Detailed information for compound 1292460

Basic information

Technical information
  • TDR Targets ID: 1292460
  • Name: 4-(2-ethyl-2-methyloxan-4-yl)-1,3-thiazol-2-a mine
  • MW: 226.338 | Formula: C11H18N2OS
  • H donors: 1 H acceptors: 1 LogP: 2.18 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC1(C)OCCC(C1)c1csc(n1)N
  • InChi: 1S/C11H18N2OS/c1-3-11(2)6-8(4-5-14-11)9-7-15-10(12)13-9/h7-8H,3-6H2,1-2H3,(H2,12,13)
  • InChiKey: AECHTYJNUUZQBK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(2-ethyl-2-methyl-tetrahydropyran-4-yl)thiazol-2-amine
  • 4-(2-ethyl-2-methyl-4-tetrahydropyranyl)-2-thiazolamine
  • [4-(2-ethyl-2-methyl-tetrahydropyran-4-yl)thiazol-2-yl]amine
  • 4-(2-ethyl-2-methyl-oxan-4-yl)-1,3-thiazol-2-amine
  • BAS 00399164
  • 4-(2-ethyl-2-methyltetrahydro-2H-pyran-4-yl)-1,3-thiazol-2-amine
  • MLS000060908
  • SMR000069136
  • 4-(2-Ethyl-2-methyl-tetrahydro-pyran-4-yl)-thiazol-2-ylamine
  • Oprea1_771606
  • Oprea1_651376

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Equus caballus Ferritin light chain Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0037 0.0245 0.0245
Entamoeba histolytica cysteine proteinase 2 0.0087 0.1858 0.4054
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0031 0.0056 0.0056
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0031 0.0056 0.5
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0031 0.0056 0.0125
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0037 0.0245 0.0245
Onchocerca volvulus 0.0037 0.0245 0.0372
Entamoeba histolytica cysteine protease, putative 0.0087 0.1858 0.4054
Loa Loa (eye worm) hypothetical protein 0.0056 0.0852 0.0959
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0245 0.0245
Echinococcus multilocularis GPCR, family 2 0.0032 0.0072 0.0072
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0031 0.0056 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0168 0.45 0.5751
Onchocerca volvulus Cathepsin L homolog 0.0031 0.0056 0.0085
Echinococcus granulosus g protein coupled receptor 0.0037 0.0245 0.0245
Giardia lamblia Cathepsin L precursor 0.0031 0.0056 0.5
Schistosoma mansoni hypothetical protein 0.0037 0.0245 0.0245
Schistosoma mansoni cathepsin F (C01 family) 0.0168 0.45 0.45
Echinococcus granulosus dro:myosuppressin receptor 0.0037 0.0245 0.0245
Schistosoma mansoni neuropeptide F-like receptor 0.0037 0.0245 0.0245
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0168 0.45 0.5065
Loa Loa (eye worm) glutaminase 2 0.027 0.7783 0.8761
Echinococcus multilocularis serotonin receptor 0.0037 0.0245 0.0245
Schistosoma mansoni hypothetical protein 0.0032 0.0072 0.0072
Schistosoma mansoni opsin-like receptor 0.0037 0.0245 0.0245
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0031 0.0056 0.0056
Schistosoma mansoni opsin-like receptor 0.0037 0.0245 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0168 0.45 0.5751
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Loa Loa (eye worm) cathepsin B 0.0031 0.0056 0.0063
Brugia malayi cathepsin F-like cysteine proteinase 0.0031 0.0056 0.0072
Brugia malayi fibroinase precursor 0.0031 0.0056 0.0072
Entamoeba histolytica cysteine protease, putative 0.0087 0.1858 0.4054
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0245 0.0245
Schistosoma mansoni adenoreceptor 0.0037 0.0245 0.0245
Echinococcus multilocularis cathepsin b 0.0031 0.0056 0.0056
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0037 0.0245 0.0245
Echinococcus multilocularis cysteine protease 0.0168 0.45 0.45
Echinococcus granulosus biogenic amine 5HT receptor 0.0037 0.0245 0.0245
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0168 0.45 0.5751
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0245 0.0245
Schistosoma mansoni cathepsin B (C01 family) 0.0031 0.0056 0.0056
Brugia malayi Dopamine receptor 0.0037 0.0245 0.0315
Echinococcus multilocularis snurportin 1 0.0303 0.8883 0.8883
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0031 0.0056 0.0125
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0031 0.0056 0.0125
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.45 1
Schistosoma mansoni biogenic amine receptor 0.0037 0.0245 0.0245
Schistosoma mansoni hypothetical protein 0.0032 0.0072 0.0072
Echinococcus granulosus alpha 1A adrenergic receptor 0.0037 0.0245 0.0245
Echinococcus multilocularis sex peptide receptor 0.0037 0.0245 0.0245
Echinococcus granulosus sex peptide receptor 0.0037 0.0245 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0168 0.45 0.5751
Entamoeba histolytica cysteine protease, putative 0.0087 0.1858 0.4054
Echinococcus multilocularis neuropeptide FF receptor 2 0.0037 0.0245 0.0245
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0168 0.45 0.45
Echinococcus multilocularis orexin receptor type 2 0.0037 0.0245 0.0245
Schistosoma mansoni histamine h1 receptor 0.0037 0.0245 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.1858 0.2332
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0245 0.0245
Brugia malayi ORL1-like opioid receptor 0.0037 0.0245 0.0315
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0068 0.1257 0.1415
Brugia malayi Cathepsin L-like precursor 0.0056 0.0852 0.1095
Plasmodium vivax serine-repeat antigen (SERA) 0.0031 0.0056 0.0125
Entamoeba histolytica cysteine proteinase, putative 0.0087 0.1858 0.4054
Entamoeba histolytica cysteine protease, putative 0.0087 0.1858 0.4054
Onchocerca volvulus 0.0037 0.0245 0.0372
Loa Loa (eye worm) melatonin receptor type 1A 0.0037 0.0245 0.0276
Onchocerca volvulus 0.0168 0.45 0.6834
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0113 0.2698 0.5946
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Echinococcus granulosus neuropeptide receptor A26 0.0037 0.0245 0.0245
Brugia malayi RE15519p 0.0037 0.0245 0.0315
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Brugia malayi larval opioid receptor 0.0037 0.0245 0.0315
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Loa Loa (eye worm) hypothetical protein 0.0031 0.0056 0.0063
Brugia malayi beta-lactamase family protein 0.0043 0.0459 0.059
Loa Loa (eye worm) hypothetical protein 0.0043 0.0459 0.0517
Entamoeba histolytica cysteine proteinase, putative 0.0087 0.1858 0.4054
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0245 0.0245
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0037 0.0245 0.0245
Echinococcus granulosus neuropeptide receptor 0.0037 0.0245 0.0245
Onchocerca volvulus 0.0168 0.45 0.6834
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0031 0.0056 0.0125
Onchocerca volvulus 0.0043 0.0459 0.0697
Brugia malayi G protein-coupled receptor F59B2.13 0.0037 0.0245 0.0315
Brugia malayi hypothetical protein 0.0037 0.0245 0.0315
Echinococcus granulosus cathepsin L 0.0087 0.1858 0.1858
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0056 0.0852 0.1095
Echinococcus granulosus cathepsin L cysteine proteinase 0.0168 0.45 0.45
Echinococcus granulosus g protein coupled receptor 0.0037 0.0245 0.0245
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.084 0.084
Plasmodium vivax unspecified product 0.0056 0.0852 0.1894
Entamoeba histolytica cysteine protease, putative 0.0087 0.1858 0.4054
Loa Loa (eye worm) TYRA-2 protein 0.0037 0.0245 0.0276
Plasmodium falciparum cysteine proteinase falcipain 1 0.0087 0.1858 0.4054
Echinococcus granulosus cathepsin l1 0.0113 0.2698 0.2698
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0031 0.0056 0.0125
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Brugia malayi Cathepsin L-like precursor 0.0168 0.45 0.5782
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Brugia malayi Cathepsin L-like precursor 0.0113 0.2698 0.3467
Onchocerca volvulus 0.0037 0.0245 0.0372
Plasmodium vivax vivapain-2 0.0168 0.45 1
Brugia malayi Cathepsin L-like precursor 0.0168 0.45 0.5782
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.2279 0.2928
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Onchocerca volvulus Cathepsin L homolog 0.0168 0.45 0.6834
Brugia malayi cathepsin Z-like cysteine proteinase 0.0031 0.0056 0.0072
Giardia lamblia Cathepsin B precursor 0.0031 0.0056 0.5
Echinococcus multilocularis allatostatin A receptor 0.0037 0.0245 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0168 0.45 0.5751
Brugia malayi G-protein coupled receptor 0.0037 0.0245 0.0315
Echinococcus multilocularis neuropeptide receptor 0.0037 0.0245 0.0245
Brugia malayi cathepsin L-like cysteine proteinase 0.0031 0.0056 0.0072
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.1257 0.1616
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Brugia malayi G-protein coupled receptor 0.0037 0.0245 0.0315
Echinococcus multilocularis neuropeptide Y receptor 0.0037 0.0245 0.0245
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0031 0.0056 0.0125
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.084 0.084
Brugia malayi putative neuropeptide receptor 0.0037 0.0245 0.0315
Brugia malayi hypothetical protein 0.0037 0.0245 0.0315
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0031 0.0056 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0168 0.45 0.5751
Trypanosoma cruzi cysteine protease, putative 0.0087 0.1858 0.4054
Brugia malayi follicle stimulating hormone receptor 0.0037 0.0245 0.0315
Leishmania major cathepsin L-like protease 0.0168 0.45 1
Brugia malayi neuropeptide F receptor 0.0037 0.0245 0.0315
Schistosoma mansoni hypothetical protein 0.0032 0.0072 0.0072
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0459 0.0459
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0037 0.0245 0.0245
Echinococcus granulosus cathepsin b 0.0031 0.0056 0.0056
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0087 0.1858 0.1858
Giardia lamblia Cathepsin B precursor 0.0031 0.0056 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0072 0.0072
Loa Loa (eye worm) fibroinase 0.0168 0.45 0.5065
Loa Loa (eye worm) hypothetical protein 0.0043 0.0459 0.0517
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0245 0.0245
Brugia malayi hypothetical protein 0.0037 0.0245 0.0315
Schistosoma mansoni neuropeptide receptor 0.0037 0.0245 0.0245
Echinococcus granulosus serotonin receptor 0.0037 0.0245 0.0245
Onchocerca volvulus 0.0037 0.0245 0.0372
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.084 0.084
Giardia lamblia Cysteine protease 0.0031 0.0056 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.0459 0.0517
Echinococcus granulosus GPCR family 2 0.0032 0.0072 0.0072
Entamoeba histolytica cysteine protease, putative 0.0087 0.1858 0.4054
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0037 0.0245 0.0245
Schistosoma mansoni cathepsin F (C01 family) 0.0168 0.45 0.45
Onchocerca volvulus 0.0043 0.0459 0.0697
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0031 0.0056 0.0056
Echinococcus granulosus neuropeptide s receptor 0.0037 0.0245 0.0245
Brugia malayi neuropeptide F receptor 0.0037 0.0245 0.0315
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0168 0.45 0.5065
Echinococcus granulosus peptide allatostatin:somatostatin 0.0037 0.0245 0.0245
Schistosoma mansoni cathepsin S (C01 family) 0.0031 0.0056 0.0056
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0037 0.0245 0.0276
Plasmodium falciparum cysteine proteinase falcipain 3 0.0168 0.45 1
Brugia malayi hypothetical protein 0.0037 0.0245 0.0315
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0037 0.0245 0.0245
Echinococcus multilocularis cathepsin b 0.0031 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Trichomonas vaginalis set domain proteins, putative 0.0233 0.6584 0.8449
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0037 0.0245 0.0245
Plasmodium vivax unspecified product 0.0087 0.1858 0.4128
Entamoeba histolytica cysteine protease, putative 0.0087 0.1858 0.4054
Echinococcus multilocularis fmrfamide receptor 0.0037 0.0245 0.0245
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0037 0.0245 0.0245
Echinococcus multilocularis neuropeptide receptor 0.0037 0.0245 0.0245
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0459 0.1021
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Schistosoma mansoni hypothetical protein 0.0037 0.0245 0.0245
Echinococcus multilocularis cysteine protease 0.0168 0.45 0.45
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0072 0.0093
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0056 0.0852 0.0959
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Schistosoma mansoni biogenic amine receptor 0.0037 0.0245 0.0245
Entamoeba histolytica cysteine protease, putative 0.0087 0.1858 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0087 0.1858 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.0087 0.1858 0.2387
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Leishmania major cathepsin L-like protease 0.0168 0.45 1
Giardia lamblia Hypothetical protein 0.0031 0.0056 0.5
Mycobacterium ulcerans glutaminase 0.027 0.7783 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0037 0.0245 0.0245
Echinococcus granulosus tachykinin peptides receptor 99D 0.0037 0.0245 0.0245
Toxoplasma gondii cathepsin CPC2 0.0031 0.0056 0.0125
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0245 0.0245
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0245 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0168 0.45 0.5751
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0459 0.0459
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0168 0.45 0.5751
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0245 0.0245
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.45 1
Leishmania major cathepsin L-like protease 0.0168 0.45 1
Onchocerca volvulus 0.0037 0.0245 0.0372
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0037 0.0245 0.0245
Echinococcus granulosus somatostatin receptor 0.0037 0.0245 0.0245
Toxoplasma gondii cathepsin B 0.0031 0.0056 0.0125
Giardia lamblia Cysteine protease 0.0031 0.0056 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0168 0.45 0.5751
Brugia malayi hypothetical protein 0.0037 0.0245 0.0315
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0037 0.0245 0.0245
Onchocerca volvulus 0.0037 0.0245 0.0372
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0245 0.0245
Brugia malayi AKH receptor 0.0037 0.0245 0.0315
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0031 0.0056 0.0056
Brugia malayi Dopamine receptor protein 1 0.0037 0.0245 0.0315
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.45 1
Plasmodium vivax vivapain-3 0.0087 0.1858 0.4128
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.084 0.084
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.084 0.084
Echinococcus multilocularis cathepsin L cysteine protease 0.0168 0.45 0.45
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Echinococcus multilocularis neuropeptides capa receptor 0.0037 0.0245 0.0245
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0245 0.0245
Entamoeba histolytica cysteine protease, putative 0.0087 0.1858 0.4054
Entamoeba histolytica cysteine protease, putative 0.0087 0.1858 0.4054
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0459 0.0522
Loa Loa (eye worm) hypothetical protein 0.0031 0.0056 0.0063
Giardia lamblia Cathepsin B precursor 0.0031 0.0056 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0168 0.45 0.5751
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0245 0.0245
Mycobacterium leprae Probable lipase LipE 0.0043 0.0459 0.5
Onchocerca volvulus 0.0168 0.45 0.6834
Echinococcus granulosus neuropeptide Y receptor 0.0037 0.0245 0.0245
Schistosoma mansoni biogenic amine (5HT) receptor 0.0037 0.0245 0.0245
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0031 0.0056 0.5
Onchocerca volvulus Cathepsin L homolog 0.0168 0.45 0.6834
Schistosoma mansoni neuropeptide receptor 0.0037 0.0245 0.0245
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0168 0.45 0.5751
Echinococcus multilocularis serotonin receptor 0.0037 0.0245 0.0245
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0031 0.0056 0.0056
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0031 0.0056 0.5
Echinococcus multilocularis fmrfamide receptor 0.0037 0.0245 0.0245
Echinococcus granulosus cathepsin b 0.0031 0.0056 0.0056
Echinococcus granulosus cathepsin L 0.0031 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Loa Loa (eye worm) cysteine protease 0.0168 0.45 0.5065
Onchocerca volvulus 0.0037 0.0245 0.0372
Echinococcus granulosus cathepsin L cysteine protease 0.0087 0.1858 0.1858
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0031 0.0056 0.0063
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0056 0.0072
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.805 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0087 0.1858 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0168 0.45 0.5751
Loa Loa (eye worm) beta-lactamase 0.0043 0.0459 0.0517
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0245 0.0245
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0459 0.0522
Onchocerca volvulus Neuropeptide F receptor homolog 0.0037 0.0245 0.0372
Giardia lamblia Cathepsin L precursor 0.0031 0.0056 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0087 0.1858 0.4054
Echinococcus granulosus g protein coupled receptor 0.0037 0.0245 0.0245
Brugia malayi Papain family cysteine protease containing protein 0.0087 0.1858 0.2387
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0037 0.0245 0.0245
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0245 0.0245
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Loa Loa (eye worm) hypothetical protein 0.0031 0.0056 0.0063
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Echinococcus multilocularis dro:myosuppressin receptor 0.0037 0.0245 0.0245
Echinococcus multilocularis somatostatin receptor 0.0037 0.0245 0.0245
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.45 1
Echinococcus multilocularis G protein coupled receptor 139 0.0037 0.0245 0.0245
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.2279 0.2565
Onchocerca volvulus 0.0037 0.0245 0.0372
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0168 0.45 0.5751
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Loa Loa (eye worm) hypothetical protein 0.0113 0.2698 0.3037
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0037 0.0245 0.0245
Onchocerca volvulus 0.0037 0.0245 0.0372
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0031 0.0056 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0087 0.1858 0.4054
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Toxoplasma gondii preprocathepsin c precursor, putative 0.0031 0.0056 0.0125
Plasmodium vivax unspecified product 0.0031 0.0056 0.0125
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0459 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0168 0.45 1
Schistosoma mansoni biogenic amine receptor 0.0037 0.0245 0.0245
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0037 0.0245 0.0315
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Brugia malayi Tachykinin-like peptides receptor 99D 0.0037 0.0245 0.0315
Echinococcus granulosus neuropeptide Y receptor 0.0037 0.0245 0.0245
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0087 0.1858 0.1858
Brugia malayi Pre-SET motif family protein 0.0204 0.567 0.7285
Echinococcus granulosus neuropeptide FF receptor 2 0.0037 0.0245 0.0245
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.45 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0459 0.0522
Trypanosoma cruzi cysteine proteinase, putative 0.0087 0.1858 0.4054
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0168 0.45 0.5751
Entamoeba histolytica cysteine protease, putative 0.0087 0.1858 0.4054
Onchocerca volvulus 0.0037 0.0245 0.0372
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0037 0.0245 0.0245
Brugia malayi glutaminase DH11.1 0.027 0.7783 1
Brugia malayi beta-lactamase family protein 0.0043 0.0459 0.059
Schistosoma mansoni amine GPCR 0.0037 0.0245 0.0245
Leishmania major cathepsin L-like protease 0.0168 0.45 1
Giardia lamblia Cathepsin B precursor 0.0031 0.0056 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.084 0.0946
Giardia lamblia Cysteine protease 0.0031 0.0056 0.5
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Onchocerca volvulus 0.0168 0.45 0.6834
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0031 0.0056 0.0056
Plasmodium vivax vivapain-1 0.0087 0.1858 0.4128
Onchocerca volvulus 0.0043 0.0459 0.0697
Plasmodium vivax serine-repeat antigen (SERA) 0.0031 0.0056 0.0125
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0459 0.0907
Echinococcus granulosus orexin receptor type 2 0.0037 0.0245 0.0245
Onchocerca volvulus 0.0037 0.0245 0.0372
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0168 0.45 0.5751
Loa Loa (eye worm) hypothetical protein 0.0113 0.2698 0.3037
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0037 0.0245 0.0276
Brugia malayi Cathepsin L-like precursor 0.0168 0.45 0.5782
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0245 0.0245
Echinococcus multilocularis neuropeptide Y receptor 0.0037 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0031 0.0056 0.0063
Brugia malayi cathepsin B-like cysteine proteinase 0.0031 0.0056 0.0072
Loa Loa (eye worm) hypothetical protein 0.01 0.2279 0.2565
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Brugia malayi Melatonin receptor type 1A 0.0037 0.0245 0.0315
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Brugia malayi putative neuropeptide receptor NPR1 0.0037 0.0245 0.0315
Schistosoma mansoni hypothetical protein 0.0037 0.0245 0.0245
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0245 0.0245
Echinococcus multilocularis G-protein coupled receptor, putative 0.0037 0.0245 0.0245
Loa Loa (eye worm) neuropeptide F receptor 0.0037 0.0245 0.0276
Trypanosoma cruzi cruzipain precursor, putative 0.0168 0.45 1
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0459 0.0907
Echinococcus multilocularis g-protein coupled receptor 0.0037 0.0245 0.0245
Brugia malayi Cathepsin L-like precursor 0.0168 0.45 0.5782
Echinococcus granulosus g-protein coupled receptor 0.0037 0.0245 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0168 0.45 0.5751
Echinococcus granulosus cathepsin l cysteine peptidase 0.0168 0.45 0.45
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.45 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0245 0.0245
Brugia malayi Cathepsin L-like precursor 0.0168 0.45 0.5782
Entamoeba histolytica cysteine proteinase, putative 0.0087 0.1858 0.4054
Trichomonas vaginalis esterase, putative 0.0043 0.0459 0.0522
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0056 0.0072
Schistosoma mansoni neuropeptide receptor 0.0037 0.0245 0.0245
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0459 0.0522
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0037 0.0245 0.0245
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0072 0.0081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.45 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0056 0.0072
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0168 0.45 0.5751
Leishmania major cathepsin L-like protease 0.0168 0.45 1
Giardia lamblia Cathepsin L-like protease 0.0031 0.0056 0.5
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0037 0.0245 0.0245
Trypanosoma cruzi cysteine proteinase, putative 0.0087 0.1858 0.4054
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0037 0.0245 0.0315
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.45 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0245 0.0245
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.084 0.084
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.567 0.6382
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0168 0.45 0.5751
Loa Loa (eye worm) glutaminase 0.027 0.7783 0.8761
Leishmania major cathepsin L-like protease 0.0168 0.45 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0459 0.0517
Echinococcus granulosus allatostatin A receptor 0.0037 0.0245 0.0245
Entamoeba histolytica cysteine protease, putative 0.0087 0.1858 0.4054
Loa Loa (eye worm) hypothetical protein 0.0032 0.0072 0.0081
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0168 0.45 0.45
Schistosoma mansoni glutaminase 0.027 0.7783 0.7783
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0037 0.0245 0.0315
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.1858 0.2332
Onchocerca volvulus Cathepsin F homolog 0.0168 0.45 0.6834
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.45 1
Schistosoma mansoni neuropeptide F-like receptor 0.0037 0.0245 0.0245
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0056 0.0852 0.0959
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.8883 1
Brugia malayi Dopamine receptor protein 2 0.0037 0.0245 0.0315
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0072 0.0093
Schistosoma mansoni hypothetical protein 0.0068 0.1257 0.1257
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0245 0.0245
Trypanosoma cruzi cruzipain precursor, putative 0.0056 0.0852 0.1791
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Giardia lamblia Cathepsin L precursor 0.0031 0.0056 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0168 0.45 0.5751
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0037 0.0245 0.0245
Leishmania major cathepsin L-like protease 0.0168 0.45 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0168 0.45 1
Echinococcus granulosus cysteine protease 0.0087 0.1858 0.1858
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0459 0.0517
Brugia malayi Serotonin receptor 0.0037 0.0245 0.0315
Giardia lamblia Encystation-specific protease 0.0031 0.0056 0.5
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0087 0.1858 0.1858
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0037 0.0245 0.0245
Brugia malayi Cathepsin L-like precursor 0.0168 0.45 0.5782
Echinococcus granulosus 7tm_1 domain containing protein 0.0037 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0031 0.0056 0.0063
Loa Loa (eye worm) hypothetical protein 0.0113 0.2698 0.3037
Brugia malayi hypothetical protein 0.0037 0.0245 0.0315
Giardia lamblia Cathepsin B precursor 0.0031 0.0056 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.2698 0.342
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0037 0.0245 0.0245
Toxoplasma gondii cathepsin CPL 0.0168 0.45 1
Trypanosoma cruzi cysteine peptidase, putative 0.0056 0.0852 0.1791
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0459 0.0459
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Echinococcus granulosus biogenic amine 5HT receptor 0.0037 0.0245 0.0245
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0245 0.0245
Onchocerca volvulus 0.0168 0.45 0.6834
Echinococcus multilocularis neuropeptide receptor A26 0.0037 0.0245 0.0245
Schistosoma mansoni alpha-1 adrenergic receptor 0.0037 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0056 0.0852 0.0959
Schistosoma mansoni myosin xvIII 0.0037 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Giardia lamblia Cathepsin B precursor 0.0031 0.0056 0.5
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0037 0.0245 0.0276
Schistosoma mansoni hypothetical protein 0.0303 0.8883 0.8883
Brugia malayi beta-lactamase 0.0043 0.0459 0.059
Brugia malayi Cathepsin L-like precursor 0.0113 0.2698 0.3467
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Echinococcus multilocularis neuropeptide s receptor 0.0037 0.0245 0.0245
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0031 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.084 0.108
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0245 0.0245
Onchocerca volvulus 0.0037 0.0245 0.0372
Echinococcus multilocularis cathepsin L 0.0087 0.1858 0.1858
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0245 0.0245
Loa Loa (eye worm) G-protein coupled receptor 0.0037 0.0245 0.0276
Brugia malayi Papain family cysteine protease containing protein 0.0168 0.45 0.5782
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0245 0.0245
Echinococcus granulosus hypothetical protein 0.0037 0.0245 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.2698 0.342
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0168 0.45 1
Loa Loa (eye worm) neuropeptide F receptor 0.0037 0.0245 0.0276
Brugia malayi G protein-coupled receptor 0.0037 0.0245 0.0315
Loa Loa (eye worm) ctsf protein 0.0168 0.45 0.5065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0245 0.0245
Leishmania major cathepsin L-like protease 0.0168 0.45 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0168 0.45 0.5751
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0168 0.45 0.5751
Echinococcus granulosus neuropeptides capa receptor 0.0037 0.0245 0.0245
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0031 0.0056 0.0056
Echinococcus granulosus snurportin 1 0.0303 0.8883 0.8883
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0459 0.0459
Trypanosoma cruzi cysteine peptidase, putative 0.0168 0.45 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0245 0.0245
Schistosoma mansoni growth hormone secretagogue receptor 0.0037 0.0245 0.0245
Giardia lamblia Hypothetical protein 0.0031 0.0056 0.5
Schistosoma mansoni amine GPCR 0.0037 0.0245 0.0245
Echinococcus granulosus neuropeptides capa receptor 0.0037 0.0245 0.0245
Giardia lamblia Cathepsin L precursor 0.0031 0.0056 0.5
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0037 0.0245 0.0315
Echinococcus granulosus G protein coupled receptor 139 0.0037 0.0245 0.0245
Entamoeba histolytica cysteine proteinase, putative 0.0168 0.45 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0037 0.0245 0.0245
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0037 0.0245 0.0245
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0031 0.0056 0.0125
Echinococcus multilocularis cathepsin L cysteine protease 0.0168 0.45 0.45
Schistosoma mansoni cathepsin F (C01 family) 0.0113 0.2698 0.2698
Loa Loa (eye worm) hypothetical protein 0.0043 0.0459 0.0517
Giardia lamblia Cathepsin L precursor 0.0031 0.0056 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0245 0.0245
Schistosoma mansoni biogenic amine (5HT) receptor 0.0037 0.0245 0.0245
Onchocerca volvulus 0.0037 0.0245 0.0372
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0031 0.0056 0.0056
Giardia lamblia Cysteine protease 0.0031 0.0056 0.5
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0031 0.0056 0.0056
Schistosoma mansoni neuropeptide receptor 0.0037 0.0245 0.0245
Brugia malayi cathepsin L precursor 0.0031 0.0056 0.0072
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0037 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0037 0.0245 0.0245
Onchocerca volvulus 0.0037 0.0245 0.0372
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.084 0.084
Brugia malayi hypothetical protein 0.0037 0.0245 0.0315
Toxoplasma gondii ABC1 family protein 0.0043 0.0459 0.1021
Brugia malayi Serotonin receptor 0.0037 0.0245 0.0315
Giardia lamblia Cathepsin B precursor 0.0031 0.0056 0.5
Trichomonas vaginalis glutaminase, putative 0.027 0.7783 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0168 0.45 0.5751
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0245 0.0245
Schistosoma mansoni cathepsin C 0.0031 0.0056 0.0056
Brugia malayi hypothetical protein 0.0037 0.0245 0.0315
Brugia malayi cathepsin F-like cysteine proteinase 0.0056 0.0852 0.1095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0168 0.45 0.5751
Leishmania major cysteine peptidase A (CPA) 0.0168 0.45 1
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0031 0.0056 0.0125
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0037 0.0245 0.0245
Brugia malayi sulfakinin receptor protein 0.0037 0.0245 0.0315
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.2279 0.2928
Onchocerca volvulus 0.0031 0.0056 0.0085
Brugia malayi Cathepsin L-like cysteine proteinase 0.0113 0.2698 0.3467
Trypanosoma cruzi cysteine peptidase, putative 0.0168 0.45 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0245 0.0245
Leishmania major hypothetical protein, conserved 0.0043 0.0459 0.0907
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.45 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0031 0.0056 0.0056
Brugia malayi cathepsin L-like precursor 0.0113 0.2698 0.3467
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0459 0.0522
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0031 0.0056 0.0056
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0031 0.0056 0.0125
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0031 0.0056 0.0063
Schistosoma mansoni amine GPCR 0.0037 0.0245 0.0245
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0037 0.0245 0.0245
Onchocerca volvulus 0.0037 0.0245 0.0372
Giardia lamblia Cathepsin L precursor 0.0031 0.0056 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0037 0.0245 0.0276
Schistosoma mansoni opsin-like receptor 0.0037 0.0245 0.0245
Onchocerca volvulus 0.0168 0.45 0.6834
Schistosoma mansoni neuropeptide f receptor 76f 0.0037 0.0245 0.0245
Onchocerca volvulus 0.0037 0.0245 0.0372
Onchocerca volvulus 0.0037 0.0245 0.0372
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.45 1
Schistosoma mansoni amine GPCR 0.0037 0.0245 0.0245
Brugia malayi cathepsin Z-like cysteine proteinase 0.0031 0.0056 0.0072
Entamoeba histolytica cysteine proteinase, putative 0.0168 0.45 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0087 0.1858 0.4054
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0037 0.0245 0.0372
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0168 0.45 0.5751
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0245 0.0245
Echinococcus multilocularis cathepsin L 0.0031 0.0056 0.0056
Entamoeba histolytica cysteine protease, putative 0.0168 0.45 1
Brugia malayi RNA, U transporter 1 0.0081 0.167 0.2146
Entamoeba histolytica cysteine protease, putative 0.0087 0.1858 0.4054
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0037 0.0245 0.0315
Loa Loa (eye worm) hypothetical protein 0.0043 0.0459 0.0517
Onchocerca volvulus 0.0168 0.45 0.6834
Giardia lamblia Cathepsin L-like protease 0.0031 0.0056 0.5
Onchocerca volvulus 0.0233 0.6584 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Echinococcus granulosus neuropeptide receptor 0.0037 0.0245 0.0245
Brugia malayi GnHR receptor homolog 0.0037 0.0245 0.0315
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0037 0.0245 0.0276
Echinococcus granulosus cathepsin l1 0.0168 0.45 0.45
Giardia lamblia Cathepsin B precursor 0.0031 0.0056 0.5
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0031 0.0056 0.0056
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0459 0.0907
Toxoplasma gondii cathepsin CPC1 0.0031 0.0056 0.0125
Onchocerca volvulus 0.0113 0.2698 0.4098
Entamoeba histolytica cysteine proteinase 1, putative 0.0087 0.1858 0.4054
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0459 0.059
Echinococcus granulosus fmrfamide receptor 0.0037 0.0245 0.0245
Brugia malayi hypothetical protein 0.0037 0.0245 0.0315
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0168 0.45 0.5751
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0031 0.0056 0.0072
Trypanosoma cruzi cysteine peptidase, putative 0.0168 0.45 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0037 0.0245 0.0245
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0031 0.0056 0.0125
Loa Loa (eye worm) G-protein coupled receptor 0.0037 0.0245 0.0276
Plasmodium vivax vivapain-2 0.0168 0.45 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0072 0.0072
Schistosoma mansoni hypothetical protein 0.0037 0.0245 0.0245
Echinococcus granulosus 7TM GPCR rhodopsin 0.0037 0.0245 0.0245
Entamoeba histolytica cysteine proteinase, putative 0.0113 0.2698 0.5946
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0031 0.0056 0.5
Schistosoma mansoni amine GPCR 0.0037 0.0245 0.0245
Echinococcus multilocularis neuropeptides capa receptor 0.0037 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0276
Schistosoma mansoni hypothetical protein 0.0032 0.0072 0.0072
Brugia malayi hypothetical protein 0.0037 0.0245 0.0315
Schistosoma mansoni cathepsin s 0.0056 0.0852 0.0852
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0168 0.45 0.5065
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0245 0.0245
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0031 0.0056 0.0056

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) > 10 % Binding affinity to Plasmodium falciparum AMA1 at 200 uM by surface plasmon resonance method ChEMBL. 25559643
Activity (binding) > 10 % Binding affinity to SPSB2 (unknown origin) at 200 uM by surface plasmon resonance method ChEMBL. 25559643
Activity (binding) > 10 % Binding affinity to carbonic anhydrase 2 (unknown origin) at 200 uM by surface plasmon resonance method ChEMBL. 25559643
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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