Detailed information for compound 1287226

Basic information

Technical information
  • TDR Targets ID: 1287226
  • Name: N-methyl-N-[4-[(7-methyl-4-oxopyrido[1,2-a]py rimidin-2-yl)methoxy]phenyl]benzenesulfonamid e
  • MW: 435.496 | Formula: C23H21N3O4S
  • H donors: 0 H acceptors: 3 LogP: 2.22 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2n(c1)c(=O)cc(n2)COc1ccc(cc1)N(S(=O)(=O)c1ccccc1)C
  • InChi: 1S/C23H21N3O4S/c1-17-8-13-22-24-18(14-23(27)26(22)15-17)16-30-20-11-9-19(10-12-20)25(2)31(28,29)21-6-4-3-5-7-21/h3-15H,16H2,1-2H3
  • InChiKey: PGPXQSUZYLYRPT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-methyl-N-[4-[(7-methyl-4-oxo-pyrido[1,2-a]pyrimidin-2-yl)methoxy]phenyl]benzenesulfonamide
  • N-methyl-N-[4-[(7-methyl-4-oxo-2-pyrido[1,2-a]pyrimidinyl)methoxy]phenyl]benzenesulfonamide
  • N-[4-[(4-keto-7-methyl-pyrido[1,2-a]pyrimidin-2-yl)methoxy]phenyl]-N-methyl-benzenesulfonamide
  • ZINC03428555
  • MLS000774263
  • SMR000365334
  • T5340063

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus geminin 0.0171 0.3456 0.3599
Echinococcus granulosus tankyrase 0.0032 0.0207 0.0215
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.2831 0.3943
Echinococcus granulosus poly (ADP ribose) polymerase 0.0067 0.103 0.1073
Schistosoma mansoni hypothetical protein 0.0171 0.3456 0.3599
Loa Loa (eye worm) hypothetical protein 0.0057 0.0779 0.1085
Onchocerca volvulus 0.0058 0.0818 1
Brugia malayi hypothetical protein 0.0286 0.6143 0.6397
Entamoeba histolytica hypothetical protein 0.0032 0.0207 0.0215
Brugia malayi WGR domain containing protein 0.0433 0.9603 1
Entamoeba histolytica zinc finger protein, putative 0.0032 0.0207 0.0215
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.6143 0.6397
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0206 0.4277 0.4454
Echinococcus multilocularis geminin 0.0171 0.3456 0.3599
Entamoeba histolytica hypothetical protein 0.0032 0.0207 0.0215
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0631 0.0658
Schistosoma mansoni hypothetical protein 0.0058 0.0818 0.0852
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0238 0.503 0.5238
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7721 1
Leishmania major hypothetical protein, conserved 0.0057 0.0779 1
Brugia malayi Tnks protein 0.0032 0.0207 0.0215
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0631 0.088
Echinococcus granulosus poly (ADP ribose) polymerase 0.0135 0.2606 0.2714
Trypanosoma brucei poly(adp-ribose) polymerase 0.0238 0.503 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0631 0.0658
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0259 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0207 0.0268
Echinococcus granulosus WGR domain containing protein 0.0135 0.2606 0.2714
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0207 0.0268
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0207 0.0268
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.3492 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7721 1
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0433 0.9603 1
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0099 0.1783 0.1857
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.7721 0.804
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7721 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.2831 0.3943
Loa Loa (eye worm) hypothetical protein 0.0286 0.6143 0.8556
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0207 0.0268
Loa Loa (eye worm) tnks protein 0.0032 0.0207 0.0288
Entamoeba histolytica hypothetical protein 0.0032 0.0207 0.0215
Echinococcus granulosus poly ADP ribose polymerase 1 0.0433 0.9603 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7721 1
Schistosoma mansoni hypothetical protein 0.0034 0.0259 0.027
Echinococcus multilocularis tankyrase 0.0032 0.0207 0.0215
Leishmania major DNA repair protein, putative 0.0057 0.0779 1
Schistosoma mansoni hypothetical protein 0.0171 0.3456 0.3599
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0057 0.0779 0.1549
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0238 0.503 0.5238
Echinococcus granulosus poly adp ribose polymerase 2 0.0238 0.503 0.5238
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0207 0.0268
Loa Loa (eye worm) hypothetical protein 0.033 0.7179 1
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0171 0.3454 0.481
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0433 0.9603 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7721 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.3492 1
Brugia malayi MH2 domain containing protein 0.0144 0.2831 0.2948
Entamoeba histolytica hypothetical protein 0.0067 0.103 0.1073
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0238 0.503 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0631 0.088
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0207 0.0268
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0207 0.0268
Schistosoma mansoni survival motor neuron protein 0.0058 0.0818 0.0852
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0057 0.0779 0.1549
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7721 1
Echinococcus granulosus poly (ADP ribose) polymerase 0.0067 0.103 0.1073
Loa Loa (eye worm) hypothetical protein 0.0034 0.0259 0.0361
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.3492 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0207 0.0268
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.7721 0.5
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0238 0.503 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7721 1
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.6143 0.6397
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0207 0.0268
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.7721 0.804
Brugia malayi WGR domain containing protein 0.0238 0.503 0.5238
Onchocerca volvulus DNA ligase 3 homolog 0.0057 0.0779 0.9359
Loa Loa (eye worm) hypothetical protein 0.0238 0.503 0.7006
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0818 0.0852
Trypanosoma brucei DNA repair protein, putative 0.0057 0.0779 0.1549
Entamoeba histolytica hypothetical protein 0.0032 0.0207 0.0215
Schistosoma mansoni tankyrase 0.0032 0.0207 0.0215
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7721 1
Echinococcus granulosus poly (ADP ribose) polymerase 0.0067 0.103 0.1073
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.7721 1
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0433 0.9603 1
Trypanosoma cruzi DNA repair protein, putative 0.0057 0.0779 0.1549

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 17.7407 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 23.7558 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 125.8925 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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