TDR Targets

Basic information

Technical information

TDR Targets ID: 1286579
Name: ethyl 6-methyl-2-[(2-phenylacetyl)amino]-5,7- dihydro-4H-thieno[5,4-c]pyridine-3-carboxylat e hydrochloride
MW: 394.916 | Formula: C19H23ClN2O3S
H donors: 1 H acceptors: 2 LogP: 4.18 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)c1c(NC(=O)Cc2ccccc2)sc2c1CCN(C2)C.Cl
InChi: 1S/C19H22N2O3S.ClH/c1-3-24-19(23)17-14-9-10-21(2)12-15(14)25-18(17)20-16(22)11-13-7-5-4-6-8-13;/h4-8H,3,9-12H2,1-2H3,(H,20,22);1H
InChiKey: DHRPCMQEZWAIGH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-methyl-2-[(1-oxo-2-phenylethyl)amino]-5,7-dihydro-4H-thieno[5,4-c]pyridine-3-carboxylic acid ethyl ester hydrochloride
6-methyl-2-[(2-phenylacetyl)amino]-5,7-dihydro-4H-thieno[5,4-c]pyridine-3-carboxylic acid ethyl ester hydrochloride
ethyl 6-methyl-2-(2-phenylethanoylamino)-5,7-dihydro-4H-thieno[5,4-c]pyridine-3-carboxylate hydrochloride

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	l(3)mbt-like 1 (Drosophila)	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Giardia intestinalis	Putative fructose-1,6-bisphosphate aldolase	Starlite/ChEMBL	No references
Homo sapiens	K(lysine) acetyltransferase 2A	Starlite/ChEMBL	No references
Homo sapiens	flap structure-specific endonuclease 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium falciparum	flap endonuclease 1	Get druggable targets OG5_127472	All targets in OG5_127472
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	Get druggable targets OG5_127781	All targets in OG5_127781
Giardia lamblia	Flap structure-specific endonuclease	Get druggable targets OG5_127472	All targets in OG5_127472
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	flap endonuclease-1, putative	Get druggable targets OG5_127472	All targets in OG5_127472
Plasmodium falciparum	histone acetyltransferase GCN5	Get druggable targets OG5_127781	All targets in OG5_127781
Treponema pallidum	fructose-bisphosphate aldolase	Get druggable targets OG5_129214	All targets in OG5_129214
Cryptosporidium parvum	flap endonuclease 1	Get druggable targets OG5_127472	All targets in OG5_127472
Plasmodium knowlesi	flap endonuclease 1, putative	Get druggable targets OG5_127472	All targets in OG5_127472
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania mexicana	flap endonuclease-1 (FEN-1), putative	Get druggable targets OG5_127472	All targets in OG5_127472
Plasmodium yoelii	histone acetyltransferase GCN5-related	Get druggable targets OG5_127781	All targets in OG5_127781
Cryptosporidium hominis	histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Leishmania braziliensis	flap endonuclease-1 (FEN-1), putative	Get druggable targets OG5_127472	All targets in OG5_127472
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Echinococcus multilocularis	endonuclease exonuclease phosphatase	Get druggable targets OG5_130415	All targets in OG5_130415
Leishmania donovani	flap endonuclease-1 (FEN-1), putative	Get druggable targets OG5_127472	All targets in OG5_127472
Neospora caninum	flap endonuclease-1, putative	Get druggable targets OG5_127472	All targets in OG5_127472
Theileria parva	histone acetyltransferase Gcn5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Plasmodium vivax	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Neospora caninum	hypothetical protein	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Schistosoma japonicum	ko:K04799 flap endonuclease-1, putative	Get druggable targets OG5_127472	All targets in OG5_127472
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_130415	All targets in OG5_130415
Loa Loa (eye worm)	acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Babesia bovis	histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Candida albicans	bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Giardia lamblia	Histone acetyltransferase GCN5	Get druggable targets OG5_127781	All targets in OG5_127781
Cryptosporidium parvum	GCN5 like acetylase + bromodomain	Get druggable targets OG5_127781	All targets in OG5_127781
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Schistosoma japonicum	ko:K06062 p300/CBP-associated factor, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Candida albicans	bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium yoelii	flap endonuclease-1-related	Get druggable targets OG5_127472	All targets in OG5_127472
Schistosoma japonicum	Lethal(3)malignant brain tumor-like 4 protein, putative	Get druggable targets OG5_130415	All targets in OG5_130415
Schistosoma japonicum	Lethal(3)malignant brain tumor-like 3 protein, putative	Get druggable targets OG5_130415	All targets in OG5_130415
Echinococcus granulosus	endonuclease exonuclease phosphatase	Get druggable targets OG5_130415	All targets in OG5_130415
Babesia bovis	XPG N-terminal domain and XPG I-region domain containing protein	Get druggable targets OG5_127472	All targets in OG5_127472
Schistosoma mansoni	flap endonuclease-1	Get druggable targets OG5_127472	All targets in OG5_127472
Echinococcus granulosus	flap endonuclease 1	Get druggable targets OG5_127472	All targets in OG5_127472
Plasmodium vivax	flap endonuclease 1, putative	Get druggable targets OG5_127472	All targets in OG5_127472
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	Get druggable targets OG5_127472	All targets in OG5_127472
Leishmania infantum	flap endonuclease-1 (FEN-1), putative	Get druggable targets OG5_127472	All targets in OG5_127472
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	Get druggable targets OG5_127472	All targets in OG5_127472
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Entamoeba histolytica	Flap nuclease, putative	Get druggable targets OG5_127472	All targets in OG5_127472
Trypanosoma brucei gambiense	flap endonuclease-1 (FEN-1), putative	Get druggable targets OG5_127472	All targets in OG5_127472
Entamoeba histolytica	acetyltransferase, GNAT family	Get druggable targets OG5_127781	All targets in OG5_127781
Loa Loa (eye worm)	flap endonuclease-1	Get druggable targets OG5_127472	All targets in OG5_127472
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	Get druggable targets OG5_127781	All targets in OG5_127781
Brugia malayi	acetyltransferase, GNAT family protein	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus granulosus	histone acetyltransferase KAT2B	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium berghei	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Leishmania major	flap endonuclease-1 (FEN-1), putative	Get druggable targets OG5_127472	All targets in OG5_127472
Giardia lamblia	Fructose-bisphosphate aldolase	Get druggable targets OG5_129214	All targets in OG5_129214
Plasmodium knowlesi	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Trypanosoma congolense	flap endonuclease-1 (FEN-1), putative	Get druggable targets OG5_127472	All targets in OG5_127472
Theileria parva	flap endonuclease 1, putative	Get druggable targets OG5_127472	All targets in OG5_127472
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	Get druggable targets OG5_127472	All targets in OG5_127472
Echinococcus granulosus	histone acetyltransferase KAT2B	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	flap endonuclease 1	Get druggable targets OG5_127472	All targets in OG5_127472
Plasmodium berghei	flap endonuclease 1, putative	Get druggable targets OG5_127472	All targets in OG5_127472
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Brugia malayi	Flap endonuclease-1	Get druggable targets OG5_127472	All targets in OG5_127472
Cryptosporidium hominis	flap endonuclease 1	Get druggable targets OG5_127472	All targets in OG5_127472
Neospora caninum	Bromodomain containing protein, related	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	exonuclease, putative	flap structure-specific endonuclease 1	380 aa	322 aa	24.5 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	25.8 %
Candida albicans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	358 aa	22.6 %
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	25.5 %
Candida albicans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	358 aa	22.6 %
Mycobacterium ulcerans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	26.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0117	0.1178	0.1485
Loa Loa (eye worm)	hypothetical protein	0.001	0.0004	0.0007
Plasmodium falciparum	ataxin-2 like protein, putative	0.0056	0.0501	1
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0025	0.0165	0.0165
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0051	0.0456	0.1191
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.013	0.1677
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.013	0.1677
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0051	0.045	0.8794
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0256	0.0257
Trichomonas vaginalis	chromobox protein, putative	0.0143	0.1462	0.3861
Onchocerca volvulus		0.0039	0.0322	0.0757
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0051	0.045	0.0877
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.0322	0.0426
Loa Loa (eye worm)	hypothetical protein	0.002	0.0105	0.0187
Brugia malayi	CHD4 protein	0.0025	0.0165	0.0184
Brugia malayi	latrophilin 2 splice variant baaae	0.0253	0.2672	0.472
Schistosoma mansoni	chromobox protein	0.0023	0.0147	0.0112
Schistosoma mansoni	hypothetical protein	0.0046	0.0398	0.0445
Schistosoma mansoni	smad	0.0035	0.0278	0.0286
Echinococcus multilocularis	mothers against decapentaplegic 2	0.0016	0.0063	0.0063
Trichomonas vaginalis	chromobox protein, putative	0.0086	0.0838	0.2204
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0192	0.0488
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0514	0.1343
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0227	0.2388	0.2388
Brugia malayi	beta-lactamase family protein	0.0039	0.0322	0.0469
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0078	0.0185
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.005	0.0444	0.8715
Trichomonas vaginalis	chromobox protein, putative	0.0023	0.0147	0.037
Mycobacterium ulcerans	beta-lactamase	0.0039	0.0322	0.1159
Plasmodium falciparum	flap endonuclease 1	0.0031	0.0236	0.2509
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0612	0.1094
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0113	0.1136	0.143
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0506	0.0906
Echinococcus granulosus	Chromo domain	0.0023	0.0147	0.0194
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0026	0.018	0.0457
Brugia malayi	acetyltransferase, GNAT family protein	0.0175	0.1816	0.3172
Schistosoma mansoni	chromobox protein	0.0143	0.1462	0.1865
Loa Loa (eye worm)	hypothetical protein	0.008	0.0771	0.1379
Mycobacterium tuberculosis	Probable lipase LipE	0.0039	0.0322	0.0761
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0322	0.0577
Echinococcus granulosus	GPCR family 2	0.0117	0.1178	0.1556
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0322	0.0835
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0025	0.0164	0.0217
Brugia malayi	Niemann-Pick C1 protein precursor	0.0112	0.1117	0.1907
Echinococcus multilocularis	smad	0.0035	0.0278	0.0278
Brugia malayi	CHE-14 protein	0.0048	0.0417	0.0639
Loa Loa (eye worm)	transcription factor SMAD2	0.0518	0.5591	1
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0023	0.0147	0.0112
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0023	0.0147	0.2596
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.013	0.1245
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0256	0.0256
Echinococcus granulosus	Niemann Pick C1 protein	0.0159	0.1644	0.2173
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0306	0.0793
Brugia malayi	hypothetical protein	0.0023	0.0147	0.0152
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.0568	0.0673
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0147	0.0263
Brugia malayi	hypothetical protein	0.0327	0.3486	0.6192
Schistosoma mansoni	flap endonuclease-1	0.0028	0.0203	0.0186
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0256	0.0257
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0147	0.037
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0039	0.0322	0.0761
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0353	0.3775	1
Onchocerca volvulus		0.0039	0.0322	0.0757
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.003	0.0218	0.0558
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0051	0.045	0.0595
Loa Loa (eye worm)	flap endonuclease-1	0.0031	0.0236	0.0422
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.005	0.0444	0.0444
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0022	0.013	0.0172
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.003	0.0218	0.0558
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0039	0.0322	0.0761
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0172	0.1788	0.6566
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0604	0.0721
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.003	0.0218	0.0558
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0048	0.0417	0.0745
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0144	0.147	0.1876
Loa Loa (eye worm)	MH2 domain-containing protein	0.0016	0.0063	0.0113
Leishmania major	hypothetical protein, conserved	0.0056	0.0501	1
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0023	0.0147	0.0046
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0236	0.0312
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0322	0.0835
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0117	0.1178	0.1556
Schistosoma mansoni	hypothetical protein	0.0117	0.1178	0.1485
Echinococcus multilocularis	dnaJ subfamily B	0.0406	0.4357	0.4357
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0051	0.0456	0.8735
Echinococcus granulosus	Protein patched homolog 1	0.0048	0.0417	0.0551
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0023	0.0147	0.2596
Onchocerca volvulus		0.0023	0.0147	0.0245
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0144	0.147	0.2546
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0147	0.0263
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3775	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0017	0.0078	0.0026
Echinococcus granulosus	dnaJ subfamily B	0.0406	0.4357	0.576
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0147	0.0263
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0144	0.147	0.147
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0078	0.0185
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0021	0.0122	0.1499
Mycobacterium tuberculosis	Probable hydrolase	0.0039	0.0322	0.0761
Brugia malayi	ImpB/MucB/SamB family protein	0.0051	0.0448	0.0696
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0306	0.0793
Echinococcus granulosus	histone acetyltransferase KAT2B	0.017	0.1762	0.233
Trypanosoma cruzi	PAB1-binding protein , putative	0.0056	0.0501	1
Toxoplasma gondii	isocitrate dehydrogenase	0.005	0.0444	0.8126
Trichomonas vaginalis	flap endonuclease-1, putative	0.0031	0.0236	0.0605
Loa Loa (eye worm)	mbt repeat family protein	0.0058	0.0524	0.0937
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.013	0.1677
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.037	0.396	0.7083
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0051	0.0456	0.8358
Brugia malayi	chromobox protein homolog 3	0.008	0.0771	0.1281
Mycobacterium ulcerans	lipase LipD	0.0039	0.0322	0.1159
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0192	0.049
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0078	0.0185
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0192	0.0488
Trypanosoma cruzi	PAB1-binding protein , putative	0.0056	0.0501	1
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0023	0.0147	0.0046
Echinococcus granulosus	expressed conserved protein	0.0105	0.1043	0.1378
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0322	0.0577
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0147	0.037
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0023	0.0147	0.0147
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0051	0.045	0.045
Echinococcus multilocularis	sterol regulatory element binding protein	0.0048	0.0417	0.0417
Toxoplasma gondii	isocitrate dehydrogenase	0.005	0.0444	0.8126
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3775	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.013	0.1677
Echinococcus multilocularis	Chromo domain	0.0023	0.0147	0.0147
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.013	0.1677
Brugia malayi	M-phase phosphoprotein, mpp8	0.0023	0.0147	0.0152
Brugia malayi	Smad1	0.0035	0.0278	0.0389
Brugia malayi	mbt repeat family protein	0.0058	0.0524	0.0833
Onchocerca volvulus		0.0327	0.3486	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0147	0.0263
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0022	0.013	0.0233
Brugia malayi	RNA binding protein	0.0065	0.0604	0.0978
Loa Loa (eye worm)	MH1 domain-containing protein	0.0016	0.0063	0.0113
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0066	0.0612	0.0612
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0306	0.0793
Echinococcus granulosus	flap endonuclease 1	0.0031	0.0236	0.0312
Brugia malayi	beta-lactamase	0.0039	0.0322	0.0469
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0417	0.1085
Leishmania major	DNA polymerase eta, putative	0.0036	0.0282	0.4826
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0022	0.013	0.1245
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0322	0.1159
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0017	0.0078	0.0493
Echinococcus granulosus	SAM and MBT domain containing protein	0.0058	0.0524	0.0692
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.013	0.1677
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0306	0.0793
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0524	0.0937
Brugia malayi	MH2 domain containing protein	0.0035	0.0278	0.0389
Loa Loa (eye worm)	MBCTL1	0.0066	0.0612	0.1094
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0051	0.045	0.1174
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0253	0.0652
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0322	0.0835
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3775	1
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0185	0.0471
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0023	0.0147	0.037
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.0322	0.0322
Brugia malayi	Pre-SET motif family protein	0.0033	0.0256	0.0348
Loa Loa (eye worm)	TAR-binding protein	0.0065	0.0604	0.108
Schistosoma mansoni	microtubule-associated protein tau	0.0697	0.7565	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0322	0.0835
Brugia malayi	Isocitrate dehydrogenase	0.005	0.0444	0.0688
Loa Loa (eye worm)	nuclear factor I	0.002	0.0105	0.0187
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0017	0.0078	0.0493
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0322	0.0761
Echinococcus multilocularis	dna polymerase eta	0.0051	0.0448	0.0448
Echinococcus multilocularis	Chromobox protein 3	0.0023	0.0147	0.0147
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3775	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.013	0.0121
Giardia lamblia	GTOR	0.0051	0.045	0.0877
Schistosoma mansoni	hypothetical protein	0.0046	0.0398	0.0445
Onchocerca volvulus		0.0039	0.0322	0.0757
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0035	0.0278	0.0278
Trypanosoma brucei	unspecified product	0.0022	0.013	0.1677
Loa Loa (eye worm)	hypothetical protein	0.0253	0.2672	0.4779
Leishmania major	DNA polymerase eta, putative	0.0051	0.0448	0.8745
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0604	0.0721
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0051	0.045	0.8854
Brugia malayi	MH1 domain containing protein	0.0035	0.0278	0.0389
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.013	0.1677
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.013	0.1245
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0022	0.013	0.0089
Mycobacterium tuberculosis	Probable lipase LipD	0.0039	0.0322	0.0761
Echinococcus granulosus	tar DNA binding protein	0.0065	0.0604	0.0798
Onchocerca volvulus		0.0023	0.0147	0.0245
Schistosoma mansoni	hypothetical protein	0.0117	0.1178	0.1485
Echinococcus multilocularis	Smad4	0.0035	0.0278	0.0278
Brugia malayi	Heterochromatin protein 1	0.0143	0.1462	0.2531
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0027	0.0185	0.0471
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0058	0.0524	0.0524
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0322	0.0577
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.003	0.0218	0.0558
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0117	0.1178	0.1556
Giardia lamblia	Flap structure-specific endonuclease	0.0031	0.0236	0.029
Loa Loa (eye worm)	RNA binding protein	0.0065	0.0604	0.108
Entamoeba histolytica	acetyltransferase, GNAT family	0.0047	0.0409	0.0765
Schistosoma mansoni	chromobox protein	0.0023	0.0147	0.0112
Mycobacterium ulcerans	esterase/lipase LipP	0.0039	0.0322	0.1159
Schistosoma mansoni	hypothetical protein	0.0253	0.2672	0.3477
Trichomonas vaginalis	set domain proteins, putative	0.026	0.2748	0.7273
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.0544	1
Schistosoma mansoni	sex comb on midleg homolog	0.0058	0.0524	0.0614
Echinococcus multilocularis	tar DNA binding protein	0.0065	0.0604	0.0604
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.003	0.0218	0.0558
Loa Loa (eye worm)	MH1 domain-containing protein	0.0035	0.0278	0.0498
Loa Loa (eye worm)	hypothetical protein	0.0327	0.3486	0.6235
Echinococcus granulosus	chromobox protein 1	0.0143	0.1462	0.1933
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0322	0.0761
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0117	0.1178	0.2106
Echinococcus multilocularis	GPCR, family 2	0.0117	0.1178	0.1178
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0058	0.0524	0.0614
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0322	0.0345
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0023	0.0147	0.0046
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0051	0.045	0.0877
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0051	0.045	0.0515
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0051	0.045	0.8794
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0306	0.0793
Schistosoma mansoni	DNA polymerase eta	0.0051	0.0448	0.0513
Echinococcus multilocularis	mothers against decapentaplegic 6	0.0016	0.0063	0.0063
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0031	0.0236	0.3738
Echinococcus granulosus	microtubule associated protein 2	0.0697	0.7565	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0051	0.0456	0.0603
Echinococcus multilocularis	polycomb protein SCMH1	0.0058	0.0524	0.0524
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0051	0.045	0.1174
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0017	0.0078	0.0078
Loa Loa (eye worm)	heterochromatin protein 1	0.0143	0.1462	0.2615
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0192	0.049
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0078	0.0185
Trypanosoma brucei	DNA polymerase eta, putative	0.0051	0.0448	0.8807
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.013	0.1677
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0086	0.0838	0.2264
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.013	0.1677
Entamoeba histolytica	hypothetical protein	0.0023	0.0147	0.0046
Schistosoma mansoni	hypothetical protein	0.035	0.3744	0.4907
Echinococcus granulosus	tumor protein p63	0.0383	0.4103	0.5423
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.013	0.1677
Trypanosoma cruzi	DNA polymerase eta, putative	0.0051	0.0448	0.8745
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.005	0.0444	0.8649
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0117	0.1178	0.2016
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0017	0.0078	0.0103
Entamoeba histolytica	hypothetical protein	0.0023	0.0147	0.0046
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3775	1
Echinococcus granulosus	mothers against decapentaplegic 6	0.0016	0.0063	0.0084
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0368	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0448	0.0801
Brugia malayi	Associated with TFs and helicases family protein	0.0023	0.0147	0.0152
Echinococcus multilocularis	Niemann Pick C1 protein	0.0159	0.1644	0.1644
Brugia malayi	isocitrate dehydrogenase	0.005	0.0444	0.0688
Schistosoma mansoni	hypothetical protein	0.0117	0.1178	0.1485
Schistosoma mansoni	hypothetical protein	0.0046	0.0398	0.0445
Loa Loa (eye worm)	MH2 domain-containing protein	0.0518	0.5591	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.005	0.0444	0.0444
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0514	0.1343
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0051	0.045	0.07
Echinococcus multilocularis	chromobox protein 2	0.0023	0.0147	0.0147
Echinococcus granulosus	mothers against decapentaplegic 5	0.0035	0.0278	0.0368
Brugia malayi	Calcitonin receptor-like protein seb-1	0.037	0.396	0.705
Loa Loa (eye worm)	MH2 domain-containing protein	0.0035	0.0278	0.0498
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0147	0.037
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0306	0.0793
Leishmania major	DNA polymerase kappa, putative	0.0022	0.013	0.1245
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0023	0.0147	0.037
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0256	0.0458
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.008	0.0771	0.2068
Echinococcus multilocularis	expressed conserved protein	0.0105	0.1043	0.1043
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0065	0.0604	0.108
Brugia malayi	hypothetical protein	0.0056	0.0501	0.0792
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0051	0.045	0.1174
Echinococcus multilocularis	dna polymerase kappa	0.0022	0.013	0.013
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0039	0.0322	0.0761
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0256	0.0338
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0066	0.0612	0.0808
Plasmodium falciparum	histone acetyltransferase GCN5	0.0047	0.0409	0.7402
Echinococcus granulosus	polycomb protein SCMH1	0.0058	0.0524	0.0692
Schistosoma mansoni	patched 1	0.0048	0.0417	0.0471
Echinococcus granulosus	histone acetyltransferase MYST2	0.0066	0.0612	0.0808
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0025	0.0164	0.0164
Onchocerca volvulus		0.0063	0.0581	0.1512
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0112	0.1117	0.2708
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.003	0.0218	0.0558
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0147	0.037
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0322	0.0345
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0322	0.0835
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0147	0.037
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0604	0.0721
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0038	0.0306	0.5565
Loa Loa (eye worm)	hypothetical protein	0.0117	0.1178	0.2106
Trichomonas vaginalis	chromobox protein, putative	0.0023	0.0147	0.037
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0535	0.0957
Brugia malayi	Protein cec-1.	0.0023	0.0147	0.0152
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0144	0.147	0.1944
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0051	0.045	0.8794
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0147	0.0263
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0144	0.147	0.147
Brugia malayi	MH1 domain containing protein	0.002	0.0105	0.0075
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0041	0.0336	0.629
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0025	0.0165	0.0218
Toxoplasma gondii	ABC1 family protein	0.0039	0.0322	0.5863
Loa Loa (eye worm)	acetyltransferase	0.0175	0.1816	0.3249
Schistosoma mansoni	chromobox protein	0.0143	0.1462	0.1865
Schistosoma mansoni	hypothetical protein	0.0046	0.0398	0.0445
Schistosoma mansoni	cpg binding protein	0.0028	0.0203	0.0187
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0203	0.0253
Trichomonas vaginalis	conserved hypothetical protein	0.008	0.0771	0.2026
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0117	0.1178	0.1178
Echinococcus multilocularis	tumor protein p63	0.0383	0.4103	0.4103
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0175	0.1816	0.1816
Loa Loa (eye worm)	beta-lactamase	0.0039	0.0322	0.0577
Echinococcus granulosus	chromobox protein 2	0.0023	0.0147	0.0194
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.0322	0.0577
Echinococcus granulosus	smad	0.0035	0.0278	0.0368
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.013	0.1245
Echinococcus granulosus	dna polymerase kappa	0.0022	0.013	0.0172
Echinococcus multilocularis	isocitrate dehydrogenase	0.005	0.0444	0.0444
Plasmodium vivax	ataxin-2 like protein, putative	0.0056	0.0501	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0056	0.0501	0.9192
Entamoeba histolytica	Flap nuclease, putative	0.0031	0.0236	0.029
Trichomonas vaginalis	chromobox protein, putative	0.0086	0.0838	0.2204
Schistosoma mansoni	hypothetical protein	0.0406	0.4357	0.5724
Echinococcus granulosus	cpg binding protein	0.003	0.0221	0.0293
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0057	0.0513	0.06
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0306	0.0793
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.005	0.0444	0.0587
Brugia malayi	hypothetical protein	0.0036	0.0284	0.04
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0035	0.0278	0.0368
Echinococcus granulosus	dna polymerase eta	0.0051	0.0448	0.0592
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0147	0.037
Toxoplasma gondii	chromodomain helicase DNA binding protein CHD1/SWI2/SNF2	0.0023	0.0147	0.2596
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3775	1
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0023	0.0147	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0008	0.0014
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0221	0.0566
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0335	0.087
Plasmodium vivax	flap endonuclease 1, putative	0.0031	0.0236	0.2509
Loa Loa (eye worm)	CHromoDomain protein family member	0.0025	0.0165	0.0295
Brugia malayi	MH2 domain containing protein	0.0035	0.0278	0.0389
Echinococcus multilocularis	protein patched	0.0048	0.0417	0.0417
Trichomonas vaginalis	chromobox protein, putative	0.0023	0.0147	0.037
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.0322	0.5989
Brugia malayi	Valyl-tRNA synthetase	0.0023	0.0147	0.0152
Mycobacterium tuberculosis	Probable esterase LipL	0.0039	0.0322	0.0761
Plasmodium falciparum	ataxin-2 like protein, putative	0.0056	0.0501	1
Trypanosoma cruzi	target of rapamycin kinase 3	0.0041	0.0336	0.6098
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0031	0.0236	0.425
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.005	0.0444	0.0444
Loa Loa (eye worm)	hypothetical protein	0.037	0.396	0.7083
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0058	0.0524	0.1345
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0023	0.0147	0.0194
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0066	0.0612	0.0731
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3775	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.013	0.1245
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0017	0.0078	0.0019
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0036	0.0282	0.511
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0604	0.0721
Schistosoma mansoni	smad1 5 8 and	0.0035	0.0278	0.0286
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0035	0.0278	0.0278
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0023	0.0147	0.0112
Trichomonas vaginalis	chromobox protein, putative	0.0143	0.1462	0.3861
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0256	0.4623
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0228	0.2401	0.4296
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0022	0.013	0.0325
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0147	0.037
Loa Loa (eye worm)	helicase	0.0023	0.0147	0.0263
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0192	0.049
Entamoeba histolytica	hypothetical protein	0.0023	0.0147	0.0046
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0192	0.0488
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.013	0.1677
Trichomonas vaginalis	DNA polymerase eta, putative	0.0022	0.013	0.0325
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.005	0.0444	0.8649
Echinococcus multilocularis	Niemann Pick C1 protein	0.0112	0.1117	0.1117
Loa Loa (eye worm)	phosphatidylinositol 3	0.0017	0.0078	0.0139
Giardia lamblia	Histone acetyltransferase GCN5	0.0047	0.0409	0.0765
Echinococcus multilocularis	microtubule associated protein 2	0.0697	0.7565	0.7565
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0144	0.147	0.1944
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0051	0.0456	0.1191
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.005	0.0444	0.0507
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0078	0.0185
Onchocerca volvulus		0.0057	0.0513	0.1315
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0172	0.1788	1
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0023	0.0147	0.0152
Echinococcus granulosus	chromobox protein 1	0.0143	0.1462	0.1933
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0025	0.0165	0.0135
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0221	0.0566
Brugia malayi	Latrophilin receptor protein 2	0.0117	0.1178	0.2016
Schistosoma mansoni	Smad4	0.0035	0.0278	0.0286
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0192	0.049
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3775	1
Leishmania major	hypothetical protein, conserved	0.0039	0.0322	0.5781
Echinococcus multilocularis	protein dispatched 1	0.0055	0.0491	0.0491
Brugia malayi	Pre-SET motif family protein	0.0228	0.2401	0.423
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0051	0.0456	0.8358
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0041	0.0336	0.6098
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0256	0.0257
Echinococcus granulosus	mothers against decapentaplegic 2	0.0016	0.0063	0.0084
Brugia malayi	MH1 domain containing protein	0.002	0.0105	0.0075
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0322	0.5781
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0266	0.0684
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0604	0.0721
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0024	0.0155	0.2224
Echinococcus multilocularis	flap endonuclease 1	0.0031	0.0236	0.0236
Schistosoma mansoni	hypothetical protein	0.0023	0.0147	0.0112
Brugia malayi	RNA recognition motif domain containing protein	0.0065	0.0604	0.0978
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0172	0.1788	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0335	0.087
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0251	0.2654	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0335	0.087
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0203	0.0364
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0014	0.004	0.0086
Echinococcus multilocularis	cpg binding protein	0.003	0.0221	0.0221
Echinococcus granulosus	Smad4	0.0035	0.0278	0.0368
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0581	0.1039
Trypanosoma cruzi	DNA polymerase eta, putative	0.0036	0.0282	0.4826
Trichomonas vaginalis	conserved hypothetical protein	0.008	0.0771	0.2026
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0335	0.087
Brugia malayi	MH1 domain containing protein	0.0035	0.0278	0.0389
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0117	0.1178	0.1178
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1117	0.1998
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0031	0.0236	0.4046
Brugia malayi	Flap endonuclease-1	0.0031	0.0236	0.0312
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0022	0.013	0.013
Schistosoma mansoni	cpg binding protein	0.003	0.0221	0.0211
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0035	0.0278	0.0286
Brugia malayi	TAR-binding protein	0.0065	0.0604	0.0978
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0501	0.0896
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.005	0.0444	0.8715
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.003	0.0218	0.0558
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0335	0.087
Schistosoma mansoni	hypothetical protein	0.0025	0.0164	0.0134
Plasmodium vivax	SET domain protein, putative	0.0033	0.0256	0.3073
Echinococcus multilocularis	chromobox protein 1	0.0143	0.1462	0.1462
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.005	0.0444	0.0444
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.013	0.1677
Brugia malayi	mbt repeat family protein	0.0058	0.0524	0.0833
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0147	0.037
Brugia malayi	SET domain containing protein	0.0025	0.0167	0.0188
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.0322	0.0469
Schistosoma mansoni	sex comb on midleg homolog	0.0058	0.0524	0.0614
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0147	0.0263
Trichomonas vaginalis	Heterochromatin protein, putative	0.0023	0.0147	0.037
Echinococcus granulosus	sterol regulatory element binding protein	0.0048	0.0417	0.0551
Schistosoma mansoni	smad1 5 8 and	0.0035	0.0278	0.0286
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.003	0.0218	0.0558
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.005	0.0444	0.8649
Brugia malayi	MH2 domain containing protein	0.0518	0.5591	1
Treponema pallidum	fructose-bisphosphate aldolase	0.0353	0.3775	0.5
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.037	0.396	0.705
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0175	0.1816	0.2337
Loa Loa (eye worm)	isocitrate dehydrogenase	0.005	0.0444	0.0794
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0051	0.045	0.8794
Schistosoma mansoni	cellular tumor antigen P53	0.0056	0.0506	0.0591
Onchocerca volvulus		0.0058	0.0524	0.1345
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0063	0.0113
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.013	0.1677
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0144	0.147	0.263
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0322	0.0577
Giardia lamblia	Fructose-bisphosphate aldolase	0.0353	0.3775	1
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.0322	0.4953
Loa Loa (eye worm)	phosphatidylinositol 3	0.0051	0.045	0.0805
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0322	0.0577
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0227	0.2388	0.3157
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0023	0.0147	0.037
Echinococcus multilocularis	chromobox protein 1	0.0143	0.1462	0.1462
Trypanosoma brucei	PAB1-binding protein , putative	0.0056	0.0501	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0.0322	0.1159
Schistosoma mansoni	smad1 5 8 and	0.0035	0.0278	0.0286
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0066	0.0612	0.0612
Onchocerca volvulus		0.0028	0.0203	0.0409
Echinococcus granulosus	Chromobox protein 3	0.0023	0.0147	0.0194
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0144	0.147	0.1876
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0225	0.0575
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0066	0.0612	0.0992
Brugia malayi	beta-lactamase family protein	0.0039	0.0322	0.0469
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.0256	0.0256
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0353	0.3775	1
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.005	0.0444	0.1242
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0147	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0417	0.0745
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0144	0.147	0.1876
Trichomonas vaginalis	hypothetical protein	0.0023	0.0147	0.037
Echinococcus granulosus	Niemann Pick C1 protein	0.0112	0.1117	0.1477
Schistosoma mansoni	cpg binding protein	0.003	0.0221	0.0211
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0322	0.0761
Loa Loa (eye worm)	Smad1	0.0035	0.0278	0.0498
Onchocerca volvulus		0.0056	0.0506	0.1294
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0225	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0322	0.0577
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0322	0.5781
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0022	0.013	0.0089
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0051	0.045	0.8854
Trichomonas vaginalis	esterase, putative	0.0039	0.0322	0.0835
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0031	0.0236	0.3738
Onchocerca volvulus		0.026	0.2748	0.7843
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.005	0.0444	0.8384
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0225	0.0575
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.005	0.0444	0.8384

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.1413 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398]	ChEMBL.	No reference
Potency (functional)	0.7943 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ]	ChEMBL.	No reference
Potency (functional)	= 19.9526 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)]	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1401325

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1286579