5378
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0235 0.0813
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0019 0.0047 0.0162
Echinococcus multilocularis conserved hypothetical protein 0.0019 0.0047 0.0088
Echinococcus granulosus lipoxygenase domain containing protein 0.0058 0.0466 0.1375
Brugia malayi dehydrogenases, short chain protein 9 0.0019 0.0047 0.0043
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0087 0.0769 0.0868
Entamoeba histolytica hypothetical protein 0.0036 0.0225 0.0628
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0019 0.0047 0.0162
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0432 0.1318
Echinococcus multilocularis muscleblind protein 0.0294 0.2985 0.9102
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.012 0.1121 0.3384
Echinococcus multilocularis carbonyl reductase 1 0.0019 0.0047 0.0088
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0161 0.1566 0.1763
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0236 0.0667
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0047 0.0143
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0321 0.3278 0.3721
Echinococcus granulosus steroid dehydrogenase 0.0019 0.0047 0.0088
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0025
Onchocerca volvulus Serine\/threonine kinase homolog 0.0285 0.2886 0.2852
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0047 0.0162
Echinococcus multilocularis importin subunit beta 1 0.003 0.0163 0.0444
Loa Loa (eye worm) oxidoreductase 0.0019 0.0047 0.0025
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0019 0.0047 0.0043
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.018 0.1771 0.3717
Loa Loa (eye worm) oxidoreductase 0.0019 0.0047 0.0025
Echinococcus multilocularis chromobox protein 1 0.0069 0.0583 0.1734
Mycobacterium ulcerans aldehyde dehydrogenase 0.018 0.1767 0.6355
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0128 0.0119
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0461 0.136
Schistosoma mansoni hypothetical protein 0.002 0.0055 0.0169
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0236 0.0817
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0599 0.1191
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0432 0.1269
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0025
Trypanosoma brucei polo-like protein kinase 0.0285 0.2886 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0599 0.0658
Brugia malayi Heterochromatin protein 1 0.0069 0.0583 0.0655
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0025
Leishmania major short chain dehydrogenase, putative 0.0019 0.0047 0.0162
Echinococcus multilocularis carbonyl reductase 1 0.0019 0.0047 0.0088
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0235 0.0694
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0047 0.0143
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0128 0.0119
Brugia malayi beta-lactamase family protein 0.0071 0.0599 0.0674
Loa Loa (eye worm) oxidoreductase 0.0019 0.0047 0.0025
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0236 0.0817
Plasmodium falciparum LCCL domain-containing protein 0.0058 0.0466 1
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0019 0.0047 0.0162
Schistosoma mansoni chromobox protein 0.0069 0.0583 0.178
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0019 0.0047 0.0088
Loa Loa (eye worm) dehydrogenase 0.0019 0.0047 0.0025
Loa Loa (eye worm) hypothetical protein 0.0119 0.1114 0.1246
Brugia malayi Doublecortin family protein 0.0058 0.0466 0.0522
Trichomonas vaginalis CAMK family protein kinase 0.0141 0.1348 0.1307
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0075 0.0175
Echinococcus granulosus Polycystic kidney disease protein 0.0058 0.0466 0.1375
Schistosoma mansoni carbonyl reductase 0.0019 0.0047 0.0143
Loa Loa (eye worm) oxidoreductase 0.0019 0.0047 0.0025
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0047 0.0043
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0047 0.0162
Loa Loa (eye worm) oxidoreductase 0.0019 0.0047 0.0025
Onchocerca volvulus 0.0027 0.0128 0.0082
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0461 0.136
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0193 0.2651
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0102 0.1317
Loa Loa (eye worm) hypothetical protein 0.0071 0.0599 0.0658
Brugia malayi hypothetical protein 0.0019 0.0047 0.0043
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0235 0.0189
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0047 0.0143
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0025
Mycobacterium ulcerans glutaminase 0.0272 0.2754 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0225 0.0687
Echinococcus granulosus chromobox protein 1 0.0069 0.0583 0.1734
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0226 0.2261 0.688
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0019 0.0047 0.0088
Entamoeba histolytica hypothetical protein 0.0036 0.0225 0.0628
Loa Loa (eye worm) hypothetical protein 0.0041 0.0284 0.0297
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0047 0.0143
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0025
Echinococcus granulosus oxidoreductase 0.0019 0.0047 0.0088
Loa Loa (eye worm) hypothetical protein 0.0058 0.0466 0.0505
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0047 0.0043
Echinococcus multilocularis L aminoadipate semialdehyde 0.0087 0.0769 0.2304
Loa Loa (eye worm) hypothetical protein 0.0071 0.0599 0.0658
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0078 0.011
Loa Loa (eye worm) hypothetical protein 0.003 0.0163 0.0158
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0599 0.0555
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0136 0.1298 0.3961
Leishmania major 3-keto-dihydrosphingosine reductase 0.0019 0.0047 0.0162
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.018 0.1771 0.637
Onchocerca volvulus 0.0087 0.0769 0.0726
Plasmodium falciparum importin beta, putative 0.003 0.0163 0.2767
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0019 0.0047 0.0025
Echinococcus multilocularis snurportin 1 0.0321 0.3278 1
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0236 0.0667
Leishmania major hypothetical protein, conserved 0.0019 0.0047 0.0162
Brugia malayi RNA, U transporter 1 0.0086 0.0757 0.0853
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0102 0.0354
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0235 0.0813
Echinococcus granulosus hypothetical protein 0.0019 0.0047 0.0088
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0019 0.0047 0.0088
Leishmania major hypothetical protein, conserved 0.0019 0.0047 0.0162
Echinococcus granulosus intermediate filament protein 0.0027 0.0128 0.0338
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.018 0.1767 0.5365
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0078 0.029
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0047 0.0043
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0078 0.027
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0019 0.0047 0.0162
Schistosoma mansoni serine/threonine protein kinase 0.0285 0.2886 0.8803
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0599 0.2077
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0047 0.0162
Schistosoma mansoni importin beta-1 0.003 0.0163 0.0497
Echinococcus granulosus zinc finger protein 0.0019 0.0044 0.008
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0019 0.0047 0.0162
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0102 0.0204
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0236 0.0665
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0019 0.0047 0.0088
Leishmania major short chain dehydrogenase, putative 0.0019 0.0047 0.0162
Echinococcus granulosus muscleblind protein 0.0294 0.2985 0.9102
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0289 0.0243
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.018 0.1767 0.6124
Echinococcus multilocularis lipoxygenase domain containing protein 0.0058 0.0466 0.1375
Echinococcus granulosus snurportin 1 0.0321 0.3278 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0285 0.2886 0.8796
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0047 0.0043
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0257 0.0211
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0047 0.0143
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0047 0.0043
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0599 0.1829
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0583 0.0639
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.018 0.1771 0.6139
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0163 0.0565
Echinococcus multilocularis musashi 0.0027 0.0128 0.0338
Brugia malayi hypothetical protein 0.0058 0.0466 0.0522
Echinococcus multilocularis lamin dm0 0.0027 0.0128 0.0338
Brugia malayi serine/threonine-protein kinase plk-2 0.0285 0.2886 0.3284
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0047 0.0162
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0226 0.2261 0.688
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0236 0.0665
Entamoeba histolytica hypothetical protein 0.0024 0.0102 0.0195
Schistosoma mansoni polycystin 1-related 0.0058 0.0466 0.1423
Onchocerca volvulus 0.0131 0.1243 0.1202
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0047 0.0043
Echinococcus granulosus retinol dehydrogenase 11 0.0019 0.0047 0.0088
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0019 0.0047 0.0162
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.018 0.1767 0.3708
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0599 0.1783
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0078 0.0183
Trichomonas vaginalis esterase, putative 0.0071 0.0599 0.0555
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0236 0.0667
Loa Loa (eye worm) oxidoreductase 0.0019 0.0047 0.0025
Schistosoma mansoni retinal dehydrogenase 0.0019 0.0047 0.0143
Trichomonas vaginalis CAMK family protein kinase 0.0285 0.2886 0.2852
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0289 0.0243
Entamoeba histolytica hypothetical protein 0.0036 0.0225 0.0628
Echinococcus multilocularis zinc finger protein 0.0019 0.0044 0.008
Trypanosoma cruzi short chain dehydrogenase, putative 0.0019 0.0047 0.0162
Loa Loa (eye worm) hypothetical protein 0.0087 0.0769 0.0852
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.018 0.1771 0.2012
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0236 0.0667
Schistosoma mansoni bromodomain containing protein 0.0061 0.0499 0.1521
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0047 0.0162
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0102 0.0354
Echinococcus granulosus RUN 0.0058 0.0466 0.1375
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0047 0.0043
Onchocerca volvulus 0.003 0.0167 0.0121
Plasmodium vivax importin-beta 2, putative 0.003 0.0163 0.1081
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0214 0.0602
Echinococcus multilocularis retinol dehydrogenase 13 0.0019 0.0047 0.0088
Trichomonas vaginalis CAMK family protein kinase 0.0285 0.2886 0.2852
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0372 0.189
Brugia malayi Dehydrogenases, short chain protein 2 0.0019 0.0047 0.0043
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0372 0.7749
Leishmania major GTP-binding protein, putative 0.0022 0.0078 0.027
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0235 0.0189
Schistosoma mansoni lipoxygenase 0.0226 0.2261 0.6897
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0432 0.1318
Onchocerca volvulus 0.0058 0.0466 0.0422
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0019 0.0047 0.0162
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0047 0.0043
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0163 0.0675
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0078 0.027
Echinococcus granulosus carbonyl reductase 1 0.0019 0.0047 0.0088
Schistosoma mansoni ran 0.0022 0.0078 0.0238
Loa Loa (eye worm) beta-lactamase 0.0071 0.0599 0.0658
Echinococcus multilocularis steroid dehydrogenase 0.0019 0.0047 0.0088
Loa Loa (eye worm) hypothetical protein 0.0037 0.0236 0.0242
Mycobacterium ulcerans aldehyde dehydrogenase 0.018 0.1767 0.6355
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0599 0.5143
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0019 0.0047 0.0162
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0019 0.0047 0.0162
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0047 0.0043
Brugia malayi Inositol-1 0.0037 0.0235 0.0257
Loa Loa (eye worm) glutaminase 0.0272 0.2754 0.3122
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0599 0.2041
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0102 0.0055
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0236 0.0817
Mycobacterium leprae Probable lipase LipE 0.0071 0.0599 1
Brugia malayi Retinol dehydrogenase 12 0.0019 0.0047 0.0043
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0102 0.0119
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0047 0.0162
Echinococcus granulosus L aminoadipate semialdehyde 0.0087 0.0769 0.2304
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0078 0.027
Schistosoma mansoni lipoxygenase 0.0121 0.1135 0.3462
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0102 0.0514
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0019 0.0047 0.0162
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0025
Trypanosoma cruzi short chain dehydrogenase, putative 0.0019 0.0047 0.0162
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0289 0.0243
Echinococcus multilocularis chromobox protein 1 0.0069 0.0583 0.1734
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0599 0.0555
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0078 0.0061
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0236 0.0817
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0047 0.0162
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0025
Schistosoma mansoni inositol monophosphatase 0.0037 0.0235 0.0716
Schistosoma mansoni kinase 0.0145 0.1388 0.4235
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0599 0.1191
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0235 0.0661
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0047 0.0143
Echinococcus multilocularis carbonyl reductase 1 0.0019 0.0047 0.0088
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0599 0.1191
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0047 0.0143
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0236 0.019
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0019 0.0047 0.0162
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0047 0.0043
Leishmania major hypothetical protein, conserved 0.0019 0.0047 0.0162
Trichomonas vaginalis CAMK family protein kinase 0.0285 0.2886 0.2852
Leishmania major hypothetical protein, conserved 0.0019 0.0047 0.0162
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.0047 0.0162
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0235 0.0813
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0102 0.0055
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0236 0.0258
Schistosoma mansoni ran 0.0022 0.0078 0.0238
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0193 0.0316
Onchocerca volvulus 0.0058 0.0466 0.0422
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0136 0.0089
Leishmania major dehydrogenase-like protein 0.0019 0.0047 0.0162
Leishmania major short chain dehydrogenase/reductase, putative 0.0019 0.0047 0.0162
Toxoplasma gondii ABC1 family protein 0.0071 0.0599 0.3212
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0047 0.0143
Loa Loa (eye worm) hypothetical protein 0.004 0.0264 0.0274
Echinococcus multilocularis muscleblind protein 1 0.0294 0.2985 0.9102
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0102 0.2943
Mycobacterium ulcerans hypothetical protein 0.0071 0.0599 0.2041
Echinococcus granulosus carbonyl reductase 1 0.0019 0.0047 0.0088
Trichomonas vaginalis CAMK family protein kinase 0.0285 0.2886 0.2852
Loa Loa (eye worm) oxidoreductase 0.0019 0.0047 0.0025
Onchocerca volvulus 0.0071 0.0599 0.0555
Echinococcus granulosus hypothetical protein 0.0019 0.0047 0.0088
Leishmania major importin beta-1 subunit, putative 0.0024 0.0102 0.0354
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0102 0.0055
Schistosoma mansoni glutaminase 0.0272 0.2754 0.8402
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0047 0.0043
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0078 0.0183
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0131 0.1243 0.3791
Schistosoma mansoni carbonyl reductase 0.0019 0.0047 0.0143
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0047 0.0143
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0047 0.0043
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0019 0.0047 0.0143
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.0047 0.0162
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.0047 0.0162
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.0047 0.0162
Loa Loa (eye worm) oxidoreductase 0.0019 0.0047 0.0025
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0236 0.0667
Brugia malayi Bromodomain containing protein 0.0073 0.062 0.0697
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0235 0.0189
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0834 0.8767 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.018 0.1767 0.5365
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0136 0.1298 0.3961
Leishmania major pteridine reductase 1 0.0019 0.0047 0.0162
Echinococcus multilocularis steroid dehydrogenase 0.0019 0.0047 0.0088
Mycobacterium ulcerans aldehyde dehydrogenase 0.018 0.1767 0.6355
Brugia malayi hypothetical protein 0.0019 0.0047 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0257 0.0211
Schistosoma mansoni chromobox protein 0.0069 0.0583 0.178
Leishmania major hypothetical protein, conserved 0.005 0.0372 0.1289
Brugia malayi PHD-finger family protein 0.0024 0.01 0.0103
Brugia malayi hypothetical protein 0.0119 0.1114 0.1261
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0047 0.0162
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0235 0.0664
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0285 0.2886 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.0047 0.0162
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0599 0.0555
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0236 0.019
Brugia malayi beta-lactamase 0.0071 0.0599 0.0674
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0079 0.0187
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0599 0.0658
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0019 0.0047 0.0088
Onchocerca volvulus 0.0071 0.0599 0.0555
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0236 0.0719
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0047 0.0143
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0128 0.0136
Loa Loa (eye worm) dehydrogenase 0.0019 0.0047 0.0025
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0087 0.0769 0.2347
Mycobacterium tuberculosis Conserved protein 0.0071 0.0599 0.1191
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0047 0.0143
Brugia malayi hypothetical protein 0.0036 0.0225 0.0246
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0599 0.2041
Schistosoma mansoni zinc finger protein 0.0019 0.0044 0.0136
Schistosoma mansoni carbonyl reductase 0.0019 0.0047 0.0143
Schistosoma mansoni lamin 0.0027 0.0128 0.0392
Onchocerca volvulus Huntingtin homolog 0.0119 0.1114 0.1072
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0018 0.0056
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.018 0.1771 0.5378
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0047 0.0143
Loa Loa (eye worm) doublecortin family protein 0.0058 0.0466 0.0505
Schistosoma mansoni aldehyde dehydrogenase 0.018 0.1767 0.5391
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0019 0.0047 0.0162
Schistosoma mansoni hypothetical protein 0.0036 0.0225 0.0687
Echinococcus multilocularis retinol dehydrogenase 11 0.0019 0.0047 0.0088
Loa Loa (eye worm) hypothetical protein 0.0037 0.024 0.0246
Brugia malayi Pre-SET motif family protein 0.012 0.1121 0.1269
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0599 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0025
Brugia malayi Bromodomain containing protein 0.0037 0.0239 0.0262
Loa Loa (eye worm) hypothetical protein 0.0136 0.1298 0.1457
Schistosoma mansoni aldehyde dehydrogenase 0.018 0.1767 0.5391
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.018 0.1771 0.637
Brugia malayi Muscleblind-like protein 0.0294 0.2985 0.3398
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.0163
Leishmania major short chain dehydrogenase-like protein 0.0019 0.0047 0.0162
Schistosoma mansoni lamin 0.0027 0.0128 0.0392
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0018 0.0056
Loa Loa (eye worm) hypothetical protein 0.0039 0.0257 0.0266
Brugia malayi oxidoreductase 0.0019 0.0047 0.0043
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0047 0.0143
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0079 0.0187
Loa Loa (eye worm) hypothetical protein 0.0294 0.2985 0.3386
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0047 0.0162
Onchocerca volvulus 0.0071 0.0599 0.0555
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0078 0.0742
Plasmodium vivax multidomain scavenger receptor, putative 0.0058 0.0466 0.3906
Schistosoma mansoni rab6-interacting 0.0058 0.0466 0.1423
Echinococcus granulosus lamin dm0 0.0027 0.0128 0.0338
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0372 0.1289
Echinococcus granulosus chromobox protein 1 0.0069 0.0583 0.1734
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0019 0.0047 0.0143
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0019 0.0047 0.0088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0432 0.1269
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0102 0.0354
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0102 0.0204

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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