Detailed information for compound 1290319

Basic information

Technical information
  • TDR Targets ID: 1290319
  • Name: N-(2-methoxy-4-nitrophenyl)-3-methylbutanamid e
  • MW: 252.266 | Formula: C12H16N2O4
  • H donors: 1 H acceptors: 3 LogP: 2.16 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1NC(=O)CC(C)C)[N+](=O)[O-]
  • InChi: 1S/C12H16N2O4/c1-8(2)6-12(15)13-10-5-4-9(14(16)17)7-11(10)18-3/h4-5,7-8H,6H2,1-3H3,(H,13,15)
  • InChiKey: SCAHEYINNGJMHS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-methoxy-4-nitro-phenyl)-3-methyl-butanamide
  • N-(2-methoxy-4-nitro-phenyl)-3-methyl-butyramide
  • MLS000698790
  • N-{4-nitro-2-methoxyphenyl}-3-methylbutanamide
  • SMR000227671
  • STK098140
  • AK-968/40641142
  • Oprea1_065516
  • ZINC04524510

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0058 0.0164 0.0628
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0058 0.0164 0.049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0101 0.03
Brugia malayi glutaminase DH11.1 0.0276 0.1233 0.1195
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0089 0.0319 0.0851
Schistosoma mansoni cellular tumor antigen P53 0.0197 0.0847 0.2507
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0058 0.0173
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0058 0.0173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0048 0.0143
Trypanosoma cruzi hypothetical protein, conserved 0.0286 0.1283 0.9336
Loa Loa (eye worm) hypothetical protein 0.0162 0.0675 0.063
Echinococcus granulosus methionine tRNA synthetase 0.0111 0.0427 0.059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0515 0.3491
Trichomonas vaginalis Heterochromatin protein, putative 0.0058 0.0164 0.049
Leishmania major 4-coumarate:coa ligase-like protein 0.0552 0.2584 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0089 0.0319 0.0422
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0058 0.0164 0.0966
Entamoeba histolytica hypothetical protein 0.0058 0.0164 0.0458
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0164 0.049
Schistosoma mansoni tar DNA-binding protein 0.0453 0.2098 0.6431
Giardia lamblia GTOR 0.0045 0.0101 0.0169
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0058 0.0164 0.0458
Onchocerca volvulus 0.071 0.3354 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0413 0.1901 1
Mycobacterium ulcerans bacterioferritin BfrA 0.0069 0.022 0.0522
Echinococcus multilocularis calpain A 0.0082 0.0282 0.0364
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0058 0.0164 0.049
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0162 0.0675 0.2346
Toxoplasma gondii isocitrate dehydrogenase 0.0113 0.0436 0.3163
Toxoplasma gondii tRNA ligases class I (M) protein 0.0043 0.009 0.0367
Brugia malayi RNA recognition motif domain containing protein 0.0453 0.2098 0.2064
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0113 0.0436 0.2935
Plasmodium vivax methionine--tRNA ligase, putative 0.0043 0.009 0.0227
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0113 0.0436 0.2892
Brugia malayi AMP-binding enzyme family protein 0.0162 0.0675 0.0634
Mycobacterium ulcerans glutaminase 0.0276 0.1233 0.4584
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0164 0.0628
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0058 0.0164 0.049
Plasmodium falciparum heterochromatin protein 1 0.0058 0.0164 0.0628
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0024 0.0071
Brugia malayi Cathepsin L-like precursor 0.0034 0.0048 0.0005
Brugia malayi AMP-binding enzyme family protein 0.0162 0.0675 0.0634
Schistosoma mansoni tar DNA-binding protein 0.0453 0.2098 0.6431
Schistosoma mansoni hypothetical protein 0.0058 0.0164 0.0365
Loa Loa (eye worm) hypothetical protein 0.0552 0.2584 0.2548
Plasmodium vivax SET domain protein, putative 0.0089 0.0319 0.1465
Loa Loa (eye worm) hypothetical protein 0.1003 0.4788 0.4763
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0111 0.0427 0.024
Brugia malayi Associated with TFs and helicases family protein 0.0058 0.0164 0.0121
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0058 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0164 0.049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0056 0.0167
Mycobacterium ulcerans acyl-CoA synthetase 0.0162 0.0675 0.2346
Schistosoma mansoni apoferritin-2 0.0069 0.022 0.054
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0058 0.0164 0.049
Schistosoma mansoni ferritin 0.0069 0.022 0.054
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0058 0.0164 0.049
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0029 0.0085
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0286 0.1283 0.1245
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0515 0.3491
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0552 0.2584 1
Brugia malayi AMP-binding enzyme family protein 0.0552 0.2584 0.2551
Trypanosoma cruzi hypothetical protein, conserved 0.0286 0.1283 0.9336
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0162 0.0675 0.2473
Plasmodium vivax methionine--tRNA ligase, putative 0.0111 0.0427 0.2047
Schistosoma mansoni hypothetical protein 0.0205 0.0883 0.2619
Brugia malayi SET domain containing protein 0.0061 0.018 0.0138
Loa Loa (eye worm) hypothetical protein 0.0058 0.0164 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0013 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0045 0.0133
Onchocerca volvulus 0.0094 0.0341 0.0885
Trichomonas vaginalis glutaminase, putative 0.0276 0.1233 0.3677
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0058 0.0164 0.049
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0162 0.0675 0.2346
Trichomonas vaginalis penicillin-binding protein, putative 0.0286 0.1283 0.3825
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0048 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0164 0.049
Trichomonas vaginalis conserved hypothetical protein 0.0198 0.0849 0.2532
Onchocerca volvulus 0.0162 0.0675 0.1897
Loa Loa (eye worm) hypothetical protein 0.0286 0.1283 0.1241
Schistosoma mansoni chromobox protein 0.0058 0.0164 0.0365
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0058 0.0173
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0162 0.0675 0.5091
Trypanosoma brucei phosphoglycerate kinase 0.0063 0.019 0.1017
Schistosoma mansoni hypothetical protein 0.0317 0.1434 0.4348
Brugia malayi beta-lactamase family protein 0.0286 0.1283 0.1245
Schistosoma mansoni alpha-glucosidase 0.014 0.0565 0.1621
Trichomonas vaginalis D-aminoacylase, putative 0.0286 0.1283 0.3825
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0162 0.0675 0.063
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0172 0.0721 0.5461
Schistosoma mansoni smad1 5 8 and 0.0141 0.0571 0.1641
Loa Loa (eye worm) hypothetical protein 0.0043 0.009 0.0042
Loa Loa (eye worm) MH2 domain-containing protein 0.0141 0.0571 0.0526
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0086 0.0303 0.0397
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0172 0.0721 0.2119
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0056 0.0032
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0043 0.009 0.0166
Loa Loa (eye worm) hypothetical protein 0.0552 0.2584 0.2548
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0069 0.022 0.2062
Brugia malayi AMP-binding enzyme family protein 0.0162 0.0675 0.0634
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0082 0.0282 0.0364
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0111 0.0427 0.0381
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.039 0.179 0.1823
Trichomonas vaginalis conserved hypothetical protein 0.0198 0.0849 0.2532
Mycobacterium tuberculosis Conserved protein 0.0286 0.1283 0.1234
Loa Loa (eye worm) hypothetical protein 0.0058 0.0164 0.0117
Brugia malayi mothers against decapentaplegic homolog 3 0.0063 0.019 0.0147
Schistosoma mansoni glutaminase 0.0276 0.1233 0.3718
Brugia malayi chromobox protein homolog 3 0.0198 0.0849 0.0809
Echinococcus multilocularis muscleblind protein 0.018 0.0764 0.1114
Mycobacterium ulcerans acyl-CoA synthetase 0.0552 0.2584 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0141 0.0571 0.0814
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0118 0.046 0.3116
Plasmodium falciparum methionine--tRNA ligase, putative 0.0043 0.009 0.0227
Loa Loa (eye worm) hypothetical protein 0.0286 0.1283 0.1241
Brugia malayi Cathepsin L-like precursor 0.0034 0.0048 0.0005
Mycobacterium tuberculosis Probable esterase LipL 0.0286 0.1283 0.1234
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0162 0.0675 0.0528
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0317 0.1434 0.1397
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.0515 0.3531
Brugia malayi Isocitrate dehydrogenase 0.0113 0.0436 0.0395
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0162 0.0675 0.3385
Loa Loa (eye worm) hypothetical protein 0.0552 0.2584 0.2548
Mycobacterium ulcerans esterase/lipase LipP 0.0286 0.1283 0.4784
Brugia malayi AMP-binding enzyme family protein 0.0552 0.2584 0.2551
Leishmania major acetyl-CoA synthetase, putative 0.0162 0.0675 0.2473
Echinococcus granulosus beta LACTamase domain containing family member 0.0286 0.1283 0.1921
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0413 0.1901 0.7261
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0587 0.2124
Schistosoma mansoni chromobox protein 0.0058 0.0164 0.0365
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0164 0.049
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0063 0.019 0.1072
Echinococcus multilocularis smad 0.0141 0.0571 0.0814
Trichomonas vaginalis chromobox protein, putative 0.0213 0.0923 0.2751
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0058 0.0164 0.049
Mycobacterium ulcerans acyl-CoA synthetase 0.0162 0.0675 0.2346
Schistosoma mansoni smad 0.0063 0.019 0.0445
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0058 0.0164 0.0365
Brugia malayi Muscleblind-like protein 0.018 0.0764 0.0724
Loa Loa (eye worm) MH1 domain-containing protein 0.0141 0.0571 0.0526
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0058 0.0164 0.0966
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0552 0.2584 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0058 0.0015
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0101 0.0082
Mycobacterium ulcerans acetyl-CoA synthetase 0.0162 0.0675 0.2346
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0111 0.0427 0.2823
Echinococcus granulosus Chromo domain 0.0058 0.0164 0.0181
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0063 0.019 0.1072
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0286 0.1283 0.3874
Echinococcus multilocularis chromobox protein 2 0.0058 0.0164 0.0181
Mycobacterium tuberculosis Probable lipase LipD 0.0286 0.1283 0.1234
Onchocerca volvulus 0.0162 0.0675 0.1897
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0172 0.0721 0.5087
Echinococcus multilocularis Chromo domain 0.0058 0.0164 0.0181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0069 0.0205
Loa Loa (eye worm) hypothetical protein 0.0078 0.0262 0.0215
Echinococcus granulosus mothers against decapentaplegic 6 0.0063 0.019 0.0221
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0089 0.0319 0.2219
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0172 0.0721 0.5087
Entamoeba histolytica acyl-CoA synthetase, putative 0.0552 0.2584 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0058 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0013 0.0038
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0058 0.0164 0.0181
Echinococcus multilocularis calpain family protein 1, d 0.0055 0.0149 0.0157
Mycobacterium tuberculosis Probable hydrolase 0.0286 0.1283 0.1234
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0101 0.0082
Schistosoma mansoni smad1 5 8 and 0.0141 0.0571 0.1641
Trichomonas vaginalis antibiotic synthetase, putative 0.0162 0.0675 0.2013
Brugia malayi MH1 domain containing protein 0.0078 0.0263 0.0221
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0058 0.0164 0.0181
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0172 0.0721 0.2149
Trichomonas vaginalis D-aminoacylase, putative 0.0286 0.1283 0.3825
Toxoplasma gondii hypothetical protein 0.0049 0.0122 0.0625
Echinococcus multilocularis muscleblind protein 1 0.018 0.0764 0.1114
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0091 0.0326
Loa Loa (eye worm) hypothetical protein 0.0413 0.1901 0.1862
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.0675 0.0976
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0058 0.0164 0.0365
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0111 0.0427 0.0876
Echinococcus granulosus TGF beta signal transducer SmadC 0.0141 0.0571 0.0814
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0091 0.0267
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0552 0.2584 0.2744
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0164 0.049
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.0515 0.3531
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0045 0.0133
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0286 0.1283 0.1234
Mycobacterium ulcerans bacterioferritin BfrB 0.0069 0.022 0.0522
Schistosoma mansoni microtubule-associated protein tau 0.0683 0.3225 0.9967
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0045 0.0133
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0101 0.0208
Onchocerca volvulus 0.0147 0.0602 0.1675
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0058 0.0173
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0063 0.019 0.1072
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0058 0.0164 0.0458
Mycobacterium leprae Probable lipase LipE 0.0286 0.1283 0.4497
Chlamydia trachomatis phosphoglycerate kinase 0.0172 0.0721 0.3484
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0515 0.3491
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0162 0.0675 0.1925
Mycobacterium ulcerans acyl-CoA synthetase 0.0162 0.0675 0.2346
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0285 0.1276 0.191
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0162 0.0675 0.063
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0164 0.049
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0552 0.2584 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0102 0.038 0.2506
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0515 0.3491
Trichomonas vaginalis D-aminoacylase, putative 0.0286 0.1283 0.3825
Trichomonas vaginalis ferritin, putative 0.0069 0.022 0.0656
Loa Loa (eye worm) hypothetical protein 0.0197 0.0847 0.0803
Schistosoma mansoni smad 0.0141 0.0571 0.1641
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0058 0.0164 0.0628
Loa Loa (eye worm) hypothetical protein 0.0058 0.0164 0.0117
Loa Loa (eye worm) Smad1 0.0141 0.0571 0.0526
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0164 0.049
Trichomonas vaginalis set domain proteins, putative 0.071 0.3354 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0113 0.0436 0.0604
Schistosoma mansoni hypothetical protein 0.0317 0.1434 0.4348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0048 0.0143
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0515 0.3491
Onchocerca volvulus 0.0286 0.1283 0.3736
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0285 0.1276 0.191
Schistosoma mansoni tar DNA-binding protein 0.0453 0.2098 0.6431
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0048 0.0143
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0162 0.0675 0.0528
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0162 0.0675 0.0528
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0162 0.0675 0.2346
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0162 0.0675 0.2346
Schistosoma mansoni chromobox protein 0.0353 0.1608 0.4893
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0304 0.1371 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0113 0.0436 0.2892
Brugia malayi TAR-binding protein 0.0453 0.2098 0.2064
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.0675 0.0976
Loa Loa (eye worm) tyrosyl-tRNA synthetase 0.0069 0.0219 0.0172
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0413 0.1901 0.1951
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0164 0.049
Entamoeba histolytica hypothetical protein 0.0058 0.0164 0.0458
Onchocerca volvulus 0.0058 0.0164 0.0352
Schistosoma mansoni ferritin light chain 0.0069 0.022 0.054
Schistosoma mansoni alpha glucosidase 0.0036 0.0058 0.0031
Toxoplasma gondii isocitrate dehydrogenase 0.0113 0.0436 0.3163
Schistosoma mansoni apoferritin-2 0.0069 0.022 0.054
Mycobacterium ulcerans acyl-CoA synthetase 0.0162 0.0675 0.2346
Loa Loa (eye worm) hypothetical protein 0.0286 0.1283 0.1241
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0048 0.0143
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1279 0.1915
Trichomonas vaginalis conserved hypothetical protein 0.014 0.0567 0.169
Echinococcus multilocularis methionine tRNA synthetase 0.0111 0.0427 0.059
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0101 0.0339
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0058 0.0107
Leishmania major 4-coumarate:coa ligase-like protein 0.0552 0.2584 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0048 0.0143
Treponema pallidum phosphoglycerate kinase 0.0172 0.0721 1
Plasmodium vivax phosphoglycerate kinase, putative 0.0172 0.0721 0.3632
Loa Loa (eye worm) hypothetical protein 0.0058 0.0164 0.0117
Loa Loa (eye worm) glutaminase 0.0276 0.1233 0.1191
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0162 0.0675 0.0528
Trypanosoma cruzi cruzipain precursor, putative 0.0129 0.0515 0.3531
Loa Loa (eye worm) isocitrate dehydrogenase 0.0113 0.0436 0.039
Echinococcus granulosus tar DNA binding protein 0.0453 0.2098 0.3189
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0162 0.0675 0.0528
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0101 0.0165
Loa Loa (eye worm) calpain family protein 1 0.0055 0.0149 0.0102
Loa Loa (eye worm) hypothetical protein 0.0286 0.1283 0.1241
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0048 0.0143
Toxoplasma gondii ABC1 family protein 0.0286 0.1283 1
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0132 0.0454
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0113 0.0436 0.1531
Loa Loa (eye worm) MH2 domain-containing protein 0.0063 0.019 0.0143
Entamoeba histolytica phosphoglycerate kinase, putative 0.0172 0.0721 0.2654
Mycobacterium ulcerans acyl-CoA synthetase 0.0552 0.2584 1
Echinococcus granulosus smad 0.0141 0.0571 0.0814
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0048 0.0143
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0113 0.0436 0.2935
Loa Loa (eye worm) hypothetical protein 0.0413 0.1901 0.1862
Onchocerca volvulus 0.0055 0.0149 0.0306
Brugia malayi AMP-binding enzyme family protein 0.0162 0.0675 0.0634
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0043 0.009 0.0065
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0162 0.0675 0.0634
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0056 0.0167
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0132 0.0707
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0101 0.0053
Loa Loa (eye worm) hypothetical protein 0.0043 0.009 0.0042
Echinococcus granulosus Chromobox protein 3 0.0058 0.0164 0.0181
Onchocerca volvulus 0.0286 0.1283 0.3736
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0162 0.0675 0.0528
Loa Loa (eye worm) hypothetical protein 0.0413 0.1901 0.1862
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0132 0.0636
Echinococcus multilocularis mothers against decapentaplegic 5 0.0141 0.0571 0.0814
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0162 0.0675 0.4741
Loa Loa (eye worm) hypothetical protein 0.0089 0.0319 0.0273
Onchocerca volvulus 0.0552 0.2584 0.767
Mycobacterium ulcerans phosphoglycerate kinase 0.0172 0.0721 0.253
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0058 0.0075
Entamoeba histolytica hypothetical protein 0.0285 0.1276 0.4844
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1003 0.4788 0.4763
Trichomonas vaginalis chromobox protein, putative 0.0058 0.0164 0.049
Echinococcus multilocularis mothers against decapentaplegic 6 0.0063 0.019 0.0221
Echinococcus multilocularis beta LACTamase domain containing family member 0.0286 0.1283 0.1921
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1279 0.1915
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0058 0.0039
Brugia malayi Cathepsin L-like precursor 0.0034 0.0048 0.0005
Loa Loa (eye worm) hypothetical protein 0.0043 0.009 0.0042
Brugia malayi MH1 domain containing protein 0.0141 0.0571 0.053
Schistosoma mansoni methionine-tRNA synthetase 0.0111 0.0427 0.119
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0162 0.0675 0.063
Brugia malayi isocitrate dehydrogenase 0.0113 0.0436 0.0395
Leishmania major cathepsin L-like protease 0.0129 0.0515 0.1842
Loa Loa (eye worm) hypothetical protein 0.0162 0.0675 0.063
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0304 0.1371 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0048 0.0143
Loa Loa (eye worm) hypothetical protein 0.0155 0.064 0.0595
Brugia malayi Smad1 0.0141 0.0571 0.053
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0162 0.0675 0.4709
Leishmania major hypothetical protein, conserved 0.0286 0.1283 0.487
Echinococcus granulosus expressed protein 0.0069 0.022 0.0268
Mycobacterium tuberculosis Probable lipase LipE 0.0286 0.1283 0.1234
Mycobacterium ulcerans acyl-CoA synthetase 0.0162 0.0675 0.2346
Brugia malayi RNA binding protein 0.0453 0.2098 0.2064
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0058 0.0039
Loa Loa (eye worm) hypothetical protein 0.0055 0.0149 0.0102
Onchocerca volvulus 0.0162 0.0675 0.1897
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0043 0.009 0.0065
Brugia malayi protein ZK524.3 0.0043 0.009 0.0047
Schistosoma mansoni smad1 5 8 and 0.0141 0.0571 0.1641
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0058 0.0015
Entamoeba histolytica hypothetical protein 0.0285 0.1276 0.4844
Onchocerca volvulus 0.0162 0.0675 0.1897
Schistosoma mansoni Smad4 0.0063 0.019 0.0445
Loa Loa (eye worm) hypothetical protein 0.0078 0.0262 0.0215
Loa Loa (eye worm) latrophilin receptor protein 2 0.0317 0.1434 0.1393
Brugia malayi Phosphoglycerate kinase 0.0172 0.0721 0.068
Echinococcus granulosus microtubule associated protein 2 0.0683 0.3225 0.4942
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0167 0.0124
Leishmania major mitochondrial DNA polymerase beta 0.0304 0.1371 0.5217
Mycobacterium tuberculosis Conserved protein 0.0286 0.1283 0.1234
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0048 0.0005
Brugia malayi Cathepsin L-like precursor 0.0034 0.0048 0.0005
Loa Loa (eye worm) hypothetical protein 0.0058 0.0164 0.0117
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0111 0.0427 0.5345
Trichomonas vaginalis penicillin-binding protein, putative 0.0286 0.1283 0.3825
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0453 0.2098 0.206
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0162 0.0675 0.0528
Loa Loa (eye worm) glutaminase 2 0.0276 0.1233 0.1191
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0048 0.0143
Schistosoma mansoni phosphoglycerate kinase 0.0172 0.0721 0.2111
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0063 0.019 0.0429
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1003 0.4788 0.4765
Toxoplasma gondii propionate-CoA ligase 0.0162 0.0675 0.5091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0048 0.0143
Toxoplasma gondii cathepsin CPL 0.0034 0.0048 0.0028
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0132 0.0579
Loa Loa (eye worm) hypothetical protein 0.018 0.0764 0.072
Loa Loa (eye worm) helicase 0.0058 0.0164 0.0117
Echinococcus multilocularis chromobox protein 1 0.0353 0.1608 0.2426
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0058 0.0173
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0089 0.0319 0.0851
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0172 0.0721 0.2149
Entamoeba histolytica hypothetical protein 0.0285 0.1276 0.4844
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0101 0.0057
Loa Loa (eye worm) hypothetical protein 0.0317 0.1434 0.1393
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0048 0.0143
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.0515 0.3531
Mycobacterium ulcerans beta-lactamase 0.0286 0.1283 0.4784
Schistosoma mansoni tar DNA-binding protein 0.0453 0.2098 0.6431
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0162 0.0675 0.0528
Echinococcus multilocularis Chromobox protein 3 0.0058 0.0164 0.0181
Loa Loa (eye worm) hypothetical protein 0.0172 0.0721 0.0676
Echinococcus multilocularis leucyl tRNA synthetase 0.0043 0.009 0.0065
Echinococcus granulosus lysosomal alpha glucosidase 0.0162 0.0675 0.0976
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0552 0.2584 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0045 0.0133
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0515 0.3491
Onchocerca volvulus 0.0058 0.0164 0.0352
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0162 0.0675 0.4741
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0091 0.0326
Echinococcus multilocularis mothers against decapentaplegic 2 0.0063 0.019 0.0221
Brugia malayi MH1 domain containing protein 0.0078 0.0263 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.014 0.0567 0.169
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0515 0.3491
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0113 0.0436 0.2095
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0058 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0056 0.0167
Loa Loa (eye worm) hypothetical protein 0.0286 0.1283 0.1241
Leishmania major phosphoglycerate kinase C, glycosomal 0.0172 0.0721 0.2654
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0317 0.1434 0.2156
Echinococcus multilocularis Smad4 0.0141 0.0571 0.0814
Trichomonas vaginalis antibiotic synthetase, putative 0.0162 0.0675 0.2013
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0058 0.0173
Onchocerca volvulus 0.0069 0.0219 0.0517
Echinococcus multilocularis expressed protein 0.0069 0.022 0.0268
Plasmodium vivax acetyl-CoA synthetase, putative 0.0162 0.0675 0.3385
Brugia malayi hypothetical protein 0.0311 0.1404 0.1367
Plasmodium falciparum acyl-CoA synthetase 0.0413 0.1901 1
Brugia malayi methionyl-tRNA synthetase 0.0111 0.0427 0.0385
Echinococcus multilocularis tar DNA binding protein 0.0453 0.2098 0.3189
Brugia malayi Latrophilin receptor protein 2 0.0317 0.1434 0.1397
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0162 0.0675 0.0634
Trypanosoma brucei phosphoglycerate kinase 0.0172 0.0721 0.5057
Loa Loa (eye worm) hypothetical protein 0.0286 0.1283 0.1241
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0317 0.1434 0.2156
Loa Loa (eye worm) hypothetical protein 0.0311 0.1404 0.1363
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.0587 0.4035
Loa Loa (eye worm) hypothetical protein 0.0058 0.0164 0.0117
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0162 0.0675 0.0975
Treponema pallidum bacterioferrin (TpF1) 0.0069 0.022 0.2062
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0058 0.0164 0.049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0056 0.0167
Plasmodium vivax acyl-CoA synthetase, putative 0.0413 0.1901 1
Schistosoma mansoni alpha-glucosidase 0.014 0.0565 0.1621
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0058 0.0164 0.049
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0162 0.0675 0.1925
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0013 0.0038
Giardia lamblia Methionyl-tRNA synthetase 0.0111 0.0427 0.5345
Loa Loa (eye worm) hypothetical protein 0.0051 0.0132 0.0085
Loa Loa (eye worm) heterochromatin protein 1 0.0353 0.1608 0.1567
Schistosoma mansoni hypothetical protein 0.0285 0.1276 0.3853
Brugia malayi Phosphoglycerate kinase 0.0063 0.019 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0048 0.0143
Loa Loa (eye worm) MH1 domain-containing protein 0.0063 0.019 0.0143
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0304 0.1371 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0048 0.0143
Plasmodium falciparum phosphoglycerate kinase 0.0172 0.0721 0.3632
Brugia malayi Calcitonin receptor-like protein seb-1 0.1003 0.4788 0.4765
Echinococcus granulosus chromobox protein 1 0.0353 0.1608 0.2426
Loa Loa (eye worm) RNA binding protein 0.0453 0.2098 0.206
Echinococcus multilocularis microtubule associated protein 2 0.0683 0.3225 0.4942
Loa Loa (eye worm) hypothetical protein 0.018 0.0764 0.072
Schistosoma mansoni chromobox protein 0.0353 0.1608 0.4893
Brugia malayi hypothetical protein 0.0285 0.1276 0.1238
Schistosoma mansoni Smad4 0.0063 0.019 0.0445
Schistosoma mansoni hypothetical protein 0.0685 0.3236 1
Schistosoma mansoni transcription factor LCR-F1 0.0285 0.1276 0.3853
Plasmodium vivax heterochromatin protein 1, putative 0.0058 0.0164 0.0628
Mycobacterium ulcerans acyl-CoA synthetase 0.0552 0.2584 1
Trichomonas vaginalis chromobox protein, putative 0.0058 0.0164 0.049
Trichomonas vaginalis chromobox protein, putative 0.0213 0.0923 0.2751
Echinococcus granulosus chromobox protein 2 0.0058 0.0164 0.0181
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0058 0.0164 0.0458
Echinococcus granulosus tumor protein p63 0.1348 0.6477 1
Echinococcus multilocularis geminin 0.0205 0.0883 0.1299
Loa Loa (eye worm) hypothetical protein 0.0058 0.0164 0.0117
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0515 0.3491
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0082 0.0282 0.0734
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0058 0.0173
Onchocerca volvulus 0.0311 0.1404 0.4102
Brugia malayi Valyl-tRNA synthetase 0.0058 0.0164 0.0121
Mycobacterium tuberculosis Conserved hypothetical protein 0.016 0.0666 0.0518
Loa Loa (eye worm) hypothetical protein 0.0198 0.0849 0.0805
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0082 0.0282 0.0734
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0286 0.1283 0.1234
Schistosoma mansoni hypothetical protein 0.0317 0.1434 0.4348
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0162 0.0675 0.0528
Loa Loa (eye worm) hypothetical protein 0.0413 0.1901 0.1862
Schistosoma mansoni hypothetical protein 0.0317 0.1434 0.4348
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0058 0.0173
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0132 0.0636
Schistosoma mansoni ferritin 0.0069 0.022 0.054
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0162 0.0675 0.0975
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0111 0.0427 0.1274
Echinococcus granulosus chromobox protein 1 0.0353 0.1608 0.2426
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0089 0.0319 0.0851
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0048 0.0143
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0286 0.1283 0.1234
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.019 0.1072
Mycobacterium leprae conserved hypothetical protein 0.0286 0.1283 0.4497
Leishmania major leucyl-tRNA synthetase, putative 0.0043 0.009 0.0166
Schistosoma mansoni hypothetical protein 0.0205 0.0883 0.2619
Schistosoma mansoni hypothetical protein 0.0058 0.0167 0.0373
Leishmania major 4-coumarate:coa ligase-like protein 0.0552 0.2584 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0132 0.0454
Brugia malayi beta-lactamase family protein 0.0286 0.1283 0.1245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0048 0.0143
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0198 0.0849 0.2424
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0552 0.2584 1
Brugia malayi Pre-SET motif family protein 0.0089 0.0319 0.0277
Mycobacterium ulcerans acyl-CoA synthetase 0.0162 0.0675 0.2346
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0058 0.0164 0.049
Entamoeba histolytica hypothetical protein 0.0058 0.0164 0.0458
Brugia malayi Glycosyl hydrolases family 31 protein 0.0162 0.0675 0.0635
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0162 0.0675 0.2473
Brugia malayi methionyl-tRNA synthetase 0.0043 0.009 0.0047
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.014 0.0565 0.04
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0162 0.0675 0.2346
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0172 0.0721 0.5461
Mycobacterium tuberculosis Possible penicillin-binding protein 0.183 0.8834 1
Trypanosoma brucei hypothetical protein, conserved 0.0286 0.1283 0.9332
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0162 0.0675 0.4741
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0132 0.0454
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0515 0.3491
Brugia malayi calpain family protein 1 0.0078 0.0262 0.022
Mycobacterium ulcerans hypothetical protein 0.0286 0.1283 0.4784
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0162 0.0675 0.2346
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0147 0.0602 0.1738
Echinococcus granulosus muscleblind protein 0.018 0.0764 0.1114
Schistosoma mansoni Smad4 0.0141 0.0571 0.1641
Mycobacterium ulcerans hypothetical protein 0.016 0.0666 0.231
Leishmania major cathepsin L-like protease 0.0129 0.0515 0.1842
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0048 0.0143
Loa Loa (eye worm) oxidoreductase 0.0162 0.0675 0.063
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0587 0.4071
Brugia malayi Cathepsin L-like precursor 0.0034 0.0048 0.0005
Plasmodium vivax hypothetical protein, conserved 0.0286 0.1283 0.6666
Brugia malayi Cathepsin L-like precursor 0.0034 0.0048 0.0005
Mycobacterium ulcerans lipase LipD 0.0286 0.1283 0.4784
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0058 0.0164 0.0181
Loa Loa (eye worm) hypothetical protein 0.0063 0.019 0.0143
Entamoeba histolytica acyl-coA synthetase, putative 0.0552 0.2584 1
Echinococcus multilocularis chromobox protein 1 0.0353 0.1608 0.2426
Echinococcus multilocularis isocitrate dehydrogenase 0.0113 0.0436 0.0604
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0048 0.0143
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0111 0.0427 0.2866
Brugia malayi Pre-SET motif family protein 0.0624 0.2933 0.2902
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0048 0.0143
Schistosoma mansoni methionine-tRNA synthetase 0.0043 0.009 0.0132
Toxoplasma gondii methionyl-tRNA synthetase 0.0111 0.0427 0.3089
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.039 0.179 0.1823
Loa Loa (eye worm) TAR-binding protein 0.0453 0.2098 0.206
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0058 0.0164 0.049
Echinococcus granulosus GPCR family 2 0.0317 0.1434 0.2156
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0172 0.0721 0.0581
Echinococcus multilocularis tumor protein p63 0.1348 0.6477 1
Echinococcus multilocularis ferritin 0.0069 0.022 0.0268
Echinococcus granulosus ferritin 0.0069 0.022 0.0268
Loa Loa (eye worm) CHromoDomain protein family member 0.0058 0.0164 0.0117
Leishmania major methionyl-tRNA synthetase, putative 0.0111 0.0427 0.1495
Schistosoma mansoni survival motor neuron protein 0.0058 0.0167 0.0373
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0058 0.001
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0058 0.0164 0.0121
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0082 0.0282 0.0364
Schistosoma mansoni ferritin light chain 0.0069 0.022 0.054
Brugia malayi MH1 domain containing protein 0.0141 0.0571 0.053
Trichomonas vaginalis chromobox protein, putative 0.0353 0.1608 0.4793
Giardia lamblia Phosphoglycerate kinase 0.0172 0.0721 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0286 0.1283 0.1241
Mycobacterium ulcerans hypothetical protein 0.0552 0.2584 1
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0164 0.0628
Plasmodium vivax hypothetical protein, conserved 0.0043 0.009 0.0227
Brugia malayi MH2 domain containing protein 0.0141 0.0571 0.053
Mycobacterium ulcerans acyl-CoA synthetase 0.0162 0.0675 0.2346
Loa Loa (eye worm) hypothetical protein 0.0078 0.0263 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0011 0.0034
Brugia malayi calpain family protein 1 0.0078 0.0262 0.022
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0058 0.0164 0.0365
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0113 0.0436 0.0251
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0058 0.0164 0.0966
Echinococcus granulosus calpain A 0.0082 0.0282 0.0364
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0101 0.0339
Brugia malayi hypothetical protein 0.0051 0.0132 0.0089
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0172 0.0721 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0162 0.0675 0.5091
Trypanosoma brucei phosphoglycerate kinase, putative 0.0063 0.019 0.1017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0045 0.0133
Onchocerca volvulus 0.0155 0.064 0.1791
Trypanosoma brucei phosphoglycerate kinase 0.0172 0.0721 0.5057
Brugia malayi MH2 domain containing protein 0.0063 0.019 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0048 0.0143
Loa Loa (eye worm) hypothetical protein 0.0685 0.3236 0.3203
Leishmania major hypothetical protein, conserved 0.0051 0.0132 0.0332
Loa Loa (eye worm) calpain family protein 1 0.0078 0.0262 0.0215
Echinococcus granulosus histone lysine methyltransferase setb 0.0089 0.0319 0.0422
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0101 0.03
Plasmodium falciparum methionine--tRNA ligase 0.0111 0.0427 0.2047
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.039 0.179 0.1823
Schistosoma mansoni tar DNA-binding protein 0.0453 0.2098 0.6431
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0048 0.0143
Echinococcus granulosus geminin 0.0205 0.0883 0.1299
Mycobacterium tuberculosis Conserved protein 0.0286 0.1283 0.1234
Brugia malayi hypothetical protein 0.0058 0.0164 0.0121
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.019 0.1072
Schistosoma mansoni acetyl-CoA synthetase 0.0162 0.0675 0.1967
Brugia malayi M-phase phosphoprotein, mpp8 0.0058 0.0164 0.0121
Brugia malayi Heterochromatin protein 1 0.0353 0.1608 0.1571
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0162 0.0675 0.1925
Schistosoma mansoni ferritin 0.0069 0.022 0.054
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0317 0.1434 0.2156
Brugia malayi hypothetical protein 0.0286 0.1279 0.1241
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0091 0.0326
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0162 0.0675 0.4709
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0058 0.0039
Loa Loa (eye worm) hypothetical protein 0.0286 0.1279 0.1237
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0101 0.0398
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0286 0.1283 0.3874
Schistosoma mansoni phosphoglycerate kinase 0.0172 0.0721 0.2111
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0113 0.0436 0.0604
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0101 0.0208
Trichomonas vaginalis chromobox protein, putative 0.0058 0.0164 0.049
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0101 0.0208
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0162 0.0675 0.0528
Mycobacterium ulcerans acyl-CoA synthetase 0.0162 0.0675 0.2346
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0048 0.0143
Echinococcus multilocularis GPCR, family 2 0.0317 0.1434 0.2156
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0162 0.0675 0.4741
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0078 0.0262 0.0673
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0048 0.0143
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0113 0.0436 0.1218
Brugia malayi MH2 domain containing protein 0.0141 0.0571 0.053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0515 0.3491
Leishmania major acetyl-CoA synthetase, putative 0.0162 0.0675 0.2473
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0011 0.0034
Trypanosoma brucei glucosidase, putative 0.0036 0.0058 0.0014
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0162 0.0675 0.2346
Entamoeba histolytica hypothetical protein 0.0285 0.1276 0.4844
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.039 0.179 0.1823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0045 0.0133
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0058 0.0164 0.049
Schistosoma mansoni ferritin 0.0069 0.022 0.054
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0056 0.0061
Brugia malayi beta-lactamase 0.0286 0.1283 0.1245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0048 0.0143
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0213 0.0923 0.2646
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0624 0.2933 0.2898
Loa Loa (eye worm) nuclear factor I 0.0078 0.0263 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0101 0.03
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0552 0.2584 1
Echinococcus granulosus mothers against decapentaplegic 2 0.0063 0.019 0.0221
Trichomonas vaginalis esterase, putative 0.0286 0.1283 0.3825
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0048 0.0143
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0113 0.0436 0.0604
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.019 0.0559
Brugia malayi latrophilin 2 splice variant baaae 0.0685 0.3236 0.3206
Entamoeba histolytica acyl-CoA synthetase, putative 0.0552 0.2584 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0149 0.0102
Echinococcus multilocularis phosphoglycerate kinase 1 0.0172 0.0721 0.1047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0045 0.0133
Leishmania major phosphoglycerate kinase B, cytosolic 0.0172 0.0721 0.2654
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0101 0.0398
Loa Loa (eye worm) hypothetical protein 0.0413 0.1901 0.1862
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0137 0.0672
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0162 0.0675 0.2346
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0111 0.0427 0.1352
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0058 0.0164 0.0365
Echinococcus granulosus phosphoglycerate kinase 1 0.0172 0.0721 0.1047
Loa Loa (eye worm) beta-lactamase 0.0286 0.1283 0.1241
Onchocerca volvulus 0.0286 0.1283 0.3736
Brugia malayi CHD4 protein 0.0058 0.0164 0.0121
Echinococcus granulosus Smad4 0.0141 0.0571 0.0814
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0113 0.0436 0.0604
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0058 0.0164 0.0181
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0164 0.049
Leishmania major cathepsin L-like protease 0.0129 0.0515 0.1842
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0317 0.1434 0.2156
Onchocerca volvulus 0.0058 0.0167 0.0359
Trichomonas vaginalis chromobox protein, putative 0.0353 0.1608 0.4793
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0058 0.0164 0.049
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0113 0.0436 0.0604
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0113 0.0436 0.2095
Brugia malayi AMP-binding enzyme family protein 0.0552 0.2584 0.2551
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0141 0.0571 0.0814
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0515 0.3491
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0089 0.0319 0.0422
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0101 0.0208
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0286 0.1283 0.4784
Brugia malayi Protein cec-1. 0.0058 0.0164 0.0121
Trichomonas vaginalis hypothetical protein 0.0058 0.0164 0.049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0056 0.0167
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0141 0.0571 0.1641
Schistosoma mansoni leucyl-tRNA synthetase 0.0043 0.009 0.0132
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0162 0.0675 0.0528
Onchocerca volvulus 0.0197 0.0847 0.2417
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0552 0.2584 0.2744

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0058 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 0.02 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.122 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (binding) 25.1189 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6427 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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