Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.4111 | 0.4111 |
Onchocerca volvulus | 0.0033 | 0.4274 | 0.5 | |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.0141 | 0.0141 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.4274 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.4274 | 0.4274 |
Echinococcus granulosus | lamin | 0.0033 | 0.4274 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.4274 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.4274 | 0.4274 |
Onchocerca volvulus | 0.0033 | 0.4274 | 0.5 | |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.4274 | 0.4274 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.4274 | 0.4274 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.5371 | 0.5371 |
Schistosoma mansoni | lamin | 0.0033 | 0.4274 | 0.7957 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.4274 | 0.7957 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.4274 | 0.4274 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0141 | 0.0141 |
Echinococcus multilocularis | lamin | 0.0033 | 0.4274 | 1 |
Echinococcus multilocularis | musashi | 0.0033 | 0.4274 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.5371 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.4274 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.4274 | 0.7957 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.5371 | 0.5371 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 2.2387 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.9341 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.