Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific demethylase 4A | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0114 | 0.9845 | 0.9845 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0114 | 0.9845 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.9845 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.314 | 0.3189 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.9845 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0043 | 0.0925 | 0.0925 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.9845 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.9845 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.9845 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0114 | 0.9845 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.9845 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0073 | 0.468 | 0.4754 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0043 | 0.0925 | 0.0939 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.9845 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0925 | 0.0939 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0049 | 0.1721 | 0.1721 |
Schistosoma mansoni | jumonji domain containing protein | 0.0092 | 0.7041 | 0.7152 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0925 | 0.0939 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0114 | 0.9845 | 0.9845 |
Schistosoma mansoni | kinase | 0.0058 | 0.2842 | 0.2887 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.9845 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0114 | 0.9845 | 0.9845 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 0.9845 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0043 | 0.0925 | 0.0925 |
Echinococcus granulosus | jumonji domain containing protein | 0.0049 | 0.1721 | 0.1721 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.9845 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0114 | 0.9845 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.9845 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0043 | 0.0925 | 0.0925 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0114 | 0.9845 | 1 |
Giardia lamblia | Kinase, PLK | 0.0114 | 0.9845 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.7444 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.