Detailed information for compound 1289315

Basic information

Technical information
  • TDR Targets ID: 1289315
  • Name: 8-[[cyclopentyl-[(1-cyclopentyltetrazol-5-yl) methyl]amino]methyl]-3,6-dihydro-2H-[1,4]diox ino[2,3-g]quinolin-7-one
  • MW: 450.533 | Formula: C24H30N6O3
  • H donors: 1 H acceptors: 5 LogP: 3.33 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1nc2cc3OCCOc3cc2cc1CN(C1CCCC1)Cc1nnnn1C1CCCC1
  • InChi: 1S/C24H30N6O3/c31-24-17(11-16-12-21-22(13-20(16)25-24)33-10-9-32-21)14-29(18-5-1-2-6-18)15-23-26-27-28-30(23)19-7-3-4-8-19/h11-13,18-19H,1-10,14-15H2,(H,25,31)
  • InChiKey: GKHUQDRFHVFTHY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-[[cyclopentyl-[(1-cyclopentyl-5-tetrazolyl)methyl]amino]methyl]-3,6-dihydro-2H-[1,4]dioxino[2,3-g]quinolin-7-one
  • 8-[[cyclopentyl-[(1-cyclopentyl-1,2,3,4-tetrazol-5-yl)methyl]amino]methyl]-3,6-dihydro-2H-[1,4]dioxino[2,3-g]quinolin-7-one
  • MLS000123009
  • 8-{[Cyclopentyl-(1-cyclopentyl-1H-tetrazol-5-ylmethyl)-amino]-methyl}-2,3-dihydro-6H-[1,4]dioxino[2,3-g]quinolin-7-one
  • ASN 05298911
  • SMR000123699
  • Oprea1_588426

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni mannose-6-phosphate isomerase 0.0294 0.2857 0.349
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0001 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1095 0.1338
Loa Loa (eye worm) 6-phosphofructokinase 0.0214 0.2027 0.2475
Brugia malayi steroid hormone receptor 0.002 0.0001 0.0002
Schistosoma mansoni thyroid hormone receptor 0.002 0.0001 0.0002
Loa Loa (eye worm) jmjC domain-containing protein 0.0119 0.1031 0.1258
Trypanosoma brucei phosphomannose isomerase 0.0294 0.2857 0.4517
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0144 0.0257
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0058 0.0397 0.0614
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0001 0.0001
Echinococcus granulosus tar DNA binding protein 0.0125 0.1095 0.1951
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0558 0.068
Plasmodium vivax 6-phosphofructokinase, putative 0.0058 0.0397 0.1391
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0308 0.1077
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0138 0.068
Echinococcus granulosus hexokinase 0.0242 0.2319 0.413
Echinococcus granulosus PHD finger protein rhinoceros 0.0057 0.0393 0.07
Loa Loa (eye worm) hypothetical protein 0.0035 0.0158 0.0191
Brugia malayi Hexokinase family protein 0.0242 0.2319 0.2833
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0188 0.1756 0.1756
Brugia malayi RNA recognition motif domain containing protein 0.0125 0.1095 0.1338
Brugia malayi Thioredoxin reductase 0.0057 0.0389 0.0475
Schistosoma mansoni thyroid hormone receptor 0.002 0.0001 0.0002
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0022 0.0026 0.0026
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0067 0.0488 0.0597
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0214 0.2027 0.3206
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0389 0.0615
Schistosoma mansoni zinc finger protein 0.0046 0.0269 0.0329
Echinococcus granulosus citrate lyase subunit beta protein 0.0072 0.0546 0.0972
Brugia malayi Hexokinase family protein 0.0075 0.0575 0.0702
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.081 0.0989
Brugia malayi MH2 domain containing protein 0.0352 0.3459 0.4225
Schistosoma mansoni hypothetical protein 0.003 0.0108 0.0132
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0001 0.0002
Brugia malayi nuclear receptor NHR-88 0.002 0.0001 0.0002
Brugia malayi hypothetical protein 0.0032 0.0125 0.0153
Onchocerca volvulus Alhambra homolog 0.0057 0.0393 0.0883
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0212 0.2002 1
Plasmodium falciparum mannose-6-phosphate isomerase, putative 0.0294 0.2857 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0043 0.0077
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0001 0.0001
Trichomonas vaginalis phosphofructokinase, putative 0.0214 0.2027 0.2477
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0001 0.0002
Schistosoma mansoni 6-phosphofructokinase 0.0214 0.2027 0.2477
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0281 0.1386
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0532 0.0948
Loa Loa (eye worm) MH2 domain-containing protein 0.0352 0.3459 0.4224
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0115 0.0205
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0158 0.0778
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0281 0.0444
Mycobacterium ulcerans hypothetical protein 0.0072 0.0546 0.0667
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0068 0.0504 0.0797
Schistosoma mansoni glutaminase 0.0805 0.8186 1
Trichomonas vaginalis phosphofructokinase, putative 0.0214 0.2027 0.2477
Loa Loa (eye worm) hypothetical protein 0.0087 0.0704 0.0858
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0389 0.0389
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0001 0.0002
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.007 0.0526 0.0831
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.0168 0.1542 0.1884
Loa Loa (eye worm) glutathione reductase 0.0057 0.0389 0.0473
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0212 0.2002 0.2446
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0001 0.0002
Schistosoma mansoni 6-phosphofructokinase 0.0214 0.2027 0.2477
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0308 0.1077
Trypanosoma cruzi Putative Phosphatase/Protein of unknown function DUF89, putative 0.0107 0.0912 0.1443
Trichomonas vaginalis CAMK family protein kinase 0.0278 0.2694 0.3291
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0089 0.0718 0.2515
Echinococcus granulosus hexokinase 0.0242 0.2319 0.413
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0558 0.0682
Loa Loa (eye worm) glutaminase 0.0805 0.8186 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.081 0.0988
Echinococcus granulosus geminin 0.0168 0.1542 0.2747
Leishmania major hypothetical protein, conserved 0.0107 0.0912 0.1443
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0308 0.1077
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0115 0.0205
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.5614 0.5614
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0281 0.0343
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0294 0.2857 0.349
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.5614 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0001 0.0002
Entamoeba histolytica mannose-6-phosphate isomerase, putative 0.0135 0.1196 0.3663
Loa Loa (eye worm) hypothetical protein 0.0091 0.0743 0.0906
Onchocerca volvulus 0.0242 0.2319 0.5229
Echinococcus multilocularis GPCR, family 2 0.0031 0.0115 0.0115
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0001 0.0003
Toxoplasma gondii phosphomannose isomerase type I protein 0.0294 0.2857 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0558 0.0682
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0001 0.0002
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0138 0.1236 0.4327
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0043 0.0043
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0001 0.0002
Schistosoma mansoni jumonji domain containing protein 0.015 0.1353 0.1652
Schistosoma mansoni bromodomain containing protein 0.0132 0.1167 0.1426
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0058 0.0397 0.1475
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0057 0.0393 0.048
Echinococcus granulosus Smad4 0.0024 0.0043 0.0077
Echinococcus granulosus smad 0.0024 0.0043 0.0077
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0001 0.0002
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0281 0.0343
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.022 0.2087 0.7304
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.022 0.2087 0.7746
Loa Loa (eye worm) 6-phosphofructokinase 0.0214 0.2027 0.2475
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0212 0.2002 0.2445
Entamoeba histolytica phosphofructokinase, putative 0.0214 0.2027 0.6835
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0258 0.0315
Schistosoma mansoni hypothetical protein 0.0057 0.0393 0.048
Trypanosoma cruzi phosphomannose isomerase, putative 0.0294 0.2857 0.4517
Echinococcus multilocularis hexokinase 0.0242 0.2319 0.2319
Toxoplasma gondii phosphofructokinase PFKII 0.0058 0.0397 0.1391
Toxoplasma gondii hexokinase 0.0242 0.2319 0.8117
Echinococcus multilocularis hexokinase type 2 0.0242 0.2319 0.2319
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0212 0.2002 0.3166
Plasmodium vivax glutathione reductase, putative 0.0057 0.0389 0.1361
Loa Loa (eye worm) hypothetical protein 0.0057 0.0393 0.0478
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0258 0.0315
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0281 0.0343
Loa Loa (eye worm) hexokinase 0.0242 0.2319 0.2831
Leishmania major ATP-dependent phosphofructokinase 0.0214 0.2027 0.3206
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0558 0.0682
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0043 0.0043
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0072 0.0546 0.0667
Mycobacterium ulcerans mannose-6-phosphate isomerase ManA 0.0294 0.2857 0.349
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0212 0.2002 0.3166
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0294 0.2857 0.3489
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0281 0.017
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0001 0.0003
Trichomonas vaginalis glutaminase, putative 0.0805 0.8186 1
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1095 0.1338
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0212 0.2002 0.2002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0001 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1095 0.1338
Plasmodium vivax hexokinase, putative 0.0242 0.2319 0.8117
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0218 0.0264
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0125 0.1094 0.1948
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0001 0.0003
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.022 0.2087 0.2549
Schistosoma mansoni hypothetical protein 0.0022 0.0024 0.003
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0031 0.0115 0.0139
Echinococcus granulosus GPCR family 2 0.0031 0.0115 0.0205
Echinococcus multilocularis tar DNA binding protein 0.0125 0.1095 0.1095
Leishmania major trypanothione reductase 0.0057 0.0389 0.0615
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.1151 0.4984
Brugia malayi RNA binding protein 0.0125 0.1095 0.1338
Trypanosoma cruzi Putative Phosphatase/Protein of unknown function DUF89, putative 0.0107 0.0912 0.1443
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0072 0.0546 0.0863
Loa Loa (eye worm) hypothetical protein 0.0035 0.0158 0.0191
Loa Loa (eye worm) hexokinase 0.0242 0.2319 0.2831
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0308 0.1077
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0074 0.056 0.2762
Mycobacterium ulcerans glutaminase 0.0805 0.8186 1
Schistosoma mansoni smad1 5 8 and 0.0024 0.0043 0.0053
Brugia malayi MH1 domain containing protein 0.0024 0.0043 0.0053
Trichomonas vaginalis CAMK family protein kinase 0.0278 0.2694 0.3291
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0158 0.0788
Treponema pallidum hexokinase (hxk) 0.0242 0.2319 1
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.022 0.2087 0.7304
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0397 0.0485
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0058 0.0397 0.1391
Trypanosoma brucei hexokinase 0.0242 0.2319 0.3666
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0029 0.0035
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0397 0.0485
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0001 0.0002
Trypanosoma cruzi polo-like protein kinase, putative 0.0278 0.2694 0.4259
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0281 0.017
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0115 0.0115
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0389 0.1361
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0138 0.068
Brugia malayi glucose-6-phosphate dehydrogenase 0.0212 0.2002 0.2446
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0294 0.2857 0.349
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0281 0.0343
Trypanosoma brucei phosphomannomutase 0.0042 0.0236 0.0374
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0001 0.0001
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0001 0.0003
Brugia malayi TAR-binding protein 0.0125 0.1095 0.1338
Onchocerca volvulus 0.0047 0.0281 0.0631
Entamoeba histolytica hexokinase 2 0.0242 0.2319 0.7947
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0397 0.0485
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0144 0.0176
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0001 0.0003
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.1151 0.5679
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0389 0.0473
Trypanosoma brucei hexokinase 0.0242 0.2319 0.3666
Loa Loa (eye worm) hypothetical protein 0.0034 0.0144 0.0174
Brugia malayi Bromodomain containing protein 0.0155 0.1408 0.172
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0125 0.1094 0.1094
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0001 0.0002
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0043 0.0077
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0089 0.0718 0.2515
Loa Loa (eye worm) hypothetical protein 0.0067 0.0488 0.0595
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0281 0.0343
Loa Loa (eye worm) hexokinase type II 0.0242 0.2319 0.2831
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0214 0.2027 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0043 0.0051
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.1303 0.6426
Leishmania major phosphomannose isomerase 0.0294 0.2857 0.4517
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0558 0.0558
Trypanosoma cruzi ISWI complex protein 0.003 0.0108 0.0171
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0001 0.0002
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.022 0.2087 0.2549
Brugia malayi glutathione reductase 0.0057 0.0389 0.0475
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0158 0.0552
Loa Loa (eye worm) hypothetical protein 0.0165 0.1516 0.185
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.029 0.2821 0.2821
Brugia malayi Bromodomain containing protein 0.0069 0.0514 0.0628
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.1151 0.5679
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0393 0.1375
Trichomonas vaginalis CAMK family protein kinase 0.0278 0.2694 0.3291
Brugia malayi Hexokinase family protein 0.0152 0.1378 0.1683
Brugia malayi hexokinase type II 0.0077 0.0597 0.0729
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0281 0.1386
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0144 0.0257
Trypanosoma cruzi phosphomannose isomerase, putative 0.0294 0.2857 0.4517
Trypanosoma brucei hypothetical protein, conserved 0.0627 0.6325 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0001 0.0001
Brugia malayi MH1 domain containing protein 0.0024 0.0043 0.0053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0001 0.0001
Giardia lamblia Kinase, PLK 0.0278 0.2694 1
Schistosoma mansoni coup transcription factor 0.002 0.0001 0.0002
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0058 0.0397 0.1984
Trypanosoma cruzi hexokinase, putative 0.0242 0.2319 0.3666
Leishmania major hypothetical protein, conserved 0.003 0.0108 0.0171
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0393 0.1375
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0022 0.0026 0.0047
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0138 0.068
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.1151 0.5679
Plasmodium falciparum histone acetyltransferase GCN5 0.0077 0.0597 0.2089
Echinococcus multilocularis geminin 0.0168 0.1542 0.1542
Loa Loa (eye worm) RNA binding protein 0.0125 0.1095 0.1337
Loa Loa (eye worm) hypothetical protein 0.0445 0.4433 0.5414
Mycobacterium ulcerans 6-phosphofructokinase 0.0214 0.2027 0.2477
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0001 0.0002
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0072 0.0546 0.0667
Loa Loa (eye worm) hypothetical protein 0.0035 0.0158 0.0191
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0001 0.0003
Onchocerca volvulus Hexokinase homolog 0.0152 0.1378 0.3106
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0158 0.0193
Giardia lamblia Histone acetyltransferase GCN5 0.0077 0.0597 0.2215
Brugia malayi nuclear hormone receptor 0.002 0.0001 0.0002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0258 0.0258
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0058 0.0397 0.0485
Trichomonas vaginalis phosphofructokinase, putative 0.0214 0.2027 0.2477
Schistosoma mansoni serine/threonine protein kinase 0.0278 0.2694 0.3291
Leishmania major phosphomannomutase, putative 0.0042 0.0236 0.0374
Echinococcus granulosus lysine specific demethylase 5A 0.0073 0.0558 0.0994
Trichomonas vaginalis CAMK family protein kinase 0.0278 0.2694 0.3291
Entamoeba histolytica phosphomannose isomerase, putative 0.0294 0.2857 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0058 0.0397 0.1391
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0044 0.0257 0.0257
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.1151 0.5679
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0258 0.0315
Leishmania major hexokinase, putative 0.0242 0.2319 0.3666
Trypanosoma cruzi hypothetical protein, conserved 0.0627 0.6325 1
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1095 0.1338
Loa Loa (eye worm) hypothetical protein 0.0077 0.0597 0.0727
Brugia malayi MH2 domain containing protein 0.0024 0.0043 0.0053
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0138 0.068
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0278 0.2694 0.4259
Loa Loa (eye worm) hypothetical protein 0.0139 0.1247 0.1522
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0001 0.0002
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0115 0.0141
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0281 0.0444
Echinococcus multilocularis lysine specific demethylase 5A 0.007 0.0519 0.0519
Leishmania major hexokinase, putative 0.0242 0.2319 0.3666
Loa Loa (eye worm) hypothetical protein 0.0047 0.0281 0.0342
Echinococcus multilocularis phosphomannomutase 0.0042 0.0236 0.0236
Schistosoma mansoni nuclear hormone receptor 0.002 0.0001 0.0002
Plasmodium falciparum thioredoxin reductase 0.0057 0.0389 0.1361
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0389 0.0693
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0214 0.2027 0.3206
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0072 0.0546 0.0667
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0308 0.0486
Echinococcus granulosus hexokinase type 2 0.0242 0.2319 0.413
Onchocerca volvulus 0.0242 0.2319 0.5229
Echinococcus multilocularis zinc finger protein 0.0046 0.0269 0.0269
Trichomonas vaginalis CAMK family protein kinase 0.0278 0.2694 0.3291
Loa Loa (eye worm) hypothetical protein 0.0077 0.0597 0.0727
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0001 0.0002
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0188 0.1756 0.3128
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0212 0.2002 0.3166
Mycobacterium ulcerans hypothetical protein 0.0072 0.0546 0.0667
Loa Loa (eye worm) hypothetical protein 0.0035 0.0158 0.0191
Brugia malayi PHD-finger family protein 0.0023 0.0029 0.0035
Trichomonas vaginalis phosphofructokinase, putative 0.0214 0.2027 0.2477
Onchocerca volvulus 0.0152 0.1378 0.3106
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0089 0.0718 0.2515
Toxoplasma gondii phosphomannomutase 0.0042 0.0236 0.0828
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0144 0.0176
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0072 0.0546 0.0863
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0281 0.0343
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0001 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0047 0.0281 0.0342
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0058 0.0397 0.1984
Trichomonas vaginalis CAMK family protein kinase 0.0138 0.1229 0.1502
Brugia malayi acetyltransferase, GNAT family protein 0.029 0.2821 0.3446
Loa Loa (eye worm) TAR-binding protein 0.0125 0.1095 0.1337
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0558 0.0682
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0281 0.0343
Echinococcus multilocularis mannose 6 phosphate isomerase 0.0294 0.2857 0.2857
Mycobacterium tuberculosis Conserved protein 0.0072 0.0546 0.2692
Plasmodium vivax phosphomannomutase, putative 0.0042 0.0236 0.0828
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0049 0.0308 0.0374
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0212 0.2002 0.2446
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0144 0.0144
Loa Loa (eye worm) phosphofructokinase 0.0214 0.2027 0.2475
Schistosoma mansoni zinc finger protein 0.003 0.0108 0.0132
Mycobacterium ulcerans hypothetical protein 0.0047 0.0281 0.0343
Entamoeba histolytica phosphofructokinase, putative 0.0214 0.2027 0.6835
Trichomonas vaginalis CAMK family protein kinase 0.0278 0.2694 0.3291
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0558 0.0682
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0558 0.0994
Echinococcus granulosus histone acetyltransferase KAT2B 0.0278 0.2689 0.4789
Loa Loa (eye worm) bromodomain containing protein 0.0042 0.023 0.0279
Trypanosoma brucei hexokinase, putative 0.0242 0.2319 0.3666
Echinococcus multilocularis peregrin 0.0069 0.0514 0.0514
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0115 0.0139
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0308 0.0486
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.1303 0.6426
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0258 0.046
Onchocerca volvulus Putative phosphomannomutase 0.0042 0.0236 0.053
Brugia malayi 6-phosphofructokinase 0.0214 0.2027 0.2477
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0072 0.0546 0.0667
Loa Loa (eye worm) hypothetical protein 0.0047 0.0281 0.0342
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0089 0.0718 0.0877
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0294 0.2857 0.3489
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0043 0.0051
Trichomonas vaginalis mannose-6-phosphate isomerase, putative 0.0294 0.2857 0.349
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.081 0.0989
Plasmodium falciparum phosphomannomutase, putative 0.0042 0.0236 0.0828
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.081 0.0988
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0397 0.0485
Toxoplasma gondii 6-phosphofructokinase 0.0058 0.0397 0.1391
Mycobacterium tuberculosis Probable reductase 0.013 0.1151 0.5679
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0001 0.0002
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0488 0.0597
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0258 0.0314
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0212 0.2002 0.3567
Loa Loa (eye worm) hexokinase 0.0152 0.1378 0.1682
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0001 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0001 0.0002
Trypanosoma cruzi polo-like protein kinase, putative 0.0278 0.2694 0.4259
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0397 0.0485
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0144 0.0144
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0558 0.0682
Loa Loa (eye worm) Smad1 0.0024 0.0043 0.0051
Brugia malayi PHD-finger family protein 0.0056 0.0379 0.0463
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0258 0.0315
Echinococcus granulosus jumonji domain containing protein 0.008 0.0627 0.1118
Loa Loa (eye worm) glutaminase 2 0.0805 0.8186 1
Loa Loa (eye worm) transcription factor SMAD2 0.0352 0.3459 0.4224
Echinococcus granulosus histone acetyltransferase KAT2B 0.0089 0.0718 0.1279
Trichomonas vaginalis CAMK family protein kinase 0.0138 0.1229 0.1502
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.5614 0.5614
Entamoeba histolytica serine/threonine protein kinase, putative 0.0278 0.2694 0.9378
Brugia malayi hexokinase 0.0242 0.2319 0.2833
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0138 0.1236 0.151
Echinococcus multilocularis citrate lyase subunit beta protein 0.0072 0.0546 0.0546
Echinococcus multilocularis PHD finger protein rhinoceros 0.0057 0.0393 0.0393
Echinococcus granulosus 6 phosphofructokinase 0.0214 0.2027 0.3611
Loa Loa (eye worm) phosphomannomutase 2 0.0042 0.0236 0.0287
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0278 0.2694 0.3289
Schistosoma mansoni smad 0.0024 0.0043 0.0053
Onchocerca volvulus 0.0445 0.4433 1
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.1151 0.5679
Plasmodium falciparum glutathione reductase 0.0057 0.0389 0.1361
Giardia lamblia PHD finger protein 15 0.0057 0.0393 0.1458
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.029 0.2821 0.3446
Schistosoma mansoni hypothetical protein 0.0031 0.0115 0.0141
Trypanosoma cruzi hypothetical protein, conserved 0.0627 0.6325 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0278 0.2694 0.3291
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0397 0.0485
Trypanosoma cruzi ISWI complex protein 0.003 0.0108 0.0171
Plasmodium vivax 6-phosphofructokinase, putative 0.0058 0.0397 0.1391
Brugia malayi jmjC domain containing protein 0.0073 0.0558 0.0682
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0144 0.0176
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0532 0.0532
Entamoeba histolytica hexokinase 1 0.0242 0.2319 0.7947
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0558 0.2752
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0278 0.2694 0.4798
Schistosoma mansoni phosphomannomutase 0.0042 0.0236 0.0289
Trypanosoma cruzi phosphomannomutase, putative 0.0042 0.0236 0.0374
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.022 0.2087 0.2549
Plasmodium falciparum hexokinase 0.0242 0.2319 0.8117
Mycobacterium leprae probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO 0.0159 0.1454 0.6718
Loa Loa (eye worm) PHD-finger family protein 0.0057 0.0393 0.0478
Loa Loa (eye worm) hypothetical protein 0.0099 0.0821 0.1001
Plasmodium falciparum phd finger protein, putative 0.0057 0.0393 0.1375
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0125 0.1095 0.1337
Leishmania major hypothetical protein, conserved 0.0049 0.0308 0.0486
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0033
Brugia malayi MH2 domain containing protein 0.0024 0.0043 0.0053
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0281 0.0444
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0001 0.0001
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0001 0.0001
Brugia malayi Bromodomain containing protein 0.0083 0.0654 0.0799
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.1303 0.6426
Schistosoma mansoni kinase 0.0141 0.1268 0.1548
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0281 0.0343
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.022 0.2087 0.7304
Leishmania major hypothetical protein, conserved 0.0627 0.6325 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0258 0.046
Onchocerca volvulus 0.0242 0.2319 0.5229
Brugia malayi phosphomannomutase 2 0.0042 0.0236 0.0289
Schistosoma mansoni Smad4 0.0024 0.0043 0.0053
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0393 0.1375
Echinococcus granulosus peregrin 0.0069 0.0514 0.0916
Schistosoma mansoni smad1 5 8 and 0.0024 0.0043 0.0053
Brugia malayi phosphofructokinase 0.0214 0.2027 0.2477
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0281 0.0343
Echinococcus multilocularis 6 phosphofructokinase 0.0214 0.2027 0.2027
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0558 0.0882
Schistosoma mansoni hypothetical protein 0.0168 0.1542 0.1884
Loa Loa (eye worm) hexokinase 0.0075 0.0575 0.0701
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0214 0.2027 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0158 0.0552
Entamoeba histolytica phosphofructokinase, putative 0.0214 0.2027 0.6835
Trypanosoma brucei polo-like protein kinase 0.0278 0.2694 0.4259
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1095 0.1338
Echinococcus multilocularis smad 0.0024 0.0043 0.0043
Trichomonas vaginalis CAMK family protein kinase 0.0278 0.2694 0.3291
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0001 0.0003
Echinococcus multilocularis hexokinase 0.0242 0.2319 0.2319
Brugia malayi PHD-finger family protein 0.0057 0.0393 0.048
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0024 0.0043
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0212 0.2002 0.8635
Echinococcus multilocularis Smad4 0.0024 0.0043 0.0043
Trypanosoma cruzi hexokinase, putative 0.0242 0.2319 0.3666
Entamoeba histolytica acetyltransferase, GNAT family 0.0077 0.0597 0.1375
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0001 0.0001
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0278 0.2694 0.2694
Brugia malayi glutaminase DH11.1 0.0805 0.8186 1
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0558 0.0682
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0043 0.0053
Brugia malayi Smad1 0.0024 0.0043 0.0053
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.0041 0.0218 0.0266
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0001 0.0002
Trichomonas vaginalis phosphomannomutase, putative 0.0042 0.0236 0.0289
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0001 0.0002
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0044 0.0257 0.0314
Echinococcus multilocularis hexokinase 0.0242 0.2319 0.2319
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0308 0.0486
Echinococcus granulosus phosphomannomutase 0.0042 0.0236 0.0421
Brugia malayi hypothetical protein 0.0445 0.4433 0.5415
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0072 0.0546 0.2692
Trypanosoma brucei Putative Phosphatase/Protein of unknown function DUF89, putative 0.0107 0.0912 0.1443
Mycobacterium tuberculosis Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho 0.0159 0.1454 0.7173
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0001 0.0002
Echinococcus multilocularis jumonji domain containing protein 0.008 0.0627 0.0627
Onchocerca volvulus Serine\/threonine kinase homolog 0.0278 0.2694 0.6075
Schistosoma mansoni hypothetical protein 0.0031 0.0115 0.0141
Loa Loa (eye worm) hypothetical protein 0.0035 0.0158 0.0191
Echinococcus granulosus hexokinase 0.0242 0.2319 0.413
Brugia malayi hypothetical protein 0.0049 0.0308 0.0376
Loa Loa (eye worm) hypothetical protein 0.0076 0.0582 0.071
Schistosoma mansoni hypothetical protein 0.0031 0.0115 0.0141
Schistosoma mansoni hypothetical protein 0.0031 0.0115 0.0141
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0058 0.0397 0.1391
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.1303 0.5851
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0058 0.0397 0.1713
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0281 0.0343
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0558 0.1953
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0115 0.0141
Plasmodium vivax mannose-6-phosphate isomerase, putative 0.0294 0.2857 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0044 0.0257 0.0458
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0072 0.0546 0.0863
Echinococcus granulosus zinc finger protein 0.0046 0.0269 0.0479
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0144 0.0176
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0389 0.1918
Trypanosoma brucei ISWI complex protein 0.003 0.0108 0.0171
Toxoplasma gondii thioredoxin reductase 0.0057 0.0389 0.1361
Schistosoma mansoni hexokinase 0.0242 0.2319 0.2833
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0281 0.017
Brugia malayi ecdysteroid receptor 0.002 0.0001 0.0002
Loa Loa (eye worm) acetyltransferase 0.029 0.2821 0.3445
Trichomonas vaginalis bromodomain-containing protein, putative 0.0089 0.0718 0.0877
Echinococcus granulosus neuropeptide s receptor 0.0558 0.5614 1
Schistosoma mansoni smad1 5 8 and 0.0024 0.0043 0.0053
Brugia malayi jmjC domain containing protein 0.0188 0.1756 0.2145
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0214 0.2027 0.8744
Echinococcus granulosus mannose 6 phosphate isomerase 0.0294 0.2857 0.5088
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0001 0.0002
Echinococcus granulosus FTZ F1 alpha 0.002 0.0001 0.0003
Trypanosoma brucei trypanothione reductase 0.0057 0.0389 0.0615
Brugia malayi 6-phosphofructokinase 0.0214 0.2027 0.2477

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 59.38 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Activators of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells. (Class of assay: confirmatory) [Related pubchem assays: 1829 (Project Summary), 1814 (Primary HTS)] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) 28.1838 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (binding) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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