Detailed information for compound 1291331

Basic information

Technical information
  • TDR Targets ID: 1291331
  • Name: 4-(3,4-dimethoxyphenyl)-3,4,5,6-tetrahydro-1H -benzo[h]quinazoline-2-thione
  • MW: 352.45 | Formula: C20H20N2O2S
  • H donors: 1 H acceptors: 0 LogP: 3.32 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)C1NC(=NC2=C1CCc1c2cccc1)S
  • InChi: 1S/C20H20N2O2S/c1-23-16-10-8-13(11-17(16)24-2)18-15-9-7-12-5-3-4-6-14(12)19(15)22-20(25)21-18/h3-6,8,10-11,18H,7,9H2,1-2H3,(H2,21,22,25)
  • InChiKey: UPWWMFGRFVAGGJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(3,4-Dimethoxy-phenyl)-3,4,5,6-tetrahydro-1H-benzo[h]quinazoline-2-thione
  • MLS000590036
  • SMR000219249
  • A3149/0133162

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Wolbachia endosymbiont of Brugia malayi recombinase A Get druggable targets OG5_130095 All targets in OG5_130095
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Treponema pallidum recombinase A Get druggable targets OG5_130095 All targets in OG5_130095
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. Get druggable targets OG5_130095 All targets in OG5_130095
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans recombinase A Get druggable targets OG5_130095 All targets in OG5_130095
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis recombinase RecA Get druggable targets OG5_130095 All targets in OG5_130095
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. Get druggable targets OG5_130095 All targets in OG5_130095
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0024 0.0073
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0121 0.1076
Treponema pallidum recombinase A 0.013 0.0541 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0372 0.6779
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0026 0.005 0.0611
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0372 0.4778
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0011 0.0034
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.0734 0.1749
Brugia malayi Cathepsin L-like precursor 0.0019 0.0017 0.0054
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0121 0.1954
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0188 0.1541
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0606 0.5233
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0171 0.0734 0.6335
Loa Loa (eye worm) inositol-1 0.0041 0.0121 0.1042
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0065 0.0235 0.2267
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0098 0.1092
Echinococcus granulosus lamin 0.0033 0.0082 0.0336
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0372 0.6741
Schistosoma mansoni heat shock protein 0.0019 0.0018 0.003
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0026 0.005 0.0032
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0094
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0264 0.2563
Onchocerca volvulus 0.0099 0.0394 0.3006
Loa Loa (eye worm) hypothetical protein 0.0039 0.0111 0.0958
Trichomonas vaginalis esterase, putative 0.0039 0.0111 0.0748
Plasmodium vivax heat shock protein 90, putative 0.0019 0.0018 0.0011
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0121 0.05
Mycobacterium leprae Conserved hypothetical protein 0.0764 0.3518 1
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0111 0.0748
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0111 0.0748
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0111 0.0975
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0024 0.0119
Onchocerca volvulus 0.0039 0.0111 0.0748
Mycobacterium ulcerans hypothetical protein 0.0039 0.0111 0.177
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0017 0.0147
Loa Loa (eye worm) hypothetical protein 0.0262 0.1158 1
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0111 0.0975
Echinococcus granulosus endoplasmin 0.0019 0.0018 0.0064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0393 0.1626
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0098 0.0372
Schistosoma mansoni hypothetical protein 0.0518 0.2361 1
Trypanosoma cruzi DNA repair protein, putative 0.004 0.0117 0.1042
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0108 0.094
Brugia malayi TAR-binding protein 0.0141 0.059 0.5047
Schistosoma mansoni hypothetical protein 0.0038 0.0106 0.0404
Mycobacterium tuberculosis Conserved protein 0.0039 0.0111 0.0093
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0098 0.0405
Leishmania major hypothetical protein, conserved 0.0224 0.098 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0111 0.0958
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.0393 0.3393
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0108 0.0721
Plasmodium falciparum heat shock protein 90, putative 0.0177 0.0761 1
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1272 1
Brugia malayi beta-lactamase family protein 0.0039 0.0111 0.0873
Mycobacterium ulcerans lipase LipD 0.0039 0.0111 0.177
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0061 0.0594
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0264 0.2563
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.022 0.0202
Trypanosoma cruzi cruzipain precursor, putative 0.0071 0.0264 0.2569
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0019 0.0018 0.0078
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0024 0.0115
Echinococcus granulosus lamin dm0 0.0033 0.0082 0.0336
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0108 0.8739
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0024 0.0119
Echinococcus multilocularis GPCR, family 2 0.0017 0.0011 0.0019
Loa Loa (eye worm) hypothetical protein 0.0055 0.0186 0.1603
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0264 0.2569
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0121 0.1069
Echinococcus granulosus lysosomal alpha glucosidase 0.0171 0.0734 0.31
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0024 0.0073
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0108 0.0721
Brugia malayi Pre-SET motif family protein 0.0251 0.1109 0.9574
Echinococcus granulosus cathepsin l1 0.0019 0.0017 0.006
Onchocerca volvulus 0.0033 0.0082 0.0517
Onchocerca volvulus 0.0033 0.0082 0.0517
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0108 0.0721
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.2014 0.9388 0.9387
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0186 0.0744
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1109 0.9578
Loa Loa (eye worm) ctsf protein 0.0019 0.0017 0.0147
Loa Loa (eye worm) hypothetical protein 0.0033 0.0082 0.0707
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0264 0.2569
Echinococcus multilocularis cysteine protease 0.0019 0.0017 0.0034
Mycobacterium tuberculosis Conserved protein 0.0039 0.0111 0.0093
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0121 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0024 0.0207
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0121 0.1965
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0024 0.0118
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0082 0.0871
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.022 0.0519
Schistosoma mansoni alpha-glucosidase 0.0147 0.0622 0.2599
Mycobacterium tuberculosis Conserved protein 0.0039 0.0111 0.0093
Trypanosoma cruzi heat shock protein, putative 0.0019 0.0018 0.0008
Brugia malayi Pre-SET motif family protein 0.0036 0.0098 0.0762
Mycobacterium ulcerans hypothetical protein 0.0026 0.005 0.0611
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0111 0.1262
Toxoplasma gondii Hsp90 domain-containing protein 0.0177 0.0761 1
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0111 0.0093
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0061 0.0459
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0121 0.0282
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0024 1
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.013 0.0541 0.1494
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0393 0.0934
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.022 0.0577
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0528
Loa Loa (eye worm) hypothetical protein 0.0039 0.0111 0.0958
Brugia malayi Cathepsin L-like precursor 0.0019 0.0017 0.0054
Loa Loa (eye worm) hypothetical protein 0.0036 0.0098 0.0849
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0131 0.0544 0.0527
Brugia malayi hypothetical protein 0.0028 0.0061 0.0439
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0011 0.0001
Onchocerca volvulus 0.0055 0.0186 0.1343
Loa Loa (eye worm) TAR-binding protein 0.0141 0.059 0.5093
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0108 0.0929
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0011 0.0094
Loa Loa (eye worm) hypothetical protein 0.0039 0.0111 0.0958
Plasmodium vivax heat shock protein, putative 0.0177 0.0761 1
Mycobacterium tuberculosis Conserved protein 0.0026 0.005 0.0032
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0131 0.0544 0.2295
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0106 0.0828
Toxoplasma gondii ABC1 family protein 0.0039 0.0111 0.1262
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0393 0.1655
Echinococcus granulosus tumor protein p63 0.0373 0.1682 0.7122
Brugia malayi Probable ClpP-like protease 0.0094 0.0372 0.3152
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0017 0.0026
Echinococcus multilocularis lamin 0.0033 0.0082 0.0189
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0111 0.0259
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0017 0.0034
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0108 0.094
Echinococcus granulosus tar DNA binding protein 0.0141 0.059 0.249
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0111 0.0426
Onchocerca volvulus 0.0039 0.0111 0.0748
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0024 0.0094
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0026 0.005 0.0611
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.0544 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0248 0.1091 0.1075
Echinococcus multilocularis geminin 0.0518 0.2361 0.5643
Loa Loa (eye worm) beta-lactamase 0.0039 0.0111 0.0958
Trypanosoma brucei glucosidase, putative 0.0038 0.0108 0.0933
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0264 0.2563
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0026 0.005 0.0343
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0111 0.177
Echinococcus granulosus intermediate filament protein 0.0033 0.0082 0.0336
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0111 0.0459
Onchocerca volvulus Huntingtin homolog 0.0262 0.1158 0.9091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0264 0.2563
Brugia malayi Inositol-1 0.0041 0.0121 0.0957
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0024 0.0051
Loa Loa (eye worm) hypothetical protein 0.0039 0.0111 0.0958
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0061 0.0459
Trichomonas vaginalis heat shock protein, putative 0.0019 0.0018 0.0006
Chlamydia trachomatis recombinase RecA 0.013 0.0541 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0111 0.0093
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0111 0.0093
Brugia malayi beta-lactamase 0.0039 0.0111 0.0873
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0372 0.6741
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0111 0.177
Echinococcus multilocularis cysteine protease 0.0019 0.0017 0.0034
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0264 0.2569
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.0372 0.1539
Schistosoma mansoni alpha glucosidase 0.0038 0.0108 0.0412
Loa Loa (eye worm) hypothetical protein 0.0032 0.0079 0.0683
Trypanosoma cruzi DNA repair protein, putative 0.004 0.0117 0.1042
Echinococcus multilocularis musashi 0.0033 0.0082 0.0189
Schistosoma mansoni tar DNA-binding protein 0.0141 0.059 0.2464
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0024 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0264 0.2563
Schistosoma mansoni alpha-glucosidase 0.0147 0.0622 0.2599
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0098 0.0372
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0108 0.0843
Schistosoma mansoni hypothetical protein 0.0518 0.2361 1
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0082 0.062
Brugia malayi Cathepsin L-like precursor 0.0019 0.0017 0.0054
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0372 0.4778
Leishmania major hypothetical protein, conserved 0.0028 0.0061 0.0459
Loa Loa (eye worm) hypothetical protein 0.0094 0.0372 0.3216
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0264 0.2563
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0026 0.005 0.0611
Schistosoma mansoni tar DNA-binding protein 0.0141 0.059 0.2464
Mycobacterium ulcerans recombinase A 0.013 0.0541 0.9943
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0061 0.0451
Loa Loa (eye worm) cysteine protease 0.0019 0.0017 0.0147
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0121 0.1076
Brugia malayi Glycosyl hydrolases family 31 protein 0.0171 0.0734 0.6301
Toxoplasma gondii exonuclease III APE 0.002 0.0024 0.0094
Loa Loa (eye worm) fibroinase 0.0019 0.0017 0.0147
Brugia malayi RNA recognition motif domain containing protein 0.0141 0.059 0.5047
Mycobacterium ulcerans hypothetical protein 0.0026 0.005 0.0611
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.0544 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0121 0.0825
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0111 0.0873
Echinococcus granulosus geminin 0.0518 0.2361 1
Brugia malayi follicle stimulating hormone receptor 0.0256 0.1131 0.976
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0108 0.0721
Brugia malayi hypothetical protein 0.0262 0.1158 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0111 0.0958
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0141 0.059 0.5093
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0108 0.0444
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0017 0.0034
Echinococcus granulosus GPCR family 2 0.0017 0.0011 0.0034
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0101 0.0083
Leishmania major cathepsin L-like protease 0.0071 0.0264 0.2569
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0131 0.0544 0.5473
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0111 0.0748
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0082 0.1223
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0024 0.0064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0393 0.1626
Schistosoma mansoni tar DNA-binding protein 0.0141 0.059 0.2464
Schistosoma mansoni ap endonuclease 0.002 0.0024 0.0056
Onchocerca volvulus Huntingtin homolog 0.0262 0.1158 0.9091
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0024 0.0094
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0111 0.0093
Brugia malayi beta-lactamase family protein 0.0039 0.0111 0.0873
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0011 0.0034
Echinococcus multilocularis endoplasmin 0.0019 0.0018 0.0036
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.0372 0.1013
Echinococcus multilocularis lamin dm0 0.0033 0.0082 0.0189
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0101 0.0236
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0131 0.0544 0.1295
Trypanosoma cruzi hypothetical protein, conserved 0.0224 0.098 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0108 0.0721
Leishmania major cathepsin L-like protease 0.0071 0.0264 0.2569
Schistosoma mansoni intermediate filament proteins 0.0033 0.0082 0.0303
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0017 0.0147
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0108 0.0721
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0111 0.0426
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.0734 0.1749
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0011 0.0094
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0061 0.0594
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0111 0.0093
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0061 0.0594
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0026 0.005 0.0343
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0017 0.006
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0026 0.005 0.0343
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0098 0.0228
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0147
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0111 0.0748
Schistosoma mansoni tar DNA-binding protein 0.0141 0.059 0.2464
Onchocerca volvulus 0.0039 0.0111 0.0748
Schistosoma mansoni inositol monophosphatase 0.0041 0.0121 0.0467
Brugia malayi Cathepsin L-like precursor 0.0019 0.0017 0.0054
Brugia malayi intermediate filament protein 0.0033 0.0082 0.062
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0011 0.0019
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0606 0.5233
Loa Loa (eye worm) RNA binding protein 0.0141 0.059 0.5093
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0092 0.0379
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0188 0.1541
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0017 0.0034
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.022 0.0202
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0017 0.0034
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0017 0.0026
Leishmania major heat shock protein, putative 0.0019 0.0018 0.0008
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0393 0.1655
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0019 0.0018 0.0008
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.0372 0.4778
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0264 0.2563
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0082 0.0707
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0024 0.0056
Schistosoma mansoni inositol monophosphatase 0.0041 0.0121 0.0467
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0121 0.1076
Toxoplasma gondii hypothetical protein 0.0033 0.0082 0.0871
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0108 0.094
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.0544 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0017 0.006
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0082 0.0871
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0108 0.0721
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.0193 0.1824
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0111 0.0958
Echinococcus multilocularis citrate lyase subunit beta protein 0.0026 0.005 0.0113
Mycobacterium ulcerans beta-lactamase 0.0039 0.0111 0.177
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0061 0.0594
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0098 0.0228
Toxoplasma gondii heat shock protein 75, putative 0.0019 0.0018 0.0011
Loa Loa (eye worm) hypothetical protein 0.0038 0.0106 0.0914
Brugia malayi Cathepsin L-like precursor 0.0019 0.0017 0.0054
Brugia malayi hypothetical protein 0.0018 0.0014 0.003
Schistosoma mansoni lamin 0.0033 0.0082 0.0303
Trypanosoma brucei hypothetical protein, conserved 0.0224 0.098 1
Brugia malayi MH2 domain containing protein 0.0144 0.0606 0.5188
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.0393 0.3331
Loa Loa (eye worm) heat shock protein 75 0.0019 0.0018 0.0154
Brugia malayi Cathepsin L-like precursor 0.0019 0.0017 0.0054
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0017 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.0224 0.098 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0188 0.162
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0024 0.0676
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0264 0.2563
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0108 0.0721
Loa Loa (eye worm) hypothetical protein 0.0262 0.1158 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0121 0.1393
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0906 0.4181 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0098 0.0372
Schistosoma mansoni aldehyde dehydrogenase 0.0131 0.0544 0.2269
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0372 0.4778
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0108 0.1217
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0033 0.0082 0.0183
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0256 0.1131 0.9763
Brugia malayi Hsp90 protein 0.0019 0.0018 0.0061
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0024
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.0372 0.0885
Brugia malayi RNA binding protein 0.0141 0.059 0.5047
Wolbachia endosymbiont of Brugia malayi recombinase A 0.013 0.0541 1
Leishmania major hypothetical protein, conserved 0.0039 0.0111 0.0975
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.004 0.0117 0.1035
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0108 0.0251
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.022 0.092
Schistosoma mansoni lamin 0.0033 0.0082 0.0303
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0024 0.009
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.0372 0.6779
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0188 0.162
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0108 0.8739
Leishmania major cathepsin L-like protease 0.0071 0.0264 0.2569
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0121 0.0825
Trichomonas vaginalis heat shock protein, putative 0.0019 0.0018 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0264 0.2563
Onchocerca volvulus 0.0036 0.0098 0.0647
Toxoplasma gondii aldehyde dehydrogenase 0.0131 0.0544 0.7083
Schistosoma mansoni aldehyde dehydrogenase 0.0131 0.0544 0.2269
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0111 0.0748
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0121 0.0825
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.0372 0.1568
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0024 0.0006
Echinococcus granulosus citrate lyase subunit beta protein 0.0026 0.005 0.02
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0026 0.005 0.0263
Onchocerca volvulus 0.0286 0.1272 1
Echinococcus multilocularis tar DNA binding protein 0.0141 0.059 0.1405
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0264 0.2563
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0393 0.1626
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0393 0.0934
Plasmodium vivax SET domain protein, putative 0.0036 0.0098 0.1092
Schistosoma mansoni tar DNA-binding protein 0.0141 0.059 0.2464
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0082 0.0707
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0098 0.0372
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0111 0.0093
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0019 0.0018 0.0006
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0024 0.0073
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0111 0.0968
Schistosoma mansoni ap endonuclease 0.002 0.0024 0.0056
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0111 0.0093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0264 0.2563
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0011 0.0019
Echinococcus multilocularis tumor protein p63 0.0373 0.1682 0.4019
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0111 0.0266
Mycobacterium leprae Probable lipase LipE 0.0039 0.0111 0.0266
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0019 0.0018 0.0036
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0108 0.0721
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0019 0.0018 0.0064

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 20.01 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Inhibitors of DnaB-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2223, AID489010, AID492950] ChEMBL. No reference
AC50 (functional) = 41.58 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Non-Covalent Inhibitors of RecA-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2223, AID489010, AID492950] ChEMBL. No reference
EC50 (functional) = 11.2 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2097, AID2223, AID489010, AID492950] ChEMBL. No reference
Potency (functional) 0.631 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5119 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 21.1923 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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