Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.221 | 0.221 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.221 | 0.221 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.1325 | 0.1325 |
Brugia malayi | RNA binding protein | 0.0063 | 0.221 | 0.3536 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.1325 | 0.1325 |
Brugia malayi | MH2 domain containing protein | 0.0115 | 0.6249 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.221 | 0.1796 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.1325 | 0.1325 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.221 | 0.3536 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.221 | 0.3536 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.1325 | 0.1325 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0115 | 0.6249 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.221 | 0.221 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.221 | 0.221 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0115 | 0.6249 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.221 | 0.1796 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.221 | 0.221 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.221 | 0.1796 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.1325 | 0.1325 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.1325 | 0.212 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.221 | 0.221 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.221 | 0.221 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.1325 | 0.1325 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.1325 | 0.1325 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.