Detailed information for compound 1292540

Basic information

Technical information
  • TDR Targets ID: 1292540
  • Name: STOCK1N-67600
  • MW: 440.876 | Formula: C23H21ClN2O5
  • H donors: 1 H acceptors: 4 LogP: 1.89 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1C[C@H]2C[C@@H](C1)c1n(C2)c(=O)ccc1)Cc1c(=O)oc2c(c1C)cc(c(c2)O)Cl
  • InChi: 1S/C23H21ClN2O5/c1-12-15-6-17(24)19(27)8-20(15)31-23(30)16(12)7-22(29)25-9-13-5-14(11-25)18-3-2-4-21(28)26(18)10-13/h2-4,6,8,13-14,27H,5,7,9-11H2,1H3/t13-,14+/m1/s1
  • InChiKey: RAXNGZMLLUDZAC-KGLIPLIRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, beta, acid Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi O-Glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Onchocerca volvulus Glucosylceramidase homolog Get druggable targets OG5_129423 All targets in OG5_129423
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0233 0.0233
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0441 0.0269
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0233 0.0453
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0239 0.0086
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0233 0.0058
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.5233 0.697
Brugia malayi MH2 domain containing protein 0.0119 0.3509 0.3509
Loa Loa (eye worm) hypothetical protein 0.005 0.1187 0.0976
Mycobacterium tuberculosis Conserved protein 0.0043 0.0973 0.0918
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.5398 0.7198
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0973 0.0811
Mycobacterium ulcerans lipase LipD 0.0043 0.0973 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0239 0.0086
Schistosoma mansoni hypothetical protein 0.0205 0.6393 1
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.743 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0239 0.0239
Plasmodium falciparum thioredoxin reductase 0.0057 0.1432 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.1004 0.114
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0239 0.0086
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0233 0.0058
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.6393 0.6328
Schistosoma mansoni survival motor neuron protein 0.0048 0.1126 0.1528
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.1242 0.1085
Echinococcus granulosus chromobox protein 1 0.007 0.1855 0.2314
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0925 0.1115
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0239 0.0086
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0239 0.0239
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0973 0.0918
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0233 0.0091
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1004 0.133
Onchocerca volvulus 0.0043 0.0973 0.1194
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0973 0.0811
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0239 0.0086
Brugia malayi beta-lactamase family protein 0.0043 0.0973 0.0973
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0239 0.0239
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0973 0.0918
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.1432 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0239 0.0239
Toxoplasma gondii thioredoxin reductase 0.0057 0.1432 1
Mycobacterium ulcerans hypothetical protein 0.0043 0.0973 1
Schistosoma mansoni hypothetical protein 0.0048 0.1126 0.1528
Trichomonas vaginalis chromobox protein, putative 0.007 0.1855 0.1708
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.6393 0.6328
Echinococcus granulosus dna polymerase eta 0.005 0.1187 0.1393
Loa Loa (eye worm) hypothetical protein 0.0043 0.0973 0.0758
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0233 0.1576
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.1242 0.8491
Schistosoma mansoni chromobox protein 0.007 0.1855 0.27
Trypanosoma brucei unspecified product 0.0021 0.0233 0.1576
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0233 0.0078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0239 0.0005
Loa Loa (eye worm) hypothetical protein 0.0022 0.0239 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0825 0.066
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.6393 0.6328
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.1004 0.114
Loa Loa (eye worm) hypothetical protein 0.0031 0.0541 0.0315
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0441 0.0269
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0239 0.0239
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.1432 0.1446
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0177 0.1177
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0973 0.6779
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0825 0.066
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.6393 0.6328
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0239 0.0086
Schistosoma mansoni chromobox protein 0.007 0.1855 0.27
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0239 0.01
Echinococcus multilocularis geminin 0.0205 0.6393 0.857
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.743 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0239 0.0239
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0239 0.0086
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.1432 0.173
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0973 0.0811
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0233 0.0078
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0239 0.0086
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.1242 0.8491
Echinococcus multilocularis chromobox protein 1 0.007 0.1855 0.2314
Loa Loa (eye worm) hypothetical protein 0.0022 0.0239 0.0005
Echinococcus granulosus geminin 0.0205 0.6393 0.857
Leishmania major DNA polymerase eta, putative 0.0035 0.0689 0.4081
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0233 0.0453
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.1004 0.114
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.1432 0.173
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0239 0.0005
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.4381 0.4845
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0239 0.0086
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0973 0.0811
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0233 0.1576
Schistosoma mansoni coup transcription factor 0.0022 0.0239 0.01
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0239 0.01
Mycobacterium tuberculosis Probable reductase 0.013 0.3892 0.4282
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0233 0.1576
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0239 0.0086
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0177 0.1177
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0233 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0239 0.0239
Echinococcus granulosus chromobox protein 1 0.007 0.1855 0.2314
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0239 0.0239
Onchocerca volvulus 0.0043 0.0973 0.1194
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0233 0.1576
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.3509 0.3354
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0233 0.1576
Trichomonas vaginalis chromobox protein, putative 0.007 0.1855 0.1708
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0973 0.0918
Mycobacterium tuberculosis Conserved protein 0.0043 0.0973 0.0918
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1004 0.133
Echinococcus multilocularis dna polymerase eta 0.005 0.1187 0.1393
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0233 0.1576
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0973 0.0811
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0973 1
Leishmania major DNA polymerase kappa, putative 0.0021 0.0233 0.0453
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0973 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0239 0.0239
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.1432 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0233 0.1576
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0239 0.0239
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0825 0.0952
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0973 0.0918
Plasmodium vivax glutathione reductase, putative 0.0057 0.1432 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0239 0.0239
Echinococcus multilocularis chromobox protein 1 0.007 0.1855 0.2314
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0973 0.0918
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0177 0.5
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0239 0.01
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0239 0.0005
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.4381 0.4845
Leishmania major trypanothione reductase 0.0057 0.1432 1
Brugia malayi ecdysteroid receptor 0.0022 0.0239 0.0239
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0239 0.01
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.6393 0.6328
Trypanosoma cruzi DNA polymerase eta, putative 0.005 0.1187 0.805
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.1098 1
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0233 0.0713
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0239 0.0005
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0239 0.01
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0035 0.0689 0.4081
Brugia malayi Thioredoxin reductase 0.0057 0.1432 0.1432
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0239 0.01
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.1432 0.1227
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.6764 0.6706
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.5398 0.8399
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0239 0.01
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0239 0.0005
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.1004 0.1004
Loa Loa (eye worm) hypothetical protein 0.0039 0.0825 0.0606
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0233 0.1576
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0239 0.01
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.6393 0.6328
Loa Loa (eye worm) beta-lactamase 0.0043 0.0973 0.0758
Mycobacterium ulcerans beta-lactamase 0.0043 0.0973 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0239 0.0005
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0233 0.1576
Plasmodium falciparum glutathione reductase 0.0057 0.1432 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0239 0.0005
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0239 0.0086
Brugia malayi chromobox protein homolog 3 0.0039 0.0825 0.0825
Trypanosoma brucei DNA polymerase eta, putative 0.005 0.1187 0.828
Onchocerca volvulus 0.0031 0.0541 0.0491
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1004 0.133
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0973 0.1098
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0233 0.1576
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0239 0.0086
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0925 0.0762
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0233 0.0713
Brugia malayi Heterochromatin protein 1 0.007 0.1855 0.1855
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0973 0.1282
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0239 0.0239
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.3892 0.8565
Brugia malayi hypothetical protein 0.0235 0.743 0.743
Loa Loa (eye worm) hypothetical protein 0.0022 0.0239 0.0005
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.1004 0.0789
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0233 0.0453
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.1098 0.7342
Treponema pallidum NADH oxidase 0.002 0.0177 0.5
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0177 0.1177
Loa Loa (eye worm) hypothetical protein 0.0043 0.0973 0.0758
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.1242 0.1469
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.1855 0.166
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0177 0.5
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.3892 0.4282
Onchocerca volvulus 0.0043 0.0973 0.1194
Brugia malayi glutathione reductase 0.0057 0.1432 0.1432
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0973 0.1282
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.1098 1
Onchocerca volvulus 0.0048 0.1126 0.1442
Trypanosoma brucei trypanothione reductase 0.0057 0.1432 1
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.3892 0.4282
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0973 0.0918
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0973 0.6349
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.3892 0.4282
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0973 0.0973
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.3509 0.3354
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0233 0.1576
Loa Loa (eye worm) hypothetical protein 0.0043 0.0973 0.0758
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0239 0.01
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.1126 0.1126
Loa Loa (eye worm) hypothetical protein 0.0043 0.0973 0.0758
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0239 0.01
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0239 0.0086
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.1242 0.8491
Loa Loa (eye worm) hypothetical protein 0.0235 0.743 0.7369
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0239 0.0239
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0973 0.0758
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0239 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0239 0.0239
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0239 0.01
Loa Loa (eye worm) hypothetical protein 0.0022 0.0239 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.6393 0.6328
Loa Loa (eye worm) hypothetical protein 0.0022 0.0239 0.0005
Brugia malayi nuclear receptor NHR-88 0.0022 0.0239 0.0239
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0925 0.0762
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0233 0.0078
Leishmania major DNA polymerase eta, putative 0.005 0.1187 0.805
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.6764 0.6706
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0239 0.0239
Loa Loa (eye worm) glutathione reductase 0.0057 0.1432 0.1227
Loa Loa (eye worm) acetyltransferase 0.0175 0.5398 0.5288
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0233 0.0066
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0239 0.0086
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0239 0.0086
Brugia malayi ImpB/MucB/SamB family protein 0.005 0.1187 0.1187
Loa Loa (eye worm) hypothetical protein 0.0022 0.0239 0.0005
Schistosoma mansoni hypothetical protein 0.0205 0.6393 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.4381 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0177 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0239 0.0005
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.0689 0.4081
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.1004 0.114
Brugia malayi beta-lactamase 0.0043 0.0973 0.0973
Loa Loa (eye worm) hypothetical protein 0.0043 0.0973 0.0758
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0239 0.0005
Echinococcus granulosus dna polymerase kappa 0.0021 0.0233 0.0078
Leishmania major hypothetical protein, conserved 0.0043 0.0973 0.6349
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0973 0.0918
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.3892 0.4282
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0973 0.6349
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.5398 0.5398
Brugia malayi nuclear hormone receptor 0.0022 0.0239 0.0239
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0233 0.0453
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0239 0.0086
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.8854 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0973 0.1098
Giardia lamblia DINP protein human, muc B family 0.0021 0.0233 0.0617
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.6393 1
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0233 0.1576
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0239 0.01
Trichomonas vaginalis esterase, putative 0.0043 0.0973 0.0811
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0973 0.6349
Brugia malayi beta-lactamase family protein 0.0043 0.0973 0.0973
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0233 0.0453
Mycobacterium tuberculosis Conserved protein 0.0043 0.0973 0.0918
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0239 0.0239
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.3892 0.4282
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0177 0.0177
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0233 0.1576
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0239 0.0086
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.4381 0.4845
Loa Loa (eye worm) hypothetical protein 0.0022 0.0239 0.0005
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0177 0.1177
Toxoplasma gondii ABC1 family protein 0.0043 0.0973 0.6349
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.1242 0.1085
Schistosoma mansoni DNA polymerase eta 0.005 0.1187 0.1625
Loa Loa (eye worm) hypothetical protein 0.0043 0.0973 0.0758
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0233 0.0091
Brugia malayi steroid hormone receptor 0.0022 0.0239 0.0239

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.0596 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (binding) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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