TDR Targets

Basic information

Technical information

TDR Targets ID: 1290151
Name: T5592163
MW: 439.57 | Formula: C24H29N3O3S
H donors: 0 H acceptors: 2 LogP: 3.47 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1N1CCN(CC1)C(=O)c1ccccc1SCC(=O)N1CCCC1
InChi: 1S/C24H29N3O3S/c1-30-21-10-4-3-9-20(21)25-14-16-27(17-15-25)24(29)19-8-2-5-11-22(19)31-18-23(28)26-12-6-7-13-26/h2-5,8-11H,6-7,12-18H2,1H3
InChiKey: SGAYIQBVMPIUDD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	RAN, member RAS oncogene family		No references
Homo sapiens	ATM serine/threonine kinase	Starlite/ChEMBL	No references
Homo sapiens	snurportin 1		No references
Homo sapiens	karyopherin (importin) beta 1		No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium berghei	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	ko:K04728 ataxia telangectasia mutated family protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania infantum	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania donovani	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	similar to putative phosphatidylinositol kinase involved in telomere length regulation	Get druggable targets OG5_128955	All targets in OG5_128955
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania mexicana	phosphatidylinositol 3-kinase-like protein	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma mansoni	importin beta-1	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium hominis	importin-beta2	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	Get druggable targets OG5_128955	All targets in OG5_128955
Neospora caninum	GTP-binding nuclear protein Ran, related	Get druggable targets OG5_127514	All targets in OG5_127514
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium knowlesi	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Toxoplasma gondii	HEAT repeat-containing protein	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Brugia malayi	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Babesia bovis	GTP-binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	serine protein kinase ATM	Get druggable targets OG5_128955	All targets in OG5_128955
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania infantum	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Theileria parva	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Plasmodium falciparum	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	Importin subunit beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma congolense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania major	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium hominis	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium vivax	importin-beta 2, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Echinococcus granulosus	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma congolense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Leishmania donovani	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	importin beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania major	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei gambiense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Neospora caninum	phosphatidylinositol 3- and 4-kinase domain- containing protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Cryptosporidium parvum	importin/karyopherin	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	Get druggable targets OG5_131808	All targets in OG5_131808
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_131808	All targets in OG5_131808
Echinococcus granulosus	serine protein kinase ATM	Get druggable targets OG5_128955	All targets in OG5_128955
Candida albicans	identical to the C terminus of CaP19.5580 potential phosphatidylinositol kinase	Get druggable targets OG5_128955	All targets in OG5_128955
Echinococcus multilocularis	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	RNA, U transporter 1	Get druggable targets OG5_131808	All targets in OG5_131808
Schistosoma japonicum	ko:K07936 GTP-binding nuclear protein Ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Neospora caninum	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	Importin subunit beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Snurportin-1, putative	Get druggable targets OG5_131808	All targets in OG5_131808
Plasmodium yoelii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania mexicana	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Toxoplasma gondii	FATC domain-containing protein	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma brucei gambiense	phosphatidylinositol kinase domain protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Candida albicans	similar to putative phosphatidylinositol kinase involved in telomere length regulation	Get druggable targets OG5_128955	All targets in OG5_128955
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Echinococcus granulosus	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania braziliensis	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium knowlesi	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania braziliensis	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Entamoeba histolytica	Ran family GTPase	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	IPR000971,Globin;IPR012292,Globin-related;IPR009050,Globin-like,domain-containing	Get druggable targets OG5_128955	All targets in OG5_128955
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania infantum	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Cryptosporidium parvum	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania mexicana	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium berghei	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei gambiense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania donovani	phosphatidylinositol 3-kinase-like protein	Get druggable targets OG5_128955	All targets in OG5_128955
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Babesia bovis	importin beta subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Theileria parva	GTP-binding nuclear protein ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania braziliensis	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium yoelii	importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania major	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	Importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	patched 1	0.0041	0.0262	0.0645
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0131	0.4985
Echinococcus multilocularis	neuropeptide receptor A26	0.0478	0.5294	0.5294
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0026	0.008	0.0205
Echinococcus multilocularis	Niemann Pick C1 protein	0.0138	0.1374	0.1374
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0047	0.0326	0.0326
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0028	0.011	0.458
Schistosoma mansoni	ran	0.0026	0.008	0.0198
Brugia malayi	jmjC domain containing protein	0.0094	0.0863	0.2201
Plasmodium falciparum	phd finger protein, putative	0.0029	0.0114	0.2114
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0047	0.0326	0.0616
Schistosoma mansoni	ap endonuclease	0.004	0.0241	0.0593
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0026	0.008	0.2134
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0026	0.008	0.0152
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0026	0.008	0.3334
Echinococcus granulosus	biogenic amine 5HT receptor	0.0129	0.1273	0.2405
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.004	0.0241	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	0.1403
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0262	0.0645
Echinococcus multilocularis	protein dispatched 1	0.0047	0.033	0.033
Schistosoma mansoni	smad1 5 8 and	0.0024	0.0067	0.0165
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0024	0.0067	0.0067
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.004	0.0241	0.0456
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0047	0.0326	0.0832
Echinococcus granulosus	smad	0.0024	0.0067	0.0127
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0114	0.3797
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0037	0.0091
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0186	0.7724
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0026	0.008	0.3334
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	0.1403
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	0.1403
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0047	0.0326	0.0616
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0022	0.0037	0.041
Leishmania major	importin beta-1 subunit, putative	0.0028	0.011	0.458
Schistosoma mansoni	hypothetical protein	0.004	0.0245	0.0603
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	0.1403
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0897	0.2205
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.0465	0.1143
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0236	0.2507	0.6167
Echinococcus multilocularis	expressed conserved protein	0.0091	0.0829	0.0829
Echinococcus multilocularis	importin subunit beta 1	0.0035	0.0186	0.0186
Schistosoma mansoni	hypothetical protein	0.0047	0.0326	0.0803
Schistosoma mansoni	jumonji domain containing protein	0.0074	0.0642	0.1578
Loa Loa (eye worm)	hypothetical protein	0.0236	0.2508	0.6168
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.0114	0.0281
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0148	0.1495	0.3812
Schistosoma mansoni	hypothetical protein	0.0346	0.3764	0.9258
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0047	0.0326	0.0326
Echinococcus granulosus	snurportin 1	0.0372	0.4066	0.768
Schistosoma mansoni	hypothetical protein	0.004	0.0245	0.0603
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0294	0.0294
Brugia malayi	follicle stimulating hormone receptor	0.0236	0.2507	0.6394
Echinococcus multilocularis	lysine specific demethylase 5A	0.0035	0.0184	0.0184
Echinococcus granulosus	lysine specific demethylase 5A	0.0035	0.0184	0.0347
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.004	0.0241	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0326	0.0803
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	0.1403
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0026	0.008	0.008
Brugia malayi	jmjC domain containing protein	0.0035	0.0184	0.0468
Giardia lamblia	PHD finger protein 15	0.0029	0.0114	0.4744
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0022	0.0037	0.1526
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0026	0.0082	0.3415
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	0.1403
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0022	0.0037	0.1526
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.011	0.4212
Loa Loa (eye worm)	hypothetical protein	0.0049	0.035	0.086
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0047	0.0326	0.0803
Toxoplasma gondii	exonuclease III APE	0.004	0.0241	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	0.1403
Trypanosoma cruzi	target of rapamycin kinase 3	0.0022	0.0037	0.1526
Giardia lamblia	GTOR	0.0022	0.0037	0.1526
Brugia malayi	MH2 domain containing protein	0.0024	0.0067	0.0171
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.004	0.0241	1
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0026	0.008	0.3334
Schistosoma mansoni	hypothetical protein	0.0346	0.3764	0.9258
Loa Loa (eye worm)	Smad1	0.0024	0.0067	0.0165
Brugia malayi	latrophilin 2 splice variant baaae	0.0101	0.0954	0.2433
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0022	0.0037	0.0037
Echinococcus granulosus	importin subunit beta 1	0.0035	0.0186	0.0352
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.0114	0.0281
Brugia malayi	exodeoxyribonuclease III family protein	0.004	0.0241	0.0615
Echinococcus multilocularis	Niemann Pick C1 protein	0.0097	0.0897	0.0897
Echinococcus granulosus	neuropeptide s receptor	0.0478	0.5294	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0294	0.075
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.004	0.0241	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	0.1403
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.0114	0.0114
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0037	0.0091
Plasmodium vivax	importin-beta 2, putative	0.0035	0.0186	0.6586
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1273	0.3132
Echinococcus multilocularis	protein patched	0.0041	0.0262	0.0262
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0022	0.0037	0.1526
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0026	0.008	0.3334
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0022	0.0037	0.0091
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	0.1403
Leishmania major	GTP-binding protein, putative	0.0026	0.008	0.3334
Loa Loa (eye worm)	MH1 domain-containing protein	0.0024	0.0067	0.0165
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	0.1403
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	0.1403
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0022	0.0037	0.1526
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	0.1403
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0372	0.4066	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0138	0.1374	0.2595
Schistosoma mansoni	ap endonuclease	0.004	0.0241	0.0593
Echinococcus granulosus	mothers against decapentaplegic 5	0.0024	0.0067	0.0127
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	0.1403
Loa Loa (eye worm)	MH2 domain-containing protein	0.0024	0.0067	0.0165
Echinococcus multilocularis	Smad4	0.0024	0.0067	0.0067
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0094	0.0863	0.0863
Echinococcus multilocularis	serine protein kinase ATM	0.003	0.0131	0.0131
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	0.1403
Schistosoma mansoni	hypothetical protein	0.0047	0.0326	0.0803
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.004	0.0241	0.0241
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0022	0.0037	0.0091
Echinococcus granulosus	jumonji domain containing protein	0.004	0.0243	0.046
Echinococcus multilocularis	serotonin receptor	0.0129	0.1273	0.1273
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.003	0.0131	0.5421
Echinococcus multilocularis	survival motor neuron protein 1	0.0236	0.2508	0.2508
Trichomonas vaginalis	ap endonuclease, putative	0.004	0.0241	0.9197
Brugia malayi	Importin beta-1 subunit	0.0035	0.0186	0.0475
Schistosoma mansoni	smad1 5 8 and	0.0024	0.0067	0.0165
Schistosoma mansoni	hypothetical protein	0.0047	0.0326	0.0803
Schistosoma mansoni	hypothetical protein	0.0048	0.0341	0.0838
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0294	0.0556
Echinococcus multilocularis	geminin	0.0346	0.3764	0.3764
Brugia malayi	MH1 domain containing protein	0.0024	0.0067	0.0171
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0294	0.0724
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0262	0.0645
Entamoeba histolytica	hypothetical protein	0.0037	0.0206	0.2301
Schistosoma mansoni	importin beta-1	0.0035	0.0186	0.0458
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0022	0.0037	0.1526
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.0184	0.0452
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0022	0.0037	0.1526
Entamoeba histolytica	hypothetical protein	0.0028	0.011	0.1232
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	0.1403
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0024	0.0067	0.0067
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0094	0.0863	0.163
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.0184	0.0452
Echinococcus multilocularis	peregrin	0.0029	0.0114	0.0114
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.004	0.0241	0.5
Schistosoma mansoni	Smad4	0.0024	0.0067	0.0165
Echinococcus multilocularis	serotonin receptor	0.0129	0.1273	0.1273
Schistosoma mansoni	hypothetical protein	0.0047	0.0326	0.0803
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	0.1403
Echinococcus multilocularis	snurportin 1	0.0372	0.4066	0.4066
Schistosoma mansoni	smad	0.0024	0.0067	0.0165
Echinococcus granulosus	serine protein kinase ATM	0.003	0.0131	0.0247
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0022	0.0037	0.1546
Brugia malayi	RNA, U transporter 1	0.0099	0.0926	0.236
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0037	0.0094
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	0.1403
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0022	0.0037	0.1546
Echinococcus multilocularis	jumonji domain containing protein	0.004	0.0243	0.0243
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0341	0.0838
Echinococcus granulosus	survival motor neuron protein 1	0.0236	0.2508	0.4737
Loa Loa (eye worm)	transcription factor SMAD2	0.0359	0.3922	0.9645
Brugia malayi	hypothetical protein	0.0236	0.2508	0.6395
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0082	0.0203
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0206	0.039
Brugia malayi	Bromodomain containing protein	0.0029	0.0114	0.0292
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0022	0.0037	0.007
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	0.1403
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.0037	0.1526
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0097	0.0897	1
Schistosoma mansoni	hypothetical protein	0.0037	0.0206	0.0507
Schistosoma mansoni	hypothetical protein	0.004	0.0245	0.0603
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.004	0.0241	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	0.1403
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.0037	0.1526
Brugia malayi	hypothetical protein	0.0037	0.0206	0.0526
Entamoeba histolytica	hypothetical protein	0.0037	0.0206	0.2301
Brugia malayi	MH2 domain containing protein	0.0359	0.3922	1
Echinococcus granulosus	neuropeptide receptor A26	0.0478	0.5294	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0148	0.1495	0.3677
Brugia malayi	Smad1	0.0024	0.0067	0.0171
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	0.1403
Echinococcus multilocularis	smad	0.0024	0.0067	0.0067
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.0114	0.0216
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0022	0.0037	0.1526
Schistosoma mansoni	hypothetical protein	0.0029	0.0114	0.0281
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0024	0.0067	0.0165
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0294	0.0724
Echinococcus granulosus	peregrin	0.0029	0.0114	0.0216
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0262	0.0495
Brugia malayi	MH2 domain containing protein	0.0024	0.0067	0.0171
Brugia malayi	CHE-14 protein	0.0041	0.0262	0.0669
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0148	0.1495	0.3812
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.011	0.4212
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0262	0.0262
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.003	0.0131	0.5421
Loa Loa (eye worm)	hypothetical protein	0.0051	0.037	0.0909
Loa Loa (eye worm)	jmjC domain-containing protein	0.0035	0.0184	0.0452
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1495	0.3677
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0098	0.0914	0.2248
Schistosoma mansoni	hypothetical protein	0.0372	0.4066	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0341	0.0869
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.004	0.0241	1
Echinococcus multilocularis	neuropeptide s receptor	0.0478	0.5294	0.5294
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0206	0.0206
Toxoplasma gondii	FATC domain-containing protein	0.003	0.0131	0.4596
Trichomonas vaginalis	ran, putative	0.0026	0.008	0.3067
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	0.1403
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0954	0.2347
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0037	0.0094
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	0.1403
Toxoplasma gondii	HEAT repeat-containing protein	0.0035	0.0186	0.7314
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	0.1403
Entamoeba histolytica	hypothetical protein	0.0037	0.0206	0.2301
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.004	0.0241	0.269
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0262	0.0495
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.004	0.0241	1
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0022	0.0037	0.041
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0262	1
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0022	0.0037	0.1526
Echinococcus granulosus	geminin	0.0346	0.3764	0.711
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1273	0.3132
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0022	0.0037	0.1526
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	0.1403
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.004	0.0241	0.0593
Trichomonas vaginalis	importin beta-1, putative	0.0028	0.011	0.4212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0022	0.0037	0.1526
Schistosoma mansoni	smad1 5 8 and	0.0024	0.0067	0.0165
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	0.1403
Echinococcus granulosus	expressed conserved protein	0.0091	0.0829	0.1566
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0206	0.0507
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.003	0.0131	0.0333
Plasmodium falciparum	importin beta, putative	0.0035	0.0186	0.6586
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0294	0.0724
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0114	0.3797
Schistosoma mansoni	ran	0.0026	0.008	0.0198
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	0.1403
Entamoeba histolytica	Ran family GTPase	0.0026	0.008	0.0897
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0024	0.0067	0.0127
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0294	0.0556
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0186	0.7724
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.003	0.0131	0.0322
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	0.1403
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0294	0.0724
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0022	0.0037	0.007
Loa Loa (eye worm)	MH2 domain-containing protein	0.0359	0.3922	0.9645
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0114	0.0281
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0022	0.0037	0.0037
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0022	0.0037	0.1526
Entamoeba histolytica	hypothetical protein	0.0037	0.0206	0.2301
Echinococcus granulosus	Niemann Pick C1 protein	0.0097	0.0897	0.1694
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.004	0.0241	1
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0026	0.008	0.0198
Entamoeba histolytica	hypothetical protein	0.003	0.0131	0.1458
Trichomonas vaginalis	ap endonuclease, putative	0.004	0.0241	0.9197
Treponema pallidum	exodeoxyribonuclease (exoA)	0.004	0.0241	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	0.1403
Brugia malayi	Latrophilin receptor protein 2	0.0047	0.0326	0.0832
Echinococcus granulosus	Smad4	0.0024	0.0067	0.0127
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0294	0.0294
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0022	0.0037	0.1526
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.004	0.0241	1
Onchocerca volvulus		0.0048	0.0341	1
Echinococcus granulosus	GPCR family 2	0.0047	0.0326	0.0616
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0037	0.1403
Schistosoma mansoni	hypothetical protein	0.004	0.0245	0.0603
Schistosoma mansoni	hypothetical protein	0.0101	0.0954	0.2347
Brugia malayi	MH1 domain containing protein	0.0024	0.0067	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0186	0.0458
Brugia malayi	PHD-finger family protein	0.0029	0.0114	0.0292
Brugia malayi	Niemann-Pick C1 protein precursor	0.0097	0.0897	0.2286
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.0114	0.2114
Echinococcus multilocularis	GPCR, family 2	0.0047	0.0326	0.0326
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0129	0.1273	0.3132

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.4109 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262]	ChEMBL.	No reference
Potency (functional)	= 8.9125 um	PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	29.9349 uM	PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1395242

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1290151