Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | snurportin 1 | No references | |
Homo sapiens | karyopherin (importin) beta 1 | No references | |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0509 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.3712 | 0.3712 |
Schistosoma mansoni | importin beta-1 | 0.0035 | 0.0691 | 0.0691 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.3712 | 1 |
Leishmania major | importin beta-1 subunit, putative | 0.0028 | 0.0509 | 0.5 |
Echinococcus granulosus | importin subunit beta 1 | 0.0035 | 0.0691 | 0.0691 |
Trichomonas vaginalis | importin beta-1, putative | 0.0028 | 0.0509 | 0.5 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0035 | 0.0691 | 0.0691 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0028 | 0.0509 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.3712 | 0.3712 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0035 | 0.0691 | 0.5 |
Brugia malayi | RNA, U transporter 1 | 0.0099 | 0.2465 | 0.6639 |
Plasmodium vivax | importin-beta 2, putative | 0.0035 | 0.0691 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0691 | 0.0691 |
Brugia malayi | Importin beta-1 subunit | 0.0035 | 0.0691 | 0.1861 |
Plasmodium falciparum | importin beta, putative | 0.0035 | 0.0691 | 0.5 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0028 | 0.0509 | 0.5 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0028 | 0.0509 | 0.5 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0035 | 0.0691 | 0.5 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0035 | 0.0691 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.4467 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 3.2944 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 95.2834 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.