Detailed information for compound 1292369

Basic information

Technical information
  • TDR Targets ID: 1292369
  • Name: 1-[(2-chlorophenyl)carbamoylamino]-N-(pyridin -3-ylmethyl)cyclohexane-1-carboxamide
  • MW: 386.875 | Formula: C20H23ClN4O2
  • H donors: 3 H acceptors: 3 LogP: 2.93 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC1(CCCCC1)C(=O)NCc1cccnc1)Nc1ccccc1Cl
  • InChi: 1S/C20H23ClN4O2/c21-16-8-2-3-9-17(16)24-19(27)25-20(10-4-1-5-11-20)18(26)23-14-15-7-6-12-22-13-15/h2-3,6-9,12-13H,1,4-5,10-11,14H2,(H,23,26)(H2,24,25,27)
  • InChiKey: HXAREXXWDIDEPQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(2-chlorophenyl)carbamoylamino]-N-(3-pyridylmethyl)cyclohexane-1-carboxamide
  • 1-[[[(2-chlorophenyl)amino]-oxomethyl]amino]-N-(3-pyridylmethyl)-1-cyclohexanecarboxamide
  • ASN 08832156

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0131 0.0721 0.0848
Toxoplasma gondii histone lysine methyltransferase SET1 0.0118 0.0641 0.4327
Brugia malayi CCR4 0.0019 0.0021 0.0039
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0166 0.0927
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0253 0.1481 0.9168
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0019 0.0021 0.0039
Brugia malayi MH1 domain containing protein 0.0058 0.0265 0.0504
Schistosoma mansoni nocturnin 0.0019 0.0021 0.0024
Brugia malayi MH1 domain containing protein 0.0032 0.0102 0.0194
Echinococcus granulosus Aminotransferase class III 0.0023 0.0042 0.0049
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0059 0.0271 0.0576
Loa Loa (eye worm) hypothetical protein 0.0415 0.2496 0.4749
Brugia malayi MH2 domain containing protein 0.0857 0.5256 1
Brugia malayi glutaminase DH11.1 0.0274 0.1612 0.3066
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0059 0.0271 0.0576
Trichomonas vaginalis ap endonuclease, putative 0.0096 0.0498 0.1098
Echinococcus granulosus dnaJ subfamily B 0.0494 0.2988 0.3513
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0253 0.1481 0.1481
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0096 0.0498 0.2778
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0224 0.1252
Brugia malayi PHD-finger family protein 0.0034 0.011 0.0209
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.016 0.0898 0.2021
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0024 0.0028
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0019 0.0021 0.0024
Toxoplasma gondii ABC1 family protein 0.0253 0.1481 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0415 0.2496 0.4749
Echinococcus granulosus transcription factor btf3 0.0035 0.012 0.0141
Brugia malayi exodeoxyribonuclease III family protein 0.0096 0.0498 0.0947
Entamoeba histolytica hypothetical protein 0.0035 0.012 0.1275
Loa Loa (eye worm) glutaminase 2 0.0274 0.1612 0.3066
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0019 0.0021 0.0417
Schistosoma mansoni smad1 5 8 and 0.0058 0.0265 0.0312
Brugia malayi beta-lactamase family protein 0.0253 0.1481 0.2818
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0023 0.0045 0.0249
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0019 0.0021 0.0116
Echinococcus granulosus lysine specific demethylase 5A 0.0049 0.021 0.0246
Mycobacterium tuberculosis Probable lipase LipE 0.0253 0.1481 0.1481
Loa Loa (eye worm) nuclear factor I 0.0032 0.0102 0.0194
Brugia malayi jmjC domain containing protein 0.011 0.0586 0.1116
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0023 0.0042 0.008
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.0042 0.0049
Schistosoma mansoni smad1 5 8 and 0.0058 0.0265 0.0312
Mycobacterium tuberculosis Probable aminotransferase 0.016 0.0898 0.0898
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0056 0.0375
Leishmania major mitochondrial DNA polymerase beta 0.0302 0.1791 1
Loa Loa (eye worm) PHD-finger family protein 0.0061 0.0283 0.0538
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0039
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0283 0.1667 0.196
Echinococcus granulosus cpg binding protein 0.0066 0.0313 0.0368
Echinococcus multilocularis cpg binding protein 0.0066 0.0313 0.0368
Echinococcus multilocularis Aminotransferase class III 0.0023 0.0042 0.0049
Leishmania major hypothetical protein, conserved 0.0045 0.0184 0.1027
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0166 0.0927
Schistosoma mansoni ap endonuclease 0.0096 0.0498 0.0585
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0023 0.0045 0.0249
Toxoplasma gondii hypothetical protein 0.0049 0.0205 0.1385
Schistosoma mansoni smad 0.0026 0.0063 0.0074
Echinococcus multilocularis peregrin 0.0041 0.0154 0.0181
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0096 0.0498 0.336
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0091 0.0469 0.0552
Trichomonas vaginalis glutaminase, putative 0.0274 0.1612 0.3663
Echinococcus multilocularis smad 0.0058 0.0265 0.0312
Brugia malayi MH2 domain containing protein 0.0026 0.0063 0.012
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0283 0.1667 0.3171
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0058 0.0265 0.0312
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0023 0.0042 0.0049
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0024 0.0028
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.0078 0.0092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0142 0.0786 0.0924
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0019 0.0021 0.0039
Entamoeba histolytica hypothetical protein 0.0144 0.0798 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0019 0.0021 0.0039
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0023 0.0045 0.0302
Entamoeba histolytica hypothetical protein 0.0144 0.0798 1
Mycobacterium leprae conserved hypothetical protein 0.0253 0.1481 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0058 0.0265 0.0504
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0023 0.0042 0.0284
Echinococcus granulosus ornithine aminotransferase 0.0023 0.0042 0.0049
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.011 0.0741
Giardia lamblia PHD finger protein 15 0.0034 0.011 0.1865
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.016 0.0898 0.5952
Loa Loa (eye worm) MH2 domain-containing protein 0.0058 0.0265 0.0504
Loa Loa (eye worm) hypothetical protein 0.0253 0.1481 0.2818
Schistosoma mansoni Smad4 0.0026 0.0063 0.0074
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0253 0.1481 0.1741
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0023 0.0042 0.0042
Trichomonas vaginalis penicillin-binding protein, putative 0.0253 0.1481 0.3362
Echinococcus multilocularis cysteine protease atg4b 0.0059 0.0271 0.0318
Brugia malayi Latrophilin receptor protein 2 0.0131 0.0721 0.1373
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0019 0.0021 0.0116
Schistosoma mansoni cpg binding protein 0.0057 0.0257 0.0302
Loa Loa (eye worm) hypothetical protein 0.0131 0.0721 0.1373
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0019 0.0021 0.014
Brugia malayi hypothetical protein 0.0144 0.0798 0.1519
Loa Loa (eye worm) hypothetical protein 0.0114 0.0612 0.1164
Schistosoma mansoni hypothetical protein 0.0061 0.0283 0.0333
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0031 0.0037
Trypanosoma cruzi mitochondrial protein 99, putative 0.0019 0.0021 0.0116
Schistosoma mansoni Smad4 0.0058 0.0265 0.0312
Echinococcus multilocularis mothers against decapentaplegic 2 0.0026 0.0063 0.0074
Loa Loa (eye worm) hypothetical protein 0.0032 0.0102 0.0194
Echinococcus multilocularis Peptidase C54 0.0059 0.0271 0.0318
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0019 0.0021 0.0417
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0096 0.0498 0.0585
Echinococcus multilocularis jumonji domain containing protein 0.0047 0.0192 0.0225
Brugia malayi F/Y-rich N-terminus family protein 0.0037 0.0134 0.0254
Leishmania major pantothenate kinase subunit, putative 0.0019 0.0021 0.0116
Schistosoma mansoni smad1 5 8 and 0.0058 0.0265 0.0312
Entamoeba histolytica peptidase, C54 family 0.0023 0.0045 0.0308
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0019 0.0021 0.0116
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.1791 1
Entamoeba histolytica peptidase, C54 family 0.0023 0.0045 0.0308
Loa Loa (eye worm) Smad1 0.0058 0.0265 0.0504
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0023 0.0042 0.0042
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0019 0.0021 0.0116
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.011 0.0129
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0019 0.0021 0.0116
Plasmodium vivax hypothetical protein, conserved 0.0034 0.011 0.0741
Mycobacterium tuberculosis Conserved protein 0.0253 0.1481 0.1481
Brugia malayi hypothetical protein 0.0025 0.0056 0.0106
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0283 0.1667 0.196
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.2988 0.3513
Schistosoma mansoni autophagin-1 (C54 family) 0.0059 0.0271 0.0318
Schistosoma mansoni hypothetical protein 0.0131 0.0721 0.0848
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0019 0.0021 0.0024
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.0896 0.0896
Schistosoma mansoni synaptojanin 0.0019 0.0021 0.0024
Schistosoma mansoni hypothetical protein 0.0338 0.201 0.2363
Loa Loa (eye worm) hypothetical protein 0.0034 0.011 0.0209
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0795 0.4439
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0059 0.0271 0.0318
Echinococcus multilocularis beta LACTamase domain containing family member 0.0253 0.1481 0.1741
Echinococcus multilocularis microtubule associated protein 2 0.1377 0.8505 1
Plasmodium vivax hypothetical protein, conserved 0.0253 0.1481 1
Echinococcus granulosus Smad4 0.0058 0.0265 0.0312
Echinococcus granulosus traf and tnf receptor associated protein 0.0019 0.0021 0.0024
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0039
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0019 0.0021 0.0116
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0019 0.0021 0.0039
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0019 0.0021 0.0116
Entamoeba histolytica peptidase, C54 family 0.0023 0.0045 0.0308
Loa Loa (eye worm) hypothetical protein 0.0253 0.1481 0.2818
Brugia malayi MH1 domain containing protein 0.0032 0.0102 0.0194
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0415 0.2496 0.4749
Echinococcus multilocularis neutral sphingomyelinase 0.0019 0.0021 0.0024
Brugia malayi CXXC zinc finger family protein 0.0057 0.0257 0.0489
Echinococcus multilocularis fetal alzheimer antigen, falz 0.007 0.0339 0.0398
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0059 0.0271 0.0576
Loa Loa (eye worm) hypothetical protein 0.013 0.0712 0.1354
Trichomonas vaginalis D-aminoacylase, putative 0.0253 0.1481 0.3362
Leishmania major endonuclease/exonuclease protein-like protein 0.0019 0.0021 0.0116
Trichomonas vaginalis esterase, putative 0.0253 0.1481 0.3362
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0019 0.0021 0.0116
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0253 0.1481 0.1481
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0031 0.0059
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0039
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.012 0.2409
Brugia malayi jmjC domain containing protein 0.0049 0.021 0.0399
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0019 0.0021 0.0039
Entamoeba histolytica hypothetical protein 0.0144 0.0798 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0056 0.031
Echinococcus granulosus mothers against decapentaplegic 5 0.0058 0.0265 0.0312
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.016 0.0898 0.5456
Schistosoma mansoni hypothetical protein 0.0131 0.0721 0.0848
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0059 0.0271 0.1512
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0019 0.0021 0.0116
Mycobacterium ulcerans hypothetical protein 0.016 0.0898 0.5456
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0795 0.4439
Mycobacterium ulcerans beta-lactamase 0.0253 0.1481 0.9168
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0039
Toxoplasma gondii exonuclease III APE 0.0096 0.0498 0.336
Brugia malayi beta-lactamase 0.0253 0.1481 0.2818
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0253 0.1481 0.2818
Leishmania major basic transcription factor 3a, putative 0.0035 0.012 0.0669
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0019 0.0021 0.014
Loa Loa (eye worm) hypothetical protein 0.0142 0.0786 0.1495
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0019 0.0021 0.014
Brugia malayi Pre-SET motif family protein 0.0628 0.3823 0.7273
Mycobacterium leprae Probable lipase LipE 0.0253 0.1481 1
Toxoplasma gondii NAC domain-containing protein 0.0035 0.012 0.0809
Leishmania major hypothetical protein, conserved 0.0019 0.0021 0.0116
Echinococcus multilocularis lysine specific demethylase 5A 0.0041 0.0154 0.0181
Schistosoma mansoni smad 0.0058 0.0265 0.0312
Trypanosoma cruzi mitochondrial protein 99, putative 0.0019 0.0021 0.0116
Schistosoma mansoni methyl-cpg binding protein mbd 0.0051 0.0216 0.0255
Mycobacterium ulcerans glutaminase 0.0274 0.1612 1
Mycobacterium tuberculosis Probable lipase LipD 0.0253 0.1481 0.1481
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0058 0.0265 0.0312
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0046
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0019 0.0021 0.0024
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.018 0.1028 0.1209
Onchocerca volvulus 0.0253 0.1481 0.3362
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.0678 0.0797
Loa Loa (eye worm) ICD-1 protein 0.0035 0.012 0.0228
Schistosoma mansoni cpg binding protein 0.0066 0.0313 0.0368
Onchocerca volvulus Alhambra homolog 0.0034 0.011 0.0205
Schistosoma mansoni Smad4 0.0026 0.0063 0.0074
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0087 0.0441 0.0519
Echinococcus granulosus synaptojanin 1 0.0019 0.0021 0.0024
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0019 0.0021 0.0116
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.012
Schistosoma mansoni cript-related 0.0019 0.0021 0.0024
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0059 0.0271 0.0576
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0096 0.0498 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0107 0.0567 0.0666
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0056 0.0375
Brugia malayi follicle stimulating hormone receptor 0.023 0.1338 0.2546
Trichomonas vaginalis set domain proteins, putative 0.0714 0.4364 1
Entamoeba histolytica peptidase, C54 family 0.0023 0.0045 0.0308
Schistosoma mansoni hypothetical protein 0.0131 0.0721 0.0848
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.0795 0.4439
Plasmodium vivax ornithine aminotransferase, putative 0.0023 0.0042 0.0284
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.011 0.0129
Schistosoma mansoni hypothetical protein 0.0284 0.1675 0.1969
Trichomonas vaginalis D-aminoacylase, putative 0.0253 0.1481 0.3362
Leishmania major hypothetical protein, conserved 0.0253 0.1481 0.8269
Echinococcus granulosus peregrin 0.0041 0.0154 0.0181
Mycobacterium tuberculosis Conserved protein 0.0253 0.1481 0.1481
Schistosoma mansoni transcription factor btf3 0.0035 0.012 0.0141
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0142 0.0786 0.0924
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.012 0.0809
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0023 0.0045 0.0249
Onchocerca volvulus 0.0253 0.1481 0.3362
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0023 0.0045 0.0249
Loa Loa (eye worm) hypothetical protein 0.0153 0.0855 0.1627
Brugia malayi MH2 domain containing protein 0.0058 0.0265 0.0504
Echinococcus multilocularis mothers against decapentaplegic 5 0.0058 0.0265 0.0312
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0019 0.0021 0.0039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0283 0.1667 0.196
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0142 0.0786 0.0924
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0283 0.1667 0.196
Loa Loa (eye worm) hypothetical protein 0.0025 0.0056 0.0106
Echinococcus granulosus microtubule associated protein 2 0.1377 0.8505 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0096 0.0498 0.6133
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0131 0.0721 0.0848
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0091 0.0469 0.0552
Loa Loa (eye worm) hypothetical protein 0.0253 0.1481 0.2818
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0019 0.0021 0.0024
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0096 0.0498 0.2902
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 0.1338 0.2546
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0019 0.0021 0.014
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0009 0.0011
Trypanosoma brucei RNA editing exonuclease 2 0.0019 0.0021 0.0116
Onchocerca volvulus 0.0091 0.0469 0.1033
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0019 0.0021 0.0116
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0096 0.0498 0.2778
Brugia malayi beta-NAC-like protein 0.0035 0.012 0.0228
Brugia malayi Pre-SET motif family protein 0.0091 0.0469 0.0893
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0333 0.0633
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0253 0.1481 0.2818
Entamoeba histolytica peptidase, C54 family 0.0059 0.0271 0.3216
Mycobacterium tuberculosis Conserved protein 0.0253 0.1481 0.1481
Brugia malayi MH2 domain containing protein 0.0058 0.0265 0.0504
Loa Loa (eye worm) MH2 domain-containing protein 0.0857 0.5256 1
Echinococcus granulosus zinc finger protein 0.0061 0.0284 0.0334
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0131 0.0721 0.0848
Schistosoma mansoni cpg binding protein 0.0066 0.0313 0.0368
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0019 0.0021 0.0116
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0063 0.012
Echinococcus multilocularis mothers against decapentaplegic 6 0.0026 0.0063 0.0074
Schistosoma mansoni hypothetical protein 0.0494 0.2988 0.3513
Brugia malayi latrophilin 2 splice variant baaae 0.0284 0.1675 0.3186
Schistosoma mansoni carbon catabolite repressor protein 0.0019 0.0021 0.0024
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0628 0.3823 0.7273
Schistosoma mansoni ap endonuclease 0.0096 0.0498 0.0585
Mycobacterium tuberculosis Probable esterase LipL 0.0253 0.1481 0.1481
Schistosoma mansoni zinc finger protein 0.0061 0.0284 0.0334
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0019 0.0021 0.0116
Echinococcus multilocularis Smad4 0.0058 0.0265 0.0312
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0302 0.1791 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0096 0.0498 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0019 0.0021 0.0024
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.011 0.0586 0.069
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0096 0.0498 0.2778
Plasmodium vivax exodeoxyribonuclease III, putative 0.0019 0.0021 0.014
Schistosoma mansoni zinc finger protein 0.0045 0.0184 0.0216
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0019 0.0021 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.012 0.0228
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0019 0.0021 0.0039
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0009 0.0011
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0056 0.031
Schistosoma mansoni bromodomain containing protein 0.0191 0.1094 0.1287
Schistosoma mansoni transcription factor LCR-F1 0.0144 0.0798 0.0939
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0253 0.1481 0.1481
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.012 0.0669
Plasmodium falciparum ornithine aminotransferase 0.0023 0.0042 0.0845
Onchocerca volvulus 0.0057 0.0257 0.0544
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0059 0.0271 0.1512
Echinococcus granulosus geminin 0.0338 0.201 0.2363
Echinococcus multilocularis zinc finger protein 0.0061 0.0284 0.0334
Schistosoma mansoni hypothetical protein 0.0019 0.0021 0.0024
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0021 0.0116
Leishmania major hypothetical protein, conserved 0.0019 0.0021 0.0116
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.011 0.0209
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0283 0.1667 0.196
Schistosoma mansoni hypothetical protein 0.0131 0.0721 0.0848
Schistosoma mansoni synaptojanin 0.0019 0.0021 0.0024
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0144 0.0798 0.0939
Brugia malayi hypothetical protein 0.0153 0.0855 0.1627
Brugia malayi mothers against decapentaplegic homolog 3 0.0026 0.0063 0.012
Loa Loa (eye worm) bromodomain containing protein 0.0052 0.0228 0.0434
Schistosoma mansoni hypothetical protein 0.0338 0.201 0.2363
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0019 0.0021 0.0116
Echinococcus multilocularis traf and tnf receptor associated protein 0.0019 0.0021 0.0024
Leishmania major hypothetical protein, conserved 0.0025 0.0056 0.031
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0257 0.0489
Schistosoma mansoni hypothetical protein 0.0144 0.0798 0.0939
Schistosoma mansoni microtubule-associated protein tau 0.1377 0.8505 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0049 0.021 0.0399
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0059 0.0271 0.0576
Schistosoma mansoni hypothetical protein 0.0034 0.011 0.0129
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0019 0.0021 0.0024
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0051 0.0216 0.0255
Echinococcus multilocularis GPCR, family 2 0.0131 0.0721 0.0848
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0131 0.0721 0.1373
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0009 0.0011
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.012 0.1275
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0026 0.0063 0.0098
Mycobacterium ulcerans hypothetical protein 0.0159 0.0896 0.5441
Echinococcus granulosus fetal alzheimer antigen falz 0.007 0.0339 0.0398
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0283 0.1667 0.196
Plasmodium vivax SET domain protein, putative 0.0091 0.0469 0.317
Entamoeba histolytica hypothetical protein 0.0144 0.0798 1
Loa Loa (eye worm) hypothetical protein 0.0284 0.1675 0.3186
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.007 0.0339 0.0398
Plasmodium falciparum DNase I-like protein, putative 0.0019 0.0021 0.0417
Trypanosoma cruzi ISWI complex protein 0.0045 0.0184 0.1027
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0009 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0469 0.0552
Brugia malayi MH1 domain containing protein 0.0058 0.0265 0.0504
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0166 0.0927
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0063 0.012
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0019 0.0021 0.0039
Mycobacterium tuberculosis Probable hydrolase 0.0253 0.1481 0.1481
Plasmodium falciparum phd finger protein, putative 0.0034 0.011 0.2204
Trichomonas vaginalis D-aminoacylase, putative 0.0253 0.1481 0.3362
Echinococcus multilocularis deoxyribonuclease 1 2 0.0019 0.0021 0.0024
Loa Loa (eye worm) latrophilin receptor protein 2 0.0131 0.0721 0.1373
Treponema pallidum exodeoxyribonuclease (exoA) 0.0096 0.0498 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.011 0.0741
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0019 0.0021 0.0039
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0019 0.0021 0.014
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0019 0.0021 0.014
Schistosoma mansoni jumonji/arid domain-containing protein 0.0049 0.021 0.0246
Onchocerca volvulus 0.0153 0.0855 0.1921
Echinococcus granulosus cysteine protease atg4b 0.0059 0.0271 0.0318
Trypanosoma brucei ISWI complex protein 0.0045 0.0184 0.1027
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.0042 0.0049
Trichomonas vaginalis penicillin-binding protein, putative 0.0253 0.1481 0.3362
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0144 0.0798 0.0939
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0031 0.0037
Echinococcus granulosus smad 0.0058 0.0265 0.0312
Mycobacterium ulcerans lipase LipD 0.0253 0.1481 0.9168
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.012 0.0669
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.1791 1
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0023 0.0042 0.5
Trichomonas vaginalis ap endonuclease, putative 0.0096 0.0498 0.1098
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0023 0.0042 0.0042
Trypanosoma brucei hypothetical protein, conserved 0.0253 0.1481 0.8269
Onchocerca volvulus 0.0714 0.4364 1
Brugia malayi PHD-finger family protein 0.0077 0.0383 0.0728
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0019 0.0021 0.014
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0059 0.0271 0.0318
Echinococcus granulosus beta LACTamase domain containing family member 0.0253 0.1481 0.1741
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0019 0.0021 0.0039
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0096 0.0498 0.0498
Mycobacterium tuberculosis Probable exported protein 0.0019 0.0021 0.0021
Plasmodium falciparum cysteine protease ATG4, putative 0.0023 0.0045 0.0898
Echinococcus granulosus methyl CpG binding domain protein 2 0.0051 0.0216 0.0255
Loa Loa (eye worm) hypothetical protein 0.0253 0.1481 0.2818
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0096 0.0498 0.0947
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.012 0.0669
Loa Loa (eye worm) beta-lactamase 0.0253 0.1481 0.2818
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.011 0.0586 0.069
Loa Loa (eye worm) hypothetical protein 0.0059 0.0271 0.0515
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0023 0.0042 0.0042
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0019 0.0021 0.0039
Echinococcus multilocularis geminin 0.0338 0.201 0.2363
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.08 0.4901 0.5762
Schistosoma mansoni neutral sphingomyelinase 0.0019 0.0021 0.0024
Mycobacterium ulcerans esterase/lipase LipP 0.0253 0.1481 0.9168
Brugia malayi Bromodomain containing protein 0.0041 0.0154 0.0292
Loa Loa (eye worm) hypothetical protein 0.0253 0.1481 0.2818
Leishmania major hypothetical protein, conserved 0.0019 0.0021 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.012 0.0228
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0019 0.0021 0.014
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0019 0.0021 0.0116
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0096 0.0498 1
Brugia malayi Peptidase family C54 containing protein 0.0059 0.0271 0.0515
Echinococcus granulosus GPCR family 2 0.0131 0.0721 0.0848
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0415 0.2496 0.4749
Schistosoma mansoni jumonji domain containing protein 0.0087 0.0445 0.0524
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.018 0.1028 0.1209
Loa Loa (eye worm) hypothetical protein 0.0057 0.0259 0.0493
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0019 0.0021 0.0417
Brugia malayi Bromodomain containing protein 0.0114 0.0611 0.1162
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0019 0.0021 0.0024
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0021 0.014
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0096 0.0498 0.0585
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0056 0.1117
Mycobacterium ulcerans hypothetical protein 0.0253 0.1481 0.9168
Echinococcus granulosus jumonji domain containing protein 0.0047 0.0192 0.0225
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.012 0.0228
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0019 0.0021 0.0116
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0096 0.0498 0.2778
Trypanosoma cruzi hypothetical protein, conserved 0.0253 0.1481 0.8269
Loa Loa (eye worm) hypothetical protein 0.0121 0.0656 0.1248
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0021 0.0116
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0091 0.0469 0.317
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0019 0.0021 0.0039
Echinococcus granulosus Peptidase C54 0.0059 0.0271 0.0318
Schistosoma mansoni jumonji/arid domain-containing protein 0.0049 0.021 0.0246
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0056 0.031
Loa Loa (eye worm) hypothetical protein 0.0253 0.1481 0.2818
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.016 0.0898 0.0898
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0107 0.0567 0.0666
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0019 0.0021 0.0417
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0283 0.1667 0.3171
Echinococcus granulosus TGF beta signal transducer SmadC 0.0058 0.0265 0.0312
Leishmania major RNA-editing complex protein MP100, putative 0.0019 0.0021 0.0116
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.011 0.0129
Brugia malayi Bromodomain containing protein 0.0226 0.1312 0.2496
Echinococcus multilocularis synaptojanin 1 0.0019 0.0021 0.0024
Schistosoma mansoni glutaminase 0.0274 0.1612 0.1895
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0131 0.0721 0.0848
Schistosoma mansoni methyl-cpg binding protein mbd 0.0051 0.0216 0.0255
Brugia malayi Smad1 0.0058 0.0265 0.0504
Echinococcus granulosus mothers against decapentaplegic 2 0.0026 0.0063 0.0074
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0019 0.0021 0.0116
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0253 0.1481 0.1741
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0059 0.0271 0.1512
Loa Loa (eye worm) transcription factor SMAD2 0.0857 0.5256 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0019 0.0021 0.0039
Echinococcus granulosus neutral sphingomyelinase 0.0019 0.0021 0.0024
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0019 0.0021 0.0116
Loa Loa (eye worm) glutaminase 0.0274 0.1612 0.3066
Trypanosoma cruzi hypothetical protein, conserved 0.0253 0.1481 0.8269
Loa Loa (eye worm) hypothetical protein 0.021 0.1212 0.2306
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0166 0.0927
Trypanosoma cruzi ISWI complex protein 0.0045 0.0184 0.1027
Onchocerca volvulus 0.0253 0.1481 0.3362
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0019 0.0021 0.014
Schistosoma mansoni hypothetical protein 0.0045 0.0184 0.0216
Echinococcus granulosus mothers against decapentaplegic 6 0.0026 0.0063 0.0074
Brugia malayi beta-lactamase family protein 0.0253 0.1481 0.2818
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0019 0.0021 0.0116
Echinococcus multilocularis transcription factor btf3 0.0035 0.012 0.0141
Echinococcus granulosus histone lysine methyltransferase setb 0.0142 0.0786 0.0924
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0019 0.0021 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0283 0.1667 0.196
Brugia malayi PHD-finger family protein 0.002 0.0024 0.0046
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0056 0.1117

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2119 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.5805 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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