Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Latrophilin receptor protein 2 | 0.0036 | 0.0536 | 0.1487 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 0.026 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0099 | 0.2338 | 0.1904 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0257 | 0.0713 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.026 | 0.0721 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.076 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0026 | 0.026 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0257 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.2708 | 0.7451 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0099 | 0.2338 | 0.1904 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0112 | 0.2708 | 0.7504 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0112 | 0.2708 | 0.7451 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0099 | 0.2338 | 0.1904 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0036 | 0.0536 | 0.1487 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.076 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1703 | 0.4605 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.026 | 0.0721 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.0076 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.076 | 0.0236 |
Schistosoma mansoni | hypothetical protein | 0.0077 | 0.1703 | 0.1232 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.076 | 0.0236 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.026 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0026 | 0.026 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.026 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.3608 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0099 | 0.2338 | 0.1904 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.076 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0099 | 0.2338 | 0.1904 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0099 | 0.2338 | 0.6404 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.026 | 0.0521 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.026 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.026 | 0.0521 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.026 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0099 | 0.2338 | 0.648 |
Brugia malayi | hypothetical protein | 0.0043 | 0.076 | 0.2106 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.3608 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0257 | 0.5 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0026 | 0.026 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0112 | 0.2708 | 0.7504 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.3608 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0257 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.026 | 0.0521 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.026 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0026 | 0.026 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.026 | 0.0721 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0536 | 0.1304 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0099 | 0.2338 | 0.1904 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.026 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.026 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0026 | 0.026 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.026 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.076 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0257 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.076 | 0.0236 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0257 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0036 | 0.0536 | 0.1304 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0077 | 0.1703 | 0.4719 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.026 | 1 |
Onchocerca volvulus | 0.0026 | 0.026 | 0.5 | |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0257 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0257 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0257 | 0.0514 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.076 | 0.0236 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0099 | 0.2338 | 0.1904 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.0076 | 0.139 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.1095 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.4668 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.6109 uM | PubChem BioAssay. qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.5131 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 12.9953 uM | PubChem BioAssay. qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for Inhibitors of TGF-b: Hit Validation in HepG2 Cells using COP promoter. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 32.6294 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.