Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucosidase, beta, acid | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0693 | 0.0693 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0066 | 0.0693 | 0.0693 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0066 | 0.0693 | 0.0693 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.6353 | 0.1027 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0693 | 0.1919 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0066 | 0.0693 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0066 | 0.0693 | 0.0693 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.021 | 0.6125 | 0.6125 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0239 | 0.723 | 0.723 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.6125 | 0.6125 |
Echinococcus multilocularis | GPCR, family 2 | 0.0066 | 0.0693 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.021 | 0.6125 | 0.6125 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.021 | 0.6125 | 0.6125 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.6353 | 0.1027 |
Echinococcus granulosus | GPCR family 2 | 0.0066 | 0.0693 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0239 | 0.723 | 0.723 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0693 | 0.1919 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0066 | 0.0693 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0143 | 0.3611 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0066 | 0.0693 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0066 | 0.0693 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0693 | 0.1919 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0143 | 0.3611 | 0.3611 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0239 | 0.723 | 0.723 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0205 | 0.5935 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0693 | 0.1919 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.3611 | 0.3611 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3.2609 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Primary Screen Confirmation. (Class of assay: confirmatory) [Related pubchem assays: 2101 ] | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Activity in Non-Mutant Spleen Homogenate Using a Red Fluorescent Substrate. (Class of assay: confirmatory) [Related pubchem assays: 2101 ] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.