Detailed information for compound 1286820

Basic information

Technical information
  • TDR Targets ID: 1286820
  • Name: N-(2,4-dimethylphenyl)-5-[furan-2-ylmethyl-[( 4-methoxyphenyl)methyl]amino]-2-methylsulfony lpyrimidine-4-carboxamide
  • MW: 520.6 | Formula: C27H28N4O5S
  • H donors: 1 H acceptors: 5 LogP: 3.85 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)CN(c1cnc(nc1C(=O)Nc1ccc(cc1C)C)S(=O)(=O)C)Cc1ccco1
  • InChi: 1S/C27H28N4O5S/c1-18-7-12-23(19(2)14-18)29-26(32)25-24(15-28-27(30-25)37(4,33)34)31(17-22-6-5-13-36-22)16-20-8-10-21(35-3)11-9-20/h5-15H,16-17H2,1-4H3,(H,29,32)
  • InChiKey: FHFLLXUYHAONLM-UHFFFAOYSA-N  


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Synonyms

  • N-(2,4-dimethylphenyl)-5-[2-furylmethyl-[(4-methoxyphenyl)methyl]amino]-2-methylsulfonyl-pyrimidine-4-carboxamide
  • N-(2,4-dimethylphenyl)-5-[2-furylmethyl-[(4-methoxyphenyl)methyl]amino]-2-methylsulfonyl-4-pyrimidinecarboxamide
  • N-(2,4-dimethylphenyl)-5-[2-furylmethyl-(4-methoxybenzyl)amino]-2-mesyl-pyrimidine-4-carboxamide
  • N-(2,4-dimethylphenyl)-5-[furan-2-ylmethyl-[(4-methoxyphenyl)methyl]amino]-2-methylsulfonyl-pyrimidine-4-carboxamide
  • D299-0695
  • NCGC00117886-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax vivapain-3 0.001 0.0267 0.0957
Plasmodium vivax glutathione reductase, putative 0.0046 0.2793 1
Loa Loa (eye worm) CYP4Cod1 0.0019 0.089 0.2557
Onchocerca volvulus Cathepsin L homolog 0.002 0.097 0.3203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0491 0.4394
Schistosoma mansoni cpg binding protein 0.0036 0.2126 0.2126
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0655 0.0813
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.1015 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.5039 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.419 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0774 0.2224
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.1015 1
Schistosoma mansoni ap endonuclease 0.0021 0.1015 0.1015
Brugia malayi Cathepsin L-like precursor 0.002 0.097 0.2784
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.6985 0.8896
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0655 0.0813
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.5039 1
Brugia malayi Cathepsin L-like precursor 0.002 0.097 0.2784
Trypanosoma brucei trypanothione reductase 0.0046 0.2793 0.5293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.097 0.951
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.001 0.0267 0.053
Loa Loa (eye worm) cytochrome P450 0.001 0.0271 0.0779
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0655 0.13
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0655 0.0805
Trypanosoma cruzi cysteine protease, putative 0.001 0.0267 0.053
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.097 0.3093
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.1986 0.5702
Onchocerca volvulus 0.002 0.097 0.3203
Schistosoma mansoni hypothetical protein 0.0017 0.0774 0.0774
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.097 0.951
Brugia malayi Cathepsin L-like precursor 0.0014 0.0491 0.1409
Onchocerca volvulus 0.002 0.097 0.3203
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.1015 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.1015 0.3262
Echinococcus multilocularis 0.001 0.0271 0.051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.5039 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.097 0.951
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.097 0.951
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.2837 1
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0655 0.0979
Plasmodium falciparum thioredoxin reductase 0.0046 0.2793 1
Leishmania major cathepsin L-like protease 0.002 0.097 0.1464
Entamoeba histolytica cysteine protease, putative 0.002 0.097 0.9387
Schistosoma mansoni cytochrome P450 0.001 0.0271 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0267 0.2006
Echinococcus granulosus cytochrome P450 2K1 0.001 0.0271 0.051
Plasmodium vivax vivapain-2 0.002 0.097 0.3471
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.6985 0.8896
Brugia malayi cytochrome P450 0.001 0.0271 0.0779
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0267 0.0768
Leishmania major cysteine peptidase A (CPA) 0.002 0.097 0.1464
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0655 0.193
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.097 0.951
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.1015 0.1561
Plasmodium falciparum thioredoxin reductase 0.0016 0.0655 0.1535
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0073 0.4748 0.4748
Schistosoma mansoni hypothetical protein 0.001 0.0271 0.0271
Onchocerca volvulus 0.002 0.097 0.3203
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.6985 0.8896
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.3482 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.5039 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0284 0.0556
Echinococcus granulosus cysteine protease 0.001 0.0267 0.0495
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.2229 0.6401
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0774 0.2224
Schistosoma mansoni ap endonuclease 0.0021 0.1015 0.1015
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0774 0.2371
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.001 0.0271 0.0538
Echinococcus granulosus cathepsin L 0.001 0.0267 0.0495
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.1015 1
Onchocerca volvulus Cathepsin L homolog 0.002 0.097 0.3203
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.3858 0.7656
Toxoplasma gondii thioredoxin reductase 0.0046 0.2793 0.6436
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.1015 0.2962
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.1015 0.2015
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.001 0.0271 0.0008
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.1015 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.097 0.951
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.5039 1
Echinococcus granulosus GPCR family 2 0.0017 0.0774 0.2371
Toxoplasma gondii exonuclease III APE 0.0021 0.1015 0.1899
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0655 0.0813
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0774 0.2371
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0354 0.1017
Leishmania major cytochrome p450-like protein 0.0019 0.089 0.1298
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.1015 0.2916
Echinococcus multilocularis cysteine protease 0.002 0.097 0.3093
Brugia malayi CXXC zinc finger family protein 0.0034 0.1986 0.5702
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.3482 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.2837 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.5039 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.097 0.3093
Loa Loa (eye worm) fibroinase 0.002 0.097 0.2784
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0491 0.2987
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0267 0.0267
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.0271 0.0779
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0354 0.1017
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0655 0.13
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.097 0.951
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0655 0.13
Brugia malayi Cytochrome P450 family protein 0.001 0.0271 0.0779
Plasmodium vivax vivapain-2 0.002 0.097 0.3471
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.5039 1
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.2793 0.8022
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0655 0.13
Brugia malayi Cathepsin L-like precursor 0.0014 0.0491 0.1409
Onchocerca volvulus 0.002 0.097 0.3203
Brugia malayi Cytochrome P450 family protein 0.0019 0.089 0.2557
Brugia malayi cathepsin L-like precursor 0.0014 0.0491 0.1409
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.097 0.2784
Schistosoma mansoni hypothetical protein 0.0038 0.2229 0.2229
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.001 0.0271 0.0538
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0284 0.0815
Loa Loa (eye worm) ctsf protein 0.002 0.097 0.2784
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.7818 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0133 0.0133
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.5039 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.097 0.2784
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0774 0.2371
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0284 0.0556
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.089 0.1767
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0655 0.13
Schistosoma mansoni cpg binding protein 0.0034 0.1986 0.1986
Plasmodium vivax vivapain-1 0.001 0.0267 0.0957
Leishmania major cathepsin L-like protease 0.002 0.097 0.1464
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.097 0.951
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0655 0.5157
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.2793 0.5543
Brugia malayi Cathepsin L-like precursor 0.002 0.097 0.2784
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.097 0.951
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0655 0.5157
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.5039 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0491 0.1409
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0655 0.13
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.089 0.2557
Schistosoma mansoni cpg binding protein 0.0036 0.2126 0.2126
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.2793 0.3342
Brugia malayi Cytochrome P450 family protein 0.0019 0.089 0.2557
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.1015 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0655 0.1535
Brugia malayi Cathepsin L-like precursor 0.002 0.097 0.2784
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.6985 0.8896
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0655 0.13
Loa Loa (eye worm) hypothetical protein 0.0055 0.3482 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.097 0.951
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.1015 0.2015
Brugia malayi Papain family cysteine protease containing protein 0.002 0.097 0.2784
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.3482 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.097 0.951
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.097 0.278
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.1015 0.3635
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.7818 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.097 0.278
Loa Loa (eye worm) hypothetical protein 0.0014 0.0491 0.1409
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0655 0.193
Schistosoma mansoni hypothetical protein 0.0017 0.0774 0.0774
Trypanosoma cruzi cysteine peptidase, putative 0.001 0.0267 0.053
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0267 0.0267
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0655 0.5157
Leishmania major cathepsin L-like protease 0.002 0.097 0.1464
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.5039 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.2229 0.6401
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.1015 1
Plasmodium falciparum glutathione reductase 0.0046 0.2793 1
Leishmania major trypanothione reductase 0.0046 0.2793 0.5289
Onchocerca volvulus Cathepsin F homolog 0.002 0.097 0.3203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.097 0.951
Onchocerca volvulus 0.002 0.097 0.3203
Brugia malayi glutathione reductase 0.0046 0.2793 0.8022
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.089 0.2557
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0267 0.0267
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0774 0.2371
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0655 0.2345
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0655 0.13
Onchocerca volvulus 0.002 0.097 0.3203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.097 0.951
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.097 0.951
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.097 0.951
Entamoeba histolytica cysteine proteinase, putative 0.002 0.097 0.9387
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0655 0.2345
Loa Loa (eye worm) hypothetical protein 0.0014 0.0491 0.1409
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0267 0.2006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.5039 1
Echinococcus multilocularis cathepsin L 0.001 0.0267 0.0495
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.5039 1
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.089 0.1767
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.1015 0.2916
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.097 0.951
Loa Loa (eye worm) glutathione reductase 0.0046 0.2793 0.8022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.097 0.951
Brugia malayi Thioredoxin reductase 0.0046 0.2793 0.8022
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0655 0.5
Leishmania major cathepsin L-like protease 0.002 0.097 0.1464
Trypanosoma cruzi cytochrome p450-like protein, putative 0.001 0.0271 0.0538
Trypanosoma brucei cytochrome P450, putative 0.0019 0.089 0.1306
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.097 0.3093
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.097 0.3093
Leishmania major cathepsin L-like protease 0.0077 0.5039 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.1015 0.1568
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.097 0.1924
Echinococcus granulosus cathepsin l1 0.0014 0.0491 0.1322
Brugia malayi Cytochrome P450 family protein 0.001 0.0271 0.0779
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0655 0.0655
Mycobacterium tuberculosis Probable reductase 0.0104 0.6985 0.8896
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.5039 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.1015 0.0986
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0655 0.0805
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0655 0.0979
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.097 0.951
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.097 0.278
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0655 0.0813
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.097 0.3093
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.097 0.951
Echinococcus multilocularis cysteine protease 0.002 0.097 0.3093
Brugia malayi Cathepsin L-like precursor 0.002 0.097 0.2784
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.089 0.8319
Echinococcus granulosus cpg binding protein 0.0036 0.2126 0.737
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0274 0.0787
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.4561 0.905
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.097 0.097
Entamoeba histolytica cysteine proteinase, putative 0.002 0.097 0.9387
Plasmodium vivax unspecified product 0.001 0.0267 0.0957
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0655 0.1535
Echinococcus multilocularis GPCR, family 2 0.0017 0.0774 0.2371
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0267 0.0768
Toxoplasma gondii cathepsin CPL 0.002 0.097 0.1782
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0267 0.0495
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0491 0.4394
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.1015 0.3262
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0491 0.0491
Loa Loa (eye worm) hypothetical protein 0.0009 0.014 0.0403
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.2793 1
Schistosoma mansoni hypothetical protein 0.0017 0.0774 0.0774
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.6985 0.8896
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0655 0.0805
Schistosoma mansoni hypothetical protein 0.0017 0.0774 0.0774
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.097 0.951
Echinococcus multilocularis cpg binding protein 0.0036 0.2126 0.737
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.097 0.951
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.097 0.951
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0267 0.053
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.6985 0.8896
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.5039 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.097 0.951
Onchocerca volvulus 0.0034 0.1986 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.097 0.951
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.7818 1
Loa Loa (eye worm) cysteine protease 0.002 0.097 0.2784
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0655 0.0805
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.097 0.097
Loa Loa (eye worm) hypothetical protein 0.002 0.097 0.2784
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0774 0.2224
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.097 0.3093
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0655 0.615
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0655 0.615
Leishmania major cathepsin L-like protease 0.002 0.097 0.1464
Loa Loa (eye worm) hypothetical protein 0.0014 0.0491 0.1409
Echinococcus granulosus cathepsin l1 0.002 0.097 0.3093
Onchocerca volvulus 0.002 0.097 0.3203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.097 0.951
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.7818 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0774 0.2224
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.5039 1
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0267 0.053
Leishmania major cathepsin L-like protease 0.0077 0.5039 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0655 0.13
Leishmania major cathepsin L-like protease 0.0077 0.5039 1
Brugia malayi Cathepsin L-like precursor 0.002 0.097 0.2784
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0655 0.0509
Plasmodium falciparum glutathione reductase 0.0016 0.0655 0.1535
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0655 0.1881

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 316.2278 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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