Detailed information for compound 1291262

Basic information

Technical information
  • TDR Targets ID: 1291262
  • Name: N-[(3-bromophenyl)methyl]-N-(1,1-dioxothiolan -3-yl)-2-(2-nitrophenoxy)acetamide
  • MW: 483.333 | Formula: C19H19BrN2O6S
  • H donors: 0 H acceptors: 5 LogP: 3.01 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1cccc(c1)CN(C1CCS(=O)(=O)C1)C(=O)COc1ccccc1[N+](=O)[O-]
  • InChi: 1S/C19H19BrN2O6S/c20-15-5-3-4-14(10-15)11-21(16-8-9-29(26,27)13-16)19(23)12-28-18-7-2-1-6-17(18)22(24)25/h1-7,10,16H,8-9,11-13H2
  • InChiKey: DLQVBDPONXKHAL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(3-bromophenyl)methyl]-N-(1,1-dioxo-3-thiolanyl)-2-(2-nitrophenoxy)acetamide
  • N-(3-bromobenzyl)-N-(1,1-diketothiolan-3-yl)-2-(2-nitrophenoxy)acetamide
  • N-[(3-bromophenyl)methyl]-N-(1,1-dioxothiolan-3-yl)-2-(2-nitrophenoxy)ethanamide
  • STOCK5S-09025

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0075 0.0033 0.0077
Brugia malayi Thioredoxin reductase 0.0085 0.0044 0.0104
Schistosoma mansoni Smad4 0.0088 0.0046 0.0045
Schistosoma mansoni ferritin 0.0165 0.0124 0.0123
Trichomonas vaginalis penicillin-binding protein, putative 0.1197 0.1165 0.2496
Giardia lamblia Histone acetyltransferase GCN5 0.0397 0.0358 0.635
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0075 0.0033 0.0032
Schistosoma mansoni tar DNA-binding protein 0.0253 0.0213 0.0211
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.1197 0.1165 0.1164
Leishmania major trypanothione reductase 0.0085 0.0044 0.0366
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0157 0.0117 0.0247
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0157 0.0117 0.0247
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0167 0.0126 1
Leishmania major cathepsin L-like protease 0.0157 0.0117 0.099
Entamoeba histolytica cysteine protease, putative 0.0157 0.0117 0.1362
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.06 0.0563 0.0562
Echinococcus granulosus bromodomain containing 2 0.0043 0.0002 0.0002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0075 0.0033 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0157 0.0117 0.0247
Loa Loa (eye worm) bromodomain containing protein 0.009 0.0048 0.0114
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0004 0.0004
Mycobacterium ulcerans phosphoglycerate kinase 0.0167 0.0126 0.002
Brugia malayi Papain family cysteine protease containing protein 0.0081 0.004 0.0093
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0778 0.0742 0.0742
Schistosoma mansoni hypothetical protein 0.0959 0.0925 0.0924
Entamoeba histolytica cysteine protease, putative 0.0081 0.004 0.0451
Echinococcus granulosus cathepsin L cysteine proteinase 0.0157 0.0117 0.0117
Mycobacterium ulcerans esterase/lipase LipP 0.1197 0.1165 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0081 0.004 0.0038
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0052 0.001 0.0075
Echinococcus granulosus FTZ F1 alpha 0.0075 0.0033 0.0033
Brugia malayi Intermediate filament tail domain containing protein 0.0302 0.0263 0.0638
Brugia malayi jmjC domain containing protein 0.0098 0.0057 0.0135
Onchocerca volvulus 0.0157 0.0117 0.0247
Trichomonas vaginalis PIKK family atypical protein kinase 0.0201 0.0161 0.0342
Trypanosoma cruzi major cysteine proteinase, putative 0.0471 0.0433 0.3711
Trypanosoma cruzi cysteine peptidase, putative 0.06 0.0563 0.4824
Trichomonas vaginalis PIKK family atypical protein kinase 0.0324 0.0285 0.0608
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.004 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0477 0.0439 0.0939
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.002 0.0046
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0109 0.0068 0.0068
Echinococcus multilocularis polybromo 1 0.0043 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0072 0.0152
Loa Loa (eye worm) fibroinase 0.0157 0.0117 0.0281
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0302 0.0263 0.0638
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.148 0.145 0.145
Schistosoma mansoni cellular tumor antigen P53 0.1412 0.1382 0.1381
Plasmodium vivax unspecified product 0.0081 0.004 0.0328
Echinococcus granulosus beta LACTamase domain containing family member 0.1197 0.1165 0.1165
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0075 0.0033 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0201 0.0161 0.0342
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0444 0.0406 0.0406
Echinococcus multilocularis serine protein kinase ATM 0.0114 0.0072 0.0072
Schistosoma mansoni nuclear hormone receptor 0.0075 0.0033 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.0563 0.4824
Plasmodium vivax unspecified product 0.0052 0.001 0.0076
Plasmodium vivax vivapain-1 0.0081 0.004 0.0328
Echinococcus multilocularis 0.0043 0.0002 0.0002
Echinococcus multilocularis GPCR, family 2 0.0444 0.0406 0.0406
Onchocerca volvulus 0.1412 0.1382 0.2962
Loa Loa (eye worm) PHD-finger family protein 0.0063 0.0021 0.0048
Trichomonas vaginalis esterase, putative 0.1197 0.1165 0.2496
Echinococcus granulosus cathepsin l cysteine peptidase 0.0157 0.0117 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0075 0.0033 0.0077
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0026 0.0284
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0201 0.0161 0.137
Toxoplasma gondii cathepsin CPL 0.0157 0.0117 0.099
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0061 0.002 0.0156
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0778 0.0742 0.0742
Loa Loa (eye worm) hypothetical protein 0.0167 0.0126 0.0305
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0157 0.0117 0.0247
Schistosoma mansoni methyl-cpg binding protein mbd 0.0052 0.001 0.0009
Schistosoma mansoni ferritin light chain 0.0165 0.0124 0.0123
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0217 0.0176 0.0174
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0081 0.004 0.0038
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0157 0.0117 0.0247
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0075 0.0033 0.0033
Brugia malayi ecdysteroid receptor 0.0075 0.0033 0.0077
Echinococcus granulosus Smad4 0.0196 0.0156 0.0156
Trypanosoma cruzi ISWI complex protein 0.0046 0.0005 0.0027
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0196 0.0156 0.0154
Schistosoma mansoni hypothetical protein 0.0778 0.0742 0.0741
Plasmodium vivax flap endonuclease 1, putative 0.0052 0.001 0.0075
Mycobacterium tuberculosis Probable dehydrogenase 0.0195 0.0155 0.0145
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0114 0.0072 0.0173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.0563 0.4824
Brugia malayi F/Y-rich N-terminus family protein 0.0046 0.0004 0.0007
Schistosoma mansoni tar DNA-binding protein 0.0253 0.0213 0.0211
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0075 0.0033 0.0033
Echinococcus multilocularis ecdysone induced protein 78C 0.0075 0.0033 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.0563 0.4824
Loa Loa (eye worm) hypothetical protein 0.0297 0.0257 0.0625
Loa Loa (eye worm) hypothetical protein 0.0075 0.0033 0.0077
Trypanosoma cruzi cysteine peptidase, putative 0.06 0.0563 0.4824
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.044 0.0402 0.0859
Loa Loa (eye worm) hypothetical protein 0.1197 0.1165 0.2844
Trypanosoma brucei phosphoglycerate kinase, putative 0.0061 0.002 0.0156
Loa Loa (eye worm) hypothetical protein 0.0109 0.0067 0.0161
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.004 0.0328
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0167 0.0126 0.0268
Entamoeba histolytica hypothetical protein 0.0882 0.0847 1
Entamoeba histolytica cysteine protease, putative 0.0081 0.004 0.0451
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.06 0.0563 0.6643
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0075 0.0033 0.0033
Loa Loa (eye worm) MH2 domain-containing protein 0.2882 0.2864 0.6997
Loa Loa (eye worm) hypothetical protein 0.0146 0.0105 0.0253
Brugia malayi Cathepsin L-like precursor 0.0157 0.0117 0.0281
Echinococcus multilocularis cysteine protease 0.0157 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.1197 0.1165 0.2844
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0075 0.0033 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0324 0.0285 0.0608
Mycobacterium tuberculosis Probable reductase 0.0195 0.0155 0.0145
Echinococcus multilocularis PH interacting protein 0.0043 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0167 0.0126 0.0305
Entamoeba histolytica hypothetical protein 0.0114 0.0072 0.0838
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.001 0.0022
Echinococcus multilocularis bromodomain containing protein 8 0.0043 0.0002 0.0002
Brugia malayi Cathepsin L-like precursor 0.0105 0.0064 0.0153
Schistosoma mansoni intermediate filament proteins 0.0302 0.0263 0.0261
Trypanosoma brucei phosphoglycerate kinase 0.0061 0.002 0.0156
Leishmania major phosphoglycerate kinase B, cytosolic 0.0167 0.0126 0.1072
Loa Loa (eye worm) steroid hormone receptor 0.0075 0.0033 0.0077
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0157 0.0117 0.3228
Plasmodium falciparum flap endonuclease 1 0.0052 0.001 0.0246
Brugia malayi jmjC domain containing protein 0.0044 0.0002 0.0001
Entamoeba histolytica cysteine protease, putative 0.0081 0.004 0.0451
Brugia malayi RNA binding protein 0.0253 0.0213 0.0516
Trypanosoma cruzi cysteine peptidase, putative 0.0157 0.0117 0.099
Entamoeba histolytica cysteine protease, putative 0.0081 0.004 0.0451
Brugia malayi Cathepsin L-like precursor 0.0157 0.0117 0.0281
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0033 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0157 0.0117 0.0247
Entamoeba histolytica ankyrin repeat protein, putative 0.0043 0.0002 0.0000002937
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0075 0.0033 0.0033
Trypanosoma brucei phosphoglycerate kinase 0.0167 0.0126 0.1072
Loa Loa (eye worm) hypothetical protein 0.014 0.0099 0.0239
Brugia malayi beta-lactamase family protein 0.1197 0.1165 0.2844
Onchocerca volvulus 0.0302 0.0263 0.056
Entamoeba histolytica cysteine protease, putative 0.0081 0.004 0.0451
Schistosoma mansoni hypothetical protein 0.0046 0.0005 0.0003
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.06 0.0563 0.0563
Trichomonas vaginalis flap endonuclease-1, putative 0.0052 0.001 0.0019
Brugia malayi Calcitonin receptor-like protein seb-1 0.1403 0.1373 0.3352
Loa Loa (eye worm) MH1 domain-containing protein 0.0088 0.0046 0.011
Loa Loa (eye worm) hypothetical protein 0.064 0.0604 0.1472
Loa Loa (eye worm) intermediate filament protein 0.0302 0.0263 0.0638
Echinococcus granulosus tumor protein p63 0.965 0.9688 0.9688
Echinococcus multilocularis CREB binding protein 0.0043 0.0002 0.0002
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0114 0.0072 0.0609
Toxoplasma gondii FATC domain-containing protein 0.0114 0.0072 0.0609
Entamoeba histolytica cysteine protease, putative 0.0081 0.004 0.0451
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0157 0.0117 0.3228
Schistosoma mansoni steroid hormone receptor ad4bp 0.0075 0.0033 0.0032
Entamoeba histolytica cysteine protease, putative 0.0081 0.004 0.0451
Onchocerca volvulus 0.0157 0.0117 0.0247
Brugia malayi Cathepsin L-like cysteine proteinase 0.0105 0.0064 0.0153
Schistosoma mansoni transcription factor LCR-F1 0.0882 0.0847 0.0846
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0157 0.0117 0.0247
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0052 0.001 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0157 0.0117 0.0247
Loa Loa (eye worm) hypothetical protein 0.1412 0.1382 0.3375
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0052 0.001 0.001
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0075 0.0033 0.0033
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0157 0.0117 0.0117
Mycobacterium ulcerans lipase LipD 0.1197 0.1165 1
Loa Loa (eye worm) hypothetical protein 0.1197 0.1165 0.2844
Loa Loa (eye worm) cysteine protease 0.0157 0.0117 0.0281
Trichomonas vaginalis PIKK family atypical protein kinase 0.0201 0.0161 0.0342
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0026 0.0207
Plasmodium vivax SET domain containing protein 0.0066 0.0024 0.0193
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0167 0.0126 0.1072
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0114 0.0072 0.0838
Echinococcus multilocularis mothers against decapentaplegic 6 0.0088 0.0046 0.0046
Leishmania major hypothetical protein, conserved 0.1197 0.1165 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0026 0.0026
Leishmania major cathepsin L-like protease 0.06 0.0563 0.4824
Trypanosoma cruzi cruzipain precursor, putative 0.06 0.0563 0.4824
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0201 0.0161 0.137
Trichomonas vaginalis ferritin, putative 0.0165 0.0124 0.0263
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0075 0.0033 0.0077
Brugia malayi Cathepsin L-like precursor 0.0157 0.0117 0.0281
Echinococcus multilocularis tumor protein p63 0.965 0.9688 0.9688
Echinococcus multilocularis musashi 0.0302 0.0263 0.0263
Trypanosoma cruzi cysteine peptidase, putative 0.06 0.0563 0.4824
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0075 0.0033 0.0033
Brugia malayi cytoplasmic intermediate filament protein 0.0162 0.0121 0.0292
Loa Loa (eye worm) phosphatidylinositol 3 0.0201 0.0161 0.039
Echinococcus granulosus ATPase family AAA domain containing protein 2B 0.0043 0.0002 0.0002
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0201 0.0161 0.137
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0167 0.0126 0.0108
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0478 0.044 0.3768
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0002 0.00000021345
Entamoeba histolytica phosphoglycerate kinase, putative 0.0167 0.0126 0.1475
Trichomonas vaginalis PIKK family atypical protein kinase 0.0359 0.032 0.0682
Schistosoma mansoni apoferritin-2 0.0165 0.0124 0.0123
Echinococcus granulosus histone acetyltransferase KAT2B 0.044 0.0402 0.0402
Schistosoma mansoni smad 0.0088 0.0046 0.0045
Echinococcus multilocularis beta LACTamase domain containing family member 0.1197 0.1165 0.1165
Echinococcus multilocularis flap endonuclease 1 0.0052 0.001 0.001
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0037 0.0035
Loa Loa (eye worm) phosphatidylinositol 3 0.06 0.0563 0.1373
Brugia malayi beta-lactamase family protein 0.1197 0.1165 0.2844
Echinococcus granulosus TGF beta signal transducer SmadC 0.0196 0.0156 0.0156
Leishmania major cysteine peptidase A (CPA) 0.0157 0.0117 0.099
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0088 0.0046 0.0046
Echinococcus multilocularis mothers against decapentaplegic 2 0.0088 0.0046 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0403 0.0364 0.0777
Echinococcus multilocularis smad 0.0196 0.0156 0.0156
Schistosoma mansoni tar DNA-binding protein 0.0253 0.0213 0.0211
Loa Loa (eye worm) hypothetical protein 0.0959 0.0925 0.2258
Leishmania major cathepsin L-like protease 0.0157 0.0117 0.099
Onchocerca volvulus Cathepsin L homolog 0.0157 0.0117 0.0247
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0589 0.0551 0.055
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.001 0.0076
Brugia malayi MH1 domain containing protein 0.0109 0.0067 0.0161
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0075 0.0033 0.0068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.0563 0.4824
Entamoeba histolytica hypothetical protein 0.0882 0.0847 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0196 0.0156 0.0377
Entamoeba histolytica hypothetical protein 0.0882 0.0847 1
Trichomonas vaginalis penicillin-binding protein, putative 0.1197 0.1165 0.2496
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.0563 0.4824
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0004 0.0003
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0075 0.0033 0.0077
Loa Loa (eye worm) hypothetical protein 0.0127 0.0086 0.0205
Schistosoma mansoni tar DNA-binding protein 0.0253 0.0213 0.0211
Schistosoma mansoni coup transcription factor 0.0075 0.0033 0.0032
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.044 0.0402 0.3441
Mycobacterium tuberculosis Possible penicillin-binding protein 0.7647 0.7669 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0161 0.012 0.0255
Toxoplasma gondii thioredoxin reductase 0.0085 0.0044 0.0366
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0444 0.0406 0.0406
Trypanosoma cruzi trypanothione reductase, putative 0.0085 0.0044 0.0366
Loa Loa (eye worm) MH2 domain-containing protein 0.0088 0.0046 0.011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.0563 0.4824
Plasmodium falciparum cysteine proteinase falcipain 3 0.0157 0.0117 0.3228
Brugia malayi Nuclear hormone receptor-like 1 0.0075 0.0033 0.0077
Schistosoma mansoni cathepsin F (C01 family) 0.0157 0.0117 0.0115
Entamoeba histolytica cysteine protease, putative 0.0081 0.004 0.0451
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.0367 0.0367
Leishmania major phosphoglycerate kinase C, glycosomal 0.0167 0.0126 0.1072
Loa Loa (eye worm) hypothetical protein 0.1197 0.1165 0.2844
Trichomonas vaginalis PIKK family atypical protein kinase 0.0324 0.0284 0.0607
Brugia malayi Pre-SET motif family protein 0.41 0.4092 1
Brugia malayi latrophilin 2 splice variant baaae 0.0959 0.0925 0.2258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0355 0.0316 0.0675
Echinococcus multilocularis ATPase family AAA domain containing protein 2B 0.0043 0.0002 0.0002
Brugia malayi acetyltransferase, GNAT family protein 0.148 0.145 0.3541
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.148 0.145 0.1449
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0105 0.0064 0.0134
Loa Loa (eye worm) hypothetical protein 0.0051 0.0009 0.0018
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0882 0.0847 0.0847
Echinococcus granulosus CREB binding protein 0.0043 0.0002 0.0002
Brugia malayi Latrophilin receptor protein 2 0.0444 0.0406 0.0988
Schistosoma mansoni Smad4 0.0088 0.0046 0.0045
Brugia malayi beta-lactamase 0.1197 0.1165 0.2844
Loa Loa (eye worm) thioredoxin reductase 0.0085 0.0044 0.0104
Schistosoma mansoni hypothetical protein 0.0444 0.0406 0.0404
Plasmodium falciparum bromodomain protein 1 0.0043 0.0002 0.00000069623
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.002 0.0156
Loa Loa (eye worm) hypothetical protein 0.0105 0.0064 0.0153
Loa Loa (eye worm) latrophilin receptor protein 2 0.0444 0.0406 0.0988
Echinococcus granulosus PH interacting protein 0.0043 0.0002 0.0002
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0114 0.0072 0.0072
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0026 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.06 0.0563 0.1205
Plasmodium falciparum cysteine proteinase falcipain 1 0.0081 0.004 0.107
Mycobacterium leprae Probable lipase LipE 0.1197 0.1165 1
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0165 0.0124 0.0105
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0195 0.0155 0.0145
Schistosoma mansoni hypothetical protein 0.0882 0.0847 0.0846
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0052 0.001 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0157 0.0117 0.0247
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0075 0.0033 0.0077
Schistosoma mansoni lamin 0.0302 0.0263 0.0261
Schistosoma mansoni thyroid hormone receptor 0.0852 0.0817 0.0816
Trichomonas vaginalis PIKK family atypical protein kinase 0.0446 0.0408 0.0872
Brugia malayi RNA recognition motif domain containing protein 0.0253 0.0213 0.0516
Loa Loa (eye worm) hypothetical protein 0.014 0.0099 0.0239
Trypanosoma cruzi cysteine proteinase, putative 0.0081 0.004 0.0328
Trypanosoma brucei phosphoglycerate kinase 0.0167 0.0126 0.1072
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.06 0.0563 0.4828
Loa Loa (eye worm) glutathione reductase 0.0085 0.0044 0.0104
Schistosoma mansoni retinoic acid receptor RXR 0.0075 0.0033 0.0032
Schistosoma mansoni phosphoglycerate kinase 0.0167 0.0126 0.0125
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.064 0.0604 0.0602
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0075 0.0033 0.0033
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0217 0.0176 0.0174
Brugia malayi Bromodomain containing protein 0.0265 0.0225 0.0547
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0127 0.0086 0.0722
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0114 0.0072 0.0173
Mycobacterium leprae conserved hypothetical protein 0.1197 0.1165 1
Mycobacterium tuberculosis Probable lipase LipD 0.1197 0.1165 0.147
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0157 0.0117 0.0247
Loa Loa (eye worm) MH2 domain-containing protein 0.0196 0.0156 0.0377
Leishmania major cathepsin L-like protease 0.06 0.0563 0.4824
Schistosoma mansoni flap endonuclease-1 0.0047 0.0005 0.0004
Schistosoma mansoni thyroid hormone receptor 0.0852 0.0817 0.0816
Echinococcus granulosus mothers against decapentaplegic 5 0.0196 0.0156 0.0156
Echinococcus multilocularis mothers against decapentaplegic 5 0.0196 0.0156 0.0156
Echinococcus granulosus ecdysone induced protein 78C 0.0075 0.0033 0.0033
Brugia malayi PHD-finger family protein 0.0113 0.0072 0.0172
Echinococcus granulosus cathepsin L 0.0081 0.004 0.004
Echinococcus multilocularis expressed protein 0.0165 0.0124 0.0124
Schistosoma mansoni cathepsin F (C01 family) 0.0157 0.0117 0.0115
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.0563 0.4824
Echinococcus granulosus peregrin 0.0073 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0075 0.0033 0.0078
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0162 0.0121 0.0292
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0157 0.0117 0.0247
Schistosoma mansoni zinc finger protein 0.0097 0.0056 0.0054
Loa Loa (eye worm) hypothetical protein 0.0302 0.0263 0.0638
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.06 0.0563 0.4828
Trypanosoma cruzi hypothetical protein, conserved 0.1197 0.1165 1
Schistosoma mansoni smad1 5 8 and 0.0196 0.0156 0.0154
Echinococcus granulosus tar DNA binding protein 0.0253 0.0213 0.0213
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0075 0.0033 0.0033
Schistosoma mansoni zinc finger protein 0.0046 0.0005 0.0003
Entamoeba histolytica Flap nuclease, putative 0.0052 0.001 0.0104
Onchocerca volvulus 0.1197 0.1165 0.2496
Trypanosoma cruzi ISWI complex protein 0.0046 0.0005 0.0027
Entamoeba histolytica cysteine proteinase, putative 0.0157 0.0117 0.1362
Entamoeba histolytica hypothetical protein 0.0882 0.0847 1
Entamoeba histolytica cysteine proteinase, putative 0.0081 0.004 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.039 0.0351 0.0749
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0075 0.0033 0.0077
Echinococcus granulosus intermediate filament protein 0.0302 0.0263 0.0263
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0075 0.0033 0.0032
Leishmania major cathepsin L-like protease 0.0157 0.0117 0.099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0446 0.0408 0.0872
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0075 0.0033 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0157 0.0117 0.0247
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0026 0.0059
Echinococcus multilocularis thyroid hormone receptor alpha 0.0852 0.0817 0.0817
Plasmodium falciparum phosphoglycerate kinase 0.0167 0.0126 0.3496
Schistosoma mansoni hypothetical protein 0.0444 0.0406 0.0404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0446 0.0408 0.0872
Mycobacterium tuberculosis Conserved protein 0.1197 0.1165 0.147
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.002 0.0156
Echinococcus granulosus lamin 0.0302 0.0263 0.0263
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.41 0.4092 1
Echinococcus granulosus serine protein kinase ATM 0.0114 0.0072 0.0072
Echinococcus granulosus fetal alzheimer antigen falz 0.007 0.0029 0.0029
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.007 0.0029 0.0027
Brugia malayi Smad1 0.0196 0.0156 0.0377
Schistosoma mansoni smad1 5 8 and 0.0196 0.0156 0.0154
Brugia malayi MH1 domain containing protein 0.0109 0.0067 0.0161
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0146 0.0105 0.0105
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.064 0.0604 0.0604
Echinococcus granulosus lamin dm0 0.0302 0.0263 0.0263
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0548 0.051 0.4373
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0026 0.0207
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0026 0.0026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.0563 0.4824
Echinococcus granulosus histone acetyltransferase KAT2B 0.1431 0.1401 0.1401
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.0057 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0046 0.0096
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0157 0.0117 0.0247
Entamoeba histolytica cysteine protease, putative 0.0081 0.004 0.0451
Schistosoma mansoni smad1 5 8 and 0.0196 0.0156 0.0154
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0033 0.0068
Brugia malayi steroid hormone receptor 0.0075 0.0033 0.0077
Echinococcus granulosus global transcription activator snf2l2 0.0043 0.0002 0.0002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0004 0.0004
Echinococcus granulosus Bromodomain containing protein 0.0043 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0075 0.0033 0.0077
Schistosoma mansoni hypothetical protein 0.0444 0.0406 0.0404
Echinococcus granulosus expressed protein 0.0165 0.0124 0.0124
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0219 0.0179 0.0179
Giardia lamblia GTOR 0.06 0.0563 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.0563 0.4824
Trichomonas vaginalis conserved hypothetical protein 0.0127 0.0086 0.018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0075 0.0033 0.0077
Schistosoma mansoni bromodomain containing protein 0.023 0.0189 0.0188
Trypanosoma brucei hypothetical protein, conserved 0.1197 0.1165 1
Onchocerca volvulus 0.0157 0.0117 0.0247
Schistosoma mansoni hypothetical protein 0.0063 0.0021 0.0019
Toxoplasma gondii bromodomain-containing protein 0.0043 0.0002 0.00000021345
Echinococcus granulosus phosphoglycerate kinase 1 0.0167 0.0126 0.0126
Mycobacterium tuberculosis Probable oxidoreductase 0.0217 0.0176 0.0174
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.06 0.0563 0.4828
Schistosoma mansoni ferritin 0.0165 0.0124 0.0123
Loa Loa (eye worm) hypothetical protein 0.0075 0.0033 0.0077
Plasmodium vivax SET domain protein, putative 0.0589 0.0551 0.4726
Loa Loa (eye worm) hypothetical protein 0.0114 0.0072 0.0173
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0566 0.0529 0.0529
Loa Loa (eye worm) hypothetical protein 0.0052 0.001 0.0022
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0217 0.0176 0.0502
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0157 0.0117 0.0247
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0157 0.0117 0.0247
Brugia malayi nuclear receptor NHR-88 0.0075 0.0033 0.0077
Echinococcus granulosus ferritin 0.0165 0.0124 0.0124
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.06 0.0563 0.1373
Onchocerca volvulus 0.0075 0.0033 0.0068
Plasmodium vivax glutathione reductase, putative 0.0085 0.0044 0.0366
Echinococcus multilocularis Bromodomain containing protein 0.0043 0.0002 0.0002
Loa Loa (eye worm) Smad1 0.0196 0.0156 0.0377
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.1197 0.1165 0.2844
Echinococcus multilocularis tar DNA binding protein 0.0253 0.0213 0.0213
Echinococcus granulosus cathepsin l1 0.0157 0.0117 0.0117
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0075 0.0033 0.0273
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0167 0.0126 0.002
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0081 0.004 0.0328
Toxoplasma gondii ABC1 family protein 0.1197 0.1165 1
Echinococcus multilocularis peregrin 0.0073 0.0032 0.0032
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0444 0.0406 0.0406
Schistosoma mansoni lamin 0.0302 0.0263 0.0261
Trichomonas vaginalis set domain proteins, putative 0.4666 0.4663 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.002 0.0156
Echinococcus multilocularis phosphoglycerate kinase 1 0.0167 0.0126 0.0126
Mycobacterium tuberculosis Probable lipase LipE 0.1197 0.1165 0.147
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0157 0.0117 0.0247
Echinococcus granulosus protein kinase C binding protein 1 0.0043 0.0002 0.0002
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0004 0.0007
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0075 0.0033 0.0032
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0195 0.0155 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0075 0.0033 0.0077
Entamoeba histolytica cysteine proteinase 2 0.0081 0.004 0.0451
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0195 0.0155 0.0145
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0075 0.0033 0.0033
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0048 0.0007 0.0011
Brugia malayi photoreceptor-specific nuclear receptor 0.0075 0.0033 0.0077
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.1197 0.1165 0.147
Schistosoma mansoni bromodomain containing protein 0.0051 0.0009 0.0007
Brugia malayi TAR-binding protein 0.0253 0.0213 0.0516
Entamoeba histolytica cysteine protease, putative 0.0081 0.004 0.0451
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0075 0.0033 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0157 0.0117 0.0247
Brugia malayi Phosphoglycerate kinase 0.0061 0.002 0.0044
Toxoplasma gondii target of rapamycin (TOR), putative 0.0446 0.0408 0.3495
Loa Loa (eye worm) hypothetical protein 0.0075 0.0033 0.0077
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0157 0.0117 0.0247
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.0563 0.4824
Entamoeba histolytica protein kinase rad3, putative 0.0114 0.0072 0.0838
Mycobacterium ulcerans hypothetical protein 0.1197 0.1165 1
Echinococcus multilocularis lamin 0.0302 0.0263 0.0263
Trichomonas vaginalis D-aminoacylase, putative 0.1197 0.1165 0.2496
Loa Loa (eye worm) hypothetical protein 0.0075 0.0033 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0324 0.0285 0.0608
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0026 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0324 0.0284 0.0607
Schistosoma mansoni Smad4 0.0196 0.0156 0.0154
Echinococcus multilocularis zinc finger protein 0.0097 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0444 0.0406 0.0988
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0157 0.0117 0.0281
Echinococcus multilocularis cathepsin L cysteine protease 0.0157 0.0117 0.0117
Onchocerca volvulus Bile acid receptor homolog 0.0075 0.0033 0.0068
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0114 0.0072 0.0609
Leishmania major phosphatidylinositol 3-kinase, putative 0.0201 0.0161 0.137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.06 0.0563 0.4824
Schistosoma mansoni ferritin 0.0165 0.0124 0.0123
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0026 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0513 0.0475 0.1015
Onchocerca volvulus 0.0157 0.0117 0.0247
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0075 0.0033 0.0033
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0114 0.0072 0.0071
Onchocerca volvulus 0.1197 0.1165 0.2496
Schistosoma mansoni hypothetical protein 0.0088 0.0046 0.0045
Trypanosoma cruzi cysteine proteinase, putative 0.0081 0.004 0.0328
Entamoeba histolytica cysteine protease, putative 0.0081 0.004 0.0451
Loa Loa (eye worm) hypothetical protein 0.0051 0.001 0.002
Schistosoma mansoni fkbp-rapamycin associated protein 0.0114 0.0072 0.0071
Mycobacterium tuberculosis Conserved protein 0.1197 0.1165 0.147
Loa Loa (eye worm) hypothetical protein 0.0052 0.001 0.0022
Brugia malayi MH2 domain containing protein 0.0196 0.0156 0.0377
Brugia malayi MH1 domain containing protein 0.0196 0.0156 0.0377
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0249 0.0209 0.1786
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0201 0.0161 0.039
Echinococcus multilocularis cysteine protease 0.0157 0.0117 0.0117
Mycobacterium tuberculosis Probable hydrolase 0.1197 0.1165 0.147
Loa Loa (eye worm) TAR-binding protein 0.0253 0.0213 0.0516
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0882 0.0847 0.0847
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.06 0.0563 0.4828
Trichomonas vaginalis PIKK family atypical protein kinase 0.0477 0.0439 0.0939
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0072 0.0152
Plasmodium falciparum histone acetyltransferase GCN5 0.0397 0.0358 1
Chlamydia trachomatis phosphoglycerate kinase 0.0167 0.0126 0.5
Brugia malayi MH2 domain containing protein 0.0088 0.0046 0.011
Schistosoma mansoni apoferritin-2 0.0165 0.0124 0.0123
Trypanosoma cruzi cysteine protease, putative 0.0081 0.004 0.0328
Loa Loa (eye worm) hypothetical protein 0.016 0.0119 0.0287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0446 0.0408 0.0872
Trichomonas vaginalis PIKK family atypical protein kinase 0.0446 0.0408 0.0872
Onchocerca volvulus 0.0157 0.0117 0.0247
Loa Loa (eye worm) transcription factor SMAD2 0.2882 0.2864 0.6997
Entamoeba histolytica cysteine proteinase, putative 0.0081 0.004 0.0451
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.002 0.0156
Echinococcus granulosus histone lysine methyltransferase setb 0.064 0.0604 0.0604
Brugia malayi intermediate filament protein 0.0302 0.0263 0.0638
Onchocerca volvulus Cathepsin L homolog 0.0157 0.0117 0.0247
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0196 0.0156 0.0156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0446 0.0408 0.0872
Brugia malayi MH1 domain containing protein 0.0196 0.0156 0.0377
Trypanosoma brucei trypanothione reductase 0.0085 0.0044 0.0366
Mycobacterium ulcerans beta-lactamase 0.1197 0.1165 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0219 0.0179 0.0179
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0157 0.0117 0.0117
Entamoeba histolytica cysteine proteinase, putative 0.0157 0.0117 0.1362
Treponema pallidum phosphoglycerate kinase 0.0167 0.0126 1
Schistosoma mansoni RAR-like nuclear receptor 0.0075 0.0033 0.0032
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0165 0.0124 0.0105
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0052 0.001 0.0075
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.1197 0.1165 0.1164
Echinococcus granulosus zinc finger protein 0.0097 0.0056 0.0056
Brugia malayi Flap endonuclease-1 0.0052 0.001 0.0021
Loa Loa (eye worm) flap endonuclease-1 0.0052 0.001 0.0021
Loa Loa (eye worm) hypothetical protein 0.0116 0.0075 0.018
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0589 0.0551 0.0551
Loa Loa (eye worm) acetyltransferase 0.148 0.145 0.3541
Trichomonas vaginalis PIKK family atypical protein kinase 0.06 0.0563 0.1205
Echinococcus multilocularis FTZ F1 alpha 0.0075 0.0033 0.0033
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0167 0.0126 0.1072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0075 0.0033 0.0077
Loa Loa (eye worm) hypothetical protein 0.0088 0.0046 0.011
Schistosoma mansoni cathepsin F (C01 family) 0.0105 0.0064 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0075 0.0033 0.0077
Schistosoma mansoni tar DNA-binding protein 0.0253 0.0213 0.0211
Onchocerca volvulus 0.1197 0.1165 0.2496
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0157 0.0117 0.0247
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0088 0.0046 0.0096
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0167 0.0126 0.1072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0201 0.0161 0.0342
Onchocerca volvulus 0.0302 0.0263 0.056
Plasmodium vivax thioredoxin reductase, putative 0.0085 0.0044 0.0366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0477 0.0439 0.0939
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0048 0.0007 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0359 0.032 0.0682
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0075 0.0033 0.0077
Brugia malayi Bromodomain containing protein 0.0152 0.0111 0.0269
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0195 0.0155 0.0291
Echinococcus granulosus bromodomain containing protein 8 0.0043 0.0002 0.0002
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0284 0.0244 0.2086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0324 0.0285 0.0608
Loa Loa (eye worm) hypothetical protein 0.1403 0.1373 0.3352
Loa Loa (eye worm) hypothetical protein 0.0052 0.001 0.0022
Brugia malayi Bromodomain containing protein 0.0073 0.0032 0.0074
Brugia malayi Cathepsin L-like precursor 0.0157 0.0117 0.0281
Echinococcus granulosus mothers against decapentaplegic 2 0.0088 0.0046 0.0046
Onchocerca volvulus 0.0105 0.0064 0.0134
Loa Loa (eye worm) hypothetical protein 0.0075 0.0033 0.0077
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0146 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0075 0.0033 0.0077
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0589 0.0551 0.4726
Echinococcus granulosus lysine specific demethylase 5A 0.0044 0.0002 0.0002
Brugia malayi glutathione reductase 0.0085 0.0044 0.0104
Echinococcus granulosus cathepsin L cysteine protease 0.0081 0.004 0.004
Echinococcus multilocularis global transcription activator snf2l2 0.0043 0.0002 0.0002
Echinococcus multilocularis fetal alzheimer antigen, falz 0.007 0.0029 0.0029
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0004 0.0007
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1403 0.1373 0.3352
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0157 0.0117 0.0247
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0075 0.0033 0.0077
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0201 0.0161 0.0161
Entamoeba histolytica cysteine proteinase, putative 0.0105 0.0064 0.0741
Echinococcus granulosus thioredoxin glutathione reductase 0.0086 0.0045 0.0045
Onchocerca volvulus 0.0589 0.0551 0.118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0105 0.0064 0.0134
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.06 0.0563 0.4828
Trichomonas vaginalis PIKK family atypical protein kinase 0.0359 0.032 0.0682
Brugia malayi cathepsin L-like precursor 0.0105 0.0064 0.0153
Echinococcus multilocularis cathepsin L 0.0081 0.004 0.004
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0167 0.0126 0.1072
Giardia lamblia Flap structure-specific endonuclease 0.0052 0.001 0.0156
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.1197 0.1165 1
Giardia lamblia Phosphoglycerate kinase 0.0167 0.0126 0.222
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0004 0.0004
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0081 0.004 0.0038
Brugia malayi Papain family cysteine protease containing protein 0.0081 0.004 0.0093
Brugia malayi Phosphoglycerate kinase 0.0167 0.0126 0.0305
Plasmodium vivax histone acetyltransferase GCN5, putative 0.044 0.0402 0.3441
Entamoeba histolytica cysteine proteinase, putative 0.0081 0.004 0.0451
Loa Loa (eye worm) hypothetical protein 0.0105 0.0064 0.0153
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0109 0.0068 0.0068
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0201 0.0161 0.0159
Brugia malayi cathepsin F-like cysteine proteinase 0.0052 0.001 0.0022
Loa Loa (eye worm) hypothetical protein 0.0075 0.0033 0.0077
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.06 0.0563 0.6643
Brugia malayi Pre-SET motif family protein 0.0589 0.0551 0.1344
Loa Loa (eye worm) beta-lactamase 0.1197 0.1165 0.2844
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0167 0.0126 0.0268
Loa Loa (eye worm) hypothetical protein 0.0157 0.0117 0.0281
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0195 0.0155 0.0145
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0157 0.0117 0.0281
Brugia malayi MH2 domain containing protein 0.0196 0.0156 0.0377
Brugia malayi hypothetical protein 0.0882 0.0847 0.2067
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0157 0.0117 0.0247
Loa Loa (eye worm) hypothetical protein 0.0214 0.0174 0.0422
Trichomonas vaginalis PIKK family atypical protein kinase 0.06 0.0563 0.1205
Mycobacterium tuberculosis Probable esterase LipL 0.1197 0.1165 0.147
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.06 0.0563 0.0563
Trichomonas vaginalis D-aminoacylase, putative 0.1197 0.1165 0.2496
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0589 0.0551 0.055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0157 0.0117 0.0247
Echinococcus granulosus dnaJ subfamily B 0.0406 0.0367 0.0367
Loa Loa (eye worm) hypothetical protein 0.1197 0.1165 0.2844
Echinococcus granulosus Bromodomain containing protein 0.0043 0.0002 0.0002
Loa Loa (eye worm) nuclear factor I 0.0109 0.0067 0.0161
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0004 0.0003
Echinococcus granulosus cathepsin l1 0.0105 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.0406 0.0367 0.0365
Echinococcus granulosus GPCR family 2 0.0444 0.0406 0.0406
Trichomonas vaginalis PIKK family atypical protein kinase 0.0355 0.0316 0.0675
Echinococcus multilocularis lamin dm0 0.0302 0.0263 0.0263
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0478 0.044 0.3768
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0253 0.0213 0.0516
Brugia malayi Papain family cysteine protease containing protein 0.0157 0.0117 0.0281
Schistosoma mansoni ferritin 0.0165 0.0124 0.0123
Echinococcus multilocularis ferritin 0.0165 0.0124 0.0124
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0075 0.0033 0.0032
Onchocerca volvulus Protein ultraspiracle homolog 0.0075 0.0033 0.0068
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0075 0.0033 0.0032
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.1197 0.1165 0.2844
Trichomonas vaginalis PIKK family atypical protein kinase 0.0324 0.0284 0.0607
Plasmodium vivax vivapain-2 0.0157 0.0117 0.099
Echinococcus multilocularis Bromodomain containing protein 0.0043 0.0002 0.0002
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0114 0.0072 0.0072
Loa Loa (eye worm) RNA binding protein 0.0253 0.0213 0.0516
Schistosoma mansoni smad 0.0196 0.0156 0.0154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0446 0.0408 0.0872
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0114 0.0072 0.0609
Schistosoma mansoni phosphoglycerate kinase 0.0167 0.0126 0.0125
Brugia malayi Cathepsin L-like precursor 0.0105 0.0064 0.0153
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0075 0.0033 0.0032
Schistosoma mansoni ferritin light chain 0.0165 0.0124 0.0123
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.064 0.0604 0.0602
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.06 0.0563 0.4828
Trichomonas vaginalis bromodomain-containing protein, putative 0.044 0.0402 0.0859
Echinococcus multilocularis bromodomain containing 2 0.0043 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0105 0.0064 0.0153
Loa Loa (eye worm) hypothetical protein 0.0088 0.0046 0.011
Echinococcus granulosus smad 0.0196 0.0156 0.0156
Schistosoma mansoni hypothetical protein 0.0444 0.0406 0.0404
Brugia malayi mothers against decapentaplegic homolog 3 0.0088 0.0046 0.011
Leishmania major cathepsin L-like protease 0.0157 0.0117 0.099
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0052 0.001 0.0075
Schistosoma mansoni cathepsin s 0.0052 0.001 0.0009
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.002 0.0156
Plasmodium falciparum glutathione reductase 0.0085 0.0044 0.1193
Echinococcus granulosus CREB binding protein 0.0043 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0477 0.0439 0.0939
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.044 0.0402 0.3441
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0088 0.0046 0.0046
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0201 0.0161 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0072 0.0152
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0082 0.0041 0.0039
Leishmania major cathepsin L-like protease 0.06 0.0563 0.4824
Echinococcus granulosus flap endonuclease 1 0.0052 0.001 0.001
Loa Loa (eye worm) ctsf protein 0.0157 0.0117 0.0281
Loa Loa (eye worm) hypothetical protein 0.0122 0.0081 0.0195
Trypanosoma cruzi hypothetical protein, conserved 0.1197 0.1165 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0157 0.0117 0.0247
Trypanosoma cruzi target of rapamycin kinase 3 0.0478 0.044 0.3768
Plasmodium vivax hypothetical protein, conserved 0.1197 0.1165 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0201 0.0161 0.137
Onchocerca volvulus 0.0157 0.0117 0.0247
Entamoeba histolytica cysteine protease, putative 0.0081 0.004 0.0451
Onchocerca volvulus 0.4666 0.4663 1
Echinococcus granulosus transcription initiation factor TFIID subunit 1 0.0043 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0075 0.0033 0.0077
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0075 0.0033 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.004 0.0328
Entamoeba histolytica cysteine proteinase, putative 0.0081 0.004 0.0451
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0026 0.0024
Echinococcus granulosus methyl CpG binding domain protein 2 0.0052 0.001 0.001
Mycobacterium tuberculosis Probable conserved lipoprotein 0.1197 0.1165 0.147
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.0057 0.0057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0004 0.0003
Echinococcus multilocularis protein kinase C binding protein 1 0.0043 0.0002 0.0002
Plasmodium vivax phosphoglycerate kinase, putative 0.0167 0.0126 0.1072
Trichomonas vaginalis D-aminoacylase, putative 0.1197 0.1165 0.2496
Brugia malayi Cathepsin L-like precursor 0.0157 0.0117 0.0281
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.0002 0.0001
Onchocerca volvulus Cathepsin F homolog 0.0157 0.0117 0.0247
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0075 0.0033 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0157 0.0117 0.0247
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0075 0.0033 0.0077
Echinococcus granulosus polybromo 1 0.0043 0.0002 0.0002
Mycobacterium tuberculosis Conserved protein 0.1197 0.1165 0.147
Trypanosoma cruzi cruzipain precursor, putative 0.0052 0.001 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0157 0.0117 0.0247
Echinococcus multilocularis Smad4 0.0196 0.0156 0.0156
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0444 0.0406 0.0406
Echinococcus granulosus cysteine protease 0.0081 0.004 0.004
Entamoeba histolytica cysteine proteinase 1, putative 0.0081 0.004 0.0451
Brugia malayi MH2 domain containing protein 0.2882 0.2864 0.6997
Trypanosoma brucei ISWI complex protein 0.0046 0.0005 0.0027
Toxoplasma gondii histone lysine methyltransferase SET1 0.0119 0.0078 0.0655
Loa Loa (eye worm) hypothetical protein 0.1197 0.1165 0.2844
Plasmodium falciparum thioredoxin reductase 0.0085 0.0044 0.1193
Plasmodium vivax vivapain-2 0.0157 0.0117 0.099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0201 0.0161 0.0342
Leishmania major hypothetical protein, conserved 0.0046 0.0005 0.0027
Onchocerca volvulus 0.0157 0.0117 0.0247
Leishmania major cathepsin L-like protease 0.0157 0.0117 0.099
Entamoeba histolytica cysteine protease, putative 0.0081 0.004 0.0451
Echinococcus granulosus mothers against decapentaplegic 6 0.0088 0.0046 0.0046
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1403 0.1373 0.3352
Plasmodium vivax vivapain-3 0.0081 0.004 0.0328
Brugia malayi FAT domain containing protein 0.0088 0.0046 0.011
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.1197 0.1165 0.147
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0075 0.0033 0.0077
Echinococcus multilocularis thioredoxin glutathione reductase 0.0086 0.0045 0.0045
Trypanosoma cruzi cysteine peptidase, putative 0.0081 0.004 0.0328
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.004 0.0082
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0444 0.0406 0.0988
Brugia malayi Cathepsin L-like precursor 0.0157 0.0117 0.0281
Brugia malayi nuclear hormone receptor 0.0075 0.0033 0.0077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0075 0.0033 0.0077
Schistosoma mansoni methyl-cpg binding protein mbd 0.0052 0.001 0.0009
Brugia malayi Cathepsin L-like precursor 0.0052 0.001 0.0022
Entamoeba histolytica acetyltransferase, GNAT family 0.0397 0.0358 0.4218
Brugia malayi Steroid receptor seven-up type 2 0.0075 0.0033 0.0077
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0201 0.0161 0.137
Echinococcus multilocularis cathepsin L cysteine protease 0.0157 0.0117 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0477 0.0439 0.0939

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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